New members of the chemokine receptor gene family.
Article Details
- CitationCopy to clipboard
Raport CJ, Schweickart VL, Chantry D, Eddy RL Jr, Shows TB, Godiska R, Gray PW
New members of the chemokine receptor gene family.
J Leukoc Biol. 1996 Jan;59(1):18-23.
- PubMed ID
- 8558062 [ View in PubMed]
- Abstract
Chemokines are relatively small peptides with potent chemoattractant and activation activities for leukocytes. Several chemokine receptors have been cloned and characterized and all are members of the G protein-coupled receptor superfamily. Using degenerate oligonucleotides and polymerase chain reaction, we have identified seven novel receptors. Two of these sequences are presented here for the first time. We have shown, with gene mapping studies, that receptors with the highest sequence similarity are closely linked on human chromosomes. This close genetic association suggests a functional relationship as well.