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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyIdentification
- Name
- Hydrocortisone
- Accession Number
- DB00741 (APRD01019, DB07886)
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Description
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.7 Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.10,11,12,13,14,15 It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.9
Hydrocortisone was granted FDA approval on 5 August 1952.16
- Structure
Structure for Hydrocortisone (DB00741)
- Synonyms
- (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione
- 11beta-hydrocortisone
- 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
- 11β-hydrocortisone
- 17-Hydroxycorticosterone
- 4-pregnen-11β,17α,21-triol-3,20-dione
- Cortisol
- Hidrocortisona
- Hydrocortisone
- Hydrocortisonum
- Kendall's compound F
- Reichstein's substance M
- External IDs
- NSC-10483
- Product Images
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Unlock Additional DataA-hydrocort Inj 1000mg/8ml Powder, for solution Intramuscular; Intravenous Hospira Healthcare Ulc 1993-12-31 2012-08-03 Canada 
A-hydrocort Inj 100mg/2ml Powder, for solution Intramuscular; Intravenous Hospira Healthcare Ulc 1992-12-31 2012-08-03 Canada A-hydrocort Inj 250mg/2ml Powder, for solution Intramuscular; Intravenous Hospira Healthcare Ulc 1992-12-31 2012-08-03 Canada A-hydrocort Inj 500mg/4ml Powder, for solution Intramuscular; Intravenous Hospira Healthcare Ulc 1992-12-31 2012-08-03 Canada Aquacort Lotion 2.5% Lotion Topical Merit Industries Inc. 1992-12-31 2002-05-14 Canada Barriere HC 1% Cream; Jelly Topical Allen & Hanburys A Glaxo Canada Ltd. Co. 1979-12-31 1998-07-29 Canada Cortate Crm 1% Cream Topical Schering Plough 1980-12-31 2013-07-31 Canada Cortate Ont 1% Ointment Topical Schering Plough 1980-12-31 2013-07-31 Canada Cortef Tablet 5 mg/1 Oral Pharmacia and Upjohn Company LLC 1952-12-15 Not applicable US 
Cortef Tablet 5 mg/1 Oral Physicians Total Care, Inc. 1952-12-15 2001-06-30 US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
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- Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Unlock Additional DataAlacort Cream 25 mg/1g Topical Crown Laboratories 2016-01-06 Not applicable US Alacort Cream 10 mg/1g Topical Crown Laboratories 1973-03-09 Not applicable US Anusol HC Cream 25 mg/1g Topical Salix Pharmaceuticals 1984-06-06 Not applicable US Colocort Suspension 100 mg/60mL Rectal Paddock Laboratories, LLC 1999-12-31 Not applicable US Home PapKit Cream 25 mg/1g Topical International Brand Management, Llc 2016-09-15 Not applicable US Hydrocortisone Ointment 25 mg/1g Topical Perrigo New York Inc 2006-06-13 Not applicable US Hydrocortisone Cream 25 mg/1g Topical Actavis Pharma, Inc. 2002-09-30 Not applicable US Hydrocortisone Cream 25 mg/1g Topical A S Medication Solutions 2002-09-30 Not applicable US Hydrocortisone Tablet 10 mg/1 Oral Hikma Pharmaceuticals USA Inc. 2015-02-23 2017-04-30 US Hydrocortisone Tablet 20 mg/1 Oral Physicians Total Care, Inc. 2007-07-05 Not applicable US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Unlock Additional Data1% Hydrocortisone Cream 1 g/100g Topical Yuyao Jessie Commodity Co.,Ltd. 2015-12-01 Not applicable US 999 Itch Relieving Ointment 1 g/100g Topical Guangdong CR. Shunfeng Pharmaceutical Co Ltd 1989-07-20 Not applicable US 999 Itch Relieving Ointment 1 g/100g Topical Guangdong CR. Shunfeng Pharmaceutical Co Ltd 1989-07-20 Not applicable US Advanced Hydrocortisone Cream 10 mg/1g Topical Ultra Seal Corporation 2011-04-05 Not applicable US AFASSCO 1% Hydrocortisone Ointment 0.01 g/1g Topical Afassco Inc. 2018-12-07 Not applicable US Aloe Cort Cream 0.57 g/57g Topical Topiderm, Inc. 1990-02-27 Not applicable US Aloe Cort Calming Cream Cream 1 g/100mL Topical USRX LLC 2019-07-08 Not applicable US Ana Cool Rapid Soothing Cooling Formula Cream 10 mg/1g Topical Ana-Cool, LLC 2015-11-25 Not applicable US Anti Itch Lotion 1 g/100g Topical Walgreen Company 2012-03-27 2018-05-11 US Anti Itch Cream 1 g/100g Topical Meijer Distribution Inc 2018-12-20 Not applicable US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Acetasol HC Hydrocortisone (1.1 g/100mL) + Acetic acid (2.41 g/100mL) Solution Auricular (otic) Physicians Total Care, Inc. 1994-12-15 2012-06-30 US Acetasol HC Hydrocortisone (1.1 g/100mL) + Acetic acid (2.41 g/100mL) Solution Auricular (otic) Actavis Pharma, Inc. 2002-09-10 2017-05-31 US Antibiotic Ear (Neo/Polym/HC) Hydrocortisone (10 mg/1mL) + Neomycin sulfate (3.5 mg/1mL) + Polymyxin B sulfate (10000 [USP'U]/1mL) Solution / drops Auricular (otic) Physicians Total Care, Inc. 1995-12-29 Not applicable US Calmurid HC Crm Hydrocortisone (10 mg) + Urea (100 mg) Cream Topical Galderma 1994-12-31 2000-08-02 Canada Casporyn HC Hydrocortisone (10 mg/1mL) + Neomycin sulfate (3.5 mg/1mL) + Polymyxin B sulfate (10000 [USP'U]/1mL) Suspension Auricular (otic) Casper Pharma Llc 2019-03-15 Not applicable US Cho-A Care Lot 1% Hydrocortisone (10 mg/50g) + Glyceryl monostearate (10 mg/50g) Lotion Topical Cho-A Pharm.Co.,Ltd. 2019-10-25 Not applicable US Cipro Hydrocortisone (10 mg/1mL) + Benzyl alcohol (9 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL) Suspension Auricular (otic) Physicians Total Care, Inc. 2009-02-12 Not applicable US Cipro HC Hydrocortisone (10 mg/1mL) + Ciprofloxacin hydrochloride (2.0 mg/1mL) Suspension Auricular (otic) A-S Medication Solutions 1999-03-15 Not applicable US Cipro HC Hydrocortisone (10 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL) Suspension Auricular (otic) ALCON LABORATORIES, INC. 1999-03-15 Not applicable US Cipro HC Hydrocortisone (10 mg/1mL) + Benzyl alcohol (9 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL) Suspension Auricular (otic) Stat Rx USA 1998-02-10 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydrocortisone (0.5 g/100g) + Hydroquinone (4 g/100g) + Tretinoin (0.025 g/100g) Emulsion Topical Sincerus Florida, LLC 2020-07-02 Not applicable US 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Hydrocortisone (0.5 g/100g) + Hydroquinone (6 g/100g) + Tretinoin (0.025 g/100g) Emulsion Topical Sincerus Florida, LLC 2020-07-02 Not applicable US 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydrocortisone (0.5 g/100g) + Hydroquinone (4 g/100g) + Tretinoin (0.025 g/100g) Emulsion Topical Sincerus Florida, LLC 2020-07-02 Not applicable US 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Hydrocortisone (0.5 g/100g) + Hydroquinone (8 g/100g) + Tretinoin (0.025 g/100g) Emulsion Topical Sincerus Florida, LLC 2020-07-02 Not applicable US Ala Quin Hydrocortisone (5 mg/1g) + Clioquinol (30 mg/1g) Cream Topical Crown Laboratories 1970-08-19 2021-11-30 US Alcortin Hydrocortisone (2 g/100g) + Diiodohydroxyquinoline (1 g/100g) Gel Topical Primus Pharmaceuticals 2003-07-25 Not applicable US Bencort Hydrocortisone (5 mg/1g) + Benzoyl peroxide (350 mg/1g) + Benzoyl peroxide (50 mg/1g) Kit Topical River's Edge Pharmaceuticals, LLC 2009-10-01 2011-01-13 US Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Hydrocortisone (2.5 g/100g) + Clindamycin phosphate (1 g/100g) + Nicotinamide (4 g/100g) Cream Topical Sincerus Florida, LLC 2019-05-10 Not applicable US Cortaine -B Aqueous Hydrocortisone (10 mg/1mL) + Chloroxylenol (1 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL) Solution / drops Auricular (otic) Physicians Total Care, Inc. 2010-09-09 2013-01-15 US Cortane-B Hydrocortisone (10 mg/1mL) + Chloroxylenol (1 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL) Lotion Topical Blansett Pharmacal Co 2017-03-20 Not applicable US - International/Other Brands
- Acticort / Aeroseb HC / Ala-Scalp / Algicirtis / Beta-HC / Cetacort / Cortaid / Delacort / Ficortril / Genacort / Glycort / Komed HC / Lacticare HC / Lubricort / Meusicort / Mildison / Nogenic HC / Nutracort / Penecort / Permicort / Polcort H / Preparation H Hydrocortisone Cream / Prevex HC / Proctocream / Remederm HC / Sanatison / Scalpicin Capilar / Schericur / Sigmacort / Synacort / Systral Hydrocort / Timocort
- Categories
- 11-Hydroxycorticosteroids
- 17-Hydroxycorticosteroids
- Adrenal Cortex Hormones
- Adrenals
- Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
- Alimentary Tract and Metabolism
- Anti-Inflammatory Agents
- Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents
- Corticosteroid Hormone Receptor Agonists
- Corticosteroids
- Corticosteroids Acting Locally
- Corticosteroids for Local Oral Treatment
- Corticosteroids for Systemic Use
- Corticosteroids for Systemic Use, Plain
- Corticosteroids, Dermatological Preparations
- Corticosteroids, Weak (Group I)
- Cytochrome P-450 CYP2A6 Inducers
- Cytochrome P-450 CYP2B6 Inducers
- Cytochrome P-450 CYP2B6 Inducers (strength unknown)
- Cytochrome P-450 CYP2C19 Inducers
- Cytochrome P-450 CYP2C19 Inducers (strength unknown)
- Cytochrome P-450 CYP2C8 Inducers
- Cytochrome P-450 CYP2C8 Inducers (strength unknown)
- Cytochrome P-450 CYP2C9 Inducers
- Cytochrome P-450 CYP2C9 Inducers (strength unknown)
- Cytochrome P-450 CYP3A Inducers
- Cytochrome P-450 CYP3A Substrates
- Cytochrome P-450 CYP3A4 Inducers
- Cytochrome P-450 CYP3A4 Inducers (strength unknown)
- Cytochrome P-450 CYP3A4 Substrates
- Cytochrome P-450 CYP3A5 Substrates
- Cytochrome P-450 CYP3A7 Substrates
- Cytochrome P-450 Enzyme Inducers
- Cytochrome P-450 Substrates
- Dermatologicals
- Fused-Ring Compounds
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Hydrocortisone and derivatives
- Hydroxycorticosteroids
- Hyperglycemia-Associated Agents
- Immunosuppressive Agents
- Intestinal Antiinflammatory Agents
- Nasal Preparations
- OAT3/SLC22A8 Substrates
- Ophthalmological and Otological Preparations
- Ophthalmologicals
- Otologicals
- P-glycoprotein inducers
- P-glycoprotein substrates
- Pregnanes
- Pregnenediones
- Pregnenes
- Sensory Organs
- Steroids
- Stomatological Preparations
- Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins
- Vasoprotectives
- UNII
- WI4X0X7BPJ
- CAS number
- 50-23-7
- Weight
- Average: 362.4599
Monoisotopic: 362.20932407 - Chemical Formula
- C21H30O5
- InChI Key
- JYGXADMDTFJGBT-VWUMJDOOSA-N
- InChI
- InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
- IUPAC Name
- (1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
- SMILES
- [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Pharmacology
- Indication
Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.10,11 Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.12 A hydrocortisone enema is indicated for ulcerative colitis,13 a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,14 and a topical cream with acyclovir is indicated to treat cold sores.15
- Associated Conditions
- Acute Gouty Arthritis
- Allergic Rhinitis (AR)
- Allergic corneal marginal ulcers
- Ankylosing Spondylitis (AS)
- Anterior Segment Inflammation
- Aspiration Pneumonitis
- Asthma
- Atopic Dermatitis (AD)
- Berylliosis
- Bullous dermatitis herpetiformis
- Chorioretinitis
- Choroiditis
- Congenital Adrenal Hyperplasia (CAH)
- Congenital Hypoplastic Anemia
- Conjunctivitis, Seasonal Allergic
- Corneal Inflammation
- Crohn's Disease (CD)
- Dermatitis exfoliative generalised
- Dermatitis, Contact
- Dermatomyositis
- Dermatosis
- Drug hypersensitivity reaction
- Epicondylitis
- Erythroblastopenia
- Herpes Labialis
- Hypercalcemia of Malignancy
- Idiopathic Thrombocytopenic Purpura
- Infection of the Fenestration Cavity
- Infection of the Mastoidectomy Cavity
- Iridocyclitis
- Iritis
- Leukemia, Acute
- Leukemias
- Loeffler's syndrome
- Lymphomas NEC
- Malignant Lymphomas
- Mycosis Fungoides (MF)
- Ophthalmia, Sympathetic
- Optic Neuritis
- Pemphigus
- Post-traumatic Osteoarthritis
- Primary adrenocortical insufficiency
- Proteinuria
- Psoriatic Arthritis
- Rheumatic heart disease, unspecified
- Rheumatoid Arthritis
- Rheumatoid Arthritis, Juvenile
- Secondary adrenocortical insufficiency
- Secondary thrombocytopenia
- Serum Sickness
- Severe Seborrheic Dermatitis
- Stevens-Johnson Syndrome
- Synovitis
- Systemic Lupus Erythematosus (SLE)
- Trichinosis
- Tuberculous Meningitis
- Ulcerative Colitis
- Acquired immune hemolytic anemia
- Acute Bursitis
- Acute Tenosynovitis
- Acute rheumatic carditis
- Disseminated Pulmonary Tuberculosis
- Fulminating Pulmonary Tuberculosis
- Non-suppurative Thyroiditis
- Severe Erythema multiforme
- Severe Psoriasis
- Subacute Bursitis
- Superficial infection of the external auditory canal with inflammation
- Symptomatic Sarcoidosis
- Systemic Dermatomyositis
- Varicella-zoster virus acute retinal necrosis
- Associated Therapies
- Pharmacodynamics
Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors, and the promotion of anti-inflammatory genes.[A187463] Hydrocortisone has a wide therapeutic index8 and a moderate duration of action.1,6 Patients should stop taking the medication if irritation or sensitization occurs.10,11,12,13,14,15
- Mechanism of action
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation.[A187463] Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.[A187463]
Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.[A187463]
Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive.[A187463] High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.[A187463]
Target Actions Organism AGlucocorticoid receptor agonistHumans AAnnexin A1 agonistHumans - Absorption
Oral hydrocortisone at a dose of 0.2-0.3mg/kg/day reached a mean Cmax of 32.69nmol/L with a mean AUC of 90.63h*nmol/L1 A 0.4-0.6mg/kg/day dose reached a mean Cmax of 70.81nmol/L with a mean AUC of 199.11h*nmol/L.1 However, the pharmacokinetics of hydrocortisone can vary by 10 times from patient to patient.1
Topical hydrocortisone cream is 4-19% bioavailable[8546995] with a Tmax of 24h.2
Hydrocortisone retention enemas are have a bioavailability of 0.810 for slow absorbers and 0.502 in rapid absorbers.4 Slow absorbers take up hydrocortisone at a rate of 0.361±0.255/h while fast absorbers take up hydrocortisone at a rate of 1.05±0.255/h.4
A 20mg IV dose of hydrocortisone has an AUC of 1163±277ng*h/mL.6
- Volume of distribution
Total hydrocortisone has a volume of distribution of 39.82L, while the free fraction has a volume of distribution of 474.38L.1
- Protein binding
Corticosteroids are generally bound to corticosteroid binding globulin[A187439] and serum albumin[A187436] in plasma. Hydrocortisone is 90.1% bound to proteins in plasma, with 56.2% bound to albumin.5
- Metabolism
Hydrocortisone is metabolised to 6-beta hydrocortisol via CYP3A, 5-beta tetrahydrocortisol via 3-oxo-5-beta-steroid 4-dehydrogenase, 5-alpha tetrahydrocortisol via 3-oxo-5-alpha-steroid 4-dehydrogenase 2, cortisone via Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticosteroid 11-beta-dehydrogenase isozyme 2, and glucuronide products.[A188321,A188318] Cortisone is further metabolized to tetrahydrocortisone and dihydrocortisol.[A188321,A188318]
- Route of elimination
Corticosteroids are eliminated predominantly in the urine.[A187436] However, data regarding the exact proportion is not readily available.7
- Half life
Total hydrocortisone via the oral route has a half life of 2.15h while the free fraction has a half life of 1.39h.1 A 20mg IV dose of hydrocortisone has a terminal half life of 1.9±0.4h.6
- Clearance
Total hydrocortisone by the oral route has a mean clearance of 12.85L/h, while the free fraction has a mean clearance of 235.78L/h.1 A 20mg IV dose of hydrocortisone has a clearance of 18.2±4.2L/h.6
- Toxicity
Data regarding acute overdoses of glucocorticoids are rare.10,11,12,13,14,15 Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency.8 Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.8
- Affected organisms
- Humans and other mammals
- Pathways
- Pharmacogenomic Effects/ADRs
- Not Available
Unlock Additional Data
Additional Data Available
Adverse Effects
Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.
Learn more Additional Data Available
Contraindications
Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.
Learn more Additional Data Available
Blackbox Warnings
Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.
Learn moreInteractions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional Data(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Hydrocortisone. (S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Hydrocortisone. 1-Testosterone The risk or severity of edema formation can be increased when 1-Testosterone is combined with Hydrocortisone. 1,10-Phenanthroline The therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Hydrocortisone. 16-Bromoepiandrosterone The risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Hydrocortisone. 19-norandrostenedione The risk or severity of edema formation can be increased when 19-norandrostenedione is combined with Hydrocortisone. 1alpha-Hydroxyvitamin D5 The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Hydrocortisone. 1alpha,24S-Dihydroxyvitamin D2 The therapeutic efficacy of 1alpha,24S-Dihydroxyvitamin D2 can be decreased when used in combination with Hydrocortisone. 2,4-thiazolidinedione The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with 2,4-thiazolidinedione. 4-hydroxycoumarin Hydrocortisone may increase the anticoagulant activities of 4-hydroxycoumarin. Additional Data Available- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - Severity
- Evidence Level
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.
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- Food Interactions
- Avoid alcohol.
References
- Synthesis Reference
Manfred Baumgarth, Dieter Orth, Jurgen Harting, Hans Schaefer, Achim Zesch, "Hydrocortisone orthoesters, pharmaceutical formulations thereof and processes for the preparation thereof." U.S. Patent US4264584, issued March, 1974.
US4264584- General References
- Werumeus Buning J, Touw DJ, Brummelman P, Dullaart RPF, van den Berg G, van der Klauw MM, Kamp J, Wolffenbuttel BHR, van Beek AP: Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism. 2017 Jun;71:7-16. doi: 10.1016/j.metabol.2017.02.005. Epub 2017 Feb 13. [PubMed:28521880]
- Aalto-Korte K, Turpeinen M: Pharmacokinetics of topical hydrocortisone at plasma level after applications once or twice daily in patients with widespread dermatitis. Br J Dermatol. 1995 Aug;133(2):259-63. doi: 10.1111/j.1365-2133.1995.tb02625.x. [PubMed:7547394]
- Aalto-Korte K, Turpeinen M: Quantifying systemic absorption of topical hydrocortisone in erythroderma. Br J Dermatol. 1995 Sep;133(3):403-8. doi: 10.1111/j.1365-2133.1995.tb02668.x. [PubMed:8546995]
- Lima JJ, Jusko WJ: Bioavailability of hydrocortisone retention enemas in relation to absorption kinetics. Clin Pharmacol Ther. 1980 Aug;28(2):262-9. doi: 10.1038/clpt.1980.159. [PubMed:7398193]
- FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J Biol Chem. 1961 Jan;236:247-51. [PubMed:13700365]
- Derendorf H, Mollmann H, Barth J, Mollmann C, Tunn S, Krieg M: Pharmacokinetics and oral bioavailability of hydrocortisone. J Clin Pharmacol. 1991 May;31(5):473-6. doi: 10.1002/j.1552-4604.1991.tb01906.x. [PubMed:2050835]
- Jung C, Greco S, Nguyen HH, Ho JT, Lewis JG, Torpy DJ, Inder WJ: Plasma, salivary and urinary cortisol levels following physiological and stress doses of hydrocortisone in normal volunteers. BMC Endocr Disord. 2014 Nov 26;14:91. doi: 10.1186/1472-6823-14-91. [PubMed:25425285]
- Ciriaco M, Ventrice P, Russo G, Scicchitano M, Mazzitello G, Scicchitano F, Russo E: Corticosteroid-related central nervous system side effects. J Pharmacol Pharmacother. 2013 Dec;4(Suppl 1):S94-8. doi: 10.4103/0976-500X.120975. [PubMed:24347992]
- Simoni R, Hill R, Vaughan M: The Isolation of Thyroxine and Cortisone: the Work of Edward C. Kendall Journal of Biological Chemistry. 2002 May 24;277(21):e10.
- FDA Approved Drug Products: Vosol Hydrocortisone and Glacial Acetic Acid Otic Drops [Link]
- FDA Approved Drug Products: Casporyn Neomycin Sulfate, Polymixin B Sulfate, and Hydrocortisone Otic Drops [Link]
- FDA Approved Drug Products: Cortef Hydrocortisone Oral Tablets [Link]
- FDA Approved Drug Products: Cortenema Hydrocortisone Rectal Enema [Link]
- FDA Approved Drug Products: Bacitracin, Neomycin, Polymyxin B, and Hydrocortisone Topical Ointment [Link]
- FDA Approved Drug Products: Xerese Topical Cream With Hydrocortisone [Link]
- FDA Approved Drug Products: Hydrocortone Hydrocortisone Oral Tablets (Discontinued) [Link]
- External Links
- Human Metabolome Database
- HMDB0000063
- KEGG Drug
- D00088
- KEGG Compound
- C00735
- PubChem Compound
- 5754
- PubChem Substance
- 46505089
- ChemSpider
- 5551
- BindingDB
- 13775
- RxNav
- 5492
- ChEBI
- 17650
- ChEMBL
- CHEMBL389621
- ZINC
- ZINC000013540519
- Therapeutic Targets Database
- DAP000718
- PharmGKB
- PA449905
- Guide to Pharmacology
- GtP Drug Page
- PDBe Ligand
- HCY
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- PDRhealth
- PDRhealth Drug Page
- Wikipedia
- Hydrocortisone
- ATC Codes
- S01CB03 — Hydrocortisone
- S01CB — Corticosteroids/antiinfectives/mydriatics in combination
- S01C — ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- S01 — OPHTHALMOLOGICALS
- S — SENSORY ORGANS
- A01AC — Corticosteroids for local oral treatment
- A01A — STOMATOLOGICAL PREPARATIONS
- A01 — STOMATOLOGICAL PREPARATIONS
- A — ALIMENTARY TRACT AND METABOLISM
- S01BA — Corticosteroids, plain
- S01B — ANTIINFLAMMATORY AGENTS
- S01 — OPHTHALMOLOGICALS
- S — SENSORY ORGANS
- S01CA — Corticosteroids and antiinfectives in combination
- S01C — ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- S01 — OPHTHALMOLOGICALS
- S — SENSORY ORGANS
- D07AA — Corticosteroids, weak (group I)
- D07A — CORTICOSTEROIDS, PLAIN
- D07 — CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
- D — DERMATOLOGICALS
- S01BB — Corticosteroids and mydriatics in combination
- S01B — ANTIINFLAMMATORY AGENTS
- S01 — OPHTHALMOLOGICALS
- S — SENSORY ORGANS
- D07XA — Corticosteroids, weak, other combinations
- D07X — CORTICOSTEROIDS, OTHER COMBINATIONS
- D07 — CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
- D — DERMATOLOGICALS
- D07BA — Corticosteroids, weak, combinations with antiseptics
- D07B — CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
- D07 — CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
- D — DERMATOLOGICALS
- S02CA — Corticosteroids and antiinfectives in combination
- S02C — CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
- S02 — OTOLOGICALS
- S — SENSORY ORGANS
- A07EA — Corticosteroids acting locally
- A07E — INTESTINAL ANTIINFLAMMATORY AGENTS
- A07 — ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
- A — ALIMENTARY TRACT AND METABOLISM
- R01AD — Corticosteroids
- R01A — DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- R01 — NASAL PREPARATIONS
- R — RESPIRATORY SYSTEM
- H02AB — Glucocorticoids
- H02A — CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
- H02 — CORTICOSTEROIDS FOR SYSTEMIC USE
- H — SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
- D07CA — Corticosteroids, weak, combinations with antibiotics
- D07C — CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
- D07 — CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
- D — DERMATOLOGICALS
- S03CA — Corticosteroids and antiinfectives in combination
- S03C — CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
- S03 — OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
- S — SENSORY ORGANS
- AHFS Codes
- 68:04.00 — Adrenals
- 84:06.00 — Anti-inflammatory Agents
- 56:36.00 — Anti-inflammatory Agents
- PDB Entries
- 2v95 / 2vdy / 4c49 / 4p6x / 5hgc / 6hgf / 6hgg / 6itp / 6itq / 6nwl
- FDA label
- Download (30 KB)
- MSDS
- Download (73.6 KB)
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Hi tech pharmacal co inc
- Allergan herbert div allergan inc
- Del ray laboratories inc
- Salix pharmaceuticals inc
- Bayer pharmaceuticals corp
- Monarch pharmaceuticals inc
- Valeant pharmaceuticals international
- Westwood squibb pharmaceuticals inc
- C and m pharmacal inc
- Pharmaceutical assoc inc div beach products
- Actavis mid atlantic llc
- Alpharma us pharmaceuticals division
- Altana inc
- Ambix laboratories div organics corp america
- Everylife
- E fougera div altana inc
- G and w laboratories inc
- Ingram pharmaceutical co
- Ivax pharmaceuticals inc
- Naska pharmacal co inc div rugby darby group cosmetics
- Perrigo new york inc
- Pharmaderm div altana inc
- Pharmafair inc
- Stiefel laboratories inc
- Syosset laboratories inc
- Taro pharmaceuticals usa inc
- Teva pharmaceuticals usa inc
- Topiderm inc
- Usl pharma inc
- Vintage pharmaceuticals inc
- Whiteworth towne paulsen inc
- Sanofi aventis us llc
- Coria laboratories ltd
- Medicis pharmaceutical corp
- Paddock laboratories inc
- Ani pharmaceuticals inc
- Teva pharmaceuticals usa
- Healthpoint ltd
- Allergan herbert skin care div allergan inc
- Pharmacia and upjohn co
- Baker norton pharmaceuticals inc
- Solvay pharmaceuticals
- Beta dermaceuticals inc
- Bluline laboratories inc
- Heran pharmaceutical inc
- Mericon industries inc
- Perrigo co
- Pfizer global research development
- Carolina medical products co
- Dermik laboratories div aventis pharmaceuticals inc
- Torch laboratories inc
- X gen pharmaceuticals inc
- Jsj pharmaceuticals llc
- Pfizer laboratories div pfizer inc
- Barr laboratories inc
- Elkins sinn div ah robins co inc
- John j ferrante
- Impax laboratories inc
- Inwood laboratories inc sub forest laboratories inc
- Lannett co inc
- Nexgen pharma inc
- Panray corp sub ormont drug and chemical co inc
- Parke davis div warner lambert co
- Purepac pharmaceutical co
- Roxane laboratories inc
- Sandoz inc
- Stiefel a gsk co
- Vintage pharmaceuticals llc
- Watson laboratories inc
- West ward pharmaceutical corp
- Merck and co inc
- Pfipharmecs div pfizer inc
- Schwarz pharma inc
- Able laboratories inc
- Hr cenci laboratories inc
- Ferndale laboratories inc
- Akorn inc
- Bel mar laboratories inc
- Colgate oral pharmaceuticals inc
- Taro pharmaceutical industries ltd
- Triax pharmaceuticals llc
- Yamanouchi europe bv
- Savage laboratories inc div altana inc
- Abbott laboratories pharmaceutical products div
- Abbott laboratories hosp products div
- Hospira inc
- Abraxis pharmaceutical products
- Baxter healthcare corp anesthesia and critical care
- International medication systems ltd
- Taro pharmaceuticals inc
- Ranbaxy laboratories inc
- Packagers
- Actavis Group
- Advanced Pharmaceutical Services Inc.
- AG Marin Pharmaceuticals
- Alaven Pharmaceutical
- Alcon Laboratories
- Amerisource Health Services Corp.
- Ani Pharmaceuticals
- Anip Acquisition Co.
- Arbor Pharmaceuticals Incorporated
- A-S Medication Solutions LLC
- Avidas Pharmaceuticals
- Bay Pharma Inc.
- Bayer Healthcare
- Bergen Brunswig
- Beta Dermaceuticals
- Bio Pharm Inc.
- Bristol-Myers Squibb Co.
- C.O. Truxton Inc.
- Cardinal Health
- Carlisle Laboratories Inc.
- Carolina Medical Products Co.
- Chattem Chemicals Inc.
- Co Med Pharmaceuticals Inc.
- Colgate Oral
- Combe Inc.
- Consolidated Midland Corp.
- Contract Pharm
- Crown Laboratories Inc.
- Cutis Pharma Inc.
- Cypress Pharmaceutical Inc.
- Darby Dental Supply Co. Inc.
- Del Ray Dermatology
- Dermik Labs
- DispenseXpress Inc.
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- Dofs Laboratories
- DPT Laboratories Ltd.
- DSC Laboratories
- E. Fougera and Co.
- ECR Pharmaceuticals
- Elkins-Sinn Inc.
- Enterprises Importfab Inc.
- Ferndale Labs
- G & W Labs
- Genesis Pharmaceutical Inc.
- Gertz
- H and H Laboratories
- H.J. Harkins Co. Inc.
- Harmony Laboratories Inc.
- Hi Tech Pharmacal Co. Inc.
- Hospira Inc.
- Inyx Usa Ltd.
- JHP Pharmaceuticals LLC
- Johnson & Johnson Healthcare
- JSJ Pharmaceuticals Inc.
- Kaiser Foundation Hospital
- Keltman Pharmaceuticals Inc.
- Lake Erie Medical and Surgical Supply
- Lehigh Valley Technologies Inc.
- Lyne Laboratories Inc.
- Major Pharmaceuticals
- Mallinckrodt Inc.
- Martin Surgical Supply
- Meda AB
- Mikart Inc.
- Murfreesboro Pharmaceutical Nursing Supply
- National Vitamin Company
- Nexgen Pharma Inc.
- Nycomed Inc.
- Paddock Labs
- Palmetto Pharmaceuticals Inc.
- Patheon Inc.
- Perrigo Co.
- Person & Covey
- Pfizer Inc.
- Pharmacia Inc.
- Pharmaderm
- Pharmedix
- Physician Partners Ltd.
- Physicians Total Care Inc.
- Preferred Pharmaceuticals Inc.
- Professional Co.
- Prometic Pharma Inc.
- Qualitest
- Ranbaxy Laboratories
- Rebel Distributors Corp.
- Redpharm Drug
- Resource Optimization and Innovation LLC
- Rising Pharmaceuticals
- River's Edge Pharmaceuticals
- Rouses Point Pharmaceuticals LLC
- Salix Pharmaceuticals
- Sandhills Packaging Inc.
- Sandoz
- Sanofi-Aventis Inc.
- Schwarz Pharma Inc.
- Solvay Pharmaceuticals
- Southwood Pharmaceuticals
- Stanley Pharmaceuticals Ltd.
- Stat Rx Usa
- Stat Scripts LLC
- Summers Labs
- Suppositoria Laboratories Inc.
- Taro Pharmaceuticals USA
- Teva Pharmaceutical Industries Ltd.
- Topiderm Inc.
- Triax Pharmaceuticals LLC
- UCB Pharma
- United Pharmaceuticals
- United Research Laboratories Inc.
- Universal Laboratories Inc.
- Upsher Smith Laboratories
- Veratex Corp.
- Vertical Pharmaceuticals Inc.
- Vintage Pharmaceuticals Inc.
- West-Ward Pharmaceuticals
- Wockhardt Ltd.
- WraSer Pharmaceuticals
- Wyeth Pharmaceuticals
- Dosage forms
Form Route Strength Powder, for solution Intramuscular; Intravenous Solution Auricular (otic) Ointment Topical 0.01 g/1g Gel Topical Cream Topical 0.57 g/57g Cream Topical 1 g/1mL Solution Topical 1 g/100g Cream Topical .05 mg/1g Lotion Topical 0.01 g/1g Ointment Topical 1 g/100g Cream; jelly Topical Cream Topical 0.01 g/1g Cream Topical 0.284 g/28.4g Suspension Auricular (otic) Spray Topical 10 g/1mL Lotion Topical Ointment Topical Tablet Oral Enema; suspension Rectal Ointment Topical 100 g/1g Cream Topical 10 mg/1g Ointment Topical Suspension Topical Lotion Topical 10 mg/1g Solution / drops Ophthalmic Gel Topical 1 mg/1g Lotion Topical 1 mg/1mL Kit Lotion Topical 0.75 g/100mL Cream Topical .284 g/28.4g Cream Topical .284 g/287.4g Cream Topical 1 g/100mL Solution Topical Kit Oral Ointment Topical 10 mg/1mL Cream Topical 0.5 g/100g Gel Topical 10 mg/1g Ointment Topical 10 mg/1g Ointment Rectal 10 mg/1g Enema Rectal Aerosol, spray Topical 1.13 g/113g Cream Topical 1 h/100g Cream Topical 10 mg/1mL Cream Topical 25 mg/1g Cream Topical 5 mg/1g Enema Rectal 100 mg/60mL Gel Topical 1 g/100g Liquid Topical 10 mg/1mL Liquid Topical 10 mg/1g Lotion Topical 1 g/1mL Lotion Topical 1 g/100.65mL Lotion Topical 10 mg/1mL Lotion Topical 25 mg/1mL Ointment Topical 25 mg/1g Ointment Topical 5 mg/1g Powder Not applicable 1 g/1g Shampoo Topical 1 g/100mL Suspension Rectal 100 mg/60mL Tablet Oral 10 mg/1 Tablet Oral 20 mg/1 Tablet Oral 5 mg/1 Emulsion Topical Ointment Topical 10 mg/1 Cream Topical 1 g Cream Topical 1.02 g/100g Cream Topical Cream Topical 140 mg/14g Ointment Topical 10 g/100g Lotion Topical 1 g/100mL Spray Topical 1 g/100g Lotion Topical 1.02 g/100g Kit Oral; Topical Lotion Topical 1 g/100g Kit Topical Liquid Topical 5 mg/1mL Liquid Topical 9 mg/1mL Spray Topical 10 mg/1mL Ointment Topical 1.02 g/100g Cream Topical 1 g/100g Cream Topical 0.009 g/1 Solution / drops Auricular (otic) Suspension Ophthalmic Suspension / drops Auricular (otic) Ointment Ophthalmic Lotion Topical 5 mg/1g Liquid Auricular (otic) Kit Topical 20 mg/1mL Lipstick Topical 0.005 g/1g Lotion Topical 0.025 mg/2.5mL Cream Topical 7.5 g/100mL Cream Topical 1 mg/1g Liquid Topical 0.28 mg/100mL Ointment Rectal Suppository Rectal Ointment Rectal; Topical Suppository Rectal Cream Topical .01 mg/1g Cream Topical 0.51 g/100g Spray Topical 500 g/1g Cream Topical 1 mg/100mL Lotion Topical Liquid Topical 1 g/100mL Liquid Topical Solution Topical 25 mg/1mL Lotion Topical 1 mL/100mL Cream Topical Cream Topical 10 mg/1L Spray Topical 10 g/1L - Prices
Unit description Cost Unit Locoid Lipocream 0.1% Cream 60 gm Tube 335.36USD tube Cortifoam 90 mg Foam 15 gm Can 239.99USD can Locoid 0.1% Solution 60ml Bottle 233.15USD bottle Locoid Lipocream 0.1% Cream 45 gm Tube 200.98USD tube Locoid 0.1% Cream 45 gm Tube 183.83USD tube Locoid 0.1% Ointment 45 gm Tube 174.86USD tube Pandel 0.1% Cream 45 gm Tube 161.37USD tube Pandel 0.1% Cream 15 gm Tube 138.56USD tube Proctocort 1% Cream 28.35 gm Tube 127.51USD tube Anusol-HC 2.5% Cream 30 gm Tube 106.45USD tube Locoid Lipocream 0.1% Cream 15 gm Tube 85.41USD tube Texacort 2.5% Solution 30ml Bottle 85.41USD bottle Cortisporin 3.5-10000-1 Solution 10ml Bottle 84.33USD bottle Proctofoam HC 1-1% Foam 10 gm Can 81.9USD can Cortisporin 3.5-10000-1 Suspension 10ml Bottle 79.55USD bottle Locoid 0.1% Solution 20ml Bottle 79.28USD bottle Cortisporin 1% Ointment 15 gm Tube 75.09USD tube Locoid 0.1% Cream 15 gm Tube 67.49USD tube Hydrocortisone Ace-Pramoxine 2.5-1% Cream 28.35 gm Tube 64.75USD tube Locoid 0.1% Ointment 15 gm Tube 62.04USD tube Hydrocortisone Valerate 0.2% Ointment 60 gm Tube 56.74USD tube Hydrocortisone 2.5% Lotion 59 gm Bottle 55.61USD bottle Westcort 0.2% Ointment 60 gm Tube 55.0USD tube Cortisporin 0.5-0.5-10000 Cream 7.5 gm Tube 54.37USD tube Westcort 0.2% Ointment 15 gm Tube 50.99USD tube Hydrocortisone Butyrate 0.1% Cream 45 gm Tube 49.43USD tube Hydrocortisone Valerate 0.2% Ointment 45 gm Tube 48.73USD tube Hydrocortisone 2.5% Lotion 59ml Bottle 47.47USD bottle Westcort 0.2% Ointment 45 gm Tube 46.97USD tube Hydrocortisone Valerate 0.2% Cream 60 gm Tube 44.99USD tube Hydrocortisone Valerate 0.2% Cream 45 gm Tube 33.99USD tube Ala Scalp 2% Lotion 29.6ml Bottle 30.99USD bottle Hydrocortisone Valerate 0.2% Ointment 15 gm Tube 30.56USD tube Westcort 0.2% Cream 15 gm Tube 25.99USD tube Hydrocortisone Valerate 0.2% Cream 15 gm Tube 19.99USD tube Cortisporin eye drops 19.74USD ml Solu-Cortef 1 g/vial 17.55USD vial Hydrocortisone 1% Lotion 118ml Bottle 15.99USD bottle Hydrocortisone Acetate 12 25 mg Suppository Box 15.01USD box Hydrocortisone 2.5% Ointment 28.35 gm Tube 13.68USD tube Hydrocortisone 2.5% Cream 30 gm Tube 13.67USD tube Colocort 100 mg/60ml Enema 60ml Bottle 13.15USD bottle Hydrocortisone 100 mg/60ml Enema 60ml Bottle 12.6USD bottle Hydrocortisone 0.5% Cream 28.35 gm Tube 11.99USD tube Hydrocortisone 1% Cream 15 gm Tube 11.99USD tube Hydrocortisone 1% Cream 28 gm Tube 11.99USD tube Hydrocortisone Acetate 1-1% Ointment 30 gm Tube 11.99USD tube Solu-Cortef 500 mg/vial 10.47USD vial Hydrocortisone hemisucc powder 9.9USD g Cortifoam 10% aerosol 9.35USD g Hydrocortisone Sod. Succinate 1 g/vial 9.01USD vial Solu-cortef (pf) 250 mg vial 8.58USD vial Cortisporin-tc ear susp 8.3USD ml Cortisporin ear suspension 7.86USD ml Solu-Cortef 250 mg/vial 7.05USD vial Cortenema (100 mg/60Ml) 100 mg/enm Enema 6.96USD enema Proctofoam-hc foam 6.77USD g Cortifoam 10 % Foam 6.14USD g Hycort (100 mg/60Ml) 100 mg/enm Enema 5.79USD enema Cortamed 2.5 % Ointment 5.67USD g Hydrocortisone Sod. Succinate 500 mg/vial 5.34USD vial Hydrocortisone powder 5.19USD g Solu-cortef (pf) 100 mg vial 4.85USD vial Solu-cortef 100 mg vial 4.63USD vial Proctocort 1% cream 4.37USD g Pandel 0.1% cream 4.34USD g Locoid 0.1% lipocream 4.3USD g Solu-Cortef 100 mg/vial 4.07USD vial Locoid 0.1% cream 3.92USD g Hydrocortisone Sod. Succinate 250 mg/vial 3.56USD vial Hydrocortisone ss 250 mg vial 3.5USD vial Anusol-hc 2.5% cream 3.45USD g Hydrocortisone acet powder 3.15USD g Proctofoam 2.89USD g A-hydrocort 100 mg vial 2.42USD each Proctocream-hc 2.5% cream 2.17USD g Hydrocortisone Sod. Succinate 100 mg/vial 2.1USD vial Hydrocortisone val 0.2% cream 2.07USD g Hytone 2.5% cream 1.46USD g Hydrocortisone buty 0.1% cream 1.31USD g First hydrocort 10% gel 1.18USD g Westcort 0.2% cream 1.17USD g Procto-kit 1% cream 1.08USD g Ala-scalp hp 2% lotion 1.03USD ml Cortef 20 mg tablet 0.9USD tablet Proctosol-hc 2.5% cream 0.89USD g Proctozone-hc 2.5% cream 0.83USD g Orabase plain paste 0.77USD g Hydrocortisone 2.5% lotion 0.6USD ml Cortef 10 mg tablet 0.55USD tablet Orabase-b 20% gel 0.55USD g Hydrocortisone 2.5% cream 0.53USD g Hydrocortisone 10 mg tablet 0.52USD tablet Cortef 5 mg tablet 0.45USD tablet Ala-cort 1% cream 0.43USD g Hydrocortisone 5 mg tablet 0.38USD tablet Corticaine 0.5% cream 0.37USD g Hydrocortisone 20 mg tablet 0.32USD tablet Prevex Hc 1 % Occlusive Cream 0.3USD g Emo-Cort 2.5 % Cream 0.26USD g Preparation h 1% cream 0.24USD g Tucks hydrocortisone ointment 0.24USD g Emo-Cort 2.5 % Lotion 0.23USD g Emo-Cort Scalp 2.5 % Lotion 0.22USD g Colocort 100 mg enema 0.21USD ml Cortenema 100 mg enema 0.21USD ml Sarna Hc 2.5 % Lotion 0.2USD g Emo-Cort 1 % Cream 0.19USD g Balneol lotion 0.18USD ml Emo-Cort 1 % Lotion 0.18USD g Lanacort 1% cool creme 0.18USD g Hyderm 0.5 % Cream 0.18USD g Hytone 1% cream 0.17USD g Cortoderm Mild 0.5 % Ointment 0.15USD g Beta hc 1% lotion 0.14USD ml Cortizone-10 1% spray 0.14USD ml Hydroval 0.2 % Cream 0.13USD g Hydroval 0.2 % Ointment 0.13USD g Aquanil hc 1% lotion 0.12USD ml Hydrocortisone plus 12 1% crm 0.12USD g Scalpicin 3% liquid 0.12USD ml Slender cortisol capsule 0.12USD capsule Cortaid 1% spray 0.1USD ml Sarna Hc 1 % Lotion 0.1USD g Hydrocortisone 0.5% cream 0.08USD g Hydrocortisone 1% cream 0.08USD g Uniderm moisturizer 0.05USD ml Cortoderm Regular 1 % Ointment 0.04USD g Hyderm 1 % Cream 0.04USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Unlock Additional DataUS5635497 No 1997-06-03 2014-06-03 US US7378405 No 2008-05-27 2026-12-19 US US7981877 No 2011-07-19 2025-01-23 US USRE39264 No 2006-09-05 2016-08-02 US US6514980 No 2003-02-04 2019-01-24 US US7223387 No 2007-05-29 2021-07-24 US Additional Data Available- Filed On
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 220 °C PhysProp water solubility 320 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992) logP 1.61 HANSCH,C ET AL. (1995) logS -2.97 ADME Research, USCD Caco2 permeability -4.66 ADME Research, USCD - Predicted Properties
Property Value Source Water Solubility 0.199 mg/mL ALOGPS logP 1.79 ALOGPS logP 1.28 ChemAxon logS -3.3 ALOGPS pKa (Strongest Acidic) 12.59 ChemAxon pKa (Strongest Basic) -2.8 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 5 ChemAxon Hydrogen Donor Count 3 ChemAxon Polar Surface Area 94.83 Å2 ChemAxon Rotatable Bond Count 2 ChemAxon Refractivity 97.4 m3·mol-1 ChemAxon Polarizability 39.45 Å3 ChemAxon Number of Rings 4 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.9918 Blood Brain Barrier + 0.9383 Caco-2 permeable - 0.5096 P-glycoprotein substrate Substrate 0.7861 P-glycoprotein inhibitor I Non-inhibitor 0.7847 P-glycoprotein inhibitor II Non-inhibitor 0.8383 Renal organic cation transporter Non-inhibitor 0.7463 CYP450 2C9 substrate Non-substrate 0.8496 CYP450 2D6 substrate Non-substrate 0.9138 CYP450 3A4 substrate Substrate 0.7407 CYP450 1A2 substrate Non-inhibitor 0.9406 CYP450 2C9 inhibitor Non-inhibitor 0.9072 CYP450 2D6 inhibitor Non-inhibitor 0.9418 CYP450 2C19 inhibitor Non-inhibitor 0.9253 CYP450 3A4 inhibitor Non-inhibitor 0.8902 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9095 Ames test Non AMES toxic 0.9132 Carcinogenicity Non-carcinogens 0.9597 Biodegradation Not ready biodegradable 0.925 Rat acute toxicity 1.8914 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.95 hERG inhibition (predictor II) Non-inhibitor 0.584
Spectra
- Mass Spec (NIST)
- Download (2.96 KB)
- Spectra
Taxonomy
- Description
- This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Hydroxysteroids
- Direct Parent
- 21-hydroxysteroids
- Alternative Parents
- Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 3-oxo delta-4-steroids / 17-hydroxysteroids / 11-beta-hydroxysteroids / Delta-4-steroids / Cyclohexenones / Tertiary alcohols / Alpha-hydroxy ketones / Secondary alcohols show 4 more
- Substituents
- Progestogin-skeleton / 21-hydroxysteroid / 20-oxosteroid / Pregnane-skeleton / 3-oxo-delta-4-steroid / 3-oxosteroid / Oxosteroid / 11-beta-hydroxysteroid / 11-hydroxysteroid / 17-hydroxysteroid show 16 more
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- 3-oxo steroid, 11beta-hydroxy steroid, 17alpha-hydroxy steroid, glucocorticoid, 20-oxo steroid, 21-hydroxy steroid, C21-steroid (CHEBI:17650) / Pregnane and derivatives [Fig], Glucocorticoids, C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives (C00735) / C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030001)
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Zinc ion binding
- Specific Function
- Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
- Gene Name
- NR3C1
- Uniprot ID
- P04150
- Uniprot Name
- Glucocorticoid receptor
- Molecular Weight
- 85658.57 Da
References
- Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS: Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006 Jul;1071:410-21. [PubMed:16891588]
- Rautanen A, Eriksson JG, Kere J, Andersson S, Osmond C, Tienari P, Sairanen H, Barker DJ, Phillips DI, Forsen T, Kajantie E: Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene. J Clin Endocrinol Metab. 2006 Nov;91(11):4544-51. Epub 2006 Aug 8. [PubMed:16895953]
- Hammer F, Stewart PM: Cortisol metabolism in hypertension. Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):337-53. [PubMed:16980198]
- Shaw JR, Gabor K, Hand E, Lankowski A, Durant L, Thibodeau R, Stanton CR, Barnaby R, Coutermarsh B, Karlson KH, Sato JD, Hamilton JW, Stanton BA: Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R1052-60. Epub 2006 Oct 12. [PubMed:17038445]
- Sher L: Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. ScientificWorldJournal. 2006 Oct 31;6:1398-404. [PubMed:17086345]
- Czock D, Keller F, Rasche FM, Haussler U: Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. [PubMed:15634032]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Structural molecule activity
- Specific Function
- Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Play...
- Gene Name
- ANXA1
- Uniprot ID
- P04083
- Uniprot Name
- Annexin A1
- Molecular Weight
- 38713.855 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Sato-Matsumura KC, Matsumura T, Nakamura H, Sawa H, Nagashima K, Koizumi H: Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes. Arch Dermatol Res. 2000 Oct;292(10):496-9. [PubMed:11142771]
- White MV, Igarashi Y, Lundgren JD, Shelhamer J, Kaliner M: Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. J Immunol. 1991 Jul 15;147(2):667-73. [PubMed:1712816]
- Serres M, Viac J, Comera C, Schmitt D: Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes. Arch Dermatol Res. 1994;286(5):268-72. [PubMed:8060156]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- SubstrateInducer
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933]
- El-Sankary W, Bombail V, Gibson GG, Plant N: Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. Drug Metab Dispos. 2002 Sep;30(9):1029-34. [PubMed:12167569]
- El-Sankary W, Plant NJ, Gibson GG, Moore DJ: Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors. Drug Metab Dispos. 2000 May;28(5):493-6. [PubMed:10772626]
- Abel SM, Back DJ: Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):827-32. doi: 10.1016/0960-0760(93)90325-q. [PubMed:8274418]
- Flockhart Table of Drug Interactions [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Oxygen binding
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP3A5
- Uniprot ID
- P20815
- Uniprot Name
- Cytochrome P450 3A5
- Molecular Weight
- 57108.065 Da
References
- Abel SM, Back DJ: Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):827-32. doi: 10.1016/0960-0760(93)90325-q. [PubMed:8274418]
- Flockhart Table of Drug Interactions [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Oxygen binding
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP3A7
- Uniprot ID
- P24462
- Uniprot Name
- Cytochrome P450 3A7
- Molecular Weight
- 57525.03 Da
References
- Abel SM, Back DJ: Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):827-32. doi: 10.1016/0960-0760(93)90325-q. [PubMed:8274418]
- Flockhart Table of Drug Interactions [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid 11-beta-monooxygenase activity
- Specific Function
- Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochro...
- Gene Name
- CYP11B1
- Uniprot ID
- P15538
- Uniprot Name
- Cytochrome P450 11B1, mitochondrial
- Molecular Weight
- 57572.44 Da
References
- Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM: Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. [PubMed:15356073]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid 11-beta-monooxygenase activity
- Specific Function
- Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
- Gene Name
- CYP11B2
- Uniprot ID
- P19099
- Uniprot Name
- Cytochrome P450 11B2, mitochondrial
- Molecular Weight
- 57559.62 Da
References
- Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM: Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. [PubMed:15356073]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP2C8
- Uniprot ID
- P10632
- Uniprot Name
- Cytochrome P450 2C8
- Molecular Weight
- 55824.275 Da
References
- Bauersachs J, Christ M, Ertl G, Michaelis UR, Fisslthaler B, Busse R, Fleming I: Cytochrome P450 2C expression and EDHF-mediated relaxation in porcine coronary arteries is increased by cortisol. Cardiovasc Res. 2002 Jun;54(3):669-75. [PubMed:12031713]
- Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid binding
- Specific Function
- Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihyd...
- Gene Name
- AKR1D1
- Uniprot ID
- P51857
- Uniprot Name
- 3-oxo-5-beta-steroid 4-dehydrogenase
- Molecular Weight
- 37376.615 Da
References
- Finken MJ, Andrews RC, Andrew R, Walker BR: Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases. J Clin Endocrinol Metab. 1999 Sep;84(9):3316-21. doi: 10.1210/jcem.84.9.6009. [PubMed:10487705]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Sterol 5-alpha reductase activity
- Specific Function
- Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation...
- Gene Name
- SRD5A2
- Uniprot ID
- P31213
- Uniprot Name
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- Molecular Weight
- 28393.015 Da
References
- Finken MJ, Andrews RC, Andrew R, Walker BR: Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases. J Clin Endocrinol Metab. 1999 Sep;84(9):3316-21. doi: 10.1210/jcem.84.9.6009. [PubMed:10487705]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid binding
- Specific Function
- Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation...
- Gene Name
- HSD11B2
- Uniprot ID
- P80365
- Uniprot Name
- Corticosteroid 11-beta-dehydrogenase isozyme 2
- Molecular Weight
- 44126.06 Da
References
- Finken MJ, Andrews RC, Andrew R, Walker BR: Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases. J Clin Endocrinol Metab. 1999 Sep;84(9):3316-21. doi: 10.1210/jcem.84.9.6009. [PubMed:10487705]
- Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR: Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29. [PubMed:25926431]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- 11-beta-hydroxysteroid dehydrogenase [nad(p)] activity
- Specific Function
- Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the rea...
- Gene Name
- HSD11B1
- Uniprot ID
- P28845
- Uniprot Name
- Corticosteroid 11-beta-dehydrogenase isozyme 1
- Molecular Weight
- 32400.665 Da
References
- Finken MJ, Andrews RC, Andrew R, Walker BR: Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases. J Clin Endocrinol Metab. 1999 Sep;84(9):3316-21. doi: 10.1210/jcem.84.9.6009. [PubMed:10487705]
- Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR: Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29. [PubMed:25926431]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Steroid hydroxylase activity
- Specific Function
- Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Const...
- Gene Name
- CYP2A6
- Uniprot ID
- P11509
- Uniprot Name
- Cytochrome P450 2A6
- Molecular Weight
- 56501.005 Da
References
- Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Oxygen binding
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP1B1
- Uniprot ID
- Q16678
- Uniprot Name
- Cytochrome P450 1B1
- Molecular Weight
- 60845.33 Da
References
- Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP2B6
- Uniprot ID
- P20813
- Uniprot Name
- Cytochrome P450 2B6
- Molecular Weight
- 56277.81 Da
References
- Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP2C9
- Uniprot ID
- P11712
- Uniprot Name
- Cytochrome P450 2C9
- Molecular Weight
- 55627.365 Da
References
- Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
- Gene Name
- CYP2C19
- Uniprot ID
- P33261
- Uniprot Name
- Cytochrome P450 2C19
- Molecular Weight
- 55930.545 Da
References
- Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Binder
- General Function
- Androgen binding
- Specific Function
- Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone...
- Gene Name
- SHBG
- Uniprot ID
- P04278
- Uniprot Name
- Sex hormone-binding globulin
- Molecular Weight
- 43778.755 Da
References
- Khoromi S, Muniyappa R, Nackers L, Gray N, Baldwin H, Wong KA, Matheny LA, Moquin B, Rainer A, Hill S, Remaley A, Johnson LL, Max MB, Blackman MR: Effects of chronic osteoarthritis pain on neuroendocrine function in men. J Clin Endocrinol Metab. 2006 Nov;91(11):4313-8. Epub 2006 Aug 15. [PubMed:16912126]
- Stroud LR, Solomon C, Shenassa E, Papandonatos G, Niaura R, Lipsitt LP, Lewinn K, Buka SL: Long-term stability of maternal prenatal steroid hormones from the National Collaborative Perinatal Project: still valid after all these years. Psychoneuroendocrinology. 2007 Feb;32(2):140-50. Epub 2007 Jan 31. [PubMed:17270355]
- Lombardi G, Mondaini N, Macchiarella A, Del Popolo G: Female sexual dysfunction and hormonal status in spinal cord injured (SCI) patients. J Androl. 2007 Sep-Oct;28(5):722-6. Epub 2007 May 9. [PubMed:17494102]
- Shifren JL, Desindes S, McIlwain M, Doros G, Mazer NA: A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. Menopause. 2007 Nov-Dec;14(6):985-94. [PubMed:17507833]
- Rizzo L, Dobrovsky V, Danilowicz K, Kral M, Cross G, Serra HA, Bruno OD: Low-dose glucocorticoids in hyperandrogenism. Medicina (B Aires). 2007;67(3):247-52. [PubMed:17628912]
- Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA: Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. doi: 10.1371/journal.pone.0052759. Epub 2012 Dec 26. [PubMed:23300763]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Binder
- General Function
- Steroid binding
- Specific Function
- Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
- Gene Name
- SERPINA6
- Uniprot ID
- P08185
- Uniprot Name
- Corticosteroid-binding globulin
- Molecular Weight
- 45140.49 Da
References
- Henley DE, Lightman SL: New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience. 2011 Apr 28;180:1-8. doi: 10.1016/j.neuroscience.2011.02.053. Epub 2011 Mar 1. [PubMed:21371536]
- Czock D, Keller F, Rasche FM, Haussler U: Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. [PubMed:15634032]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- SubstrateInducer
- General Function
- Xenobiotic-transporting atpase activity
- Specific Function
- Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Gene Name
- ABCB1
- Uniprot ID
- P08183
- Uniprot Name
- Multidrug resistance protein 1
- Molecular Weight
- 141477.255 Da
References
- Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389]
- Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. [PubMed:10213372]
- Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924]
- Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R: Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 1992 Dec 5;267(34):24248-52. [PubMed:1360010]
- Orlowski S, Mir LM, Belehradek J Jr, Garrigos M: Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J. 1996 Jul 15;317 ( Pt 2):515-22. [PubMed:8713080]
- Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibit...
- Gene Name
- SLCO1A2
- Uniprot ID
- P46721
- Uniprot Name
- Solute carrier organic anion transporter family member 1A2
- Molecular Weight
- 74144.105 Da
References
- Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. [PubMed:8779893]
- Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- Curator comments
- Cortisol demonstrated substrate activity in vitro using human OAT3 expressed on Xenopus Laevis.
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenad...
- Gene Name
- SLC22A8
- Uniprot ID
- Q8TCC7
- Uniprot Name
- Solute carrier family 22 member 8
- Molecular Weight
- 59855.585 Da
References
- VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos. 2010 Jan;31(1):1-71. doi: 10.1002/bdd.693. [PubMed:19953504]
Drug created on June 13, 2005 07:24 / Updated on July 09, 2020 11:59
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