Displaying drugs 4326 - 4350 of 5608 in total
Navitoclax
Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others.
Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of...
Investigational
Matched Synonyms: … -1-Enylmethyl]-Piperazin-1-Yl}-Benzoyl)-3-Trifluoromethanesulfonylbenzenesulfonamide ... (R)-4-(3-Morpholin-4-Yl-1-Phenylsulfanylmethyl-Propylamino)-N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex …
Matched Iupac: … 1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3- …
Matched Description: … Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's ... Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among ... It is a substance being studied in the treatment of lymphomas and other types of cancer. …
Matched Iupac: … 1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3- …
Matched Description: … Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's ... Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among ... It is a substance being studied in the treatment of lymphomas and other types of cancer. …
LDN-193189
Investigational
Matched Synonyms: … 4-(6-(4-(piperazin-1-yl)phenyl_pyrazolo[1,5-a]pyrimidin-3-yl)quinoline ... Quinoline, 4-(6-(4-(1-piperazinyl)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)- …
Matched Iupac: … 4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline …
Matched Iupac: … 4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline …
[3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium
Experimental
Matched Name: … [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium …
Matched Iupac: … N-[3-(dimethyl-oxo-$l^{5}-azanyl)propyl]dodecanamide …
Matched Iupac: … N-[3-(dimethyl-oxo-$l^{5}-azanyl)propyl]dodecanamide …
3'-Phosphate-Adenosine-5'-Diphosphate
Experimental
Matched Name: … 3'-Phosphate-Adenosine-5'-Diphosphate …
Matched Iupac: … )oxy]phosphonic acid ... [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl …
Matched Iupac: … )oxy]phosphonic acid ... [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl …
Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Experimental
Matched Name: … Di-Stearoyl-3-Sn-Phosphatidylethanolamine …
Matched Iupac: … (2-aminoethoxy)[(2S)-2,3-bis(octadecanoyloxy)propoxy]phosphinic acid …
Matched Iupac: … (2-aminoethoxy)[(2S)-2,3-bis(octadecanoyloxy)propoxy]phosphinic acid …
3-(Benzyloxy)Pyridin-2-Amine
Experimental
Matched Name: … 3-(Benzyloxy)Pyridin-2-Amine …
Matched Iupac: … 3-(benzyloxy)pyridin-2-amine …
Matched Iupac: … 3-(benzyloxy)pyridin-2-amine …
3-Aza-2,3-Dihydrogeranyl Diphosphate
Experimental
Matched Name: … 3-Aza-2,3-Dihydrogeranyl Diphosphate …
Matched Iupac: … ({2-[methyl(4-methylpent-3-en-1-yl)amino]ethyl phosphonato}oxy)phosphonate …
Matched Iupac: … ({2-[methyl(4-methylpent-3-en-1-yl)amino]ethyl phosphonato}oxy)phosphonate …
2',3'-Dideoxycytidine-5'-Monophosphate
Experimental
Matched Name: … 2',3'-Dideoxycytidine-5'-Monophosphate …
Matched Iupac: … {[(2S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid …
Matched Iupac: … {[(2S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid …
3-Amino-6-Hydroxy-Tyrosine
Experimental
Matched Name: … 3-Amino-6-Hydroxy-Tyrosine …
Matched Iupac: … (2S)-2-amino-3-(5-amino-2,4-dihydroxyphenyl)propanoic acid …
Matched Iupac: … (2S)-2-amino-3-(5-amino-2,4-dihydroxyphenyl)propanoic acid …
4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline
Experimental
Matched Name: … 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline …
Matched Iupac: … 6,7-dimethoxy-N-[3-(methylsulfanyl)phenyl]quinazolin-4-amine …
Matched Iupac: … 6,7-dimethoxy-N-[3-(methylsulfanyl)phenyl]quinazolin-4-amine …
Di-Stearoyl-3-Sn-Phosphatidylcholine
Experimental
Matched Name: … Di-Stearoyl-3-Sn-Phosphatidylcholine …
Matched Iupac: … [(2R)-2,3-bis(octadecanoyloxy)propoxy][2-(trimethylazaniumyl)ethoxy]phosphinic acid …
Matched Iupac: … [(2R)-2,3-bis(octadecanoyloxy)propoxy][2-(trimethylazaniumyl)ethoxy]phosphinic acid …
(3s)-2,3,4,5-Tetrahydropyridin-3-Amine
Experimental
Matched Name: … (3s)-2,3,4,5-Tetrahydropyridin-3-Amine …
Matched Iupac: … (3R)-2,3,4,5-tetrahydropyridin-3-amine …
Matched Iupac: … (3R)-2,3,4,5-tetrahydropyridin-3-amine …
2-(3-OXO-PROPYLSULFANYLCARBONYL)-ETHANETHIOLATE
Experimental
Matched Name: … 2-(3-OXO-PROPYLSULFANYLCARBONYL)-ETHANETHIOLATE …
Matched Iupac: … {3-oxo-3-[(3-oxopropyl)sulfanyl]propyl}sulfanide …
Matched Iupac: … {3-oxo-3-[(3-oxopropyl)sulfanyl]propyl}sulfanide …
[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL
Experimental
Matched Name: … [HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL …
Matched Iupac: … [N-hydroxy-N-(3-phenylpropyl)amino]methanol …
Matched Iupac: … [N-hydroxy-N-(3-phenylpropyl)amino]methanol …
1,3-bis-([3-[3-[3-(4-{3-[3-nitro-5-(galactopyranosyloxy)-benzoylamino]-propyl}-piperazin-1-yl)-propylamino-3,4-dioxo-cyclobutenyl]-amino-propoxy-ethoxy-ethoxy]-propyl-]amino-carbonyloxy)-2-amino-propane
Experimental
Matched Name: … 1,3-bis-([3-[3-[3-(4-{3-[3-nitro-5-(galactopyranosyloxy)-benzoylamino]-propyl}-piperazin-1-yl)-propylamino ... -3,4-dioxo-cyclobutenyl]-amino-propoxy-ethoxy-ethoxy]-propyl-]amino-carbonyloxy)-2-amino-propane …
Matched Iupac: … -1-carboximidic acid ... (Z)-N-[3-(4-{3-[(2-{14-[(E)-[(2-amino-3-{[(E)-{3-[2-(2-{3-[(2-{[3-(4-{3-[(Z)-[hydroxy(3-nitro-5-{[(2R ... ,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methylidene]amino]propyl}piperazin ... ]oxy}propoxy)(hydroxy)methylidene]amino]-5,8,11-trioxa-1-azatetradecan-1-yl}-3,4-dioxocyclobut-1-en-1 ... -1-yl)propyl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]propoxy}ethoxy)ethoxy]propyl}-C-hydroxycarbonimidoyl …
Matched Iupac: … -1-carboximidic acid ... (Z)-N-[3-(4-{3-[(2-{14-[(E)-[(2-amino-3-{[(E)-{3-[2-(2-{3-[(2-{[3-(4-{3-[(Z)-[hydroxy(3-nitro-5-{[(2R ... ,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methylidene]amino]propyl}piperazin ... ]oxy}propoxy)(hydroxy)methylidene]amino]-5,8,11-trioxa-1-azatetradecan-1-yl}-3,4-dioxocyclobut-1-en-1 ... -1-yl)propyl]amino}-3,4-dioxocyclobut-1-en-1-yl)amino]propoxy}ethoxy)ethoxy]propyl}-C-hydroxycarbonimidoyl …
Magrolimab
Magrolimab is under investigation in clinical trial NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer).
Investigational
Matched Synonyms: … Immunoglobulin g4-kappa, anti-(homo sapiens cd47 (integrin associated protein, iap, mer6, oa3)), monoclonal ... antibodygamma4 heavy chain (1-444) (vh (homo sapiens ighv1-3*01 (87.8%)-(ighd)-ighj4*01 (100%)) (8.8.10 …
Matched Description: … NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Proteins ... Blood Proteins …
Matched Description: … NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Proteins ... Blood Proteins …
CHF-6333
Investigational
Matched Synonyms: … (r)-2-(5-cyano-2-(6-(methoxycarbonyl)-7-methyl-3-oxo-8-(3-(trifluoromethyl)phenyl)-2,3,5,8-tetrahydro ... (r)-2-(5-cyano-2-(6-(methoxycarbonyl)-7-methyl-3-oxo-8-(3-(trifluoromethyl)phenyl)-2,3,5,8-tetrahydro ... oxo-8-(3-(trifluoromethyl)phenyl)-1,2,4-triazolo(4,3-a)pyrimidin-5-yl)-, methanesulfonate (1:1) …
Matched Iupac: … (2-{5-cyano-2-[(5R)-6-(methoxycarbonyl)-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-2H,3H,5H,8H-[1,2,4 …
Matched Iupac: … (2-{5-cyano-2-[(5R)-6-(methoxycarbonyl)-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-2H,3H,5H,8H-[1,2,4 …
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
Experimental
Matched Name: … 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide …
Matched Iupac: … 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide …
Matched Iupac: … 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide …
1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one
Experimental
Matched Name: … 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one …
Matched Iupac: … 1-{3-oxo-3-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]propyl}-3-phenyl-1,2-dihydroquinoxalin-2-one …
Matched Iupac: … 1-{3-oxo-3-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]propyl}-3-phenyl-1,2-dihydroquinoxalin-2-one …
Dasabuvir
Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Synonyms: … Sodium 3-(3-tert-butyl-4-methoxy-5-{6 [(methylsulfonyl)amino]naphthalene-2-yl}phenyl)-2,6-dioxo-3,6 ... N-{6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide …
Matched Iupac: … N-{6-[3-tert-butyl-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide …
Matched Description: … categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and ... [DB00503] for genotype 1b and with [DB00811] for genotype 1a of Hepatitis C [L852]. ... Dasabuvir is a non-nucleoside NS5B inhibitor which binds to the palm domain of NS5B and induces a conformational …
Matched Categories: … dasabuvir, ombitasvir, paritaprevir and ritonavir …
Matched Iupac: … N-{6-[3-tert-butyl-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide …
Matched Description: … categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and ... [DB00503] for genotype 1b and with [DB00811] for genotype 1a of Hepatitis C [L852]. ... Dasabuvir is a non-nucleoside NS5B inhibitor which binds to the palm domain of NS5B and induces a conformational …
Matched Categories: … dasabuvir, ombitasvir, paritaprevir and ritonavir …
Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate
This solid compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids. This substance targets the protein interleukin-2.
Experimental
Matched Synonyms: … Methyl N-{[(3R)-1-carbamimidoyl-3-piperidinyl]acetyl}-4-(phenylethynyl)-L-phenylalaninate …
Matched Name: … Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate …
Matched Iupac: … methyl (2S)-2-{2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetamido}-3-[4-(2-phenylethynyl)phenyl]propanoate …
Matched Description: … This substance targets the protein interleukin-2. …
Matched Name: … Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate …
Matched Iupac: … methyl (2S)-2-{2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetamido}-3-[4-(2-phenylethynyl)phenyl]propanoate …
Matched Description: … This substance targets the protein interleukin-2. …
5-[Bis(2-bromoethyl)amino]-N-(2,3-dioxopropyl)-2,4-dinitrobenzamide
Experimental
Matched Synonyms: … 2,4-Dinitro,5-[bis(2-bromoethyl)amino]-N-(2',3'-dioxopropyl)benzamide …
methyl L-phenylalaninate
Experimental
Matched Synonyms: … Methyl 3-phenyl-L-alaninate …
Matched Iupac: … methyl (2S)-2-amino-3-phenylpropanoate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Aromatic …
Matched Iupac: … methyl (2S)-2-amino-3-phenylpropanoate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Aromatic …
Lenvatinib
Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular...
Approved
Investigational
Matched Synonyms: … 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide …
Matched Iupac: … 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide …
Matched Description: … and 4; the platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. ... addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, ... differentiation, and in pathogenic angiogenesis, lymphogenesis, tumour growth and cancer progression …
Matched Salts cas: … 857890-39-2 …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Protein Kinase Inhibitors …
Matched Iupac: … 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide …
Matched Description: … and 4; the platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. ... addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, ... differentiation, and in pathogenic angiogenesis, lymphogenesis, tumour growth and cancer progression …
Matched Salts cas: … 857890-39-2 …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Protein Kinase Inhibitors …
Displaying drugs 4326 - 4350 of 5608 in total