Displaying drugs 15276 - 15296 of 15296 in total
Rivipansel
Rivipansel has been used in trials studying the other, basic science, and treatment of Pain Crisis, Renal impairment, Anemia, Sickle Cell, Sickle Cell Disease, and Sickle Cell Disorders, among others.
Investigational
Matched Iupac: … (2S)-2-{[(2R,3R,4S,5S,6R)-3-(benzoyloxy)-2-{[(1R,2R,3S,5R)-3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine- ... 4-amido)-2-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-5-({2-[2-(2-{[(3,6,8-trisulfonaphthalen ... ]methoxy}ethoxy)acetamido]ethyl}carbamoyl)cyclohexyl]oxy}-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-3- …
Matched Description: … Rivipansel has been used in trials studying the other, basic science, and treatment of Pain Crisis, Renal …
Matched Salts cas: … 1189037-60-2 …
Matched Description: … Rivipansel has been used in trials studying the other, basic science, and treatment of Pain Crisis, Renal …
Matched Salts cas: … 1189037-60-2 …
Ronacaleret
Ronacaleret is a calcium-sensing receptor antagonist.
Investigational
Matched Iupac: … 3-{3-[(2R)-3-{[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropoxy]-4,5-difluorophenyl …
Matched Description: … Ronacaleret is a calcium-sensing receptor antagonist. …
Matched Salts cas: … 702686-96-2 …
Matched Description: … Ronacaleret is a calcium-sensing receptor antagonist. …
Matched Salts cas: … 702686-96-2 …
Vaniprevir
Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C Virus Infection.
Investigational
Matched Iupac: … (1R,21S,24S)-21-tert-butyl-N-[(1R,2R)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethylcyclopropyl]-16,16-dimethyl …
Matched Description: … Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis ... C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C Virus Infection …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis ... C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C Virus Infection …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
VTX-801
VTX-801 is a replication-deficient recombinant adeno-associated viral vector (rAAV) consisting of an AAV liver tropic capsid containing a single-stranded DNA genome carrying a shortened version of the ATP7B gene (ATP7B-minigene). It is being investigated in Wilson Disease.
Investigational
Matched Description: … It is being investigated in Wilson Disease.[L45924] ... AAV liver tropic capsid containing a single-stranded DNA genome carrying a shortened version of the ATP7B ... VTX-801 is a replication-deficient recombinant adeno-associated viral vector (rAAV) consisting of an …
Onatasertib
Onatasertib (CC-223) has been used in trials studying the treatment and basic science of Multiple Myeloma, Glioblastoma Multiforme, HepatoCellular Carcinoma, Non-small Cell Lung Cancer, and Diffuse Large B-Cell Lymphoma, among others.
Investigational
Matched Iupac: … 7-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-1-[(1r,4r)-4-methoxycyclohexyl]-1H,2H,3H,4H-pyrazino[2,3-b][ ... 1,4]diazin-2-one …
Matched Description: … Onatasertib (CC-223) has been used in trials studying the treatment and basic science of Multiple Myeloma …
Matched Description: … Onatasertib (CC-223) has been used in trials studying the treatment and basic science of Multiple Myeloma …
Ontuxizumab
Ontuxizumab is a humanized monoclonal antibody that targets endosialin or tumour endothelial marker 1 (TEM-1). It is under investigation in clinical trial NCT01574716 (Sarcoma Study of Morab-004 Utilization: Research and Clinical Evaluation).
Investigational
Matched Description: … Ontuxizumab is a humanized monoclonal antibody that targets endosialin or tumour endothelial marker 1 ... It is under investigation in clinical trial NCT01574716 (Sarcoma Study of Morab-004 Utilization: Research …
ONT-093
ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.
Investigational
Matched Iupac: … 4-(2-{4-[(1E)-3-ethoxyprop-1-en-1-yl]phenyl}-4-{4-[(propan-2-yl)amino]phenyl}-1H-imidazol-5-yl)-N-(propan ... -2-yl)aniline …
Matched Description: … In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations …
Matched Description: … In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations …
Difloxacin
Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced efficacy when compared to other fluoroquinolone antibacterials.
Vet approved
Matched Iupac: … 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid …
Matched Description: … Difloxacin is a synthetic fluoroquinolone used in veterinary. ... However, it presents a reduced efficacy when compared to other fluoroquinolone antibacterials. ... As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Difloxacin is a synthetic fluoroquinolone used in veterinary. ... However, it presents a reduced efficacy when compared to other fluoroquinolone antibacterials. ... As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Onapristone
Onapristone has been used in trials studying the treatment of Prostate Cancer, Recurrent Prostate Cancer, Metastatic Prostate Cancer, Androgen-independent Prostate Cancer, and Progesterone Receptor Positive Tumor: Max 1 Line of Prior Chemotherapy, no Prior Hormone Therapy.
Investigational
Matched Iupac: … (10S,11S,14S,15R,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-14-(3-hydroxypropyl)-15-methyltetracyclo …
Matched Description: … Onapristone has been used in trials studying the treatment of Prostate Cancer, Recurrent Prostate Cancer …
Matched Description: … Onapristone has been used in trials studying the treatment of Prostate Cancer, Recurrent Prostate Cancer …
Deferitazole
Deferitazole is an iron chelator. It has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment, Impaired Renal Function, Transfusional Iron Overload, and Iron Overload Due to Repeated Red Blood Cell Transfusions.
Investigational
Matched Iupac: … (4S)-2-(2-hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-4-methyl-4,5-dihydro-1,3-thiazole-4- …
Matched Description: … It has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment …
Matched Description: … It has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment …
Stepronin
Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as well as the presence of disulfide bonds between these macromolecules and DNA.
Experimental
Matched Iupac: … 2-[2-(thiophene-2-carbonylsulfanyl)propanamido]acetic acid …
Matched Description: … Strepronin is a mucolytic drug. ... The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as ... A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties …
Matched Description: … Strepronin is a mucolytic drug. ... The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as ... A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties …
Dimenoxadol
Dimenoxadol is an opioid analgesic which produces typical opioid effects such as analgesia and sedation. It is structurally similar to methadone and is a benzilic acid derivative. In the United States it is classified as a Schedule I controlled drug.
Experimental
Illicit
Matched Iupac: … 2-(dimethylamino)ethyl 2-ethoxy-2,2-diphenylacetate …
Matched Description: … In the United States it is classified as a Schedule I controlled drug. ... It is structurally similar to methadone and is a benzilic acid derivative. …
Matched Description: … In the United States it is classified as a Schedule I controlled drug. ... It is structurally similar to methadone and is a benzilic acid derivative. …
Brifentanil
Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. This drug is classified as an opioid analgesic and was developed in the early 1990s. The effects of brifentanil are very similar to those of alfentanil, with strong but short lasting analgesia and sedation, and particularly notable...
Illicit
Matched Iupac: … N-[(3R,4S)-1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-N- ... (2-fluorophenyl)-2-methoxyacetamide …
Matched Description: … Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. ... This drug is classified as an opioid analgesic and was developed in the early 1990s. …
Matched Description: … Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. ... This drug is classified as an opioid analgesic and was developed in the early 1990s. …
Merbromin
Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, except Switzerland, France, Germany, and the United States where the drug was withdrawn from market due to the possibility...
Experimental
Matched Iupac: … disodium [2,7-dibromo-9-(2-carboxylatophenyl)-6-oxido-3-oxo-3H-xanthen-5-yl]mercurol …
Matched Description: … It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, ... Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Matched Description: … It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, ... Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Zilpaterol
Zilpaterol is a β2 adrenergic agonist sold under the trade name, Zilmax, produced by Intervet, a subsidiary of Merck & Co. Zilpaterol is typically fed to cattle in the last three to six weeks of life with a brief washout period to clear the drug from the tissues before slaughter.
Vet approved
Matched Iupac: … (9R,10R)-9-hydroxy-10-[(propan-2-yl)amino]-1,3-diazatricyclo[6.4.1.0^{4,13}]trideca-4,6,8(13)-trien-2 …
Matched Description: … Zilpaterol is typically fed to cattle in the last three to six weeks of life with a brief washout period ... Zilpaterol is a β2 adrenergic agonist sold under the trade name, Zilmax, produced by Intervet, a subsidiary …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Zilpaterol is typically fed to cattle in the last three to six weeks of life with a brief washout period ... Zilpaterol is a β2 adrenergic agonist sold under the trade name, Zilmax, produced by Intervet, a subsidiary …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Nebicapone
Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg).
Investigational
Matched Iupac: … 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethan-1-one …
Matched Description: … Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state ... on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose ... of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg). …
Matched Description: … Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state ... on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose ... of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg). …
S-Hydroxycysteine
S-hydroxycysteine is a solid. This compound belongs to the alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. It targets the proteins subtilisin BPN', glutathione S-transferase A1,...
Experimental
Matched Iupac: … (2R)-2-amino-3-(hydroxysulfanyl)propanoic acid …
Matched Description: … These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to ... the carboxylate group (alpha carbon), or a derivative thereof. ... S-hydroxycysteine is a solid. This compound belongs to the alpha amino acids and derivatives. …
Matched Description: … These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to ... the carboxylate group (alpha carbon), or a derivative thereof. ... S-hydroxycysteine is a solid. This compound belongs to the alpha amino acids and derivatives. …
Quaternium-18
Quaternium-18 is a mixture of quaternary ammonium chloride salts. Quaternium-18 Hectorite and Bentonite are the reaction products of Quaternium-18 with clays. These compounds are poorly absorbed through the skin. Acute oral and percutaneous toxicity tests in animals indicate that they exhibit little or no systemic toxic effects.
Experimental
Matched Description: … Quaternium-18 is a mixture of quaternary ammonium chloride salts. ... Acute oral and percutaneous toxicity tests in animals indicate that they exhibit little or no systemic …
Nelotanserin
Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sleep, the most restorative phase of the sleep cycle, without sacrificing REM...
Investigational
Matched Iupac: … 3-[3-(4-bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-1-(2,4-difluorophenyl)urea …
Matched Description: … Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations ... It is a highly selective antagonist at the 5-HT2A serotonin receptor. ... Nelotanserin works through a mechanism of action that is different from currently marketed drugs. …
Matched Description: … Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations ... It is a highly selective antagonist at the 5-HT2A serotonin receptor. ... Nelotanserin works through a mechanism of action that is different from currently marketed drugs. …
1-Deoxy-D-xylulose 5-phosphate
1-Deoxy-D-xylulose 5-phosphate is a solid. This compound belongs to the pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. The proteins that 1-Deoxy-D-xylulose 5-phosphate targets include 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and pyridoxine 5'-phosphate synthase. 1-Deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway.
Experimental
Matched Description: … reductoisomerase and pyridoxine 5'-phosphate synthase. 1-Deoxy-D-xylulose 5-phosphate is an intermediate in ... 1-Deoxy-D-xylulose 5-phosphate is a solid. This compound belongs to the pentose phosphates. ... These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. …
XAV-19
XAV-19 is an intravenous antibody-based treatment targeted towards SARS-CoV-2 and other coronaviruses[L16553,L16558]. The therapy concept is based on COVID-19 convalescent plasma. However, rather than using human plasma, XAV-19 is a heterologous swine glyco-humanized polyclonal antibody that targets the spike protein of SARS-CoV-2[L16553,L16558]. The therapy offers three beneficial effects: the ability...
Investigational
Matched Description: … As of July, 2020, the company is conducting a Phase 2 randomized clinical trial to define dosing safety ... Hospital to test the treatment in patients[L16553,L16558]. ... that targets the spike protein of SARS-CoV-2[L16553,L16558]. …
Displaying drugs 15276 - 15296 of 15296 in total