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Displaying drugs 76 - 100 of 106 in total

Sipuleucel-T

Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared specifically for each patient. In metastatic prostate cancer,...
Approved
Investigational
Matched Description: … Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase ... Food and Drug Administration (FDA) on April 29, 2010, to treat asymptomatic or minimally symptomatic ... Sipuleucel-T is a personalized, autologous, cellular immunotherapy. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Moxetumomab pasudotox

CD22 is a lineage-restricted B-cell antigen that is expressed solely in on B-chronic lymphocytic leukemia, hairy cell leukemia, acute lymphocytic leukemiathe and Burkitt's lymphoma. The predecessor of Moxetumab pasudotox (MxP), named BL22, was first created based on the antibody RFB4 which specifically binds to CD22. This antibody was used to...
Approved
Investigational
Matched Description: … This antibody was used to generate a recombinant immunotoxin in which a stabilized Fv segment by a disulfide ... CD22 is a lineage-restricted B-cell antigen that is expressed solely in on B-chronic lymphocytic leukemia ... , hairy cell leukemia, acute lymphocytic leukemiathe and Burkitt's lymphoma. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Belatacept

Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Investigational
Matched Description: … antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin ... and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. ... It is produced through recombinant DNA technology in mammalian CHO cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Tozinameran

The Pfizer-BioNTech COVID-19 vaccine (also known as BNT162b2, Tozinameran, and Comirnaty), is one of four advanced mRNA-based vaccines developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002,L15007,L36025] Comirnaty is a nucleoside modified mRNA (modRNA) vaccine encoding an optimized full-length version of the severe acute respiratory syndrome coronavirus 2...
Approved
Investigational
Matched Description: … Comirnaty is also approved for use as a fourth booster shot in adults 50 years of age and older. ... [A225386] Comirnaty was granted a EUA in the UK on December 2, 2020,[L26676] and in Canada on December ... and BioNTech. …
Matched Categories: … Recombinant Proteins ... Amino Acids, Peptides, and Proteins …

Antihemophilic factor human

Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) and purified from extraneous plasma-derived...
Approved
Matched Description: … Factor VIII, but does not contain the B-domain, which has no known biological function and [DB11607] ... , which is a fully recombinant factor VIII-Fc fusion protein which has an extended half-life compared ... non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential …
Matched Mixtures name: … Haemate P Powder and solvent for solution for injection or infusion ... Wilate 500, 500 IU VWF/500 IU FVIII, Powder and Solvent for Solution for Injection ... Wilate 1000, 1000 IU VWF/1000 IU FVIII, Powder and Solvent for Solution for Injection …
Matched Categories: … Hemophilia A ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250 IU ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 1000 IU …

Blinatumomab

Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed on the surface of...
Approved
Investigational
Matched Description: … recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through ... [A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed ... on the surface of malignant B-cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Gemtuzumab ozogamicin

Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody [FDA Label]. The antibody is specifically...
Approved
Investigational
Matched Description: … Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin ... By binding to the CD33 antigen on tumors, the cytotoxic agent blocks the growth of cancerous cells and ... lower dosing regimen and a different schedule in combination with chemotherapy or on its own [L941]. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Tasonermin

Tasonermin is recombinant soluble form tumor necrosis factor α produced via Escherichia coli cell culture. It was approved for use by the European Medicines Agency in April of 1999 for use as an adjunt to surgery for the subsequent removal of the tumor and in palliative care for irresectable soft...
Approved
Matched Description: … Tasonermin is recombinant soluble form tumor necrosis factor α produced via _Escherichia coli_ ... Medicines Agency in April of 1999 for use as an adjunt to surgery for the subsequent removal of the tumor and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Interferon alfacon-1

Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the...
Approved
Investigational
Matched Description: … Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. ... Four additional amino acid changes were made to facilitate the molecular construction, and a corresponding ... This protein has a molecular weight of 19,434 daltons. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

B7-H3-specific chimeric antigen receptor T cells

Investigational
Matched Synonyms: … chimeric antigen receptor (CAR) modified recombinant T cells targeting B7-H3 ... Autologous chimeric antigen receptor (CAR) T cells targeting B7-H3 ... allogeneic T cells genetically modified to express anti-B7-H3 chimeric antigen receptor (CAR) …
Matched Name: … B7-H3-specific chimeric antigen receptor T cells …

Epidermal Growth Factor Receptor variant III (EGFRvIII) chimeric antigen receptor T cells

Investigational
Matched Synonyms: … Autologous Chimeric Antigen Receptor (CAR) Modified Recombinant T Cells Targeting EGFRvIII …
Matched Name: … Epidermal Growth Factor Receptor variant III (EGFRvIII) chimeric antigen receptor T cells …

Baloramotide

Investigational
Matched Synonyms: … Cancer/testis antigen 1, recombinant ... L antigen family member 2, recombinant ... Cancer testis antigen ny-eso-1 (recombinant human) …

Rozrolimupab

Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies to replace existing anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and the prevention of Hemolytic Disease of Newborns (HDN).
Investigational
Matched Synonyms: … Recombinant human antigen-specific polyclonal antibody (pAb) against RhD antigen expressed in Chinese …
Matched Description: … Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies ... anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Timolumab

Timolumab is a recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human vascular adhesion protein-1 (VAP-1).
Investigational
Matched Synonyms: … recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human vascular adhesion …
Matched Description: … Timolumab is a recombinant, fully-human, IgG4 immunoglobulin with antigen-binding specificity for human …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Lenvervimab

Investigational
Matched Synonyms: … Recombinant hepatitis B human immunoglobulin ... Immunoglobulin g1, anti-(hepatitis b surface antigen) (human monoclonal gc1102 .gamma.1-chain), disulfide ... Hepatitis B virus neutralizing human monoclonal antibody …

Atibuclimab

Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis.
Investigational
Matched Synonyms: … IC14, (RECOMBINANT CHIMERIC MAB AGAINST HUMAN CD14) ... IMMUNOGLOBULIN G4, ANTI-(HUMAN CD14 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL IC14 .GAMMA.4-CHAIN), DISULFIDE …
Matched Description: … Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Lucatumumab

Investigational
Matched Synonyms: … Recombinant anti-CD40 monoclonal antibody …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Otlertuzumab

Otlertuzumab is under investigation in clinical trial NCT01188681 (Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia).
Investigational
Matched Synonyms: … Immunoglobulin, anti-(human cd antigen cd37) (synthetic human-mus musculus fragment tru-016), dimer …
Matched Description: … Otlertuzumab is under investigation in clinical trial NCT01188681 (Safety and Efficacy Study of TRU-016 …
Matched Categories: … Recombinant Proteins ... Amino Acids, Peptides, and Proteins …

VPM1002

The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Synonyms: … Recombinant BCG Vaccine …
Matched Description: … VPM1002 is a recombinant BCG vaccine candidate expressing listeriolysin and deficient in urease that ... This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary ... Currently, this recombinant vaccine has been found to be more efficacious and safer than BCG in preclinical …

Asunercept

Asunercept is under investigation in clinical trial NCT02853565 (A Study of CAN008 for Newly Diagnosed Glioblastoma Multiforme).
Investigational
Matched Synonyms: … FAS ANTIGEN (HUMAN EXTRACELLULAR DOMAIN FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT …
Matched Description: … Asunercept is under investigation in clinical trial NCT02853565 (A Study of CAN008 for Newly Diagnosed …
Matched Categories: … Recombinant Proteins ... Amino Acids, Peptides, and Proteins …

RLYB212

RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia.
Investigational
Matched Synonyms: … Recombinant human IgG monoclonal HPA-1a antibody …
Matched Description: … RLYB212 is a human monoclonal antibody against Antigen-1A Immunoglobulin (HPA-1A). ... It is currently being developed by Rallybio for the prevention of fetal and neonatal alloimmune thrombocytopenia …

VaxSyn

VaxSyn HIV-1 is a recombinant form of the HIV envelope protein gp 160 developed by MicroGeneSys and the National Institute of Allergy and Infectious Diseases (NIAID).
Investigational
Matched Synonyms: … Recombinant gp160 vaccine …
Matched Description: … VaxSyn HIV-1 is a recombinant form of the HIV envelope protein gp 160 developed by MicroGeneSys and the ... National Institute of Allergy and Infectious Diseases (NIAID). …

Acimtamig

Acimtamig is a tetravalent bispecific chimeric anti-human CD30 x anti-human CD16A recombinant antibody construct.
Investigational
Matched Synonyms: … tetravalent bispecific chimeric anti-human CD30 x anti-human CD16A recombinant antibody construct ... region) fusion protein with peptide linker (GGS)3 fusion protein with immunoglobulin anti-(human CD30 antigen …
Matched Description: … Acimtamig is a tetravalent bispecific chimeric anti-human CD30 x anti-human CD16A recombinant antibody …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Verpasep caltespen

Verpasep caltespen is a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7. Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a...
Investigational
Matched Synonyms: … Recombinant fusion protein of Mycobacterium bovis BCG Hsp65 and HPV16 E7 …
Matched Description: … E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen ... Verpasep caltespen is a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from ... Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be …

ALT-801

ALT-801 is under investigation in clinical trial NCT01478074 (ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia).
Investigational
Matched Categories: … Receptors, Antigen ... Recombinant Proteins ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Displaying drugs 76 - 100 of 106 in total