Displaying drugs 3676 - 3700 of 11743 in total
Silodosin
Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α1A subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α1A subtype accounts for approximately 75% of α1-adrenoceptors in the prostate. Silodosin was first approved by...
Approved
Matched Description: … Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α1Aa …
Brincidofovir
Brincidofovir is an oral antiviral drug used in the treatment of human smallpox infections. It is a lipid conjugate pro-drug of the acyclic nucleotide analogue cidofovir[L34404,A235725] - this lipid conjugate improves drug delivery to the target cells and significantly reduces the nephrotoxicity typically associated with cidofovir therapy.[A235725,A235735] Due to its...
Approved
Investigational
Matched Description: … [A235725,A235735] Due to its formulation as a pro-drug brincidofovir also carries a greater bioavailability ... It is a lipid conjugate pro-drug of the acyclic nucleotide analogue [cidofovir][L34404,A235725] - this ... The approval was granted under the agency’s Animal Rule,[L34480] which allows for a drug to be approved …
Tazarotene
Tazarotene, commonly marketed as Tazorac®, Avage®, and Zorac®, is member of the acetylenic class of retinoids. It is a prodrug that is found in topical formulations used in the treatment of various conditons, such as psoriasis, acne, and sun damaged skin (photodamage).
Approved
Investigational
Matched Description: … It is a prodrug that is found in topical formulations used in the treatment of various conditons, such …
Orphenadrine
A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Approved
Matched Description: … A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm …
Ketotifen
Ketotifen is a benzocycloheptathiophene derivative with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine. Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis. In the...
Approved
Matched Description: … Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell ... It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and ... ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a …
Amphiachyris dracunculoides pollen
Amphiachyris dracunculoides pollen is the pollen of the Amphiachyris dracunculoides plant. Amphiachyris dracunculoides pollen is mainly used in allergenic testing.
Approved
Opicapone
Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) experience motor complications over time, which calls for the management...
Approved
Investigational
Matched Description: … dopamine agonist, a monoamine oxidase B inhibitor (selegiline, rasagiline), a _catechol-O-methyl transferase ... (COMT)_ inhibitor, or amantadine, or using a modified-release formulation of levodopa. ... [A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase …
Etranacogene dezaparvovec
Hemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX. Clotting factors, including factor IX, are necessary components of the signaling cascade responsible for blood clotting and subsequent wound healing. Symptoms of hemophilia...
Approved
Investigational
Matched Description: … The therapy involves a one-time infusion of a viral vector carrying a codon-optimized DNA sequence of ... of hemophilia B that provides a new treatment modality for its patients. ... [L44181] Symptoms of hemophilia B, therefore, involve a heightened susceptibility to bleeding episodes …
Roflumilast
Roflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells like those of the smooth muscle or epithelium. The resultant increase in intracellular cAMP induced by roflumilast's inhibition of PDE4...
Approved
Matched Description: … Roflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. ... [A251385] PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme ... [L46541] On December 15, 2023, the FDA approved a new topical foam formulation of roflumilast for the …
Bacillus calmette-guerin substrain russian BCG-I live antigen
Bacillus Calmette-Guerin (BCG) substrain Russian BCG-I is a live BCG vaccine administered directly into the bladder for the adjuvant treatment of papillary urothelial cell carcinoma of the bladder. Live BCG vaccines administered intravesically have been a gold standard therapy in the adjuvant treatment of non-muscle-invasive bladder cancers for decades, used...
Approved
Matched Description: … Bacillus Calmette-Guerin (BCG) substrain Russian BCG-I is a live BCG vaccine administered directly into ... Live BCG vaccines administered intravesically have been a gold standard therapy in the adjuvant treatment ... bladder cancers for decades,[A232264] used after tumor resection, and are thought to work by stimulating a …
Gluconolactone
Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-gluconic acid. Pure gluconolactone is a white odorless crystalline powder.
Approved
Experimental
Matched Description: … Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing ... It is a cyclic ester of D-gluconic acid. Pure gluconolactone is a white odorless crystalline powder. …
Benazepril
Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor .
Approved
Investigational
Matched Description: … Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive ... cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a …
Influenza B virus B/Hubei-Wujiagang/158/2009 BX-39 antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Hard fat
Approved
Cladribine
Cladribine is a purine analogue or a chlorinated derivative of adenine that causes apoptosis of B and T lymphocytes. Cladribine was first approved in the United States in 1993 initially as a treatment for a number of hematological malignancies; currently, it is approved for the treatment of hairy cell leukemia....
Approved
Investigational
Matched Description: … Cladribine is a purine analogue or a chlorinated derivative of adenine [A263733] that causes apoptosis ... [A350] Cladribine was first approved in the United States in 1993 [A263713] initially as a treatment ... for a number of hematological malignancies; currently, it is approved for the treatment of hairy cell …
Nusinersen
An antisense oligonucleotide that induces survival motor neuron (SMN) protein expression, it was approved by the U.S. FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy (SMA). It is adminstrated as direct intrathecal injection.
Approved
Investigational
Galsulfase
Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate...
Approved
Investigational
Matched Description: … Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. ... Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant ... comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a …
Desvenlafaxine
Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271]
MDD is a highly...
Approved
Investigational
Matched Description: … [L6016,A261271]
MDD is a highly prevalent psychiatric disorder, with a lifetime prevalence estimate ... [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine …
Samidorphan
Olanzapine is an effective atypical antipsychotic that, like other antipsychotics, is associated with weight gain, metabolic dysfunction, and increased risk of type II diabetes.[A235638, A235643] Samidorphan is a novel opioid antagonist structurally related to naltrexone, with a higher affinity for opioid receptors, more potent μ-opioid receptor antagonism, higher oral bioavailability,...
Approved
Investigational
Matched Description: … , and a longer half-life, making it an attractive candidate for oral dosing. ... [A235638, A235643] Samidorphan is a novel opioid antagonist structurally related to [naltrexone], with ... [A235638, A235643]
Samidorphan was first approved as a variety of fixed-dose combination tablets with …
Silodrate
Approved
Experimental
Bordetella pertussis pertactin antigen
Bordetella pertussis pertactin antigen is a vaccine for the prophylaxis of whooping cough that contains pertactin, a membrane-associated antigen of Bordetella pertussis .
Approved
Investigational
Matched Description: … pertactin, a membrane-associated antigen of Bordetella pertussis [A31248]. ... Bordetella pertussis pertactin antigen is a vaccine for the prophylaxis of whooping cough that contains …
Paricalcitol
Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
Approved
Investigational
Matched Description: … Paricalcitol is a synthetic vitamin D analog. …
Quercus muehlenbergii pollen
Quercus muehlenbergii pollen allergenic extract is used in allergenic testing.
Approved
Displaying drugs 3676 - 3700 of 11743 in total