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Displaying drugs 326 - 350 of 356 in total
Tetraethylammonium
Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide....
Experimental
Investigational
Matched Description: … , but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium ... common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium …
Matched Categories: … Potassium Channel Blockers …
Matched Categories: … Potassium Channel Blockers …
Clopamide
Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure.
Experimental
Matched Categories: … clopamide and potassium …
Azosemide
Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.
Investigational
Matched Categories: … Sodium Potassium Chloride Symporter Inhibitors …
Canrenone
Canrenone has been used in trials studying the diagnostic of Heart Failure.
Investigational
Matched Categories: … Potassium-Sparing Diuretics …
Istaroxime
Investigational
Matched Categories: … Sodium-Potassium-Exchanging ATPase, antagonists & inhibitors …
Bamocaftor
Bamocaftor (VX-659) is under investigation in clinical trial NCT03224351 (A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis).
Investigational
Matched Salts name: … Bamocaftor potassium …
Linsidomine
Experimental
Matched Categories: … Sodium-Potassium-Exchanging ATPase, antagonists & inhibitors …
Elinogrel
A P2Y12 inhibitor and platelet aggregation inhibitor.
Investigational
Matched Salts name: … Elinogrel potassium …
Volixibat
Volixibat, also known as SHP626 or LUM002, is an investigational drug that will potentially be used for the treatment of Non-Alcoholic Steatohepatitis (NASH). If approved for use, it will be the first available agent for the treatment of NASH.
Volixibat is a selective inhibitor of the apical sodium-dependent bile acid...
Experimental
Investigational
Matched Salts name: … Volixibat potassium …
Saprisartan
Saprisartan is an AT1 receptor antagonist. It is based on medications of losartan's prototypical chemical structure. The mode of (functional) AT1 receptor antagonism has been characterized as insurmountable/noncompetitive for saprisartan. It is very likely that slow dissociation kinetics from the AT1 receptor underlie insurmountable antagonism .
Experimental
Matched Salts name: … Saprisartan potassium …
Vaniprevir
Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C Virus Infection.
Investigational
Matched Salts name: … Vaniprevir potassium …
Tegoprazan
Tegoprazan (also known as CJ-12420) is a novel therapeutic developed by CJ Healthcare Corp for treating acid-related gastrointestinal diseases.[A234215, A234220] This drug is a potent and high-selective potassium-competitive acid blocker (P-CAB) with a fast onset of action and the ability to control gastric pH for a prolonged period of time.[A234215,...
Investigational
Matched Description: … [A234215, A234220] This drug is a potent and high-selective potassium-competitive acid blocker (P-CAB …
Fimasartan
Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the...
Investigational
Matched Salts name: … Fimasartan potassium anhydrous ... Fimasartan potassium trihydrate …
Flupirtine
Flupirtine is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe. It is not approved for use in the U.S. or Canada, but is currently in phase II trials for the treatment of fibromyalgia.
Investigational
Emeramide
Emeramide has been used in trials studying the treatment of Mercury Poisoning.
Investigational
Matched Salts name: … Emeramide Potassium …
Maxy-G34
MAXY-G34 is a pegylated variant of human granulocyte-colony stimulating factor (G-CSF). This variant contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as PEGylation sites, and from which multiple undesired, naturally occurring lysines have been removed as compared to wild type human...
Investigational
Matched Description: … MAXY-G34 is pegylated with 5 kd mPEG SPA (succinimidyl propionate) groups at 3 amino acid residues, including …
Vanoxerine
Vanoxerine is a highly selective dopamine transporter antagonist. It was synthesized in the late 1970s and developed as a potential treatment for depression. Vanoxerine was later evaluated as a potential treatment for cocaine addiction due to its ability to block dopamine reuptake with a slower dissociation rate than cocaine. Although...
Investigational
Matched Description: … anti-arrhythmic and anti-atrial fibrillatory agent due to its ability to block the hKV11.1 (hERG) cardiac potassium …
Tridihexethyl
Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.
Withdrawn
Saccharin
Saccharin has been investigated for the treatment of Hypertension and Hyperglycemia.
Investigational
Matched Salts name: … Saccharin potassium …
Taurochenodeoxycholic acid
Taurochenodeoxycholic acid is an experimental drug that is normally produced in the liver. Its physiologic function is to emulsify lipids such as cholesterol in the bile. As a medication, taurochenodeoxycholic acid reduces cholesterol formation in the liver, and is likely used as a choleretic to increase the volume of bile...
Experimental
Glisoxepide
Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide,...
Investigational
Displaying drugs 326 - 350 of 356 in total