Caffeine analogs: biomedical impact.

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Daly JW

Caffeine analogs: biomedical impact.

Cell Mol Life Sci. 2007 Aug;64(16):2153-69.

PubMed ID

17514358 [ View in PubMed

]

Abstract

Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research. Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the nature and role of adenosine receptors, phosphodiesterases, and calcium release channels in physiological processes. Such xanthines and other caffeine-inspired heterocycles now provide important research tools and potential therapeutic agents for intervention in Alzheimer's disease, asthma, cancer, diabetes, and Parkinson's disease. Such compounds also have activity as analgesics, antiinflammatories, antitussives, behavioral stimulants, diuretics/natriuretics, and lipolytics. Adverse effects can include anxiety, hypertension, certain drug interactions, and withdrawal symptoms.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Caffeine	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Protein	Humans	Unknown	Inhibitor	Details
Caffeine	Ryanodine receptor 1	Protein	Humans	Unknown	Not Available	Details
Theobromine	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Protein	Humans	Unknown	Inhibitor	Details