Effects of chronic osteoarthritis pain on neuroendocrine function in men.

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Khoromi S, Muniyappa R, Nackers L, Gray N, Baldwin H, Wong KA, Matheny LA, Moquin B, Rainer A, Hill S, Remaley A, Johnson LL, Max MB, Blackman MR

Effects of chronic osteoarthritis pain on neuroendocrine function in men.

J Clin Endocrinol Metab. 2006 Nov;91(11):4313-8. Epub 2006 Aug 15.

PubMed ID
16912126 [ View in PubMed
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Abstract

CONTEXT: Chronic pain has been associated with elevated cortisol, reduced LH and testosterone (T), and/or augmented circulating or excreted catecholamines. Most endocrine studies have been conducted in patients in whom the potentially confounding effects of depression, inflammatory disease, or coexistent medication use have not been controlled. OBJECTIVE: The objective of the study was to test the hypothesis that chronic pain activates ACTH-cortisol and suppresses LH-T. DESIGN AND SETTING: This was a case control study conducted at a clinical research center. PARTICIPANTS: Participants included 16 opioid-naive men with chronic osteoarthritis pain, aged 35-65 yr with body mass index 20-30 kg/m2, and 12 healthy, opioid- and pain-free men of similar ages and body mass indexes. METHODS: We compared circulating concentrations of ACTH, cortisol, LH, and T derived from every 20-min blood sampling (2000-0800 h), and 24-h urinary excretion of cortisol, epinephrine, norepinephrine, and dopamine. RESULTS: There were no significant differences in mean or integrated concentrations of ACTH, cortisol, LH, or T, or in the corresponding approximate entropy scores in osteoarthritis patients, compared with control subjects. The 0800-h serum LH concentrations were elevated in patients vs. controls (6.42 +/- 1.65 vs. 3.99 +/- 1.54 IU/liter, mean +/- sd, P = 0.02), whereas there were no significant group differences in total or free T, SHBG, cortisol binding globulin, dehydroepiandrosterone sulfate, or urinary cortisol and catecholamines. CONCLUSIONS: These data suggest that neuroendocrine function is not significantly altered in otherwise healthy men with chronic musculoskeletal pain and that prior reports of such hormonal abnormalities may have resulted from the confounding effects of coexistent illness or medication use.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
HydrocortisoneSex hormone-binding globulinProteinHumans
Unknown
Binder
Details
Hydrocortisone aceponateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Hydrocortisone acetateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Hydrocortisone butyrateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Hydrocortisone cypionateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Hydrocortisone phosphateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Hydrocortisone probutateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails
Hydrocortisone valerateSex hormone-binding globulinProteinHumans
Unknown
Not AvailableDetails