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Displaying drugs 201 - 225 of 279 in total
Filibuvir
Filibuvir has been used in trials studying the treatment of Hepatitis, Hepatitis C, and Chronic Hepatitis C.
Investigational
Matched Categories: … RNA-Dependent RNA Polymerase, antagonists & inhibitors ... RNA Replicase, antagonists & inhibitors …
1-(2-cyclopropylethyl)-3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxy-2(1H)-quinolinone
Experimental
Matched Categories: … RNA-Dependent RNA Polymerase, antagonists & inhibitors ... RNA Replicase, antagonists & inhibitors …
Fitusiran
Fitusiran is under investigation in clinical trial NCT02554773 (An Open-label Extension Study of an Investigational Drug, ALN-AT3SC, in Patients With Moderate or Severe Hemophilia A or B).
Investigational
Matched Categories: … RNA, Antisense ... RNA, Untranslated ... RNA, Small Untranslated …
Revusiran
Revusiran is under investigation in clinical trial NCT02319005 (ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)).
Investigational
Matched Categories: … RNA, Antisense ... RNA, Untranslated ... RNA, Small Untranslated …
Bevasiranib
Bevasiranib is a small interfering RNA (siRNA) targeting vascular endothelial growth factor A (VEGF-A).
Investigational
Matched Description: … Bevasiranib is a small interfering RNA (siRNA) targeting vascular endothelial growth factor A (VEGF-A …
Matched Categories: … RNA, Antisense ... RNA, Untranslated ... RNA, Small Untranslated …
Matched Categories: … RNA, Antisense ... RNA, Untranslated ... RNA, Small Untranslated …
NTLA-2001
NTLA-2001 is a clustered regularly interspaced short palindromic repeats CRISPR/ Cas9-based gene therapy consisting of a single guide RNA targeting the human TTR gene and a messenger RNA encoding Cas9.
Investigational
Matched Description: … targeting the human TTR gene and a messenger RNA encoding Cas9. ... interspaced short palindromic repeats CRISPR/ Cas9-based gene therapy consisting of a single guide RNA …
Matched Categories: … RNA, Untranslated ... RNA, Small Untranslated …
Matched Categories: … RNA, Untranslated ... RNA, Small Untranslated …
Myxopyronin B
Experimental
Matched Categories: … DNA-Directed RNA Polymerases, antagonists & inhibitors …
Lersivirine
Lersivirine has been used in trials studying the treatment of HIV-1.
Investigational
Matched Categories: … RNA-Directed DNA Polymerase …
2'-C-methylcytidine
A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.
Experimental
Matched Description: … and viral RNA-dependent RNA polymerase activity. ... This blocks viral production of HCV RNA and thus viral replication. ... Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation …
Anpocogin
Recombinant nematode anticoagulant protein c2 (rNAPc2) is a specific inhibitor of tissue factor (TF)/factor VIIa complex with novel antithrombotic activity.
Investigational
Valopicitabine
The 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus...
Experimental
Matched Description: … chain elongation and viral RNA-dependent RNA polymerase activity. ... This blocks viral production of HCV RNA and thus viral replication. [from NCI] ... C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA …
TRK-250
TRK-250 is a small interfering RNA agent that targets human transforming growth factor-beta 1 (TGF-β1) messenger RNA.
Investigational
Matched Description: … ) messenger RNA. ... TRK-250 is a small interfering RNA agent that targets human transforming growth factor-beta 1 (TGF-β1 …
Descartes-30
Descartes-30 is an RNA-engineered off-the-shelf allogeneic mesenchymal stem cell (MSC) product developed by Cartesian Therapeutics. The RNA-engineering is performed with Cartesian Therapeutics’ proprietary RNA Armory which is a platform that activates and provides cells with mRNA-based therapeutics.
Investigational
Matched Description: … [L27531] The RNA-engineering is performed with Cartesian Therapeutics’ proprietary RNA Armory which is ... Descartes-30 is an RNA-engineered off-the-shelf allogeneic mesenchymal stem cell (MSC) product developed …
Tagetitoxin
Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.
Experimental
Matched Description: … It preferentially inhibits eukaryotic RNA polymerase. …
Besifovir dipivoxil
Besifovir dipivoxil is a small-molecule orally available inhibitor of the HBV polymerase. The HBV polymerase is the enzyme that catalyzes the production of new RNA from the existing strand of RNA. Besifovir dipivoxil is believed to inhibit viral proliferation by interrupting the replicating machinery of the virus.
Investigational
Matched Description: … RNA. ... The HBV polymerase is the enzyme that catalyzes the production of new RNA from the existing strand of …
MTL-CEBPA
MTL-CEBPA is a SMARTICLES liposomal formulation of MTL-501, a small activating RNA (saRNA) oligonucleotide.
Investigational
Matched Description: … MTL-CEBPA is a SMARTICLES liposomal formulation of MTL-501, a small activating RNA (saRNA) oligonucleotide …
Olezarsen
Olezarsen is an antisense oligonucleotide targeting messenger RNA for apolipoprotein C-III (APOC3).
Investigational
Matched Description: … Olezarsen is an antisense oligonucleotide targeting messenger RNA for apolipoprotein C-III (APOC3). …
STP-707
STP-707 is a small interfering RNA (siRNA) targeting TGF-Beta1 and COX-2 mRNA.
Investigational
Matched Description: … STP-707 is a small interfering RNA (siRNA) targeting TGF-Beta1 and COX-2 mRNA. …
Streptolydigin
Streptolydigin is an antibiotic isolated from culture filtrates of Streptomyces lydicus. It is active against gram-postive bacteria except micrococci.
Experimental
MRT5005
MRT5005 is a human cystic fibrosis transmembrane conductance regulator (hCFTR) messenger RNA (mRNA) complexed with branched polyethyleneimine (bPEI).
Investigational
Matched Description: … MRT5005 is a human cystic fibrosis transmembrane conductance regulator (hCFTR) messenger RNA (mRNA) complexed …
Displaying drugs 201 - 225 of 279 in total