Uses of GnRH agonists.

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Garner C

Uses of GnRH agonists.

J Obstet Gynecol Neonatal Nurs. 1994 Sep;23(7):563-70.

PubMed ID

7996307 [ View in PubMed

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Abstract

Gonadotropin-releasing hormone agonists are a relatively new class of drugs, which, when chronically administered, result in marked reductions in blood levels of testosterone and estrogen. These drugs include leuprolide acetate (Lupron); the first GnRH agonist to be approved in the United States, nafarelin acetate (Synarel); and goserelin acetate (Zoladex). Approved indications for these drugs, depending on the specific agent, include advanced prostate cancer, endometriosis, and precocious puberty. These and other investigational GnRH agonists are also being evaluated in many other diseases, including uterine fibroids, polycystic ovarian disease, breast cancer, fibrocystic breast disease, benign prostatic hypertrophy, and irritable bowel syndrome. Because of their therapeutic potential in many endocrinologic disorders, the GnRH agonists represent one of the most important advances in hormonal therapy in the past few decades. Thus, it appears likely that in the 1990s a greater number of patients will be receiving these agents. This article summarizes the application of GnRH agonist drugs in clinical practice, their side effects, and important information for patient use.

DrugBank Data that Cites this Article

Drugs

Nafarelin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Nafarelin	Gonadotropin-releasing hormone receptor	Protein	Humans	Yes	Agonist	Details
Nafarelin	Putative gonadotropin-releasing hormone II receptor	Protein	Humans	Yes	Agonist	Details