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Displaying drugs 7451 - 7475 of 10527 in total

Triazavirin

Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain.[A191709,A191625,A191916] It appears that Triazavirin has shown promise in reducing influenza disease severity and associated complications. Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating...
Experimental
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pexmetinib

Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab).
Investigational
Matched Iupac: … 3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-[(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-indazol-5- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Iotroxic acid

Iotroxic acid is a contrast medium molecule.
Experimental
Withdrawn
Matched Salts cas: … 68890-05-1 …

Chiniofon

Experimental

K-00546

Experimental
Matched Iupac: … 5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide …

Trestolone acetate

Trestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the C17 acetate ester of DB05830.
Experimental
Matched Iupac: … -4,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1- …

Freselestat

Experimental
Investigational
Matched Iupac: … 2-(5-amino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[(1R,2R)-1-(5-tert-butyl-1,3,4-oxadiazol-2-yl) ... -1-hydroxy-3-methylbutan-2-yl]acetamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

LY-517717

LY517717 is an investigational oral direct inhibitor of activated Factor Xa. It is believed to be Lilly's PMD-3112 (licensed from Amgen).
Investigational
Matched Iupac: … N-[(1R)-2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-2-oxo-1-phenylethyl]-1H-indole-6-carboxamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Ravuconazole

Investigational
Matched Iupac: … 4-{2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl} …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Efrotomycin

Vet approved
Matched Iupac: … -1-yl]butanimidic acid ... yl]oxan-2-yl]-N-[(2E,4E)-7-{3,4-dihydroxy-5-[(1E,3E,5E)-7-hydroxy-6-methyl-7-[(3Z)-1-methyl-2,4-dioxo ... dimethoxy-6-methyloxan-2-yl)oxy]-4-methoxy-6-methyloxan-2-yl}oxy)-5,5-dimethyl-6-[(1E,3E)-penta-1,3-dien-1- ... -1,2,3,4-tetrahydropyridin-3-ylidene]hepta-1,3,5-trien-1-yl]oxolan-2-yl}-6-methoxy-5-methylocta-2,4-dien …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pyridoxamine

Pyridoxamine has been used in trials studying the treatment of Kidney Stones.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Alvelestat

Alvelestat has been investigated for the basic science of Chronic Obstructive Pulmonary Disease.
Investigational
Matched Iupac: … N-[(5-methanesulfonylpyridin-2-yl)methyl]-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-[3-(trifluoromethyl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

CERC-301

Mk 0657 has been used in trials studying the treatment of Major Depressive Disorder.
Investigational
Matched Iupac: … (4-methylphenyl)methyl (3S,4R)-3-fluoro-4-{[(pyrimidin-2-yl)amino]methyl}piperidine-1-carboxylate …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

LY-2886721

LY2886721 has been used in trials studying the basic science of Alzheimer's Disease.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pyroxamide

Pyroxamide has been used in trials studying the treatment of Leukemia, Lymphoma, Small Intestine Cancer, Precancerous Condition, and Myelodysplastic Syndromes, among others.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PF-03814735

PF-03814735 has been used in trials studying the treatment of Solid Tumors.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

X-396

X-396 has been used in trials studying the treatment of Advanced Solid Tumors and Non-small Cell Lung Cancer.
Investigational
Matched Iupac: … 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Neladenoson bialanate

Neladenoson bialanate has been investigated for the treatment of Heart Failure.
Investigational
Matched Iupac: … 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Picloxydine

Experimental
Matched Iupac: … N-(4-chlorophenyl)-N'-(4-{[N'-(4-chlorophenyl)carbamimidamido]methanimidoyl}piperazine-1-carboximidoyl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Valopicitabine

The 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus...
Experimental
Matched Iupac: … (2R,3R,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

ONT-093

ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.
Investigational
Matched Iupac: … 4-(2-{4-[(1E)-3-ethoxyprop-1-en-1-yl]phenyl}-4-{4-[(propan-2-yl)amino]phenyl}-1H-imidazol-5-yl)-N-(propan …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Rivoceranib

Rivoceranib is under investigation in clinical trial NCT02726854 (Apatinib as Second-line Treatment of Advanced Pancreatic Cancer).
Investigational
Matched Iupac: … N-[4-(1-cyanocyclopentyl)phenyl]-2-{[(pyridin-4-yl)methyl]amino}pyridine-3-carboxamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Ensartinib

Ensartinib is under investigation in clinical trial NCT03420508 (Treating Patients With Melanoma and ALK Alterations With Ensartinib).
Investigational
Matched Iupac: … 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-{4-[(3R,5S)-3,5-dimethylpiperazine-1-carbonyl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

ORG-31710

ORG-31710 is a progestational hormone antagonist.
Experimental
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Piroctone

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.
Experimental
Matched Iupac: … 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 7451 - 7475 of 10527 in total