Leukotriene B4 receptor 1
Details
- Name
- Leukotriene B4 receptor 1
- Synonyms
- BLT
- BLT1
- BLTR
- Chemoattractant receptor-like 1
- CMKRL1
- G-protein coupled receptor 16
- GPR16
- LTB4-R 1
- P2RY7
- P2Y purinoceptor 7
- P2Y7
- Gene Name
- LTB4R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006762|Leukotriene B4 receptor 1 MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNL ALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVA RPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAF HLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVV NLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGF VAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
- Number of residues
- 352
- Molecular Weight
- 37556.925
- Theoretical pI
- 11.63
- GO Classification
- FunctionsG-protein coupled peptide receptor activity / leukotriene B4 receptor activity / leukotriene receptor activity / nucleotide bindingProcessesG-protein coupled receptor signaling pathway / immune response / inflammatory response / leukotriene signaling pathway / movement of cell or subcellular component / muscle contraction / neuropeptide signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathwayComponentsintegral component of plasma membrane / membrane raft / plasma membrane
- General Function
- Nucleotide binding
- Specific Function
- Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 20-42 55-75 92-113 139-159 179-199 222-242 269-289
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012433|Leukotriene B4 receptor 1 (LTB4R) ATGAACACTACATCTTCTGCAGCACCCCCCTCACTAGGTGTAGAGTTCATCTCTCTGCTG GCTATCATCCTGCTGTCAGTGGCGCTGGCTGTGGGGCTTCCCGGCAACAGCTTTGTGGTG TGGAGTATCCTGAAAAGGATGCAGAAGCGCTCTGTCACTGCCCTGATGGTGCTGAACCTG GCCCTGGCCGACCTGGCCGTATTGCTCACTGCTCCCTTTTTCCTTCACTTCCTGGCCCAA GGCACCTGGAGTTTTGGACTGGCTGGTTGCCGCCTGTGTCACTATGTCTGCGGAGTCAGC ATGTACGCCAGCGTCCTGCTTATCACGGCCATGAGTCTAGACCGCTCACTGGCGGTGGCC CGCCCCTTTGTGTCCCAGAAGCTACGCACCAAGGCGATGGCCCGGCGGGTGCTGGCAGGC ATCTGGGTGTTGTCCTTTCTGCTGGCCACACCCGTCCTCGCGTACCGCACAGTAGTGCCC TGGAAAACGAACATGAGCCTGTGCTTCCCGCGGTACCCCAGCGAAGGGCACCGGGCCTTC CATCTAATCTTCGAGGCTGTCACGGGCTTCCTGCTGCCCTTCCTGGCTGTGGTGGCCAGC TACTCGGACATAGGGCGTCGGCTACAGGCCCGGCGCTTCCGCCGCAGCCGCCGCACCGGC CGCCTGGTGGTGCTCATCATCCTGACCTTCGCCGCCTTCTGGCTGCCCTACCACGTGGTG AACCTGGCTGAGGCGGGCCGCGCGCTGGCCGGCCAGGCCGCCGGGTTAGGGCTCGTGGGG AAGCGGCTGAGCCTGGCCCGCAACGTGCTCATCGCACTCGCCTTCCTGAGCAGCAGCGTG AACCCCGTGCTGTACGCGTGCGCCGGCGGCGGCCTGCTGCGCTCGGCGGGCGTGGGCTTC GTCGCCAAGCTGCTGGAGGGCACGGGCTCCGAGGCGTCCAGCACGCGCCGCGGGGGCAGC CTGGGCCAGACCGCTAGGAGCGGCCCCGCCGCTCTGGAGCCCGGCCCTTCCGAGAGCCTC ACTGCCTCCAGCCCTCTCAAGTTAAACGAACTGAACTAG
- Chromosome Location
- 14
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q15722 UniProtKB Entry Name LT4R1_HUMAN GenBank Gene ID BC004545 GenAtlas ID LTB4R HGNC ID HGNC:6713 - General References
- Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP: Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. J Biol Chem. 1996 Aug 2;271(31):18363-7. [Article]
- Raport CJ, Schweickart VL, Chantry D, Eddy RL Jr, Shows TB, Godiska R, Gray PW: New members of the chemokine receptor gene family. J Leukoc Biol. 1996 Jan;59(1):18-23. [Article]
- Yokomizo T, Izumi T, Chang K, Takuwa Y, Shimizu T: A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4. [Article]
- Owman C, Nilsson C, Lolait SJ: Cloning of cDNA encoding a putative chemoattractant receptor. Genomics. 1996 Oct 15;37(2):187-94. [Article]
- Kato K, Yokomizo T, Izumi T, Shimizu T: Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J Exp Med. 2000 Aug 7;192(3):413-20. [Article]
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- Gaudreau R, Le Gouill C, Venne MH, Stankova J, Rola-Pleszczynski M: Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. J Biol Chem. 2002 Aug 30;277(35):31567-76. Epub 2002 Jun 20. [Article]