Hydrocortisone - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (4)Enzymes (6)Carriers (2)Transporters (3)

Targets (4)Enzymes (6)Carriers (2)Transporters (3)Biointeractions (14)

Identification

Name

Hydrocortisone

Accession Number

DB00741 (APRD01019, DB07886)

Type

Small Molecule

Groups

Approved, Vet Approved

Description

The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione

11beta-hydrocortisone

11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione

11β-hydrocortisone

17-Hydroxycorticosterone

4-Pregnen-11beta,17alpha,21-triol-3,20-dione

Cortisol

Hidrocortisona

Hydrocortisone

Hydrocortisonum

Kendall's compound F

Reichstein's substance M

External IDs

NSC-10483

Product Ingredients

Ingredient	UNII	CAS	InChI Key	Details
Hydrocortisone aceponate	2340UP1L2G	74050-20-7	MFBMYAOAMQLLPK-FZNHGJLXSA-N	Details
Hydrocortisone acetate	3X7931PO74	50-03-3	ALEXXDVDDISNDU-JZYPGELDSA-N	Details
Hydrocortisone butyrate	05RMF7YPWN	13609-67-1	BMCQMVFGOVHVNG-TUFAYURCSA-N	Details
Hydrocortisone cypionate	4XDY25L70B	508-99-6	DLVOSEUFIRPIRM-KAQKJVHQSA-N	Details
Hydrocortisone phosphate	2Y87E22X71	3863-59-0	BGSOJVFOEQLVMH-VWUMJDOOSA-N	Details
Hydrocortisone probutate	O6550D6K3A	72590-77-3	FOGXJPFPZOHSQS-AYVLZSQQSA-N	Details
Hydrocortisone sodium phosphate	0388G963HY	6000-74-4	RYJIRNNXCHOUTQ-OJJGEMKLSA-L	Details
Hydrocortisone sodium succinate	50LQB69S1Z	125-04-2	HHZQLQREDATOBM-CODXZCKSSA-M	Details
Hydrocortisone valerate	68717P8FUZ	57524-89-7	FZCHYNWYXKICIO-FZNHGJLXSA-N	Details

Product Images

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
A-hydrocort Inj 1000mg/8ml	Powder, for solution	1 g	Intramuscular; Intravenous	Hospira, Inc.	1993-12-31	2012-08-03	Canada
A-hydrocort Inj 100mg/2ml	Powder, for solution	100 mg	Intramuscular; Intravenous	Hospira, Inc.	1992-12-31	2012-08-03	Canada
A-hydrocort Inj 250mg/2ml	Powder, for solution	250 mg	Intramuscular; Intravenous	Hospira, Inc.	1992-12-31	2012-08-03	Canada
A-hydrocort Inj 500mg/4ml	Powder, for solution	500 mg	Intramuscular; Intravenous	Hospira, Inc.	1992-12-31	2012-08-03	Canada
Alocort 1% - Crm	Cream	1 %	Topical	Ucb Inc	1996-12-06	1998-04-21	Canada
Aquacort Lotion 2.5%	Lotion	2.5 %	Topical	Merit Industries Inc.	1992-12-31	2002-05-14	Canada
Barriere HC 1%	Cream; Jelly	1 %	Topical	Allen & Hanburys A Glaxo Canada Ltd. Co.	1979-12-31	1998-07-29	Canada
Bioelements Immediate Comfort	Lotion	.088 mL/88mL	Topical	Bioelements	2012-08-23	Not applicable	US
Cortamed Ont 25 mg/g	Ointment	25 mg	Ophthalmic	Sandoz Canada Incorporated	1992-12-31	Not applicable	Canada
Cortate Crm 1%	Cream	10 mg	Topical	Schering Plough	1980-12-31	2013-07-31	Canada
Cortate Ont 1%	Ointment	10 mg	Topical	Schering Plough	1980-12-31	2013-07-31	Canada
Cortef	Tablet	5 mg/1	Oral	Pharmacia & Upjohn Inc	1952-12-15	Not applicable	US
Cortef	Tablet	10 mg/1	Oral	Pharmacia & Upjohn Inc	1952-12-15	Not applicable	US
Cortef	Tablet	20 mg/1	Oral	Pharmacia & Upjohn Inc	1952-12-15	Not applicable	US
Cortef Tablets 10mg	Tablet	10 mg	Oral	Pfizer	1954-12-31	Not applicable	Canada
Cortef Tablets 20 mg	Tablet	20 mg	Oral	Pfizer	1954-12-31	Not applicable	Canada
Cortenema	Enema	100 mg	Rectal	Aptalis Pharma Inc.	1995-12-31	Not applicable	Canada
Cortenema	Enema	100 mg/60mL	Rectal	ANIP Acquisition Company	2012-08-10	Not applicable	US
Cortenema Sus 100mg/60ml	Enema; Suspension	100 mg	Rectal	Interfalk Canada Inc.	1986-12-31	1996-09-09	Canada
Corticreme 0.1%	Cream	1 mg	Topical	Rougier Pharma Division Of Ratiopharm Inc	1980-12-31	1999-09-27	Canada
Corticreme 1%	Cream	10 mg	Topical	Rougier Pharma Division Of Ratiopharm Inc	1980-12-31	1999-09-27	Canada
Cortifoam	Aerosol, foam	1500 mg/15g	Topical	Meda Pharmaceuticals Ltd	2015-06-30	Not applicable	US
Cortifoam	Aerosol	10 %	Rectal	Paladin Labs Inc	1983-12-31	Not applicable	Canada
Cortifoam	Aerosol, foam	1500 mg/15g	Rectal	Alaven Pharmaceutical	1982-02-12	Not applicable	US
Cortiment-10 Sup 10mg	Suppository	10 mg	Rectal	Hoechst Marion Roussel	1995-12-31	1997-02-28	Canada
Cortiment-40 Sup 40mg	Suppository	40 mg	Rectal	Hoechst Marion Roussel	1995-12-31	1997-02-28	Canada
Emo Cort Cream 2.5%	Cream	2.5 %	Topical	Glaxosmithkline Inc	1983-12-31	Not applicable	Canada
Emo Cort Lotion 2.5%	Lotion	2.5 %	Topical	Glaxosmithkline Inc	1983-12-31	2017-04-28	Canada
Emo Cort Sol 2.5% USP	Solution	2.5 %	Topical	Glaxosmithkline Inc	1986-12-31	2012-12-10	Canada
Hycort Retention Enema 100mg/60ml	Enema	100 mg	Rectal	Valeant Canada Lp Valeant Canada S.E.C.	1986-12-31	2014-04-22	Canada
Hydrocortisone	Tablet	20 mg/1	Oral	Avera Mc Kennan Hospital	2015-03-23	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Greenstone, Llc	2013-02-20	Not applicable	US
Hydrocortisone	Enema	100 mg/60mL	Rectal	ANIP Acquisition Company	2012-08-16	Not applicable	US
Hydrocortisone	Suspension	100 mg/60mL	Rectal	Breckenridge Pharmaceutical, Inc.	2010-10-15	2016-10-13	US
Hydrocortisone	Tablet	5 mg/1	Oral	Greenstone, Llc	2013-02-20	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	Kaiser Foundations Hospitals	2014-09-03	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Greenstone, Llc	2013-02-20	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Oceanside Pharmaceuticals	2013-07-03	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Rouses Point Pharm	2009-09-01	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Physicians Total Care, Inc.	2011-04-25	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Oceanside Pharmaceuticals	2013-07-03	Not applicable	US
Hydrocortisone Butyrate	Ointment	1 mg/g	Topical	Rouses Point Pharm	2009-09-01	Not applicable	US
Hydrocortisone Butyrate	Ointment	1 mg/g	Topical	Oceanside Pharmaceuticals	2009-09-01	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Rebel Distributors	2009-09-01	Not applicable	US
Hydrocortisone Butyrate	Solution	1 mg/mL	Topical	Rouses Point Pharm	2010-02-24	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Remedy Repack	2014-04-01	2016-12-21	US
Hydrocortisone Butyrate	Solution	1 mg/mL	Topical	Oceanside Pharmaceuticals	1987-02-25	Not applicable	US
Hydrocortisone Butyrate Cream (lipid) 0.1%	Cream	1 mg/g	Topical	Metacon Labs	2013-08-22	Not applicable	US
Hydrocortisone Cream 1%	Cream	1 g	Topical	D.C. Labs Limited	1982-12-31	2005-07-19	Canada
Hydrocortisone Crm 1%	Cream	10 mg	Topical	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1965-12-31	2002-07-31	Canada
Hydrocortisone Ointment 1%	Ointment	1 %	Topical	D.C. Labs Limited	1966-12-31	2003-07-11	Canada
Hydrocortisone Sodium Succinate for Injection	Powder, for solution	500 mg	Intramuscular; Intravenous	Teva	1994-12-31	Not applicable	Canada
Hydrocortisone Sodium Succinate for Injection	Powder, for solution	250 mg	Intramuscular; Intravenous	Teva	1994-04-21	Not applicable	Canada
Hydrocortisone Sodium Succinate for Injection	Powder, for solution	100 mg	Intramuscular; Intravenous	Teva	1994-12-31	Not applicable	Canada
Hydrocortisone Sodium Succinate Injection	Powder, for solution	1 g	Intramuscular; Intravenous	Teva	1994-12-31	Not applicable	Canada
Hydroval Cream 0.2%	Cream	0.2 %	Topical	Taropharma, A Division Of Taro Pharmaceuticals Inc.	2000-12-18	Not applicable	Canada
Hydroval Ointment 0.2%	Ointment	0.2 %	Topical	Taropharma, A Division Of Taro Pharmaceuticals Inc.	2000-12-18	Not applicable	Canada
Locoid	Lotion	1 mg/mL	Topical	Onset Dermatologics, LLC	2013-07-03	Not applicable	US
Locoid	Cream	1 mg/g	Topical	Onset Dermatologics, LLC	2013-07-03	Not applicable	US
Locoid	Solution	1 mg/mL	Topical	Onset Dermatologics, LLC	2013-07-02	Not applicable	US
Locoid	Ointment	1 mg/g	Topical	Onset Dermatologics, LLC	2013-07-08	Not applicable	US
Locoid Lipocream	Cream	1 mg/g	Topical	Onset Dermatologics, LLC	2013-07-03	Not applicable	US
Pandel	Cream	1 mg/g	Topical	Pharma Derm, A Division Of Fougera Pharmaceuticals Inc.	1997-02-28	Not applicable	US
Pandel	Cream	1 mg/g	Topical	Pharma Derm, A Division Of Nycomed Us Inc.	1997-02-28	2015-12-29	US
Rectocort Ont	Ointment	750 mg	Rectal; Topical	Welcker Lyster Ltd., Division Of Technilab Inc.	1980-12-31	1999-09-17	Canada
Rectocort Sup	Suppository	10 mg	Rectal	Welcker Lyster Ltd., Division Of Technilab Inc.	1975-12-31	1999-09-17	Canada
Sarna HC	Lotion	2.5 %	Topical	Glaxosmithkline Inc	1990-12-31	2014-06-02	Canada
Solu-cortef	Injection, powder, for solution	500 mg/4mL	Intramuscular; Intravenous	Pharmacia & Upjohn Inc	1955-04-27	Not applicable	US
Solu-cortef	Injection, powder, for solution	100 mg/2mL	Intramuscular; Intravenous	Pharmacia & Upjohn Inc	1955-04-27	Not applicable	US
Solu-cortef	Injection, powder, for solution	100 mg/2mL	Intramuscular; Intravascular	Cardinal Health	1955-04-27	Not applicable	US
Solu-cortef	Injection, powder, for solution	1000 mg/8mL	Intramuscular; Intravenous	Pharmacia & Upjohn Inc	1955-04-27	Not applicable	US
Solu-cortef	Injection, powder, for solution	250 mg/2mL	Intramuscular; Intravenous	Pharmacia & Upjohn Inc	1955-04-27	Not applicable	US
Solu-cortef	Injection, powder, for solution	100 mg/2mL	Intramuscular; Intravenous	Cardinal Health	1955-04-27	Not applicable	US
Solu-cortef	Injection, powder, for solution	100 mg/2mL	Intramuscular; Intravenous	Pharmacia & Upjohn Inc	1955-04-27	Not applicable	US
Solu-cortef 1 Gm Act-O-vial	Powder, for solution	1 g	Intramuscular; Intravenous	Pfizer	1967-12-31	Not applicable	Canada
Solu-cortef 100 Mg Act-O-vial	Powder, for solution	100 mg	Intramuscular; Intravenous	Pfizer	1958-12-31	Not applicable	Canada
Solu-cortef 250 Mg Act-O-vial	Powder, for solution	250 mg	Intramuscular; Intravenous	Pfizer	1962-12-31	Not applicable	Canada
Solu-cortef 500 Mg Act-O-vial	Powder, for solution	500 mg	Intramuscular; Intravenous	Pfizer	1966-12-31	Not applicable	Canada
Texacort Solution 1%	Lotion	1 %	Topical	Genderm Corporation	1988-12-31	1998-08-06	Canada
Topiderm HC 2%	Cream	2 %	Topical	Paladin Labs Inc	1990-12-31	2017-05-10	Canada
Westcort	Ointment	2 mg/g	Topical	Ranbaxy Inc.	2008-10-06	Not applicable	US
Westcort Crm 0.2%	Cream	0.2 %	Topical	Westwood Squibb, Division Of Bristol Myers Squibb Canada Inc.	1992-12-31	2006-12-18	Canada
Westcort Ont 0.2%	Ointment	0.2 %	Topical	Westwood Squibb, Division Of Bristol Myers Squibb Canada Inc.	1991-12-31	2009-04-17	Canada

Approved Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
A-hydrocort	Injection, powder, lyophilized, for solution	100 mg/2mL	Intramuscular; Intravenous	Hospira, Inc.	2011-05-12	Not applicable	US
Ala Scalp	Lotion	20 mg/mL	Topical	Crown Laboratories	1973-02-28	Not applicable	US
Alacort	Cream	10 mg/g	Topical	Crown Laboratories	1973-03-09	Not applicable	US
Alacort	Cream	25 mg/g	Topical	Crown Laboratories	1973-03-09	Not applicable	US
Anusol HC	Cream	25 mg/g	Topical	Salix Pharmaceuticals	1984-06-06	Not applicable	US
Colocort	Suspension	100 mg/60mL	Rectal	Paddock Laboratories, Inc.	1999-12-31	Not applicable	US
Home Papkit	Cream	25 mg/g	Topical	International Brand Management, Llc	2016-09-15	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2007-07-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Preferreed Pharmaceuticals Inc.	2013-01-14	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Remedy Repack	2013-06-12	2017-01-19	US
Hydrocortisone	Cream	25 mg/g	Topical	ANI Pharmaceuticals, Inc.	2016-04-01	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Qualitest	2007-07-16	Not applicable	US
Hydrocortisone	Ointment	25 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1993-05-28	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Carilion Materials Management	2007-03-30	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Taro Pharmaceuticals U.S.A., Inc.	2005-04-28	Not applicable	US
Hydrocortisone	Lotion	25 mg/mL	Topical	Perrigo New York Inc.	2008-05-23	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Amerincan Health Packaging	2011-04-01	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Physicians Total Care, Inc.	2007-07-05	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	A S Medication Solutions	2006-03-31	2017-06-20	US
Hydrocortisone	Cream	25 mg/g	Topical	Remedy Repack	2017-01-19	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	bryant ranch prepack	2007-03-30	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Actavis Mid Atlantic LLC,	2002-09-30	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	Qualitest	2007-07-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1986-12-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Unit Dose Services	2005-04-28	Not applicable	US
Hydrocortisone	Lotion	25 mg/mL	Topical	Qualitest	2003-07-30	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Stat Rx USA	2002-01-03	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Golden State Medical Supply	1973-06-18	2016-10-13	US
Hydrocortisone	Cream	10 mg/g	Topical	Lake Erie Medical Dba Quality Care Produts Llc	1976-04-30	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	Lineage Therapeutics	2007-03-30	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	Carilion Materials Management	2007-07-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Rebel Distributors	2006-03-31	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	A S Medication Solutions	2002-09-30	2017-06-20	US
Hydrocortisone	Cream	10 mg/g	Topical	ANI Pharmaceuticals, Inc.	2016-04-01	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Rebel Distributors	1986-12-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Lake Erie Medical Dba Quality Care Produts Llc	2006-03-31	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	A S Medication Solutions	1986-12-16	2017-06-20	US
Hydrocortisone	Tablet	20 mg/1	Oral	Vensun Pharmaceuticals, Inc.	2016-07-01	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	West Ward Pharmaceutical	2015-02-23	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Impax Generics	2007-03-30	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Lyne Laboratories, Inc.	2010-08-30	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Major	1973-06-18	Not applicable	US
Hydrocortisone	Ointment	25 mg/g	Topical	Physicians Total Care, Inc.	2007-11-28	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Pd Rx Pharmaceuticals, Inc.	2010-01-01	Not applicable	US
Hydrocortisone	Ointment	25 mg/1	Topical	Remedy Repack	2013-04-12	2017-04-14	US
Hydrocortisone	Lotion	25 mg/mL	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	2000-07-25	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Unit Dose Services	1986-12-16	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Qualitest	2007-07-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	A S Medication Solutions	2016-04-01	2017-06-20	US
Hydrocortisone	Tablet	5 mg/1	Oral	Amerincan Health Packaging	2014-06-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Physicians Total Care, Inc.	1995-08-04	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	Kaiser Foundations Hospitals	2010-03-05	Not applicable	US
Hydrocortisone	Ointment	25 mg/g	Topical	A S Medication Solutions	2006-06-13	2017-06-20	US
Hydrocortisone	Cream	10 mg/g	Topical	Actavis Pharma Company	2002-01-03	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Perrigo New York Inc.	2006-03-31	Not applicable	US
Hydrocortisone	Ointment	10 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1975-04-16	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Aidarex Pharmaceuticals LLC	2006-03-31	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Stat Rx USA	2004-03-12	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Proficient Rx LP	2002-09-30	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Lake Erie Medical &Surgical Supply Dba Quality Care Products Llc	2012-02-06	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Lineage Therapeutics	2007-03-30	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	Vensun Pharmaceuticals, Inc.	2016-07-01	Not applicable	US
Hydrocortisone	Ointment	10 mg/g	Topical	Cmp Pharma, Inc.	1985-07-30	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Rebel Distributors	1976-04-30	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Taro Pharmaceuticals U.S.A., Inc.	2005-04-28	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	A S Medication Solutions	2002-09-30	2017-06-20	US
Hydrocortisone	Cream	25 mg/g	Topical	A S Medication Solutions	2006-03-31	2017-06-20	US
Hydrocortisone	Tablet	20 mg/1	Oral	West Ward Pharmaceutical	1973-06-18	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Impax Generics	2007-03-30	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Preferreed Pharmaceuticals Inc.	2012-01-27	Not applicable	US
Hydrocortisone	Ointment	25 mg/g	Topical	Perrigo New York Inc.	2006-06-13	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1976-04-30	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Qualitest	2004-03-12	Not applicable	US
Hydrocortisone	Lotion	25 mg/mL	Topical	Physicians Total Care, Inc.	2008-05-08	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	1973-06-18	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Avera Mc Kennan Hospital	2015-07-22	Not applicable	US
Hydrocortisone	Ointment	25 mg/g	Topical	Remedy Repack	2013-12-17	2016-12-24	US
Hydrocortisone	Cream	25 mg/g	Topical	Directrx	2014-01-01	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Aidarex Pharmaceuticals LLC	2005-04-28	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Amerincan Health Packaging	2015-03-01	Not applicable	US
Hydrocortisone	Tablet	10 mg/1	Oral	Kaiser Foundations Hospitals	2010-03-05	Not applicable	US
Hydrocortisone	Ointment	10 mg/g	Topical	Actavis Pharma Company	2002-01-03	2017-09-30	US
Hydrocortisone	Tablet	10 mg/1	Oral	Vensun Pharmaceuticals, Inc.	2016-07-01	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	West Ward Pharmaceutical	2015-02-23	Not applicable	US
Hydrocortisone	Tablet	5 mg/1	Oral	Impax Generics	2007-03-30	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Crown Laboratories	1973-03-09	Not applicable	US
Hydrocortisone	Tablet	20 mg/1	Oral	Stat Rx USA	1973-06-18	Not applicable	US
Hydrocortisone	Cream	25 mg/g	Topical	Remedy Repack	2016-02-09	2017-03-02	US
Hydrocortisone	Tablet	20 mg/1	Oral	Lineage Therapeutics	2007-03-30	Not applicable	US
Hydrocortisone 1% In Absorbase	Ointment	10 mg/g	Topical	Solubiomix	2016-11-02	Not applicable	US
Hydrocortisone Butyrate	Ointment	1 mg/g	Topical	Taro Pharmaceuticals U.S.A., Inc.	2004-12-27	Not applicable	US
Hydrocortisone Butyrate	Solution	1 mg/mL	Topical	Taro Pharmaceuticals U.S.A., Inc.	2004-01-14	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Glenmark Pharmaceuticals Inc.,Usa	2013-12-05	Not applicable	US
Hydrocortisone Butyrate	Cream	1 mg/g	Topical	Taro Pharmaceuticals U.S.A., Inc.	2005-08-04	Not applicable	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	Gw Pharmaceuticals Ltd.	1998-08-25	Not applicable	US
Hydrocortisone Valerate	Ointment	2 mg/g	Topical	Physicians Total Care, Inc.	2005-03-15	Not applicable	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	Rebel Distributors	1998-08-25	Not applicable	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	Directrx	2014-01-01	Not applicable	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	A S Medication Solutions	1998-08-25	2017-06-20	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	Physicians Total Care, Inc.	2002-02-04	Not applicable	US
Hydrocortisone Valerate	Ointment	2 mg/g	Topical	Taro Pharmaceuticals U.S.A., Inc.	1998-08-25	Not applicable	US
Hydrocortisone Valerate	Ointment	2 mg/g	Topical	Gw Pharmaceuticals Ltd.	1998-08-25	Not applicable	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	Perrigo New York Inc.	2009-12-02	Not applicable	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	A S Medication Solutions	2009-12-02	2017-06-20	US
Hydrocortisone Valerate	Cream	2 mg/g	Topical	Taro Pharmaceuticals U.S.A., Inc.	1998-08-25	Not applicable	US
Micort HC	Cream	25 mg/g	Topical	Sebela Pharmaceuticals Inc.	2016-09-13	Not applicable	US
Pediaderm HC	Kit			Arbor Pharmaceuticals	2009-11-02	Not applicable	US
Procto-med HC	Cream	25 mg/g	Topical	Leading Pharma, Llc	2016-05-09	Not applicable	US
Procto-med HC	Cream	25 mg/g	Topical	A S Medication Solutions	2016-05-09	2017-06-20	US
Procto-pak	Cream	10 mg/g	Topical	Rising Pharmaceuticals	2012-06-01	Not applicable	US
Proctocort	Cream	10 mg/g	Topical	Salix Pharmaceuticals	2004-06-01	Not applicable	US
Proctocream HC	Cream	25 mg/g	Topical	Alaven Pharmaceutical	2011-03-18	Not applicable	US
Proctosol-HC	Cream	25 mg/g	Topical	A S Medication Solutions	2005-04-28	2017-06-20	US
Proctosol-HC	Cream	25 mg/g	Topical	Preferreed Pharmaceuticals Inc.	2014-11-19	Not applicable	US
Proctosol-HC	Cream	25 mg/g	Topical	Ranbaxy Inc.	2005-04-28	Not applicable	US
Proctozone HC	Cream	25 mg/g	Topical	Preferreed Pharmaceuticals Inc.	2012-08-21	Not applicable	US
Proctozone HC	Cream	25 mg/g	Topical	Physicians Total Care, Inc.	2007-10-30	Not applicable	US
Proctozone HC	Cream	25 mg/g	Topical	A S Medication Solutions	2012-05-01	2017-06-20	US
Proctozone HC	Cream	25 mg/g	Topical	Rising Pharmaceuticals	2012-05-01	Not applicable	US
Proctozone-HC	Cream	25 mg/g	Topical	Rising Pharmaceuticals	2015-08-03	Not applicable	US
Texacort	Solution	25 mg/mL	Topical	Mission Pharmacal	2011-12-15	Not applicable	US

Approved Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
1 Hydrocortisone Maximum Strength	Ointment	1 g/100g	Topical	American Sales Company	2012-10-17	Not applicable	US
999 Itch Relieving	Ointment	1 g/100g	Topical	Guangdong CR. Shunfeng Pharmaceutical Co Ltd	1989-07-20	Not applicable	US
999 Itch Relieving	Ointment	1 g/100g	Topical	Guangdong CR. Shunfeng Pharmaceutical Co Ltd	1989-07-20	Not applicable	US
Advanced Anti-itch Therapy	Soap	1 g/100g	Topical	Cvs Health	2016-06-10	Not applicable	US
Advanced Hydrocortisone	Cream	10 mg/g	Topical	Ultra Seal Corporation	2011-04-05	Not applicable	US
Aftate Hydrocortisone Cream	Cream	1 g/100g	Topical	Sabel Med Llc	2016-05-01	Not applicable	US
Ana Cool Rapid Soothing Cooling Formula	Cream	10 mg/g	Topical	Ana Cool, Llc	2015-11-25	Not applicable	US
Anti Itch	Cream	1 g/100g	Topical	Hyvee	2015-11-01	Not applicable	US
Anti Itch	Cream	1 g/100g	Topical	Rite Aid	2009-02-09	Not applicable	US
Anti Itch	Cream	1 g/100g	Topical	Rite Aid	2013-09-11	Not applicable	US
Anti Itch	Lotion	1 g/100g	Topical	Walgreen	2012-03-27	Not applicable	US
Anti Itch	Cream	1 g/100g	Topical	Safeway	2005-08-24	Not applicable	US
Anti Itch	Ointment	1 g/100g	Topical	Rite Aid	2005-07-25	Not applicable	US
Anti Itch Maximum Strength	Gel	1 g/100g	Topical	Meijer Distribution	1997-09-24	Not applicable	US
Anti Itch Maximum Strength	Cream	1 g/100g	Topical	Kmart Corporation	2010-12-23	Not applicable	US
Anti Itch Maximum Strength Plus	Cream	1 g/100g	Topical	Rite Aid	2011-02-16	Not applicable	US
Anti-itch	Cream	10 mg/g	Topical	Medline Industries	2010-03-01	Not applicable	US
Anti-itch Feminine Care	Cream	5 mg/g	Topical	Ohio Lab Pharma	2016-10-25	Not applicable	US
Anti-itch Scalp Relief Maximum Strength	Solution	1 g/100g	Topical	Delon Laboratories (1990) Ltd.	2014-09-08	2016-10-13	US
Anti-itch Scherer Labs	Spray	1 g/100g	Topical	Kmart Corporation	2013-04-15	Not applicable	US
Atopalm Maximum Strength Anti-itch	Ointment	1 g/100g	Topical	Neopharm Co., Ltd	2011-11-04	Not applicable	US
Atopalm Moisturizing Hydrocortisone	Cream	1 g/100g	Topical	Neopharm Co., Ltd	2011-03-17	Not applicable	US
Avedana Hydrocortisone Cream With Aloe	Ointment	1.02 g/100g	Topical	Unipack	2016-04-07	Not applicable	US
Aveeno Hydrocortisone Anti Itch	Cream	10 mg/g	Topical	Johnson & Johnson Consumer Products Company, Division Of Johnson Consumer Companies, Inc.	2012-10-08	Not applicable	US
Aveeno Hydrocortisone Anti-itch Cream	Cream	0.5 %	Topical	Johnson & Johnson	2002-05-06	2005-08-09	Canada
Berkley and Jensen Anti Itch	Cream	1 g/100g	Topical	BJWC	2014-12-09	Not applicable	US
Berkley and Jensen Hydrocortisone	Cream	1 g/100g	Topical	BJWC	2008-12-04	Not applicable	US
Biocorneum HC Advanced Scar Supervision Anti-itch	Gel	1 g/100g	Topical	Enaltus Inc	2012-05-10	Not applicable	US
Bioelements Immediate Comfort Hydrocortisone	Lotion	1 mL/100mL	Topical	Bioelements	2010-08-19	Not applicable	US
Blue-emu Anti-itch Cream	Cream	1 g/100g	Topical	Nfi Consumer Products	2015-06-01	Not applicable	US
Budpak Anti-itch	Cream	.01 g/g	Topical	Budpak Inc.	2012-12-17	Not applicable	US
Caldecort	Cream	.284 g/28.4g	Topical	Insight Pharmaceuticals	2009-07-16	Not applicable	US
Care One Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	American Sales Company	2010-05-28	Not applicable	US
Care One Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	American Sales Company	2010-11-12	Not applicable	US
Careall Hydrocortisone Maximum Strength	Cream	1 g/g	Topical	New World Imports	2016-03-11	Not applicable	US
Careall Hydrocortisone Maximum Strength	Cream	10 mg/g	Topical	New World Imports	2010-08-30	Not applicable	US
Careone Anti Itch	Cream	1 g/100g	Topical	American Sales Company	2016-05-19	Not applicable	US
Cerave Anti-itch	Cream	10 mg/g	Topical	Valeant Pharmaceuticals North America	2014-12-01	Not applicable	US
Cicatricure Ultra Moisturizing	Cream	10 mg/g	Topical	Genoma Lab USA Inc	2013-12-01	Not applicable	US
Cooling Itch Relief Well At Walgreens	Spray	1 g/100g	Topical	Walgreens	2013-03-15	Not applicable	US
Cortacet Crm 0.5%	Cream	0.5 %	Topical	Whitehall Robins Inc.	1992-12-31	2002-07-19	Canada
Cortaid 12-hour Advanced Anti-itch	Cream	1 g/100g	Topical	Valeant Pharmaceuticals North America	2012-10-01	Not applicable	US
Cortaid Intensive Therapy Cooling	Spray	10 g/mL	Topical	Valeant Pharmaceuticals North America	2012-10-01	Not applicable	US
Cortaid Maximum Strength	Cream	1 g/100g	Topical	Valeant Pharmaceuticals North America	2012-10-01	2017-01-25	US
Cortaid Maximum Strength	Cream	1 g/100g	Topical	Valeant Pharmaceuticals North America	2012-10-01	Not applicable	US
Cortibalm	Ointment	100 g/g	Topical	Dr. Dan's Llc	2001-01-10	Not applicable	US
Corticreme 0.5%	Cream	0.5 %	Topical	Rougier Pharma Division Of Ratiopharm Inc	1988-12-31	1999-09-27	Canada
Cortisil Mdx	Gel	1 g/100g	Topical	Bio Zone Laboratories, Inc.	2013-03-25	Not applicable	US
Cortisone	Lotion	1 g/100g	Topical	Cvs Health	2012-04-10	Not applicable	US
Cortisone	Ointment	1 g/100g	Topical	Cvs Health	2005-06-10	Not applicable	US
Cortisone Cream Intensive Healing	Cream	10 mg/g	Topical	Tai Guk Pharmaceutical Company, Limited	2010-01-01	Not applicable	US
Cortisone Maximum Strength	Cream	1 g/100g	Topical	Cvs Health	2010-01-05	Not applicable	US
Cortisone Maximum Strength	Gel	1 g/100g	Topical	Cvs Health	2009-12-22	Not applicable	US
Cortisone Maximum Strength	Ointment	1 g/100g	Topical	Cvs Health	2006-04-25	Not applicable	US
Cortisone Plus Aloe Maximum Strength	Cream	1 g/100g	Topical	Cvs Health	2012-02-22	Not applicable	US
Cortizone 10	Ointment	10 mg/g	Topical	Chattem, Inc.	2007-09-01	Not applicable	US
Cortizone 10	Cream	10 mg/g	Topical	Chattem, Inc.	2007-09-01	Not applicable	US
Cortizone 10 Anti-itch for Diabetics Skin	Lotion	1 g/100g	Topical	Chattem, Inc.	2014-12-22	Not applicable	US
Cortizone 10 Cooling Cream Anti-itch	Cream	1 g/100g	Topical	Chattem, Inc.	2013-12-02	Not applicable	US
Cortizone 10 Cooling Relief	Gel	10 mg/g	Topical	Chattem, Inc.	2008-10-01	Not applicable	US
Cortizone 10 Creme Ultra Moisturizing	Lotion	1 g/100g	Topical	Chattem, Inc.	2013-02-18	Not applicable	US
Cortizone 10 Easy Relief	Liquid	10 mg/mL	Topical	Chattem, Inc.	2008-10-01	Not applicable	US
Cortizone 10 for Psoriasis	Lotion	1 g/100g	Topical	Chattem, Inc.	2016-01-15	Not applicable	US
Cortizone 10 Hydratensive Healing Anti Itch	Lotion	1 g/100g	Topical	Chattem, Inc.	2010-06-01	Not applicable	US
Cortizone 10 Hydratensive Soothing Anti Itch	Lotion	1 g/100g	Topical	Chattem, Inc.	2010-06-01	Not applicable	US
Cortizone 10 Intensive Healing	Cream	10 mg/g	Topical	Chattem, Inc.	2007-12-01	Not applicable	US
Cortizone 10 Intensive Healing Feminine Itch Relief	Cream	1 g/100g	Topical	Chattem, Inc.	2014-01-01	Not applicable	US
Cortizone 10 Intensive Healing for Eczema	Lotion	10 mg/g	Topical	Chattem, Inc.	2009-12-08	Not applicable	US
Cortizone 10 Plus	Cream	10 mg/g	Topical	Chattem, Inc.	2007-09-01	Not applicable	US
Cortizone 10 Poison Ivy Relief Pads	Gel	1 g/100g	Topical	Chattem, Inc.	2013-01-20	Not applicable	US
Cvs Anti-itch Hydrocortisone	Cream	1 mg/g	Topical	Cvs Health	2014-02-25	Not applicable	US
Cvs Cools Itch Fast	Gel	1 mg/g	Topical	Cvs Health	2014-10-13	Not applicable	US
Cvs Cortisone	Cream	1 g/100g	Topical	Cvs Health	1995-08-23	Not applicable	US
Cvs Health Maxium Strentgh Cortisone	Lotion	1 mg/mL	Topical	Cvs Health	2016-04-25	Not applicable	US
Cvs Hydrocortisone With Aloe	Cream	.5 g/100g	Topical	Cvs Health	2014-10-13	Not applicable	US
Cvs Pharmacy Anti-itch	Cream	1 g/100g	Topical	Cvs Health	2013-04-30	Not applicable	US
Dermacort Anti-itch	Cream	10 mg/g	Topical	Melaleuca, Inc.	2000-08-02	Not applicable	US
Dermaquest Skin Therapy Post-skin Resurfacing Balm	Cream	10 mg/mL	Topical	Allure Labs, Inc.	2010-01-01	Not applicable	US
Dermarest Dricort 0.5% Hydrocortisone Anti-itch	Cream	0.5 %	Topical	Del Pharmaceuticals Inc.	1995-06-01	2008-12-16	Canada
Dermarest Eczema Medicated	Lotion	1.18 mL/118mL	Topical	Insight Pharmaceuticals	2010-09-20	Not applicable	US
Dg Health Hydrocortisone	Cream	1 g/100g	Topical	Dolgencorp	2011-01-14	Not applicable	US
Dg Health Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Dolgencorp	2010-01-30	Not applicable	US
Dr H Stabilizer	Lotion	.75 g/100mL	Topical	Diversified Manufacturing Corp	2016-05-16	Not applicable	US
Dr. Sheffield Hydrocortisone Anti Itch	Cream	10 mg/g	Topical	Faria Llc Dba Sheffield Pharmaceutcials	2007-07-10	Not applicable	US
Duane Reade	Cream	.284 g/28.4g	Topical	Duane Reade	2011-03-21	Not applicable	US
Duane Reade Hydrocortisone	Cream	.284 g/28.4g	Topical	Duane Reade	2011-03-18	Not applicable	US
Duane Reade Hydrocortisone Plus 12 Moisturizers	Cream	.284 g/287.4g	Topical	Duane Reade	2011-03-28	Not applicable	US
Ecolab Hydrocortisone Cream	Cream	10 mg/g	Topical	Ecolab Food Safety Specialties, Inc.	2017-03-20	Not applicable	US
Eczema Skin Mushatts N9	Cream	1 g/100mL	Topical	Product Quest Mfg.	2013-04-22	Not applicable	US
Equaline Anti Itch	Ointment	1 g/100g	Topical	Supervalu	2010-12-03	Not applicable	US
Equaline Anti Itch	Cream	1 g/100g	Topical	Supervalu	2010-11-17	Not applicable	US
Equaline Anti Itch Maximum Strength	Cream	1 g/100g	Topical	Supervalu	2011-02-25	Not applicable	US
Equaline Anti Itch Maximum Strength	Cream	1 g/100g	Topical	Supervalu	2010-10-01	Not applicable	US
Equate Hydrocortisone	Ointment	1 g/100g	Topical	Walmart Stores	2013-02-21	Not applicable	US
Equate Hydrocortisone	Cream	1 g/100g	Topical	Walmart Stores	2009-01-21	Not applicable	US
Equate Hydrocortisone	Cream	1 g/100g	Topical	Walmart Stores	2005-06-29	Not applicable	US
Equate Hydrocortisone	Cream	1 g/100g	Topical	Walmart Stores	2012-03-13	Not applicable	US
Exchange Select Hydrocortisone	Cream	1 g/100g	Topical	Army + Air Force Exchange Service	2016-02-26	Not applicable	US
Face Values Hydrocortisone With Aloe	Cream	1 g/100g	Topical	Harmon Stores	2012-04-01	Not applicable	US
Family Care Hydrocortisone	Ointment	1 g/100g	Topical	United Exchange Corporation	2014-11-24	Not applicable	US
Family Care Hydrocortisone	Cream	1 g/100g	Topical	United Exchange Corporation	2012-04-01	Not applicable	US
Family Wellness	Cream	1 g/100g	Topical	Zhejiang Jingwei Pharmaceutical Co., Ltd.	2013-03-01	Not applicable	US
Family Wellness	Cream	1 g/100g	Topical	Front Pharmaceutical Plc	2017-06-18	Not applicable	US
Family Wellness Hydrocortisone	Ointment	1 g/100g	Topical	Family Dollar Services	2012-12-05	Not applicable	US
Family Wellness Maximum Strength Hydrocortisone	Cream	1 g/100g	Topical	Family Dollar	2013-08-19	Not applicable	US
Fixmyskin Healing Balm Fragrance-free	Ointment	10 mg/mL	Topical	Lovely Skin, Inc.	2011-11-17	Not applicable	US
Fixmyskin Healing Balm Unflavored	Ointment	1 mL/100mL	Topical	Lovely Skin, Inc.	2011-11-17	Not applicable	US
Fixmyskin Healing Balm Vanilla Flavor	Ointment	1 mL/100mL	Topical	Lovely Skin, Inc.	2011-11-17	Not applicable	US
Fixmyskin Healing Balm Vanilla Fragrance	Ointment	1 mL/100mL	Topical	Lovely Skin, Inc.	2011-11-17	2016-03-12	US
Formu Care Anti Itch Maximum Strength	Cream	1 g/100g	Topical	Access Business Group	2009-08-12	Not applicable	US
Fulton Street Market Anti Itch	Cream	1 g/100g	Topical	Access Business Group	2009-08-12	Not applicable	US
Gadaderm Hydrocortisone	Cream	.5 g/100g	Topical	Gadal Laboratories, Inc.	2013-06-01	Not applicable	US
Genuine Hydrocortisone	Cream	1 g/100g	Topical	Genuine First Aid	2011-03-29	Not applicable	US
Good Neighbor Pharmacy Anti Itch	Lotion	1 g/mL	Topical	Amerisource Bergen	2005-09-09	Not applicable	US
Good Neighbor Pharmacy Hydrocortisone	Ointment	1 g/100g	Topical	Amerisource Bergen	1989-10-03	Not applicable	US
Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Amerisource Bergen	1989-10-03	Not applicable	US
Good Neighbor Pharmacy Hydrocortisone With Aloe	Cream	1 g/100g	Topical	Amerisource Bergen	1995-08-23	Not applicable	US
Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin	Cream	.5 g/100g	Topical	Amerisource Bergen	2001-09-13	Not applicable	US
Good Sense Anti Itch	Cream	1 g/100g	Topical	L. Perrigo Company	2006-03-07	Not applicable	US
Good Sense Anti Itch	Cream	1 g/100g	Topical	L. Perrigo Company	2006-02-24	Not applicable	US
Grx Hicort	Suppository	.025 g/2g	Rectal	Geritrex Llc	2013-11-12	2016-02-02	US
H-releve Anti-itch	Cream	1 g/100g	Topical	Puresource Inc.	2013-08-15	2016-01-07	US
Hair Sanity Hair Sanity Part I	Lotion / shampoo	5 mg/mL	Topical	Prime Enterprises, Inc.	2017-04-18	Not applicable	US
Harris Teeter Anti-itch	Cream	1 g/100g	Topical	Harris Teeter	2017-04-20	Not applicable	US
Harris Teeter Anti-itch Cooling Relief	Gel	10 mg/g	Topical	Harris Teeter	2017-04-19	Not applicable	US
Harris Teeter Anti-itch Intensive Healing	Cream	1 g/100g	Topical	Harris Teeter	2017-04-20	Not applicable	US
Harris Teeter Anti-itch With Aloe	Cream	10 mg/g	Topical	Harris Teeter	2017-04-19	Not applicable	US
Harris Teeter Maximum Strength Anti-itch	Ointment	10 mg/g	Topical	Harris Teeter	2017-04-17	Not applicable	US
Healerz for Itches	Cream	1 g/100g	Topical	Wellco Brands LLC	2013-02-01	Not applicable	US
Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers	Cream	1 g/100g	Topical	Health Mart	1989-10-03	Not applicable	US
Health Mart Pharmacy Hydrocortisone Maximum Strength With Aloe	Cream	1 g/100g	Topical	Health Mart	1989-10-03	Not applicable	US
Healthy Accents Cortisone Maximum Strength	Cream	1 g/100g	Topical	Dza Brands,	2010-08-25	Not applicable	US
Hem-easy Relief Herbal Anti-itch Maximum Itch Relief	Cream	10 mg/mL	Topical	Batool Pharma International, Inc	2014-08-27	2017-01-20	US
Hydro Skin	Lotion	1 g/mL	Topical	Rugby	2012-10-29	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Kroger	2017-04-13	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Dynarex Corporation	2015-12-02	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Unifirst First Aid	2013-04-15	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	Trifecta Pharmaceuticals Usa, Llc.	2015-03-10	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Safetec Of America Inc	2010-12-15	Not applicable	US
Hydrocortisone	Lotion	1 g/mL	Topical	Perrigo New York Inc.	2011-02-07	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	Proficient Rx LP	1989-10-03	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1976-04-30	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	H.E.B.	2015-09-11	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Galentic Pharma (India) Private Limited	2013-08-07	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Cvs Health	2009-05-19	Not applicable	US
Hydrocortisone	Ointment	10 mg/g	Topical	Discount Drug Mart	2012-01-30	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Dynarex Corporation	2010-02-02	Not applicable	US
Hydrocortisone	Cream	.5 g/100g	Topical	Taro Pharmaceuticals U.S.A., Inc.	2001-09-13	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Morales Distributors, Inc.	2012-09-25	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	Preferreed Pharmaceuticals Inc.	2014-01-23	Not applicable	US
Hydrocortisone	Gel	1 g/100g	Topical	H.E.B.	2010-10-02	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Unifirst First Aid	2013-04-15	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Kroger	2017-05-15	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Safeway	2015-04-07	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Dynarex Corporation	2016-10-07	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Kinray	2017-06-14	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	Water Jel Technologies	2010-04-30	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Proficient Rx LP	2001-10-01	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	A S Medication Solutions	2001-10-01	2017-06-20	US
Hydrocortisone	Ointment	10 mg/g	Topical	Moore Medical	2012-07-12	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Value Merchandisers	2012-01-30	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Kareway Product, Inc.	2013-12-12	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	H.E.B.	2014-01-18	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	A S Medication Solutions	1976-04-30	2017-06-20	US
Hydrocortisone	Cream	5 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1968-01-01	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	HART Health	1990-01-30	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	Taro Pharmaceuticals U.S.A., Inc.	1989-10-03	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Discount Drug Mart	2015-10-30	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Perrigo New York Inc.	2011-04-13	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Rebel Distributors	2011-04-13	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	First Aid Only	2015-06-10	Not applicable	US
Hydrocortisone	Ointment	10 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1975-04-06	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Qualitest	2001-10-01	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Preferreed Pharmaceuticals Inc.	2012-03-12	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	H.E.B.	2010-09-15	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Dynarex Corporation	2010-02-02	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	A S Medication Solutions	2001-10-01	2017-06-20	US
Hydrocortisone	Cream	1 g/100g	Topical	Kroger	2017-04-05	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Navarro Discount Pharmacies, LLC	2012-08-01	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	Perrigo New York Inc.	2011-08-18	Not applicable	US
Hydrocortisone	Cream	1 h/100g	Topical	Neopharm Co., Ltd	2010-09-01	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Genuine First Aid	2010-04-23	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	A S Medication Solutions	2011-08-18	2017-06-20	US
Hydrocortisone	Liquid	10 mg/mL	Topical	Cvs Health	2010-07-16	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Discount Drug Mart	2015-10-30	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Blossom Pharmaceuticals	2014-05-01	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Unifirst First Aid	2013-04-15	Not applicable	US
Hydrocortisone	Cream	.5 g/100g	Topical	Proficient Rx LP	2001-09-13	Not applicable	US
Hydrocortisone	Ointment	10 mg/g	Topical	Value Merchandisers	2012-01-30	Not applicable	US
Hydrocortisone	Cream	1 h/100g	Topical	Kareway Product, Inc.	2011-08-10	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Value Merchandisers	2012-02-29	Not applicable	US
Hydrocortisone	Ointment	1 g/100g	Topical	North Safety Products	2013-03-06	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Advanced First Aid, Inc.	2015-04-08	Not applicable	US
Hydrocortisone	Aerosol, spray	1.13 g/113g	Topical	Walmart Stores	2015-04-15	Not applicable	US
Hydrocortisone	Ointment	5 mg/g	Topical	E. Fougera & CO., A division of Fougera Pharmaceuticals Inc.	1981-01-01	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Sion Biotext Medical Ltd.	2012-07-06	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	H.E.B.	2010-09-27	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Pro Mex Llc	2013-11-15	Not applicable	US
Hydrocortisone	Cream	1 g/100g	Topical	Choice Laboratories	2010-02-02	Not applicable	US
Hydrocortisone	Cream	10 mg/mL	Topical	Uni Shield	2010-07-28	Not applicable	US
Hydrocortisone	Cream	.5 g/100g	Topical	Kaiser Foundations Hospitals	2001-09-13	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	B8 Sales, Inc.	2010-05-01	Not applicable	US
Hydrocortisone	Cream	10 mg/g	Topical	Acme United Corporation	2015-11-06	Not applicable	US
Hydrocortisone 1 Anti Itch	Ointment	1.12 g/100g	Topical	Cvs Health	2005-06-09	Not applicable	US
Hydrocortisone 1 Plus 10	Cream	1 g/100g	Topical	Rite Aid	2011-02-16	Not applicable	US
Hydrocortisone 1%	Ointment	1 g/100g	Topical	Trifecta Pharmaceuticals Usa, Llc.	2016-04-09	Not applicable	US
Hydrocortisone 1% With Healing Aloe	Cream	1 g/100g	Topical	Trifecta Pharmaceuticals Usa, Llc.	2015-12-23	Not applicable	US
Hydrocortisone Acetate	Ointment	1 g/100g	Topical	Kinray	2011-09-06	Not applicable	US
Hydrocortisone Acetate	Cream	10 mg/g	Topical	Bentlin Products LLC	2007-01-24	Not applicable	US
Hydrocortisone Acetate	Ointment	1 g/100g	Topical	Galentic Pharma (India) Private Limited	2011-09-06	Not applicable	US
Hydrocortisone Acetate	Cream	1 g/100g	Topical	Kinray	2011-07-29	Not applicable	US
Hydrocortisone Acetate Antipruritic (anti-itch)	Cream	1 g/100g	Topical	Taro Pharmaceuticals U.S.A., Inc.	2001-06-01	Not applicable	US
Hydrocortisone Anti Itch	Cream	1 g/100g	Topical	H.E.B.	2010-09-15	Not applicable	US
Hydrocortisone Anti-itch	Cream	.01 g/g	Topical	Universal Distribution Center LLC	2015-04-15	Not applicable	US
Hydrocortisone Anti-itch Plus	Cream	10 mg/g	Topical	Walmart Stores	2010-06-01	Not applicable	US
Hydrocortisone Cream	Cream	1 g/100g	Topical	Trifecta Pharmaceuticals Usa	2017-04-07	Not applicable	US
Hydrocortisone Cream 0.5%	Cream	5 mg	Topical	Technilab Pharma Inc.	1996-12-31	2005-08-05	Canada
Hydrocortisone Cream 0.5%	Cream	500 mg	Topical	D.C. Labs Limited	1982-12-31	2005-07-19	Canada
Hydrocortisone Cream 0.5% USP	Cream	0.5 %	Topical	Pharmetics (2011) Inc.	1976-12-31	2000-08-21	Canada
Hydrocortisone Cream Intensive Healing	Cream	1.02 g/100g	Topical	Walgreens	2016-06-07	Not applicable	US
Hydrocortisone Cream USP 0.5%	Cream	0.5 %	Topical	Ksl Pharmaceuticals	1994-12-31	1996-09-09	Canada
Hydrocortisone Crm 0.5%	Cream	5 mg	Topical	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1965-12-31	2002-07-31	Canada
Hydrocortisone D	Cream	1 g/100g	Topical	Nexmed Usa Inc	2011-08-19	Not applicable	US
Hydrocortisone HC	Cream	1 g/100g	Topical	Neopharm Co., Ltd	2010-12-15	Not applicable	US
Hydrocortisone Intensive Healing Formula	Cream	1 g/100g	Topical	Western Family Foods	2009-03-11	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Walgreen	1990-01-01	Not applicable	US
Hydrocortisone Maximum Strength	Ointment	1 g/100g	Topical	Walgreen	1990-01-01	Not applicable	US
Hydrocortisone Maximum Strength	Ointment	1 g/100g	Topical	A S Medication Solutions	1998-09-01	2017-06-20	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Chain Drug Consortium	2006-09-08	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Actavis Pharma Company	1997-08-01	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Nu Care Pharmaceuticals,inc.	1997-08-01	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Walgreen	2009-02-27	Not applicable	US
Hydrocortisone Maximum Strength	Ointment	1 g/100g	Topical	Actavis Pharma Company	1998-09-01	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Walgreen	2010-07-16	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Army + Air Force Exchange Service	2005-03-14	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Kroger	2008-07-24	Not applicable	US
Hydrocortisone Maximum Strength	Ointment	1 g/100g	Topical	Stephen L. La France Pharmacy, Inc.	2008-05-13	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	L&R Distributors, Inc.	2006-02-01	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Fred's	2009-09-01	Not applicable	US
Hydrocortisone Maximum Strength	Ointment	1 g/100g	Topical	Walgreen	2010-07-16	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	H.E.B.	2010-08-23	Not applicable	US
Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Preferreed Pharmaceuticals Inc.	2012-04-30	Not applicable	US
Hydrocortisone Maximum Strength	Ointment	1 g/100g	Topical	Chain Drug Consortium	2006-09-08	Not applicable	US
Hydrocortisone Maximum Strength Plus 12 Moisturizers	Cream	1 g/100g	Topical	L&R Distributors, Inc.	2010-04-05	Not applicable	US
Hydrocortisone Maximum Strength Plus 12 Moisturizers	Cream	1 g/100g	Topical	Fred's	2009-05-01	Not applicable	US
Hydrocortisone Maximum Strength With Aloe	Cream	1 g/100g	Topical	Chain Drug Marketing Association	2010-07-01	Not applicable	US
Hydrocortisone Maximum Strength With Aloe	Cream	1 g/100g	Topical	Proficient Rx LP	2009-04-21	Not applicable	US
Hydrocortisone Maximum Strength With Aloe	Cream	1 g/100g	Topical	Family Dollar Services	2007-03-22	Not applicable	US
Hydrocortisone Maximum Strength With Aloe	Cream	1 g/100g	Topical	L&R Distributors, Inc.	2005-09-23	Not applicable	US
Hydrocortisone Maximum Strength With Aloe	Cream	1 g/100g	Topical	Chain Drug Marketing Association	2010-07-01	Not applicable	US
Hydrocortisone Ointment 0.5%	Ointment	0.5 %	Topical	D.C. Labs Limited	1968-12-31	2003-07-11	Canada
Hydrocortisone Plus	Cream	10 mg/g	Topical	Walgreens	2010-06-01	Not applicable	US
Hydrocortisone Plus 10 Moisturizers	Cream	1 g/100g	Topical	Walgreen	2015-08-27	Not applicable	US
Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Taro Pharmaceuticals U.S.A., Inc.	1989-10-03	Not applicable	US
Hydrocortisone Plus 12 Moisturizers Maximum Strength	Cream	1 g/100g	Topical	Kroger	2008-07-01	Not applicable	US
Hydrocortisone Regular Strength	Cream	.5 g/100g	Topical	Walgreen	1997-01-07	2017-04-30	US
Hydrocortisone Ultra Strength	Cream	140 mg/14g	Topical	Personal Care Products	2013-07-10	Not applicable	US
Hydrocortisone With Aloe	Cream	1 g/100g	Topical	Taro Pharmaceuticals U.S.A., Inc.	1995-08-23	Not applicable	US
Hydrocortisone With Aloe	Cream	1 g/100g	Topical	Meijer Distribution	1995-08-23	Not applicable	US
Hydrocortisone With Aloe	Cream	1 g/100g	Topical	Proficient Rx LP	1995-08-23	Not applicable	US
Hydrocortisone With Aloe Maximum Strength	Cream	1 g/100g	Topical	Actavis Pharma Company	1998-07-08	Not applicable	US
Hydrocortisone With Aloe Maximum Strength	Cream	1 g/100g	Topical	Nucare Pharmaceuticals, Inc.	1998-07-08	Not applicable	US
Hydrocortisone With Aloe Maximum Strength	Cream	1 g/100g	Topical	Major	2009-04-21	Not applicable	US
Hydroskin	Lotion	1 g/100mL	Topical	Rugby	2015-08-25	Not applicable	US
Hydroskin	Cream	1 g/100g	Topical	Rugby	2012-10-29	Not applicable	US
Immediate Comfort Bioelements	Lotion	1 g/88mL	Topical	Bioelements	2012-08-23	Not applicable	US
Instant Cooling Itch Relief Cvs	Spray	1 g/100g	Topical	Cvs Health	2014-11-11	Not applicable	US
Intensive Healing Anti Itch	Cream	1 g/100g	Topical	Rite Aid	2014-03-20	Not applicable	US
Irritated Skin Treatment	Cream	0.5 %	Topical	Avon Products, Inc.	2005-07-30	2007-07-26	Canada
Itch and Rash Cream	Cream	10 mg/g	Topical	Provision Medical	2015-03-31	Not applicable	US
Itch Stuff	Lotion	1 g/100g	Topical	Solubiomix	2016-07-25	Not applicable	US
Jamp Hydrocortisone Cream USP 0.5%	Cream	0.5 %	Topical	Jamp Pharma Corporation	2006-03-16	2008-08-28	Canada
Kaiser Permanente Hydrocortisone	Cream	1 g/100g	Topical	Kaiser Foundations Hospitals	2001-06-01	Not applicable	US
Kaiser Permanente Hydrocortisone	Ointment	1 g/100g	Topical	Kaiser Foundations Hospitals	1989-10-03	Not applicable	US
Kera HC	Cream	1 g/100g	Topical	Clinical Therapeutic Solutions	2012-10-17	Not applicable	US
Kirkland Signature Hydrocortisone Plus Maximum Strength	Cream	1 g/100g	Topical	Costco Wholesale	2009-10-02	Not applicable	US
Lanacort Crm 0.5%	Cream	.5 %	Topical	Combe Incorporated	1987-12-31	1998-07-27	Canada
Leader Hydrocortisone	Cream	1 g/100g	Topical	Remedy Repack	2016-02-29	2017-02-25	US
Leader Hydrocortisone	Cream	1 g/100g	Topical	Cardinal Health	2012-02-13	Not applicable	US
Leader Hydrocortisone With Aloe	Cream	1 g/100g	Topical	Cardinal Health	2012-03-01	Not applicable	US
Lincoln	Cream	.01 g/g	Topical	Lincoln Pharmaceuticals Ltd.	2013-05-23	Not applicable	US
Live Better Hydrocortisone With Aloe	Cream	1 g/100g	Topical	The Great Atlantic + Pacific Tea Company	1995-08-23	Not applicable	US
Loesch Anti-itch Therapy	Liquid	5 mg/mL	Topical	Loesch Laboratory Consultants, Inc.	2014-06-26	Not applicable	US
Loesch HC-10 Anti-itch Therapy	Liquid	9 mg/mL	Topical	Loesch Laboratory Consultants, Inc.	2015-07-01	Not applicable	US
Lucky Supersoft Maximum Strength	Cream	1 g/100g	Topical	Delta Brands, Inc	2015-01-31	Not applicable	US
Makesense Maximum Strength	Cream	1 g/100g	Topical	Cherry Hill Sales Co	2014-06-15	Not applicable	US
Market Basket Anti-itch Cream Plus	Cream	1 g/100g	Topical	Davion, Inc.	2016-03-06	Not applicable	US
Maximum Strength Cortizone 10 Quick Shot 360 Continuous	Spray	10 mg/mL	Topical	Chattem, Inc.	2012-12-06	2016-01-20	US
Maximum Strength Hydrocortisone	Ointment	1 g/100g	Topical	DLC Laboratories, Inc.	2013-03-22	Not applicable	US
Maximum Strength Hydrocortisone	Ointment	1.02 g/100g	Topical	Walgreens	2016-06-07	Not applicable	US
Maximum Strength Hydrocortisone Cream	Cream	1.02 g/100g	Topical	Walgreens	2016-06-07	Not applicable	US
Maximum Strength Hydrocortisone Cream With Aloe	Cream	1.02 g/100g	Topical	Walgreens	2016-06-07	Not applicable	US
Maximum-H	Cream	1 g/100g	Topical	New GPC, Inc.	2009-12-01	Not applicable	US
Medi-cortisone With Aloe	Cream	1 g/100g	Topical	Medicine Shoppe International	1995-08-23	Not applicable	US
Medi-first	Cream	.009 g/1	Topical	Medique Products	2009-10-20	Not applicable	US
Medpride	Cream	10 mg/g	Topical	Shield Line LLC	2013-05-23	Not applicable	US
Meijer Anti Itch	Ointment	1 g/100g	Topical	Meijer	2015-01-15	Not applicable	US
Meijer Anti Itch Cream Plus	Cream	1 g/100g	Topical	Meijer	2015-01-15	Not applicable	US
Meijer Anti-itch With Aloe	Cream	1 g/100g	Topical	Meijer	2015-01-14	Not applicable	US
Meijer Hydrocortisone	Cream	1 g/100g	Topical	Meijer Distribution	1995-08-23	Not applicable	US
Meijer Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Meijer Distribution	1989-10-03	Not applicable	US
Meijer Intense Healing	Cream	1 g/100g	Topical	Meijer	2017-02-17	Not applicable	US
Meijer Itch and Rash Relief	Ointment	1 g/100g	Topical	Meijer Distribution	1989-10-03	Not applicable	US
Members Mark Hydrocortisone	Cream	1 g/100g	Topical	Sam's West, Inc	2007-07-13	Not applicable	US
Monistat Complete Care Instant Itch Relief	Cream	1 g/100g	Topical	Insight Pharmaceuticals	2013-11-15	Not applicable	US
Natureplex Hydrocortisone Hydro	Cream	.01 g/g	Topical	Natureplex, LLC	2008-01-22	Not applicable	US
Neosporin Eczema Essentials Anti Itch	Cream	10 mg/g	Topical	Johnson & Johnson Consumer Products Company, Division Of Johnson Consumer Companies, Inc.	2011-09-30	Not applicable	US
Nu-derm Tolereen Anti-pruritic	Lotion	5 mg/g	Topical	OMP, INC.	1988-01-01	Not applicable	US
Olp Hydrocortisone 1%	Cream	10 mg/g	Topical	Ohio Lab Pharma	2016-11-01	Not applicable	US
Our Family Hydrocortisone With Aloe	Cream	1 g/100g	Topical	Nash Finch	1995-08-23	Not applicable	US
Piyanping Antiitch	Cream	1 g/100g	Topical	Guangdong Zhanjiang Jimin Pharmaceutical Company, Ltd.	2011-04-16	Not applicable	US
Poli-A	Ointment	1 g/100g	Topical	Sato Pharmaceutical	1995-03-19	Not applicable	US
Post Peel Protectant Vitality Institute	Cream	7.5 g/100mL	Topical	Vitality Institute Medical Products	2015-03-25	Not applicable	US
Post Peel Protectant Vitality Institute	Cream	7.5 g/100mL	Topical	Vi Medical Products, Inc	2015-03-25	Not applicable	US
Post Peel Protectant Vitality Institute	Cream	7.5 g/100mL	Topical	Vi Medical Products, Inc	2015-03-25	Not applicable	US
Post Treatment Balm	Cream	1 mg/g	Topical	Allure Labs, Inc.	2015-05-12	Not applicable	US
Premier Value Hydrocortisone	Cream	1 g/100g	Topical	Pharmacy Vlaue Alliance Llc	1995-08-23	Not applicable	US
Premier Value Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Pharmacy Vlaue Alliance Llc	1989-10-03	Not applicable	US
Preparation H Hydrocortisone	Cream	10 mg/g	Topical	Pfizer	2004-01-01	Not applicable	US
Proactiv Solution Anti-itch Scalp	Liquid	.28 mg/100mL	Topical	Guthy Renker, Llc.	2010-10-07	Not applicable	US
Procure	Ointment	1 g/100g	Topical	TwinMed, LLC	2013-02-05	Not applicable	US
Procure Hydrocortisone Plus Calendula	Cream	10 mg/g	Topical	Profoot, Inc.	2017-02-14	Not applicable	US
Psoriasin Itch Control	Cream	10 mg/g	Topical	Alva Amco Pharmacal Companies, Inc.	2016-02-22	Not applicable	US
Publix Hydro	Cream	1 g/100g	Topical	Publix Supermarkets, Inc.	1995-08-23	Not applicable	US
Publix Hydro Plus	Cream	1 g/100g	Topical	Publix Supermarkets, Inc.	1989-10-03	Not applicable	US
Quadrydern	Cream	10 mg/g	Topical	Zapotol Corp.	2013-06-30	Not applicable	US
Quality Choice Anti Itch With Aloe	Ointment	1 g/100g	Topical	Chain Drug Marketing Association	2015-01-15	Not applicable	US
Quality Choice Hydrocortisone	Cream	1 g/100g	Topical	Chain Drug Marketing Association	1995-08-23	Not applicable	US
Quality Choice Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Chain Drug Marketing Association	2015-01-15	Not applicable	US
Quality Choice Maximum Strength Anti Itch	Cream	1 g/100g	Topical	Chain Drug Marketing Association	2015-01-19	Not applicable	US
Regular Strength Hydrocortisone Cream	Cream	.51 g/100g	Topical	Walgreens	2016-06-07	Not applicable	US
Rexall Anti Itch Maximum Strength Relief	Cream	1 g/100g	Topical	Dolgencorp	2010-08-31	Not applicable	US
Rexall Hydrocortisone 1	Cream	1 g/100g	Topical	Dolgencorp	2011-01-14	Not applicable	US
Rexall Hydrocortisone Plus Moisturizers	Cream	1 g/100g	Topical	Dolgencorp	2011-01-14	Not applicable	US
Rite Aid Anti-itch	Cream	1 g/100g	Topical	Rite Aid	1995-08-23	Not applicable	US
Rodan and Fields Soothe	Cream	1 mg/100mL	Topical	Cosmetic Enterprises	2009-01-01	Not applicable	US
Rugby Hydroskin	Cream	1 g/100g	Topical	Rugby	2015-07-15	Not applicable	US
Safeway Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Safeway	1989-10-03	Not applicable	US
Scalpicin Anti-itch Maximum Strength	Liquid	1 g/100mL	Topical	Reckitt Benckiser	2012-10-15	Not applicable	US
Scalpicin Maximum Strength	Liquid	1 g/100mL	Topical	Reckitt Benckiser	2012-01-16	Not applicable	US
Scalpicin Scalp Itch Medication Maximum Strength	Liquid	10 mg/g	Topical	Combe Incorporated	1992-12-15	2017-03-03	US
Schein Hydrocortisone	Cream	10 mg/g	Topical	Henry Schein	2011-04-05	Not applicable	US
Selsun Blue Scalp Itch Treatment	Liquid	1 g/100mL	Topical	Chattem, Inc.	2013-10-01	Not applicable	US
Shopko Hydrocortisone	Cream	1 g/100g	Topical	United Exchange Corporation	2011-02-08	Not applicable	US
Shopko Hydrocortisone	Ointment	1 g/100g	Topical	Shopko Stores Operating	1989-10-03	Not applicable	US
Shopko Hydrocortisone Intensive Healing Formula	Cream	1 g/100g	Topical	Shopko Stores Operating	1995-08-23	Not applicable	US
Shopko Hydrocortisone Maximum Strength	Cream	1 g/100g	Topical	Shopko Stores Operating	1995-08-23	Not applicable	US
Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength	Cream	1 g/100g	Topical	Shopko Stores Operating	1989-10-03	Not applicable	US
Shopko Hydrocortisone With Aloe	Cream	1 g/100g	Topical	United Exchange Corporation	2012-12-31	Not applicable	US
Shopko Maximum Strength	Cream	1 g/100g	Topical	Shopko Stores Operating	1995-08-23	Not applicable	US
Shoprite Hydrocortisone	Cream	1 g/100g	Topical	Wakfern Food Corporation	2013-12-12	Not applicable	US
Signature Care Anti Itch	Cream	1 g/100g	Topical	Safeway	2015-10-14	Not applicable	US
Signature Care Hydrocortisone	Cream	1 g/100g	Topical	Safeway	2015-11-10	Not applicable	US
Signature Care Hydrocortisone	Cream	1 g/100g	Topical	Safeway	2015-11-11	Not applicable	US
Signature Care Hydrocortisone	Cream	1 g/100g	Topical	Safeway	2015-10-24	Not applicable	US
Smart Sense Anti Itch	Cream	1 g/100g	Topical	Kmart Corporation	2010-09-27	Not applicable	US
Smart Sense Anti Itch	Ointment	1 g/100g	Topical	Kmart Corporation	2016-08-24	Not applicable	US
Smart Sense Anti Itch	Cream	1 g/100g	Topical	Kmart Corporation	2015-12-09	Not applicable	US
Smart Sense Anti Itch Maximum Strength	Ointment	1 g/100g	Topical	Kmart Corporation	2010-11-16	Not applicable	US
Smart Sense Anti Itch Maximum Strength	Cream	1 g/100g	Topical	Kmart Corporation	2011-03-31	Not applicable	US
Smart Sense Hydrocortisone	Cream	1 g/100g	Topical	Kmart Corporation	2013-12-17	Not applicable	US
Smart Sense Hydrocortisone	Cream	1 g/100g	Topical	Kmart Corporation	2010-09-27	Not applicable	US
Smart Sense Hydrocortisone	Cream	1 g/100g	Topical	Kmart Corporation	2015-07-08	Not applicable	US
Smart Sense Hydrocortisone	Cream	1 g/100g	Topical	Kmart Corporation	2014-02-27	Not applicable	US
Smart Sense Hydrocortisone	Ointment	1 g/100g	Topical	Kmart Corporation	2015-07-08	Not applicable	US
Soothe Rodan Fields	Lotion	1 mL/100mL	Topical	Rodan & Fields	2011-06-07	Not applicable	US
Sunmark Hydrocortisone	Ointment	1 g/100g	Topical	Mc Kesson	1989-10-03	Not applicable	US
Sunmark Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Mc Kesson	1989-10-03	Not applicable	US
Sunmark Hydrocortisone With Aloe Maximum Strength	Cream	1 g/100g	Topical	Mc Kesson	1995-08-23	Not applicable	US
Tecnu Corticool	Gel	10 mg/g	Topical	Tec Laboratories, Inc.	1999-06-23	Not applicable	US
Thera Plus	Cream	1 g/100g	Topical	Zhejiang Jingwei Pharmaceutical Co., Ltd.	2013-03-01	Not applicable	US
Topcare Hydrocortisone	Ointment	1 g/100g	Topical	Topco Associates	1989-10-03	Not applicable	US
Topcare Hydrocortisone 1% With Aloe	Cream	1 g/100g	Topical	Topco Associates	1995-08-23	Not applicable	US
Topcare Hydrocortisone Intensive Healing Formula	Cream	1 g/100g	Topical	Topco Associates	1995-08-23	Not applicable	US
Topcare Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Topco Associates	1989-10-03	Not applicable	US
Truelipids Anti-itch Barrier	Cream	1 g/100mL	Topical	Derm Deal, Llc Dba Cheryl Lee, Md Sensitive Skin Care	2014-03-01	Not applicable	US
Up and Up Anti Itch	Cream	1 g/100g	Topical	Target Corporation.	2009-11-09	Not applicable	US
Up and Up Anti Itch	Lotion	1 g/100g	Topical	Target Corporation.	2013-06-12	Not applicable	US
Up and Up Anti Itch	Cream	1 g/100g	Topical	Target Corporation.	2011-03-17	Not applicable	US
Up and Up Anti Itch	Cream	1 g/100g	Topical	Target Corporation.	2013-03-18	Not applicable	US
Up and Up Anti Itch Maximum Strength	Ointment	1 g/100g	Topical	Target Corporation.	2009-10-09	Not applicable	US
Up and Up Hydrocortisone	Ointment	1 g/100g	Topical	Target Corporation.	2015-04-16	Not applicable	US
Up and Up Hydrocortisone	Cream	1 g/100g	Topical	Target Corporation.	2015-04-07	Not applicable	US
Up and Up Hydrocortisone	Cream	1 g/100g	Topical	Target Corporation.	2015-04-01	Not applicable	US
Up and Up Hydrocortisone One Per Cent	Cream	1 g/100g	Topical	Target Corporation.	2015-04-09	Not applicable	US
Vagisil Anti-itch Creme Maximum Strength Sensitive Skin Formula	Cream	280 mg/28g	Topical	Combe Incorporated	2016-01-30	Not applicable	US
Vagisil Satin	Cream	10 mg/g	Topical	Combe Incorporated	2008-04-15	2017-03-03	US
Vanicream HC Anti-itch	Cream	1.12 g/100g	Topical	Pharmaceutical Specialties, Inc.	2016-01-26	Not applicable	US
Walgreens Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Walgreen	1989-10-03	Not applicable	US
Western Family Hydrocortisone	Cream	1 g/100g	Topical	Western Family Foods	1995-08-23	Not applicable	US
Western Family Hydrocortisone Plus 12 Moisturizers	Cream	1 g/100g	Topical	Western Family Foods	1989-10-03	Not applicable	US
Winco Maximum Strength Hydrocortisone	Cream	1 g/100g	Topical	Win Co Foods, Llc,	2015-02-16	Not applicable	US
Winco Maximum Strength Hydrocortisone	Cream	1 g/100g	Topical	Win Co Foods, Llc,	2015-02-16	Not applicable	US
Yes To Coconut Eczema Relief	Cream	10 mg/mL	Topical	Yes To Incorporated	2015-06-09	Not applicable	US
Zims Advanced Crack Creme With Hydrocortisone	Cream	10 mg/L	Topical	Natural Essentials, Inc	2014-01-01	Not applicable	US
Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe	Spray	10 g/L	Topical	Natural Essentials, Inc	2014-01-01	Not applicable	US

Unapproved/Other Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Anucort-HC	Suppository	25 mg/1	Rectal	Preferreed Pharmaceuticals Inc.	2012-03-12	Not applicable	US
Anucort-HC	Suppository	25 mg/1	Rectal	A S Medication Solutions	1990-01-15	2017-06-20	US
Anucort-HC	Suppository	25 mg/1	Rectal	Gw Pharmaceuticals Ltd.	1990-01-15	Not applicable	US
Anusol HC	Suppository	25 mg/1	Rectal	Salix Pharmaceuticals	2004-06-01	Not applicable	US
Grx Hicort	Suppository	25 mg/2g	Rectal	Geritrex Llc	2015-07-01	2016-01-01	US
Hemmorex-HC	Suppository	25 mg/1	Rectal	Laser Pharmaceuticals Llc	2013-11-12	Not applicable	US
Hemmorex-HC	Suppository	30 mg/1	Rectal	Laser Pharmaceuticals Llc	2013-11-12	Not applicable	US
Hydrocortisone	Shampoo	1 g/100mL	Topical	Dr Marder Skincare Llc	2017-06-14	Not applicable	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	Paddock Laboratories, Inc.	1990-07-01	Not applicable	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	Ascend Laboratories, LLC	2013-10-01	2016-03-01	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	Av Pak	2017-01-17	Not applicable	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	Cameron Pharmaceuticals	2017-05-01	Not applicable	US
Hydrocortisone Acetate	Suppository	30 mg/1	Rectal	Rebel Distributors	2004-06-01	Not applicable	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	A S Medication Solutions	1990-07-01	2017-06-20	US
Hydrocortisone Acetate	Suppository	30 mg/1	Rectal	Paddock Laboratories, Inc.	2003-07-07	Not applicable	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	Preferreed Pharmaceuticals Inc.	2013-08-16	Not applicable	US
Hydrocortisone Acetate	Suppository	30 mg/1	Rectal	Cameron Pharmaceuticals	2017-05-01	Not applicable	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	A S Medication Solutions	1990-07-01	2017-06-20	US
Hydrocortisone Acetate	Suppository	25 mg/1	Rectal	Granules Pharma Llc	2016-09-12	Not applicable	US
Nucort	Lotion	20 mg/g	Topical	Gentex Pharma	2010-08-16	Not applicable	US
Proctocort	Suppository	30 mg/1	Rectal	Salix Pharmaceuticals	2004-06-01	Not applicable	US
Rectacort - HC	Suppository	25 mg/1	Rectal	Acino Products, Llc.	2006-11-01	Not applicable	US
Rectacort - HC	Suppository	25 mg/1	Rectal	Remedy Repack	2017-04-06	Not applicable	US

International Brands

Name	Company
Acticort	Not Available
Aeroseb HC	Not Available
Ala-Scalp	Not Available
Algicirtis	Not Available
Aquanil HC	Not Available
Beta-HC	Not Available
Cetacort	Not Available
Cortaid	Not Available
Delacort	Not Available
Ficortril	Not Available
Genacort	Not Available
Glycort	Not Available
Komed HC	Not Available
Lacticare HC	Not Available
Lubricort	Not Available
Medicort	Not Available
Meusicort	Not Available
Micort-HC	Not Available
Mildison	Not Available
Nogenic HC	Not Available
Nutracort	Not Available
Nystaform-HC	Not Available
Otocort	Not Available
Penecort	Not Available
Permicort	Not Available
Polcort H	Not Available
Preparation H Hydrocortisone Cream	Not Available
Prepcort	Not Available
Prevex HC	Not Available
Proctocort	Not Available
Proctocream	Not Available
Protocort	Not Available
Remederm HC	Not Available
Sanatison	Not Available
Scalpicin Capilar	Not Available
Schericur	Not Available
Sigmacort	Not Available
Synacort	Not Available
Systral Hydrocort	Not Available
Timocort	Not Available

Brand mixtures

Name	Labeller	Ingredients
Acella Hydrocortisone Acetate - Pramoxine Singles	Acella Pharmaceuticals, LLC	Hydrocortisone Pramocaine
Acetasol HC	Actavis Mid Atlantic LLC,	Acetic acid Hydrocortisone
Actinac Pwr	Roussel Canada Inc.	Allantoin Chloramphenicol Hydrocortisone Nicoboxil Sulfur
Actinac Pws	Hoechst Roussel Canada Inc.	Allantoin Chloramphenicol Hydrocortisone Nicoboxil Sulfur
Ala Quin	Crown Laboratories	Clioquinol Hydrocortisone
Alcortin	Primus Pharmaceuticals	Diiodohydroxyquinoline Hydrocortisone
Alocane	Product Quest	Hydrocortisone Lidocaine
Ana-lex	Avion Pharmaceuticals, Llc	Hydrocortisone Lidocaine
Analpram Advanced	Ferndale Laboratories, Inc.	Hydrocortisone Pramocaine
Analpram E	Ferndale Laboratories, Inc.	Hydrocortisone Pramocaine
Analpram E Cream 2.5% Kit Hydrocortisone Acetate 2.5% Pramoxine Hydrochloride 1%	Sebela Pharmaceuticals Inc.	Hydrocortisone Pramocaine
Analpram HC	Ferndale Laboratories, Inc.	Hydrocortisone Pramocaine
Anodan-HC 10mg Suppositories	Odan Laboratories Ltd	Hydrocortisone Zinc sulfate
Anodan-HC Ointment	Odan Laboratories Ltd	Hydrocortisone Zinc sulfate
Antibiotic Ear (neo/polym/hc)	Physicians Total Care, Inc.	Hydrocortisone Neomycin Polymyxin B Sulfate
Anugesic-HC Ointment	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Hydrocortisone Pramocaine Zinc sulfate
Anugesic-HC Suppositories	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Hydrocortisone Pramocaine Zinc sulfate
Anusol-HC Ointment	Church & Dwight Company, Inc.	Hydrocortisone Zinc sulfate
Anusol-HC Suppositories	Church & Dwight Company, Inc.	Hydrocortisone Zinc sulfate
Calmurid HC Crm	Galderma	Hydrocortisone Urea
Cipro HC	Alcon, Inc.	Ciprofloxacin Hydrocortisone
Cipro HC Otic Suspension	Alcon, Inc.	Ciprofloxacin Hydrocortisone
Coly-mycin S	Par Pharmaceutical	Colistin Hydrocortisone Neomycin Thonzonium
Cortane-B	Blansett Pharmacal Co	Chloroxylenol Hydrocortisone Pramocaine
Cortisporin	Physicians Total Care, Inc.	Hydrocortisone Neomycin Polymyxin B Sulfate
Cortisporin-TC	Par Pharmaceutical	Colistin Hydrocortisone Neomycin Thonzonium
Cortomycin	Major	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Dermazene	Stratus Pharmaceuticals	Diiodohydroxyquinoline Hydrocortisone
Dermoscribe Ichybum	Xlma Pty Ltd	Clioquinol Hydrocortisone
Dermoscribe Seborrheic Dermatitis	Dermoscribe Pty Ltd	Hydrocortisone Salicylic acid Sulfur
Dr. Throwers Hydrotet	Dr. Thrower's Skincare, Inc.	Hydrocortisone Tretinoin
Egozinc-HC	Pharmascience Inc	Hydrocortisone Zinc sulfate
Epifoam	Meda Pharmaceuticals Ltd	Hydrocortisone Pramocaine
First Dukes Mouthwash Compounding	Cutis Pharma, Inc.	Diphenhydramine Hydrocortisone Nystatin
First Marys Mouthwash Compounding	Cutis Pharma, Inc.	Diphenhydramine Hydrocortisone Nystatin Tetracycline
Fucidin H	Leo Pharma	Fusidic Acid Hydrocortisone
Hydrocortisone Acetate and Pramoxine Hydrochloride	Acella Pharmaceuticals, LLC	Hydrocortisone Pramocaine
Hydrocortisone Acetate Pramoxine HCl	Perrigo New York Inc.	Hydrocortisone Pramocaine
Hydrocortisone Acetate, Iodoquinol	Bowyn Labs, Llc	Diiodohydroxyquinoline Hydrocortisone
Hydrocortisone and Acetic Acid	Qualitest	Acetic acid Hydrocortisone
Hydrocortisone Iodoquinol	Perrigo New York Inc.	Diiodohydroxyquinoline Hydrocortisone
Jampzinc-HC	Jamp Pharma Corporation	Hydrocortisone Zinc sulfate
Lidocaine HCl - Hydrocortisone Acetate	Pure Tek Corporation	Hydrocortisone Lidocaine
Lidocaine HCl - Hydrocortisone Acetate With Aloe	Pure Tek Corporation	Hydrocortisone Lidocaine
Lidocaine HCl and Hydrocortisone Acetate	Acella Pharmaceuticals, LLC	Hydrocortisone Lidocaine
Lidocaine Hydrochloride and Hydrocortisone Acetate	Seton Pharmaceuticals	Hydrocortisone Lidocaine
Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula	Sanofi Consumer Health Inc Sanofi Sante Grand Public Inc	Dimethicone Hydrocortisone
Neo Polycin HC	Paddock Laboratories, Inc.	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Neo-cortef 0.5% Ointment	Pfizer	Hydrocortisone Neomycin
Neo-cortef 1% Ointment	Pfizer	Hydrocortisone Neomycin
Neo-cortef Eye Ear Drops Sterile Suspension	Pharmacia & Upjohn Inc	Hydrocortisone Neomycin
Neo-poly-bac Hydro	Butler Animal Health Supply	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Neo-polycin HC	Fera Pharmaceuticals	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc With Hydrocortisone Acetate	Rebel Distributors	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Neomycin and Polymyxin B Sulfates and Hydrocortisone	Blenheim Pharmacal, Inc.	Hydrocortisone Neomycin Polymyxin B Sulfate
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone	Mwi/Vet One	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone	Henry Schein	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Neomycin, Polymyxin B Sulfates and Hydrocortisone	Physicians Total Care, Inc.	Hydrocortisone Neomycin Polymyxin B Sulfate
Novacort	Novum Pharma, Llc	Hydrocortisone Pramocaine
Odan-spor-HC	Odan Laboratories Ltd	Hydrocortisone Neomycin Polymyxin B Sulfate
Ophthocort Ont	Parke Davis Division, Warner Lambert Canada Inc.	Chloramphenicol Hydrocortisone Polymyxin B Sulfate
Otizol HC Liq	Lab Nadeau LtÉe, Division Of Technilab Inc.	Hydrocortisone Lidocaine Neomycin
Pentamycetin/hc	Sandoz Canada Incorporated	Chloramphenicol Hydrocortisone
Poison Oak	De Martini Spring Hill Pharmacy, Inc.	Hydrocortisone Phenol
Pramcort	Rochester Pharmaceuticals	Hydrocortisone Pramocaine
Pramosone	Ferndale Laboratories, Inc.	Hydrocortisone Pramocaine
Pramosone Cream	Sebela Pharmaceuticals Inc.	Hydrocortisone Pramocaine
Pramosone E	Ferndale Laboratories, Inc.	Hydrocortisone Pramocaine
Pramosone E Cream 2.5% Hydrocortisone Acetate 2.5% Pramoxine Hydrochloride 1%	Sebela Pharmaceuticals Inc.	Hydrocortisone Pramocaine
Pramox HC Cream	Dermtek Pharma Inc	Hydrocortisone Pramocaine
Pramox HC Lotion	Dermtek Pharma Inc	Hydrocortisone Pramocaine
Pramoxine-HC	Ascend Laboratories, LLC	Chloroxylenol Hydrocortisone Pramocaine
Procort	Womens Choice Pharmaceuticals, Llc	Hydrocortisone Pramocaine
Proctodan-HC Ointment	Odan Laboratories Ltd	Hydrocortisone Pramocaine Zinc sulfate
Proctodan-HC Suppositories	Odan Laboratories Ltd	Hydrocortisone Pramocaine Zinc sulfate
Proctofoam HC	Meda Pharmaceuticals Ltd	Hydrocortisone Pramocaine
Proctol Ointment	Odan Laboratories Ltd	Cinchocaine Esculin Framycetin Hydrocortisone
Proctol Suppositories	Odan Laboratories Ltd	Cinchocaine Esculin Framycetin Hydrocortisone
Proctosedyl Ointment	Aptalis Pharma Inc.	Cinchocaine Esculin Framycetin Hydrocortisone
Proctosedyl Sup	Roussel Canada Inc.	Cinchocaine Esculin Framycetin Hydrocortisone
Proctosedyl Suppositories	Aptalis Pharma Inc.	Cinchocaine Esculin Framycetin Hydrocortisone
Proctosone Ont	Technilab Pharma Inc.	Cinchocaine Esculin Hydrocortisone Neomycin
Proctosone Sup	Technilab Pharma Inc.	Cinchocaine Esculin Hydrocortisone Neomycin
Ratio-hemcort-HC	Teva	Hydrocortisone Zinc sulfate
Ratio-proctosone	Teva	Cinchocaine Esculin Framycetin Hydrocortisone
Rectogel HC	Laboratoire Riva Inc	Benzocaine Hydrocortisone Zinc sulfate
Riva-sol HC Ointment	Laboratoire Riva Inc	Hydrocortisone Zinc sulfate
Rivasol-HC Suppositories	Laboratoire Riva Inc	Hydrocortisone Zinc sulfate
Sandoz Anuzinc HC	Sandoz Canada Incorporated	Hydrocortisone Zinc sulfate
Sandoz Anuzinc HC Plus	Sandoz Canada Incorporated	Hydrocortisone Pramocaine Zinc sulfate
Sandoz Anuzinc HC Plus Suppositories	Sandoz Canada Incorporated	Hydrocortisone Pramocaine Zinc sulfate
Sandoz Anuzinc HC Suppositories	Sandoz Canada Incorporated	Hydrocortisone Zinc sulfate
Sandoz Cortimyxin	Sandoz Canada Incorporated	Hydrocortisone Neomycin Polymyxin B Sulfate
Sandoz Proctomyxin HC	Sandoz Canada Incorporated	Cinchocaine Esculin Framycetin Hydrocortisone
Sandoz Proctomyxin HC Suppositories	Sandoz Canada Incorporated	Cinchocaine Esculin Framycetin Hydrocortisone
Scarguard Md	Scarguard Labs, Llc	Hydrocortisone Phenyl trimethicone
Scarguard Md Physicians Formula	Scarguard Labs, Llc	Hydrocortisone Phenyl trimethicone
Sopamycetin/hc Ointment	Laboratoires Charton Laboratories	Chloramphenicol Hydrocortisone
Sopamycetin/hc Ont	Laboratoires Charton Laboratories	Chloramphenicol Hydrocortisone
Sopamycetin/hc Susp	Laboratoires Charton Laboratories	Chloramphenicol Hydrocortisone
Sterex Crm Plus	International Dermatologicals Inc.	Coal tar Hydrocortisone Salicylic acid Sulfur
Sterex Lot Plus	International Dermatologicals Inc.	Coal tar Hydrocortisone Salicylic acid Sulfur
Ti-U-lac HC Lotion	Merit Industries Inc.	Hydrocortisone Urea
Triple Antibiotic HC	Phoenix Pharmaceutical, Inc.	Bacitracin Hydrocortisone Neomycin Polymyxin B Sulfate
Uremol HC	Glaxosmithkline Inc	Hydrocortisone Urea
Vanoxide HC	Summers Laboratories	Benzoyl peroxide Hydrocortisone
Vioform + Hydrocortisone	Geigy Pharmaceuticals, Ciba Geigy Canada Ltd.	Clioquinol Hydrocortisone
Vioform Hydrocortisone	Paladin Labs Inc	Clioquinol Hydrocortisone
Vioform Hydrocortisone Mild	Novartis	Clioquinol Hydrocortisone
Vosol HC	ECR Pharmaceuticals Co., Inc.	Acetic acid Hydrocortisone
Vytone	Artesa Labs, Llc	Diiodohydroxyquinoline Hydrocortisone
Xerese	Valeant Pharmaceuticals North America	Aciclovir Hydrocortisone

Categories

UNII

WI4X0X7BPJ

CAS number

50-23-7

Weight

Average: 362.4599
Monoisotopic: 362.20932407

Chemical Formula

C₂₁H₃₀O₅

InChI Key

JYGXADMDTFJGBT-VWUMJDOOSA-N

InChI

InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

IUPAC Name

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[[email protected]](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Pharmacology

Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Structured Indications

Pharmacodynamics

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Mechanism of action

Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Glucocorticoid receptor	Protein	yes	agonist	Human	P04150	details
Annexin A1	Protein	yes	agonist	Human	P04083	details
Corticosteroid 11-beta-dehydrogenase isozyme 2	Protein	unknown	Not Available	Human	P80365	details
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	Protein	unknown	Not Available	Human	P14060	details

Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Volume of distribution

Not Available

Protein binding

95%

Metabolism

Primarily hepatic via CYP3A4

Substrate	Enzymes	Product
Hydrocortisone	Cytochrome P450 3A4	6-beta-hydrocortisol	Details

Route of elimination

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Half life

6-8 hours

Clearance

Not Available

Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
1,10-Phenanthroline	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with 1,10-Phenanthroline.	Experimental
2,4-thiazolidinedione	The therapeutic efficacy of Thiazolidinedione can be decreased when used in combination with Hydrocortisone.	Investigational
Acarbose	The therapeutic efficacy of Acarbose can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Acebutolol	The serum concentration of Acebutolol can be increased when it is combined with Hydrocortisone.	Approved
Aceclofenac	The risk or severity of adverse effects can be increased when Aceclofenac is combined with Hydrocortisone.	Approved
Acetaminophen	The serum concentration of Hydrocortisone can be increased when it is combined with Acetaminophen.	Approved
Acetohexamide	The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Hydrocortisone.	Withdrawn
Acetylsalicylic acid	The serum concentration of Acetylsalicylic acid can be increased when it is combined with Hydrocortisone.	Approved, Vet Approved
Adapalene	The risk or severity of adverse effects can be increased when Adapalene is combined with Hydrocortisone.	Approved
Afatinib	The serum concentration of Afatinib can be increased when it is combined with Hydrocortisone.	Approved
AICA ribonucleotide	The therapeutic efficacy of Aicar can be decreased when used in combination with Hydrocortisone.	Experimental
Albendazole	The serum concentration of Hydrocortisone can be increased when it is combined with Albendazole.	Approved, Vet Approved
Aldesleukin	Hydrocortisone may decrease the antineoplastic activities of Aldesleukin.	Approved
Aldosterone	The serum concentration of Hydrocortisone can be decreased when it is combined with Aldosterone.	Experimental
Alectinib	The serum concentration of Hydrocortisone can be increased when it is combined with Alectinib.	Approved
Alfentanil	The serum concentration of Hydrocortisone can be increased when it is combined with Alfentanil.	Approved, Illicit
Alitretinoin	The serum concentration of Alitretinoin can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Alogliptin	The therapeutic efficacy of Alogliptin can be decreased when used in combination with Hydrocortisone.	Approved
Aluminum hydroxide	The bioavailability of Hydrocortisone can be decreased when combined with Aluminum hydroxide.	Approved
Amantadine	The serum concentration of Hydrocortisone can be increased when it is combined with Amantadine.	Approved
Ambenonium	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Ambenonium.	Approved
Ambrisentan	The serum concentration of Ambrisentan can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Aminohippuric acid	The serum concentration of Hydrocortisone can be increased when it is combined with Aminohippuric acid.	Approved
Aminosalicylic Acid	The risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Hydrocortisone.	Approved
Amiodarone	The metabolism of Hydrocortisone can be decreased when combined with Amiodarone.	Approved, Investigational
Amitriptyline	The serum concentration of Hydrocortisone can be increased when it is combined with Amitriptyline.	Approved
Amlodipine	The serum concentration of Hydrocortisone can be increased when it is combined with Amlodipine.	Approved
Amphotericin B	Hydrocortisone may increase the hypokalemic activities of Amphotericin B.	Approved, Investigational
Amprenavir	The serum concentration of Hydrocortisone can be decreased when it is combined with Amprenavir.	Approved
Amsacrine	The serum concentration of Hydrocortisone can be increased when it is combined with Amsacrine.	Approved
Andrographolide	The risk or severity of adverse effects can be increased when HMPL-004 is combined with Hydrocortisone.	Investigational
Anisodamine	The risk or severity of adverse effects can be increased when Anisodamine is combined with Hydrocortisone.	Investigational
Antipyrine	The risk or severity of adverse effects can be increased when Antipyrine is combined with Hydrocortisone.	Approved
Apixaban	The serum concentration of Apixaban can be increased when it is combined with Hydrocortisone.	Approved
Apocynin	The risk or severity of adverse effects can be increased when Acetovanillone is combined with Hydrocortisone.	Investigational
Apremilast	The risk or severity of adverse effects can be increased when Apremilast is combined with Hydrocortisone.	Approved, Investigational
Aprepitant	The serum concentration of Hydrocortisone can be increased when it is combined with Aprepitant.	Approved, Investigational
Arsenic trioxide	The serum concentration of Arsenic trioxide can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Astemizole	The serum concentration of Hydrocortisone can be increased when it is combined with Astemizole.	Approved, Withdrawn
Atazanavir	The metabolism of Hydrocortisone can be decreased when combined with Atazanavir.	Approved, Investigational
Atenolol	The serum concentration of Hydrocortisone can be increased when it is combined with Atenolol.	Approved
Atomoxetine	The metabolism of Hydrocortisone can be decreased when combined with Atomoxetine.	Approved
Atorvastatin	The serum concentration of Hydrocortisone can be increased when it is combined with Atorvastatin.	Approved
Atracurium besylate	Atracurium besylate may increase the adverse neuromuscular activities of Hydrocortisone.	Approved
Axitinib	The serum concentration of Axitinib can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Azapropazone	The risk or severity of adverse effects can be increased when Azapropazone is combined with Hydrocortisone.	Withdrawn
Azelastine	The serum concentration of Hydrocortisone can be increased when it is combined with Azelastine.	Approved
Azithromycin	The serum concentration of Hydrocortisone can be increased when it is combined with Azithromycin.	Approved
Balaglitazone	The therapeutic efficacy of Balaglitazone can be decreased when used in combination with Hydrocortisone.	Investigational
Balsalazide	The risk or severity of adverse effects can be increased when Balsalazide is combined with Hydrocortisone.	Approved, Investigational
Bazedoxifene	The serum concentration of Hydrocortisone can be increased when it is combined with Bazedoxifene.	Approved, Investigational
BCG vaccine	The therapeutic efficacy of Bcg can be decreased when used in combination with Hydrocortisone.	Investigational
Bendroflumethiazide	Hydrocortisone may increase the hypokalemic activities of Bendroflumethiazide.	Approved
Benoxaprofen	The risk or severity of adverse effects can be increased when Benoxaprofen is combined with Hydrocortisone.	Withdrawn
Benzocaine	The serum concentration of Hydrocortisone can be increased when it is combined with Benzocaine.	Approved
Benzoic Acid	The therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Hydrocortisone.	Approved
Bepridil	The serum concentration of Hydrocortisone can be increased when it is combined with Bepridil.	Approved, Withdrawn
Betamethasone	The serum concentration of Betamethasone can be increased when it is combined with Hydrocortisone.	Approved, Vet Approved
Betulinic Acid	The risk or severity of adverse effects can be increased when Betulinic Acid is combined with Hydrocortisone.	Investigational
Bexarotene	The serum concentration of Hydrocortisone can be decreased when it is combined with Bexarotene.	Approved, Investigational
Biperiden	The serum concentration of Hydrocortisone can be increased when it is combined with Biperiden.	Approved
Bismuth Subcitrate	The bioavailability of Hydrocortisone can be decreased when combined with Bismuth Subcitrate.	Approved
Boceprevir	The metabolism of Hydrocortisone can be decreased when combined with Boceprevir.	Withdrawn
Bortezomib	The metabolism of Hydrocortisone can be decreased when combined with Bortezomib.	Approved, Investigational
Bosentan	The serum concentration of Hydrocortisone can be decreased when it is combined with Bosentan.	Approved, Investigational
Bosutinib	The serum concentration of Bosutinib can be increased when it is combined with Hydrocortisone.	Approved
Brentuximab vedotin	The serum concentration of Brentuximab vedotin can be increased when it is combined with Hydrocortisone.	Approved
Bromfenac	The risk or severity of adverse effects can be increased when Bromfenac is combined with Hydrocortisone.	Approved
Bromocriptine	The serum concentration of Hydrocortisone can be increased when it is combined with Bromocriptine.	Approved, Investigational
Bucillamine	The risk or severity of adverse effects can be increased when Bucillamine is combined with Hydrocortisone.	Investigational
Buformin	The therapeutic efficacy of Buformin can be decreased when used in combination with Hydrocortisone.	Withdrawn
Bumetanide	Hydrocortisone may increase the hypokalemic activities of Bumetanide.	Approved
Buprenorphine	The serum concentration of Hydrocortisone can be increased when it is combined with Buprenorphine.	Approved, Illicit, Investigational, Vet Approved
Buspirone	The serum concentration of Hydrocortisone can be increased when it is combined with Buspirone.	Approved, Investigational
Cabazitaxel	The serum concentration of Cabazitaxel can be increased when it is combined with Hydrocortisone.	Approved
Caffeine	The serum concentration of Caffeine can be increased when it is combined with Hydrocortisone.	Approved
Calcitriol	The therapeutic efficacy of Calcitriol can be decreased when used in combination with Hydrocortisone.	Approved, Nutraceutical
Calcium Carbonate	The bioavailability of Hydrocortisone can be decreased when combined with Calcium carbonate.	Approved
Camptothecin	The serum concentration of Camptothecin can be increased when it is combined with Hydrocortisone.	Experimental
Canagliflozin	The serum concentration of Canagliflozin can be increased when it is combined with Hydrocortisone.	Approved
Candesartan	The serum concentration of Hydrocortisone can be increased when it is combined with Candesartan.	Approved
Captopril	The serum concentration of Hydrocortisone can be increased when it is combined with Captopril.	Approved
Carbamazepine	The metabolism of Hydrocortisone can be increased when combined with Carbamazepine.	Approved, Investigational
Carbamazepine	The serum concentration of Hydrocortisone can be decreased when it is combined with Carbamazepine.	Approved, Investigational
Carfilzomib	The serum concentration of Carfilzomib can be increased when it is combined with Hydrocortisone.	Approved
Carprofen	The risk or severity of adverse effects can be increased when Carprofen is combined with Hydrocortisone.	Approved, Vet Approved, Withdrawn
Carvedilol	The serum concentration of Hydrocortisone can be increased when it is combined with Carvedilol.	Approved, Investigational
Caspofungin	The serum concentration of Hydrocortisone can be increased when it is combined with Caspofungin.	Approved
Castanospermine	The therapeutic efficacy of Castanospermine can be decreased when used in combination with Hydrocortisone.	Experimental
Celecoxib	The risk or severity of adverse effects can be increased when Celecoxib is combined with Hydrocortisone.	Approved, Investigational
Ceritinib	The serum concentration of Hydrocortisone can be increased when it is combined with Ceritinib.	Approved
Cerivastatin	The serum concentration of Cerivastatin can be increased when it is combined with Hydrocortisone.	Withdrawn
Chloroquine	The serum concentration of Hydrocortisone can be increased when it is combined with Chloroquine.	Approved, Vet Approved
Chlorothiazide	Hydrocortisone may increase the hypokalemic activities of Chlorothiazide.	Approved, Vet Approved
Chlorotrianisene	The serum concentration of Hydrocortisone can be increased when it is combined with Chlorotrianisene.	Withdrawn
Chlorpromazine	The serum concentration of Hydrocortisone can be increased when it is combined with Chlorpromazine.	Approved, Vet Approved
Chlorpropamide	The serum concentration of Hydrocortisone can be increased when it is combined with Chlorpropamide.	Approved
Chlorprothixene	The serum concentration of Hydrocortisone can be increased when it is combined with Chlorprothixene.	Approved, Withdrawn
Chlorthalidone	Hydrocortisone may increase the hypokalemic activities of Chlorthalidone.	Approved
Cholesterol	The serum concentration of Hydrocortisone can be increased when it is combined with Cholesterol.	Experimental
Cholestyramine	Cholestyramine can cause a decrease in the absorption of Hydrocortisone resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Cholic Acid	The serum concentration of Hydrocortisone can be decreased when it is combined with Cholic Acid.	Approved
Choline magnesium trisalicylate	The risk or severity of adverse effects can be increased when Trisalicylate-choline is combined with Hydrocortisone.	Approved
Ciglitazone	The therapeutic efficacy of Ciglitazone can be decreased when used in combination with Hydrocortisone.	Experimental
Cilazapril	The serum concentration of Hydrocortisone can be increased when it is combined with Cilazapril.	Approved
Cimetidine	The serum concentration of Hydrocortisone can be decreased when it is combined with Cimetidine.	Approved
Cinoxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Cinoxacin.	Approved, Withdrawn
Ciprofloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Ciprofloxacin.	Approved, Investigational
Cisplatin	The serum concentration of Cisplatin can be increased when it is combined with Hydrocortisone.	Approved
Citalopram	The serum concentration of Citalopram can be increased when it is combined with Hydrocortisone.	Approved
Clarithromycin	The metabolism of Hydrocortisone can be decreased when combined with Clarithromycin.	Approved
Clemastine	The metabolism of Hydrocortisone can be decreased when combined with Clemastine.	Approved
Clobazam	The serum concentration of Clobazam can be increased when it is combined with Hydrocortisone.	Approved, Illicit
Clofazimine	The serum concentration of Hydrocortisone can be increased when it is combined with Clofazimine.	Approved, Investigational
Clomifene	The serum concentration of Clomifene can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Clomipramine	The serum concentration of Hydrocortisone can be increased when it is combined with Clomipramine.	Approved, Vet Approved
Clonidine	The serum concentration of Clonidine can be increased when it is combined with Hydrocortisone.	Approved
Clonixin	The risk or severity of adverse effects can be increased when Clonixin is combined with Hydrocortisone.	Approved
Clopidogrel	The serum concentration of Clopidogrel can be increased when it is combined with Hydrocortisone.	Approved, Nutraceutical
Clotrimazole	The metabolism of Hydrocortisone can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	The serum concentration of Clozapine can be increased when it is combined with Hydrocortisone.	Approved
Cobicistat	The metabolism of Hydrocortisone can be decreased when combined with Cobicistat.	Approved
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with Hydrocortisone.	Approved
Colchicine	The serum concentration of Colchicine can be increased when it is combined with Hydrocortisone.	Approved
Colesevelam	Colesevelam can cause a decrease in the absorption of Hydrocortisone resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Colestipol	Colestipol can cause a decrease in the absorption of Hydrocortisone resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Colforsin	The serum concentration of Hydrocortisone can be increased when it is combined with Colforsin.	Experimental
Conivaptan	The serum concentration of Hydrocortisone can be increased when it is combined with Conivaptan.	Approved, Investigational
Conjugated estrogens	The serum concentration of Hydrocortisone can be increased when it is combined with Conjugated Equine Estrogens.	Approved
Corticorelin ovine triflutate	The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone.	Approved
Crizotinib	The metabolism of Hydrocortisone can be decreased when combined with Crizotinib.	Approved
Curcumin	The risk or severity of adverse effects can be increased when Curcumin is combined with Hydrocortisone.	Investigational
Cyclophosphamide	The serum concentration of Hydrocortisone can be increased when it is combined with Cyclophosphamide.	Approved, Investigational
Cyclosporine	The metabolism of Hydrocortisone can be decreased when combined with Cyclosporine.	Approved, Investigational, Vet Approved
Dabigatran etexilate	The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Hydrocortisone.	Approved
Dabrafenib	The serum concentration of Hydrocortisone can be decreased when it is combined with Dabrafenib.	Approved
Daclatasvir	The serum concentration of Hydrocortisone can be increased when it is combined with Daclatasvir.	Approved
Dactinomycin	The serum concentration of Hydrocortisone can be increased when it is combined with Dactinomycin.	Approved
Dapagliflozin	The serum concentration of Dapagliflozin can be increased when it is combined with Hydrocortisone.	Approved
Darunavir	The metabolism of Hydrocortisone can be decreased when combined with Darunavir.	Approved
Dasatinib	The serum concentration of Hydrocortisone can be increased when it is combined with Dasatinib.	Approved, Investigational
Daunorubicin	The serum concentration of Hydrocortisone can be decreased when it is combined with Daunorubicin.	Approved
Debrisoquin	The serum concentration of Debrisoquin can be increased when it is combined with Hydrocortisone.	Approved
Decamethonium	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Decamethonium.	Approved
Deferasirox	The serum concentration of Hydrocortisone can be decreased when it is combined with Deferasirox.	Approved, Investigational
Delavirdine	The metabolism of Hydrocortisone can be decreased when combined with Delavirdine.	Approved
Demecarium	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Demecarium.	Approved
Denosumab	The risk or severity of adverse effects can be increased when Denosumab is combined with Hydrocortisone.	Approved
Deoxyspergualin	The therapeutic efficacy of Deoxyspergualin can be decreased when used in combination with Hydrocortisone.	Investigational
Desipramine	The serum concentration of Hydrocortisone can be increased when it is combined with Desipramine.	Approved
Desloratadine	The serum concentration of Hydrocortisone can be increased when it is combined with Desloratadine.	Approved, Investigational
Dexamethasone	The serum concentration of Hydrocortisone can be decreased when it is combined with Dexamethasone.	Approved, Investigational, Vet Approved
Dextromethorphan	The serum concentration of Hydrocortisone can be increased when it is combined with Dextromethorphan.	Approved
Diazepam	The serum concentration of Diazepam can be increased when it is combined with Hydrocortisone.	Approved, Illicit, Vet Approved
Diclofenac	The serum concentration of Hydrocortisone can be increased when it is combined with Diclofenac.	Approved, Vet Approved
Dienestrol	The serum concentration of Hydrocortisone can be increased when it is combined with Dienestrol.	Approved
Diethylstilbestrol	The serum concentration of Hydrocortisone can be increased when it is combined with Diethylstilbestrol.	Approved
Diflunisal	The risk or severity of adverse effects can be increased when Diflunisal is combined with Hydrocortisone.	Approved
Digitoxin	The serum concentration of Digitoxin can be increased when it is combined with Hydrocortisone.	Approved
Digoxin	The serum concentration of Hydrocortisone can be decreased when it is combined with Digoxin.	Approved
Dihydroergotamine	The metabolism of Hydrocortisone can be decreased when combined with Dihydroergotamine.	Approved
Dihydrotestosterone	The serum concentration of Dihydrotestosterone can be increased when it is combined with Hydrocortisone.	Illicit
Diltiazem	The metabolism of Hydrocortisone can be decreased when combined with Diltiazem.	Approved
Dipyridamole	The serum concentration of Hydrocortisone can be increased when it is combined with Dipyridamole.	Approved
Docetaxel	The serum concentration of Docetaxel can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Domperidone	The serum concentration of Domperidone can be increased when it is combined with Hydrocortisone.	Approved, Investigational, Vet Approved
Donepezil	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Donepezil.	Approved
Doxazosin	The serum concentration of Hydrocortisone can be increased when it is combined with Doxazosin.	Approved
Doxepin	The serum concentration of Hydrocortisone can be increased when it is combined with Doxepin.	Approved
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Doxorubicin	The serum concentration of Hydrocortisone can be decreased when it is combined with Doxorubicin.	Approved, Investigational
Doxycycline	The metabolism of Hydrocortisone can be decreased when combined with Doxycycline.	Approved, Investigational, Vet Approved
Dronabinol	The serum concentration of Hydrocortisone can be increased when it is combined with Dronabinol.	Approved, Illicit
Dronedarone	The metabolism of Hydrocortisone can be decreased when combined with Dronedarone.	Approved
Droxicam	The risk or severity of adverse effects can be increased when Droxicam is combined with Hydrocortisone.	Approved
Dulaglutide	The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Hydrocortisone.	Approved
Duvelisib	The risk or severity of adverse effects can be increased when Duvelisib is combined with Hydrocortisone.	Investigational
E-6201	The risk or severity of adverse effects can be increased when E6201 is combined with Hydrocortisone.	Investigational
Ebselen	The risk or severity of adverse effects can be increased when Ebselen is combined with Hydrocortisone.	Investigational
Echothiophate	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Echothiophate.	Approved
Edoxaban	The serum concentration of Edoxaban can be increased when it is combined with Hydrocortisone.	Approved
Edrophonium	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Edrophonium.	Approved
Efavirenz	The serum concentration of Hydrocortisone can be decreased when it is combined with Efavirenz.	Approved, Investigational
Elbasvir	The serum concentration of Hydrocortisone can be increased when it is combined with Elbasvir.	Approved
Eletriptan	The serum concentration of Eletriptan can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Empagliflozin	The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Hydrocortisone.	Approved
Enalapril	The serum concentration of Hydrocortisone can be increased when it is combined with Enalapril.	Approved, Vet Approved
Enoxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Enoxacin.	Approved
Enzalutamide	The serum concentration of Hydrocortisone can be decreased when it is combined with Enzalutamide.	Approved
Epinastine	The serum concentration of Epinastine can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Epirizole	The risk or severity of adverse effects can be increased when Epirizole is combined with Hydrocortisone.	Approved
Equol	The serum concentration of Hydrocortisone can be increased when it is combined with S Equol.	Investigational
Ergonovine	The serum concentration of Hydrocortisone can be increased when it is combined with Ergonovine.	Approved
Ergotamine	The serum concentration of Hydrocortisone can be increased when it is combined with Ergotamine.	Approved
Erlotinib	The serum concentration of Erlotinib can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Erythromycin	The metabolism of Hydrocortisone can be decreased when combined with Erythromycin.	Approved, Vet Approved
Eslicarbazepine acetate	The serum concentration of Hydrocortisone can be decreased when it is combined with Eslicarbazepine acetate.	Approved
Estradiol	The serum concentration of Hydrocortisone can be increased when it is combined with Estradiol.	Approved, Investigational, Vet Approved
Estramustine	The serum concentration of Hydrocortisone can be increased when it is combined with Estramustine.	Approved
Estriol	The serum concentration of Hydrocortisone can be increased when it is combined with Estriol.	Approved, Vet Approved
Estrone	The serum concentration of Hydrocortisone can be increased when it is combined with Estrone.	Approved
Etacrynic acid	Hydrocortisone may increase the hypokalemic activities of Etacrynic acid.	Approved
Etanercept	The risk or severity of adverse effects can be increased when Etanercept is combined with Hydrocortisone.	Approved, Investigational
Ethinyl Estradiol	The serum concentration of Hydrocortisone can be increased when it is combined with Ethinyl Estradiol.	Approved
Etodolac	The risk or severity of adverse effects can be increased when Etodolac is combined with Hydrocortisone.	Approved, Investigational, Vet Approved
Etofenamate	The risk or severity of adverse effects can be increased when Etofenamate is combined with Hydrocortisone.	Approved
Etoposide	The serum concentration of Hydrocortisone can be increased when it is combined with Etoposide.	Approved
Etoricoxib	The risk or severity of adverse effects can be increased when Etoricoxib is combined with Hydrocortisone.	Approved, Investigational
Etravirine	The serum concentration of Hydrocortisone can be decreased when it is combined with Etravirine.	Approved
Everolimus	The serum concentration of Everolimus can be increased when it is combined with Hydrocortisone.	Approved
Exenatide	The therapeutic efficacy of Exenatide can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Ezetimibe	The serum concentration of Ezetimibe can be increased when it is combined with Hydrocortisone.	Approved
Felodipine	The serum concentration of Hydrocortisone can be increased when it is combined with Felodipine.	Approved, Investigational
Fenbufen	The risk or severity of adverse effects can be increased when Fenbufen is combined with Hydrocortisone.	Approved
Fenoprofen	The risk or severity of adverse effects can be increased when Fenoprofen is combined with Hydrocortisone.	Approved
Fentanyl	The serum concentration of Hydrocortisone can be increased when it is combined with Fentanyl.	Approved, Illicit, Investigational, Vet Approved
Fesoterodine	The serum concentration of Fesoterodine can be increased when it is combined with Hydrocortisone.	Approved
Fexofenadine	The serum concentration of Fexofenadine can be increased when it is combined with Hydrocortisone.	Approved
Fidaxomicin	The serum concentration of Fidaxomicin can be increased when it is combined with Hydrocortisone.	Approved
Fingolimod	Hydrocortisone may increase the immunosuppressive activities of Fingolimod.	Approved, Investigational
Fleroxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Fleroxacin.	Approved
Floctafenine	The risk or severity of adverse effects can be increased when Floctafenine is combined with Hydrocortisone.	Approved, Withdrawn
Fluconazole	The metabolism of Hydrocortisone can be decreased when combined with Fluconazole.	Approved
Flumequine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Flumequine.	Withdrawn
Fluoxetine	The serum concentration of Hydrocortisone can be increased when it is combined with Fluoxetine.	Approved, Vet Approved
Fluoxymesterone	Hydrocortisone may increase the fluid retaining activities of Fluoxymesterone.	Approved, Illicit
Flupentixol	The serum concentration of Hydrocortisone can be increased when it is combined with Flupentixol.	Approved, Withdrawn
Fluphenazine	The serum concentration of Hydrocortisone can be increased when it is combined with Fluphenazine.	Approved
Flurazepam	The serum concentration of Hydrocortisone can be increased when it is combined with Flurazepam.	Approved, Illicit
Flurbiprofen	The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Hydrocortisone.	Approved, Investigational
Fluticasone furoate	The serum concentration of Fluticasone furoate can be increased when it is combined with Hydrocortisone.	Approved
Fluvoxamine	The metabolism of Hydrocortisone can be decreased when combined with Fluvoxamine.	Approved, Investigational
Fosamprenavir	The metabolism of Hydrocortisone can be decreased when combined with Fosamprenavir.	Approved
Fosaprepitant	The serum concentration of Hydrocortisone can be increased when it is combined with Fosaprepitant.	Approved
Fosphenytoin	The metabolism of Hydrocortisone can be increased when combined with Fosphenytoin.	Approved
Fosphenytoin	The serum concentration of Hydrocortisone can be decreased when it is combined with Fosphenytoin.	Approved
Furosemide	Hydrocortisone may increase the hypokalemic activities of Furosemide.	Approved, Vet Approved
Fusidic Acid	The serum concentration of Hydrocortisone can be increased when it is combined with Fusidic Acid.	Approved
G17DT	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with G17DT.	Investigational
Galantamine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Galantamine.	Approved
Gallamine Triethiodide	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Gallamine Triethiodide.	Approved
Gatifloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Gatifloxacin.	Approved, Investigational
Gefitinib	The serum concentration of Gefitinib can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Gemcitabine	The serum concentration of Gemcitabine can be increased when it is combined with Hydrocortisone.	Approved
Gemifloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Gemifloxacin.	Approved, Investigational
Genistein	The serum concentration of Hydrocortisone can be increased when it is combined with Genistein.	Investigational
Ginkgo biloba	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Ginkgo biloba.	Approved, Nutraceutical
Glibornuride	The therapeutic efficacy of Glibornuride can be decreased when used in combination with Hydrocortisone.	Withdrawn
Gliclazide	The therapeutic efficacy of Gliclazide can be decreased when used in combination with Hydrocortisone.	Approved
Glimepiride	The therapeutic efficacy of Glimepiride can be decreased when used in combination with Hydrocortisone.	Approved
Glipizide	The therapeutic efficacy of Glipizide can be decreased when used in combination with Hydrocortisone.	Approved
Gliquidone	The therapeutic efficacy of Gliquidone can be decreased when used in combination with Hydrocortisone.	Approved
Glyburide	The serum concentration of Hydrocortisone can be increased when it is combined with Glyburide.	Approved
Glycerol Phenylbutyrate	The therapeutic efficacy of Glycerol Phenylbutyrate can be decreased when used in combination with Hydrocortisone.	Approved
Gramicidin D	The serum concentration of Hydrocortisone can be increased when it is combined with Gramicidin D.	Approved
Grazoprevir	The serum concentration of Grazoprevir can be increased when it is combined with Hydrocortisone.	Approved
Grepafloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Grepafloxacin.	Withdrawn
Gusperimus	The therapeutic efficacy of Gusperimus can be decreased when used in combination with Hydrocortisone.	Investigational
Haloperidol	The serum concentration of Hydrocortisone can be increased when it is combined with Haloperidol.	Approved
Hexestrol	The serum concentration of Hydrocortisone can be increased when it is combined with Hexestrol.	Withdrawn
Higenamine	The risk or severity of adverse effects can be increased when Higenamine is combined with Hydrocortisone.	Investigational
Huperzine A	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Huperzine A.	Investigational
Hyaluronidase	The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Hydrochlorothiazide	Hydrocortisone may increase the hypokalemic activities of Hydrochlorothiazide.	Approved, Vet Approved
Hydrocodone	The serum concentration of Hydrocodone can be decreased when it is combined with Hydrocortisone.	Approved, Illicit
Hydroflumethiazide	Hydrocortisone may increase the hypokalemic activities of Hydroflumethiazide.	Approved
Ibuprofen	The serum concentration of Ibuprofen can be increased when it is combined with Hydrocortisone.	Approved
Ibuproxam	The risk or severity of adverse effects can be increased when Ibuproxam is combined with Hydrocortisone.	Withdrawn
Icatibant	The risk or severity of adverse effects can be increased when Icatibant is combined with Hydrocortisone.	Approved
Idelalisib	The serum concentration of Hydrocortisone can be increased when it is combined with Idelalisib.	Approved
Imatinib	The metabolism of Hydrocortisone can be decreased when combined with Imatinib.	Approved
Imipramine	The serum concentration of Hydrocortisone can be increased when it is combined with Imipramine.	Approved
Indacaterol	Indacaterol may increase the hypokalemic activities of Hydrocortisone.	Approved
Indapamide	Hydrocortisone may increase the hypokalemic activities of Indapamide.	Approved
Indinavir	The metabolism of Hydrocortisone can be decreased when combined with Indinavir.	Approved
Indomethacin	The serum concentration of Hydrocortisone can be increased when it is combined with Indomethacin.	Approved, Investigational
Indoprofen	The risk or severity of adverse effects can be increased when Indoprofen is combined with Hydrocortisone.	Withdrawn
INGN 201	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with INGN 201.	Investigational
INGN 225	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with INGN 225.	Investigational
Insulin Aspart	The therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Hydrocortisone.	Approved
Insulin Detemir	The therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Hydrocortisone.	Approved
Insulin Glargine	The therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Hydrocortisone.	Approved
Insulin Glulisine	The therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Hydrocortisone.	Approved
Insulin Lispro	The therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Hydrocortisone.	Approved
Insulin Pork	The therapeutic efficacy of Insulin Pork can be decreased when used in combination with Hydrocortisone.	Approved
Irinotecan	The serum concentration of Irinotecan can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Isavuconazonium	The metabolism of Hydrocortisone can be decreased when combined with Isavuconazonium.	Approved, Investigational
Isoflurophate	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Isoflurophate.	Approved, Withdrawn
Isoniazid	The serum concentration of Isoniazid can be decreased when it is combined with Hydrocortisone.	Approved
Isoxicam	The risk or severity of adverse effects can be increased when Isoxicam is combined with Hydrocortisone.	Withdrawn
Isradipine	The metabolism of Hydrocortisone can be decreased when combined with Isradipine.	Approved
Itraconazole	The metabolism of Hydrocortisone can be decreased when combined with Itraconazole.	Approved, Investigational
Ivacaftor	The serum concentration of Hydrocortisone can be increased when it is combined with Ivacaftor.	Approved
Ivermectin	The serum concentration of Hydrocortisone can be increased when it is combined with Ivermectin.	Approved, Vet Approved
Kebuzone	The risk or severity of adverse effects can be increased when Kebuzone is combined with Hydrocortisone.	Experimental
Ketamine	The serum concentration of Hydrocortisone can be increased when it is combined with Ketamine.	Approved, Vet Approved
Ketazolam	The serum concentration of Ketazolam can be increased when it is combined with Hydrocortisone.	Approved
Ketoconazole	The metabolism of Hydrocortisone can be decreased when combined with Ketoconazole.	Approved, Investigational
Ketoprofen	The risk or severity of adverse effects can be increased when Ketoprofen is combined with Hydrocortisone.	Approved, Vet Approved
Ketorolac	The risk or severity of adverse effects can be increased when Ketorolac is combined with Hydrocortisone.	Approved
Lamivudine	The serum concentration of Lamivudine can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Lamotrigine	The serum concentration of Lamotrigine can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Lansoprazole	The serum concentration of Hydrocortisone can be increased when it is combined with Lansoprazole.	Approved, Investigational
Lapatinib	The serum concentration of Hydrocortisone can be increased when it is combined with Lapatinib.	Approved, Investigational
Ledipasvir	The serum concentration of Ledipasvir can be increased when it is combined with Hydrocortisone.	Approved
Leflunomide	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Leflunomide.	Approved, Investigational
Lenalidomide	The serum concentration of Lenalidomide can be increased when it is combined with Hydrocortisone.	Approved
Lenvatinib	The serum concentration of Lenvatinib can be increased when it is combined with Hydrocortisone.	Approved
Levetiracetam	The serum concentration of Levetiracetam can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Levofloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Levofloxacin.	Approved, Investigational
Levomilnacipran	The serum concentration of Levomilnacipran can be increased when it is combined with Hydrocortisone.	Approved
Levothyroxine	The serum concentration of Hydrocortisone can be decreased when it is combined with Levothyroxine.	Approved
Lidocaine	The serum concentration of Hydrocortisone can be increased when it is combined with Lidocaine.	Approved, Vet Approved
Linagliptin	The serum concentration of Linagliptin can be increased when it is combined with Hydrocortisone.	Approved
Liothyronine	The serum concentration of Hydrocortisone can be decreased when it is combined with Liothyronine.	Approved, Vet Approved
Liotrix	The serum concentration of Hydrocortisone can be decreased when it is combined with Liotrix.	Approved
Liraglutide	The therapeutic efficacy of Liraglutide can be decreased when used in combination with Hydrocortisone.	Approved
Lisinopril	The serum concentration of Hydrocortisone can be increased when it is combined with Lisinopril.	Approved, Investigational
Lisofylline	The risk or severity of adverse effects can be increased when Lisofylline is combined with Hydrocortisone.	Investigational
Lomefloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Lomefloxacin.	Approved
Lomitapide	The serum concentration of Hydrocortisone can be increased when it is combined with Lomitapide.	Approved
Loperamide	The serum concentration of Hydrocortisone can be increased when it is combined with Loperamide.	Approved
Lopinavir	The metabolism of Hydrocortisone can be decreased when combined with Lopinavir.	Approved
Loratadine	The serum concentration of Hydrocortisone can be increased when it is combined with Loratadine.	Approved
Lornoxicam	The risk or severity of adverse effects can be increased when Lornoxicam is combined with Hydrocortisone.	Approved
Losartan	The serum concentration of Hydrocortisone can be increased when it is combined with Losartan.	Approved
Lovastatin	The metabolism of Hydrocortisone can be decreased when combined with Lovastatin.	Approved, Investigational
Loxoprofen	The risk or severity of adverse effects can be increased when Loxoprofen is combined with Hydrocortisone.	Approved
Luliconazole	The serum concentration of Hydrocortisone can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The serum concentration of Hydrocortisone can be decreased when it is combined with Lumacaftor.	Approved
Lumiracoxib	The risk or severity of adverse effects can be increased when Lumiracoxib is combined with Hydrocortisone.	Approved, Investigational
Magaldrate	The bioavailability of Hydrocortisone can be decreased when combined with Magaldrate.	Withdrawn
Magnesium carbonate	The bioavailability of Hydrocortisone can be decreased when combined with Magnesium carbonate.	Approved
Magnesium Hydroxide	The bioavailability of Hydrocortisone can be decreased when combined with Magnesium hydroxide.	Approved
Magnesium oxide	The bioavailability of Hydrocortisone can be decreased when combined with Magnesium oxide.	Approved
Magnesium salicylate	The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Hydrocortisone.	Approved
Magnesium Trisilicate	The bioavailability of Hydrocortisone can be decreased when combined with Magnesium Trisilicate.	Approved
Malathion	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Malathion.	Approved, Investigational
Mannitol	The serum concentration of Mannitol can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Maprotiline	The serum concentration of Hydrocortisone can be increased when it is combined with Maprotiline.	Approved
Masoprocol	The risk or severity of adverse effects can be increased when Masoprocol is combined with Hydrocortisone.	Approved
Mebendazole	The serum concentration of Hydrocortisone can be increased when it is combined with Mebendazole.	Approved, Vet Approved
Meclofenamic acid	The risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Hydrocortisone.	Approved, Vet Approved
Mefenamic acid	The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Hydrocortisone.	Approved
Mefloquine	The serum concentration of Hydrocortisone can be increased when it is combined with Mefloquine.	Approved
Megestrol acetate	The serum concentration of Hydrocortisone can be increased when it is combined with Megestrol acetate.	Approved, Vet Approved
Meloxicam	The risk or severity of adverse effects can be increased when Meloxicam is combined with Hydrocortisone.	Approved, Vet Approved
Memantine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Memantine.	Approved, Investigational
Meprobamate	The serum concentration of Hydrocortisone can be increased when it is combined with Meprobamate.	Approved, Illicit
Mesalazine	The risk or severity of adverse effects can be increased when Mesalazine is combined with Hydrocortisone.	Approved
Mestranol	The serum concentration of Hydrocortisone can be increased when it is combined with Mestranol.	Approved
Metamizole	The risk or severity of adverse effects can be increased when Metamizole is combined with Hydrocortisone.	Withdrawn
Metformin	The therapeutic efficacy of Metformin can be decreased when used in combination with Hydrocortisone.	Approved
Methadone	The serum concentration of Hydrocortisone can be increased when it is combined with Methadone.	Approved
Methallenestril	The serum concentration of Hydrocortisone can be increased when it is combined with Methallenestril.	Experimental
Methanesulfonyl Fluoride	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Methanesulfonyl Fluoride.	Investigational
Methotrexate	The serum concentration of Methotrexate can be increased when it is combined with Hydrocortisone.	Approved
Methyclothiazide	Hydrocortisone may increase the hypokalemic activities of Methyclothiazide.	Approved
Methylprednisolone	The serum concentration of Methylprednisolone can be increased when it is combined with Hydrocortisone.	Approved, Vet Approved
Methyltestosterone	Hydrocortisone may increase the fluid retaining activities of Methyltestosterone.	Approved
Metolazone	Hydrocortisone may increase the hypokalemic activities of Metolazone.	Approved
Metoprolol	The serum concentration of Hydrocortisone can be increased when it is combined with Metoprolol.	Approved, Investigational
Mibefradil	The serum concentration of Hydrocortisone can be increased when it is combined with Mibefradil.	Withdrawn
Miconazole	The serum concentration of Hydrocortisone can be increased when it is combined with Miconazole.	Approved, Investigational, Vet Approved
Midazolam	The serum concentration of Hydrocortisone can be decreased when it is combined with Midazolam.	Approved, Illicit
Mifepristone	The therapeutic efficacy of Hydrocortisone can be decreased when used in combination with Mifepristone.	Approved, Investigational
Miglitol	The therapeutic efficacy of Miglitol can be decreased when used in combination with Hydrocortisone.	Approved
Miglustat	The therapeutic efficacy of Miglustat can be decreased when used in combination with Hydrocortisone.	Approved
Minaprine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Minaprine.	Approved
Mirabegron	The serum concentration of Mirabegron can be increased when it is combined with Hydrocortisone.	Approved
Mitiglinide	The therapeutic efficacy of Mitiglinide can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Mitomycin	The serum concentration of Hydrocortisone can be increased when it is combined with Mitomycin.	Approved
Mitotane	The serum concentration of Hydrocortisone can be decreased when it is combined with Mitotane.	Approved
Mitoxantrone	The serum concentration of Hydrocortisone can be decreased when it is combined with Mitoxantrone.	Approved, Investigational
Mivacurium	Mivacurium may increase the adverse neuromuscular activities of Hydrocortisone.	Approved
Mizoribine	The risk or severity of adverse effects can be increased when Mizoribine is combined with Hydrocortisone.	Investigational
Modafinil	The serum concentration of Hydrocortisone can be decreased when it is combined with Modafinil.	Approved, Investigational
Morphine	The serum concentration of Hydrocortisone can be increased when it is combined with Morphine.	Approved, Investigational
Moxifloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Moxifloxacin.	Approved, Investigational
Mycophenolate mofetil	The serum concentration of Mycophenolate mofetil can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Mycophenolic acid	The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Hydrocortisone.	Approved
Nabumetone	The risk or severity of adverse effects can be increased when Nabumetone is combined with Hydrocortisone.	Approved
Nadolol	The serum concentration of Nadolol can be increased when it is combined with Hydrocortisone.	Approved
Nafamostat	The risk or severity of adverse effects can be increased when Nafamostat is combined with Hydrocortisone.	Approved, Investigational
Nafcillin	The serum concentration of Hydrocortisone can be decreased when it is combined with Nafcillin.	Approved
Naftifine	The risk or severity of adverse effects can be increased when Naftifine is combined with Hydrocortisone.	Approved
Nalidixic Acid	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Nalidixic Acid.	Approved
Naloxegol	The serum concentration of Naloxegol can be increased when it is combined with Hydrocortisone.	Approved
Naloxone	The serum concentration of Naloxone can be increased when it is combined with Hydrocortisone.	Approved, Vet Approved
Naltrexone	The serum concentration of Hydrocortisone can be increased when it is combined with Naltrexone.	Approved, Investigational, Vet Approved
Naproxen	The risk or severity of adverse effects can be increased when Naproxen is combined with Hydrocortisone.	Approved, Vet Approved
Naringenin	The serum concentration of Hydrocortisone can be increased when it is combined with Naringenin.	Experimental
Natalizumab	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Natalizumab.	Approved, Investigational
Nateglinide	The therapeutic efficacy of Nateglinide can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Nefazodone	The metabolism of Hydrocortisone can be decreased when combined with Nefazodone.	Approved, Withdrawn
Nelfinavir	The metabolism of Hydrocortisone can be decreased when combined with Nelfinavir.	Approved
Neostigmine	The serum concentration of Hydrocortisone can be increased when it is combined with Neostigmine.	Approved, Vet Approved
Nepafenac	The risk or severity of adverse effects can be increased when Nepafenac is combined with Hydrocortisone.	Approved
Netupitant	The serum concentration of Hydrocortisone can be increased when it is combined with Netupitant.	Approved
Nevirapine	The metabolism of Hydrocortisone can be increased when combined with Nevirapine.	Approved
Nevirapine	The serum concentration of Hydrocortisone can be decreased when it is combined with Nevirapine.	Approved
Nicardipine	The serum concentration of Hydrocortisone can be increased when it is combined with Nicardipine.	Approved
Nicorandil	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Nicorandil.	Approved
Nifedipine	The serum concentration of Hydrocortisone can be decreased when it is combined with Nifedipine.	Approved
Niflumic Acid	The risk or severity of adverse effects can be increased when Niflumic Acid is combined with Hydrocortisone.	Approved
Nilotinib	The metabolism of Hydrocortisone can be decreased when combined with Nilotinib.	Approved, Investigational
Nimesulide	The risk or severity of adverse effects can be increased when Nimesulide is combined with Hydrocortisone.	Approved, Withdrawn
Nimodipine	The serum concentration of Nimodipine can be decreased when it is combined with Hydrocortisone.	Approved
Nintedanib	The serum concentration of Nintedanib can be increased when it is combined with Hydrocortisone.	Approved
Nisoldipine	The serum concentration of Hydrocortisone can be increased when it is combined with Nisoldipine.	Approved
Nitrazepam	The serum concentration of Hydrocortisone can be increased when it is combined with Nitrazepam.	Approved
Nitrendipine	The serum concentration of Hydrocortisone can be increased when it is combined with Nitrendipine.	Approved
Nitroaspirin	The risk or severity of adverse effects can be increased when Nitroaspirin is combined with Hydrocortisone.	Investigational
Nizatidine	The serum concentration of Nizatidine can be increased when it is combined with Hydrocortisone.	Approved
Norethisterone	The serum concentration of Hydrocortisone can be decreased when it is combined with Norethisterone.	Approved
Norfloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Norfloxacin.	Approved
Ofloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Ofloxacin.	Approved
Olanzapine	The serum concentration of Olanzapine can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Olaparib	The metabolism of Hydrocortisone can be decreased when combined with Olaparib.	Approved
Olopatadine	The risk or severity of adverse effects can be increased when Olopatadine is combined with Hydrocortisone.	Approved
Olsalazine	The risk or severity of adverse effects can be increased when Olsalazine is combined with Hydrocortisone.	Approved
Ombitasvir	The serum concentration of Ombitasvir can be increased when it is combined with Hydrocortisone.	Approved
Omeprazole	The serum concentration of Hydrocortisone can be increased when it is combined with Omeprazole.	Approved, Investigational, Vet Approved
Osimertinib	The serum concentration of Hydrocortisone can be increased when it is combined with Osimertinib.	Approved
Oxandrolone	Hydrocortisone may increase the fluid retaining activities of Oxandrolone.	Approved, Investigational
Oxaprozin	The risk or severity of adverse effects can be increased when Oxaprozin is combined with Hydrocortisone.	Approved
Oxymetholone	Hydrocortisone may increase the fluid retaining activities of Oxymetholone.	Approved, Illicit
Oxyphenbutazone	The risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Hydrocortisone.	Withdrawn
P-Nitrophenol	The serum concentration of Hydrocortisone can be increased when it is combined with P-Nitrophenol.	Experimental
Paclitaxel	The serum concentration of Hydrocortisone can be increased when it is combined with Paclitaxel.	Approved, Vet Approved
Palbociclib	The serum concentration of Hydrocortisone can be increased when it is combined with Palbociclib.	Approved
Palmitic Acid	The serum concentration of Hydrocortisone can be increased when it is combined with Palmitic Acid.	Experimental
Panobinostat	The serum concentration of Panobinostat can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Pantoprazole	The serum concentration of Hydrocortisone can be increased when it is combined with Pantoprazole.	Approved
Parecoxib	The risk or severity of adverse effects can be increased when Parecoxib is combined with Hydrocortisone.	Approved
Paroxetine	The serum concentration of Hydrocortisone can be increased when it is combined with Paroxetine.	Approved, Investigational
Pazopanib	The serum concentration of Pazopanib can be increased when it is combined with Hydrocortisone.	Approved
Pazufloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Pazufloxacin.	Investigational
Pefloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Pefloxacin.	Approved
Pentobarbital	The metabolism of Hydrocortisone can be increased when combined with Pentobarbital.	Approved, Vet Approved
Pentobarbital	The serum concentration of Hydrocortisone can be decreased when it is combined with Pentobarbital.	Approved, Vet Approved
Perindopril	The serum concentration of Hydrocortisone can be increased when it is combined with Perindopril.	Approved
Phenformin	The therapeutic efficacy of Phenformin can be decreased when used in combination with Hydrocortisone.	Approved, Withdrawn
Phenobarbital	The metabolism of Hydrocortisone can be increased when combined with Phenobarbital.	Approved
Phenobarbital	The serum concentration of Hydrocortisone can be decreased when it is combined with Phenobarbital.	Approved
Phenylacetic acid	The therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Hydrocortisone.	Approved
Phenylbutazone	The risk or severity of adverse effects can be increased when Phenylbutazone is combined with Hydrocortisone.	Approved, Vet Approved
Phenylbutyric acid	The therapeutic efficacy of Sodium phenylbutyrate can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Phenytoin	The metabolism of Hydrocortisone can be increased when combined with Phenytoin.	Approved, Vet Approved
Phenytoin	The serum concentration of Hydrocortisone can be decreased when it is combined with Phenytoin.	Approved, Vet Approved
Physostigmine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Physostigmine.	Approved
Pimecrolimus	The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Hydrocortisone.	Approved, Investigational
Pimozide	The serum concentration of Hydrocortisone can be increased when it is combined with Pimozide.	Approved
Pioglitazone	The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Piretanide	Hydrocortisone may increase the hypokalemic activities of Piretanide.	Experimental
Pirfenidone	The risk or severity of adverse effects can be increased when Pirfenidone is combined with Hydrocortisone.	Investigational
Piroxicam	The risk or severity of adverse effects can be increased when Piroxicam is combined with Hydrocortisone.	Approved, Investigational
Pitavastatin	The serum concentration of Pitavastatin can be increased when it is combined with Hydrocortisone.	Approved
Platelet Activating Factor	The serum concentration of Hydrocortisone can be decreased when it is combined with Platelet Activating Factor.	Experimental
Polythiazide	Hydrocortisone may increase the hypokalemic activities of Polythiazide.	Approved
Pomalidomide	The serum concentration of Pomalidomide can be increased when it is combined with Hydrocortisone.	Approved
Ponatinib	The serum concentration of Ponatinib can be increased when it is combined with Hydrocortisone.	Approved
Posaconazole	The metabolism of Hydrocortisone can be decreased when combined with Posaconazole.	Approved, Investigational, Vet Approved
Pramlintide	The therapeutic efficacy of Pramlintide can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Pravastatin	The serum concentration of Pravastatin can be increased when it is combined with Hydrocortisone.	Approved
Prazosin	The serum concentration of Hydrocortisone can be increased when it is combined with Prazosin.	Approved
Prednisolone	The serum concentration of Prednisolone can be increased when it is combined with Hydrocortisone.	Approved, Vet Approved
Prednisone	The serum concentration of Prednisone can be increased when it is combined with Hydrocortisone.	Approved, Vet Approved
Primidone	The metabolism of Hydrocortisone can be increased when combined with Primidone.	Approved, Vet Approved
Primidone	The serum concentration of Hydrocortisone can be decreased when it is combined with Primidone.	Approved, Vet Approved
Probenecid	The serum concentration of Hydrocortisone can be increased when it is combined with Probenecid.	Approved
Progesterone	The serum concentration of Hydrocortisone can be decreased when it is combined with Progesterone.	Approved, Vet Approved
Promestriene	The serum concentration of Hydrocortisone can be increased when it is combined with Promestriene.	Investigational
Promethazine	The serum concentration of Hydrocortisone can be increased when it is combined with Promethazine.	Approved
Propacetamol	The risk or severity of adverse effects can be increased when Propacetamol is combined with Hydrocortisone.	Approved
Propafenone	The serum concentration of Hydrocortisone can be increased when it is combined with Propafenone.	Approved
Propranolol	The serum concentration of Propranolol can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Protriptyline	The serum concentration of Hydrocortisone can be increased when it is combined with Protriptyline.	Approved
Prucalopride	The serum concentration of Prucalopride can be increased when it is combined with Hydrocortisone.	Approved
Prulifloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Prulifloxacin.	Investigational
PTC299	The risk or severity of adverse effects can be increased when PTC299 is combined with Hydrocortisone.	Investigational
Pyridostigmine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Pyridostigmine.	Approved
Quercetin	The serum concentration of Hydrocortisone can be increased when it is combined with Quercetin.	Experimental
Quetiapine	The serum concentration of Quetiapine can be increased when it is combined with Hydrocortisone.	Approved
Quinacrine	The serum concentration of Hydrocortisone can be increased when it is combined with Quinacrine.	Approved
Quinestrol	The serum concentration of Hydrocortisone can be increased when it is combined with Quinestrol.	Approved
Quinethazone	Hydrocortisone may increase the hypokalemic activities of Quinethazone.	Approved
Quinidine	The serum concentration of Hydrocortisone can be increased when it is combined with Quinidine.	Approved
Quinine	The serum concentration of Hydrocortisone can be increased when it is combined with Quinine.	Approved
Ranitidine	The serum concentration of Hydrocortisone can be increased when it is combined with Ranitidine.	Approved
Ranolazine	The serum concentration of Ranolazine can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Rapacuronium	Rapacuronium may increase the adverse neuromuscular activities of Hydrocortisone.	Withdrawn
Reboxetine	The serum concentration of Hydrocortisone can be increased when it is combined with Reboxetine.	Approved, Investigational
Regorafenib	The serum concentration of Hydrocortisone can be increased when it is combined with Regorafenib.	Approved
Repaglinide	The therapeutic efficacy of Repaglinide can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Reserpine	The serum concentration of Hydrocortisone can be decreased when it is combined with Reserpine.	Approved
Resveratrol	The risk or severity of adverse effects can be increased when Resveratrol is combined with Hydrocortisone.	Experimental, Investigational
Rifabutin	The metabolism of Hydrocortisone can be increased when combined with Rifabutin.	Approved
Rifabutin	The serum concentration of Hydrocortisone can be decreased when it is combined with Rifabutin.	Approved
Rifampicin	The metabolism of Hydrocortisone can be increased when combined with Rifampicin.	Approved
Rifampicin	The serum concentration of Hydrocortisone can be decreased when it is combined with Rifampicin.	Approved
Rifapentine	The metabolism of Hydrocortisone can be increased when combined with Rifapentine.	Approved
Rifapentine	The serum concentration of Hydrocortisone can be decreased when it is combined with Rifapentine.	Approved
Rifaximin	The serum concentration of Rifaximin can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Rilpivirine	The serum concentration of Hydrocortisone can be increased when it is combined with Rilpivirine.	Approved
Rindopepimut	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with CDX-110.	Investigational
Risperidone	The serum concentration of Risperidone can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Ritonavir	The metabolism of Hydrocortisone can be decreased when combined with Ritonavir.	Approved, Investigational
Rivaroxaban	The serum concentration of Rivaroxaban can be increased when it is combined with Hydrocortisone.	Approved
Rivastigmine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Rivastigmine.	Approved, Investigational
Rofecoxib	The risk or severity of adverse effects can be increased when Rofecoxib is combined with Hydrocortisone.	Investigational, Withdrawn
Roflumilast	Roflumilast may increase the immunosuppressive activities of Hydrocortisone.	Approved
Rolapitant	The serum concentration of Hydrocortisone can be increased when it is combined with Rolapitant.	Approved
Romidepsin	The serum concentration of Romidepsin can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Rosiglitazone	The therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Rosoxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Rosoxacin.	Approved
Salicylamide	The risk or severity of adverse effects can be increased when Salicylamide is combined with Hydrocortisone.	Approved
Salicylic acid	The serum concentration of Salicylic acid can be increased when it is combined with Hydrocortisone.	Approved, Vet Approved
Salsalate	The risk or severity of adverse effects can be increased when Salsalate is combined with Hydrocortisone.	Approved
Saquinavir	The metabolism of Hydrocortisone can be decreased when combined with Saquinavir.	Approved, Investigational
Saxagliptin	The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Hydrocortisone.	Approved
Scopolamine	The serum concentration of Hydrocortisone can be increased when it is combined with Scopolamine.	Approved
Secoisolariciresinol	The serum concentration of Hydrocortisone can be increased when it is combined with Secoisolariciresinol.	Investigational
Selegiline	The serum concentration of Hydrocortisone can be increased when it is combined with Selegiline.	Approved, Investigational, Vet Approved
Selexipag	The serum concentration of Selexipag can be increased when it is combined with Hydrocortisone.	Approved
Sertraline	The serum concentration of Hydrocortisone can be increased when it is combined with Sertraline.	Approved
Sildenafil	The metabolism of Hydrocortisone can be decreased when combined with Sildenafil.	Approved, Investigational
Silodosin	The serum concentration of Silodosin can be increased when it is combined with Hydrocortisone.	Approved
Siltuximab	The serum concentration of Hydrocortisone can be decreased when it is combined with Siltuximab.	Approved
Simeprevir	The serum concentration of Hydrocortisone can be increased when it is combined with Simeprevir.	Approved
Simvastatin	The serum concentration of Hydrocortisone can be increased when it is combined with Simvastatin.	Approved
Sipuleucel-T	The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Hydrocortisone.	Approved
Sirolimus	The serum concentration of Hydrocortisone can be decreased when it is combined with Sirolimus.	Approved, Investigational
Sitagliptin	The serum concentration of Sitagliptin can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Sofosbuvir	The serum concentration of Sofosbuvir can be increased when it is combined with Hydrocortisone.	Approved
Sorafenib	The serum concentration of Sorafenib can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Sparfloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Sparfloxacin.	Approved
Sphingosine	The serum concentration of Sphingosine can be increased when it is combined with Hydrocortisone.	Experimental
Spironolactone	The serum concentration of Hydrocortisone can be increased when it is combined with Spironolactone.	Approved
SRP 299	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with SRP 299.	Investigational
SRT501	The risk or severity of adverse effects can be increased when SRT501 is combined with Hydrocortisone.	Investigational
St. John's Wort	The serum concentration of Hydrocortisone can be decreased when it is combined with St. John's Wort.	Nutraceutical
Stanozolol	Hydrocortisone may increase the fluid retaining activities of Stanozolol.	Approved, Vet Approved
Staurosporine	The serum concentration of Hydrocortisone can be increased when it is combined with Staurosporine.	Experimental
Stiripentol	The serum concentration of Hydrocortisone can be increased when it is combined with Stiripentol.	Approved
Streptozocin	The serum concentration of Hydrocortisone can be decreased when it is combined with Streptozocin.	Approved
Sulfasalazine	The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Hydrocortisone.	Approved
Sulfinpyrazone	The serum concentration of Hydrocortisone can be increased when it is combined with Sulfinpyrazone.	Approved
Sulfisoxazole	The metabolism of Hydrocortisone can be decreased when combined with Sulfisoxazole.	Approved, Vet Approved
Sulindac	The risk or severity of adverse effects can be increased when Sulindac is combined with Hydrocortisone.	Approved
Sulodexide	The therapeutic efficacy of Sulodexide can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Sumatriptan	The serum concentration of Hydrocortisone can be increased when it is combined with Sumatriptan.	Approved, Investigational
Sunitinib	The serum concentration of Hydrocortisone can be increased when it is combined with Sunitinib.	Approved, Investigational
Suprofen	The risk or severity of adverse effects can be increased when Suprofen is combined with Hydrocortisone.	Approved, Withdrawn
Synthetic Conjugated Estrogens, A	The serum concentration of Hydrocortisone can be increased when it is combined with Synthetic Conjugated Estrogens, A.	Approved
Synthetic Conjugated Estrogens, B	The serum concentration of Hydrocortisone can be increased when it is combined with Synthetic Conjugated Estrogens, B.	Approved
Tacrine	The serum concentration of Hydrocortisone can be increased when it is combined with Tacrine.	Withdrawn
Tacrolimus	The risk or severity of adverse effects can be increased when Tacrolimus is combined with Hydrocortisone.	Approved, Investigational
Tacrolimus	The serum concentration of Hydrocortisone can be decreased when it is combined with Tacrolimus.	Approved, Investigational
Tamoxifen	The serum concentration of Hydrocortisone can be decreased when it is combined with Tamoxifen.	Approved
Taurocholic Acid	The serum concentration of Taurocholic Acid can be increased when it is combined with Hydrocortisone.	Experimental
Technetium Tc-99m sestamibi	The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Hydrocortisone.	Approved
Telaprevir	The serum concentration of Telaprevir can be decreased when it is combined with Hydrocortisone.	Withdrawn
Telithromycin	The metabolism of Hydrocortisone can be decreased when combined with Telithromycin.	Approved
Telmisartan	The serum concentration of Hydrocortisone can be increased when it is combined with Telmisartan.	Approved, Investigational
Temafloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Temafloxacin.	Withdrawn
Temsirolimus	The serum concentration of Temsirolimus can be increased when it is combined with Hydrocortisone.	Approved
Tenoxicam	The risk or severity of adverse effects can be increased when Tenoxicam is combined with Hydrocortisone.	Approved
Terazosin	The serum concentration of Hydrocortisone can be increased when it is combined with Terazosin.	Approved
Terfenadine	The serum concentration of Hydrocortisone can be increased when it is combined with Terfenadine.	Withdrawn
Teriflunomide	The risk or severity of adverse effects can be increased when Teriflunomide is combined with Hydrocortisone.	Approved
Tesmilifene	The serum concentration of Hydrocortisone can be decreased when it is combined with Tesmilifene.	Investigational
Testosterone	The serum concentration of Hydrocortisone can be increased when it is combined with Testosterone.	Approved, Investigational
Tiaprofenic acid	The risk or severity of adverse effects can be increased when Tiaprofenic acid is combined with Hydrocortisone.	Approved
Tibolone	The serum concentration of Hydrocortisone can be increased when it is combined with Tibolone.	Approved
Ticagrelor	The serum concentration of Ticagrelor can be increased when it is combined with Hydrocortisone.	Approved
Ticlopidine	The metabolism of Hydrocortisone can be decreased when combined with Ticlopidine.	Approved
Timolol	The serum concentration of Timolol can be increased when it is combined with Hydrocortisone.	Approved
Tinoridine	The risk or severity of adverse effects can be increased when Tinoridine is combined with Hydrocortisone.	Investigational
Tocilizumab	The serum concentration of Hydrocortisone can be decreased when it is combined with Tocilizumab.	Approved
Tofacitinib	Hydrocortisone may increase the immunosuppressive activities of Tofacitinib.	Approved, Investigational
Tolazamide	The therapeutic efficacy of Tolazamide can be decreased when used in combination with Hydrocortisone.	Approved
Tolbutamide	The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Hydrocortisone.	Approved
Tolfenamic Acid	The risk or severity of adverse effects can be increased when Tolfenamic Acid is combined with Hydrocortisone.	Approved
Tolmetin	The risk or severity of adverse effects can be increased when Tolmetin is combined with Hydrocortisone.	Approved
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with Hydrocortisone.	Approved
Topotecan	The serum concentration of Topotecan can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Torasemide	Hydrocortisone may increase the hypokalemic activities of Torasemide.	Approved
Toremifene	The serum concentration of Toremifene can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Tranilast	The risk or severity of adverse effects can be increased when Tranilast is combined with Hydrocortisone.	Approved, Investigational
Trastuzumab	Trastuzumab may increase the neutropenic activities of Hydrocortisone.	Approved, Investigational
Trastuzumab emtansine	The serum concentration of Trastuzumab emtansine can be increased when it is combined with Hydrocortisone.	Approved
Trazodone	The serum concentration of Hydrocortisone can be decreased when it is combined with Trazodone.	Approved, Investigational
Trichlormethiazide	Hydrocortisone may increase the hypokalemic activities of Trichlormethiazide.	Approved, Vet Approved
Trifluoperazine	The serum concentration of Hydrocortisone can be increased when it is combined with Trifluoperazine.	Approved
Triflupromazine	The serum concentration of Hydrocortisone can be increased when it is combined with Triflupromazine.	Approved, Vet Approved
Trimethoprim	The serum concentration of Hydrocortisone can be decreased when it is combined with Trimethoprim.	Approved, Vet Approved
Trimipramine	The serum concentration of Hydrocortisone can be increased when it is combined with Trimipramine.	Approved
Troglitazone	The therapeutic efficacy of Troglitazone can be decreased when used in combination with Hydrocortisone.	Withdrawn
Trovafloxacin	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Trovafloxacin.	Approved, Withdrawn
Tubocurarine	The risk or severity of adverse effects can be increased when Hydrocortisone is combined with Tubocurarine.	Approved
Ulipristal	The serum concentration of Ulipristal can be increased when it is combined with Hydrocortisone.	Approved
Umeclidinium	The serum concentration of Umeclidinium can be increased when it is combined with Hydrocortisone.	Approved
Valdecoxib	The risk or severity of adverse effects can be increased when Valdecoxib is combined with Hydrocortisone.	Investigational, Withdrawn
Vecuronium	The serum concentration of Vecuronium can be increased when it is combined with Hydrocortisone.	Approved
Venetoclax	The serum concentration of Venetoclax can be increased when it is combined with Hydrocortisone.	Approved
Venlafaxine	The metabolism of Hydrocortisone can be decreased when combined with Venlafaxine.	Approved
Verapamil	The metabolism of Hydrocortisone can be decreased when combined with Verapamil.	Approved
Vildagliptin	The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Vinblastine	The serum concentration of Hydrocortisone can be decreased when it is combined with Vinblastine.	Approved
Vincristine	The serum concentration of Vincristine can be increased when it is combined with Hydrocortisone.	Approved, Investigational
Vincristine	The serum concentration of Hydrocortisone can be decreased when it is combined with Vincristine.	Approved, Investigational
Vinorelbine	The serum concentration of Hydrocortisone can be increased when it is combined with Vinorelbine.	Approved, Investigational
Vismodegib	The serum concentration of Vismodegib can be increased when it is combined with Hydrocortisone.	Approved
Voglibose	The therapeutic efficacy of Voglibose can be decreased when used in combination with Hydrocortisone.	Approved, Investigational
Voriconazole	The metabolism of Hydrocortisone can be decreased when combined with Voriconazole.	Approved, Investigational
Warfarin	Hydrocortisone may increase the anticoagulant activities of Warfarin.	Approved
Zaltoprofen	The risk or severity of adverse effects can be increased when Zaltoprofen is combined with Hydrocortisone.	Approved
Zidovudine	The serum concentration of Zidovudine can be increased when it is combined with Hydrocortisone.	Approved
Zileuton	The risk or severity of adverse effects can be increased when Zileuton is combined with Hydrocortisone.	Approved, Investigational, Withdrawn
Zimelidine	The serum concentration of Hydrocortisone can be increased when it is combined with Zimelidine.	Withdrawn
Ziprasidone	The metabolism of Hydrocortisone can be decreased when combined with Ziprasidone.	Approved
Zomepirac	The risk or severity of adverse effects can be increased when Zomepirac is combined with Hydrocortisone.	Withdrawn

Food Interactions

Take with food to reduce irritation. Calcium, phosphorous, potassium, Vitamin A, C, D and zinc needs increased with long term use.

References

Synthesis Reference

Manfred Baumgarth, Dieter Orth, Jurgen Harting, Hans Schaefer, Achim Zesch, "Hydrocortisone orthoesters, pharmaceutical formulations thereof and processes for the preparation thereof." U.S. Patent US4264584, issued March, 1974.

US4264584

General References

de Weerth C, Zijl RH, Buitelaar JK: Development of cortisol circadian rhythm in infancy. Early Hum Dev. 2003 Aug;73(1-2):39-52. [PubMed:12932892 ]
Palacios R, Sugawara I: Hydrocortisone abrogates proliferation of T cells in autologous mixed lymphocyte reaction by rendering the interleukin-2 Producer T cells unresponsive to interleukin-1 and unable to synthesize the T-cell growth factor. Scand J Immunol. 1982 Jan;15(1):25-31. [PubMed:6461917 ]
KNIGHT RP Jr, KORNFELD DS, GLASER GH, BONDY PK: Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176-81. [PubMed:13233328 ]

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB14879
KEGG Drug	D00088
KEGG Compound	C00735
PubChem Compound	5754
PubChem Substance	46505089
ChemSpider	5551
BindingDB	13775
ChEBI	17650
ChEMBL	CHEMBL389621
Therapeutic Targets Database	DAP000718
PharmGKB	PA449905
IUPHAR	2868
Guide to Pharmacology	2868
HET	HCY
Drug Product Database	7532
RxList	http://www.rxlist.com/cgi/generic/hydrocortisone.htm
Drugs.com	http://www.drugs.com/cdi/hydrocortisone.html
PDRhealth	http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/hyd1199.shtml
Wikipedia	Hydrocortisone

ATC Codes

S02BA01 — Hydrocortisone

S03CA04 — Hydrocortisone and antiinfectives

S01CB03 — Hydrocortisone

S01CA03 — Hydrocortisone and antiinfectives

S02CA03 — Hydrocortisone and antiinfectives

D07AB02 — Hydrocortisone butyrate

C05AA01 — Hydrocortisone

D07BB04 — Hydrocortisone butyrate and antiseptics

D07AA02 — Hydrocortisone

D07AC16 — Hydrocortisone aceponate

S01BB01 — Hydrocortisone and mydriatics

A01AC03 — Hydrocortisone

D07BA04 — Hydrocortisone and antiseptics

D07CA01 — Hydrocortisone and antibiotics

S01BA02 — Hydrocortisone

R01AD60 — Hydrocortisone, combinations

A07EA02 — Hydrocortisone

H02AB09 — Hydrocortisone

D07XA01 — Hydrocortisone

AHFS Codes

52:08.08
68:04.00
84:06.00

PDB Entries

Not Available

FDA label

Download (30 KB)

MSDS

Download (73.6 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Active Not Recruiting	Other	Insulin Resistance	1
0	Completed	Treatment	Fibromyalgia	1
0	Recruiting	Basic Science	Depressive State	1
1	Active Not Recruiting	Treatment	Acute Myeloid Leukaemias (AML)	1
1	Active Not Recruiting	Treatment	Rotator Cuff Tear - Partial Thickness	1
1	Completed	Not Available	Infection NOS	1
1	Completed	Not Available	Relative Adrenal Insufficiency / Sepsis	1
1	Completed	Basic Science	Healthy Volunteers	2
1	Completed	Basic Science	Healthy Volunteers / Inflammatory Reaction / Pain	1
1	Completed	Other	Adrenal Insufficiency	1
1	Completed	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Acute Myeloid Leukaemias (AML) / Mixed Phenotype Acute Leukemia (MPAL) / Myelodysplastic Syndromes (MDS)	1
1	Completed	Treatment	Adrenal Insufficiency / Congenital Adrenal Hyperplasia (CAH)	1
1	Completed	Treatment	Arterial Hypotension / Blood Pressures / Infant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants	1
1	Completed	Treatment	Erythemas / Pain	1
1	Completed	Treatment	Healthy Volunteers	1
1	Completed	Treatment	Osteoarthritis of the Knees	1
1	Completed	Treatment	Psoriasis Vulgaris	1
1	Recruiting	Basic Science	BMI >30 kg/m2	1
1	Recruiting	Basic Science	Diabetes, Diabetes Mellitus Type 1	1
1	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
1	Recruiting	Treatment	Acute Myeloid Leukaemias (AML)	1
1	Recruiting	Treatment	Acute Myeloid Leukaemias (AML) / Myelodysplastic Syndrome	1
1	Recruiting	Treatment	Colorectal Cancers / Head and Neck Carcinoma	1
1	Recruiting	Treatment	Heroin Dependence / Opioid Use Disorders	1
1	Recruiting	Treatment	Lymphoblastic Leukemia, Acute, Childhood / Lymphoma, Lymphoblastic / Peripheral T-Cell Lymphoma (PTCL)	1
1	Unknown Status	Treatment	Ovarian Epithelial Cancer	1
1, 2	Active Not Recruiting	Treatment	Recurrent Childhood Acute Lymphoblastic Leukemia	1
1, 2	Completed	Diagnostic	Systemic Lupus Erythematosus (SLE)	1
1, 2	Completed	Treatment	21-Hydroxylase Deficiency / Adrenogenital Syndrome / Congenital Adrenal Hyperplasia (CAH)	1
1, 2	Completed	Treatment	Cardiac Arrest	1
1, 2	Not Yet Recruiting	Treatment	Adult Burkitt Lymphoma / B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma / Lymphoma, Large B-Cell, Diffuse (DLBCL) / MYC Gene Mutation / Plasmablastic Lymphoma	1
1, 2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
1, 2	Recruiting	Treatment	Addison's Disease / Adrenal Hyperplasia Congenital	1
1, 2	Recruiting	Treatment	Inhospital Cardiac Arrest	1
1, 2	Terminated	Basic Science	Renin Angiotensin	1
1, 2	Terminated	Treatment	Adenocarcinoma, Prostate / Recurrent Prostate Carcinoma / Stage III Prostate Cancer / Stage IV Prostate Cancer	1
1, 2	Terminated	Treatment	Anaplastic Large Cell Lymphoma / Recurrent Childhood Anaplastic Large Cell Lymphoma	1
1, 2	Terminated	Treatment	Malignant Neoplasm of Prostate	1
2	Active Not Recruiting	Supportive Care	Dermatologic Complications / Neoplasms, Malignant	1
2	Active Not Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL)	2
2	Active Not Recruiting	Treatment	Malignant Neoplasm of Prostate	1
2	Completed	Not Available	Postoperative Complications / Postoperative Pancreatitis	1
2	Completed	Prevention	Chronic Lung Disease of Prematurity	1
2	Completed	Prevention	Chronic Lung Disease of Prematurity / Encephalomalacia / Premature Births	1
2	Completed	Treatment	Acute Lymphocytic Leukemia (ALL)	1
2	Completed	Treatment	Acute Respiratory Distress Syndrome (ARDS) / Multiple Organ Failure	1
2	Completed	Treatment	Adenocarcinoma, Prostate / Malignant Neoplasm of Prostate	1
2	Completed	Treatment	Adrenal Hyperplasia, Congenital	1
2	Completed	Treatment	Adrenal Insufficiency / Congenital Adrenal Hyperplasia (CAH) / Excess Androgen	1
2	Completed	Treatment	Angioedema	1
2	Completed	Treatment	B-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia	1
2	Completed	Treatment	Blood Cancers / CLL / Graft Versus Host Disease (GVHD) / Hodgkins Disease (HD) / Leukemias / Malignancies / NHL / Smith-Magenis Syndrome	1
2	Completed	Treatment	Cardiac Output, Low	1
2	Completed	Treatment	Childhood Burkitt Lymphoma / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Small Noncleaved Cell Lymphoma / Stage II Childhood Large Cell Lymphoma / Stage II Childhood Small Noncleaved Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Small Noncleaved Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Untreated Childhood Acute Lymphoblastic Leukemia	1
2	Completed	Treatment	Hemorrhoids	1
2	Completed	Treatment	Jet Lag Syndrome	1
2	Completed	Treatment	Leukemias	1
2	Completed	Treatment	Lymphohistiocytosis, Hemophagocytic	1
2	Completed	Treatment	Malignant Neoplasm of Prostate	1
2	Completed	Treatment	Opioid Dependence	1
2	Completed	Treatment	Paediatric Sepsis / Pediatric Sepsis / Sepsis	1
2	Completed	Treatment	Prurigo Nodularis	1
2	Completed	Treatment	Rash	1
2	Completed	Treatment	Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma / T-cell Childhood Acute Lymphoblastic Leukemia	1
2	Not Yet Recruiting	Basic Science	Adolescent Development / Borderline Personality Disorder (BPD)	1
2	Recruiting	Treatment	Acute Leukemias of Ambiguous Lineage / Childhood B Acute Lymphoblastic Leukemia / KMT2A Gene Rearrangement / Mixed Phenotype Acute Leukemia (MPAL)	1
2	Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Leukemia, B-Cell / Leukemia, T-Cell / Non-Hodgkin's Lymphoma (NHL)	1
2	Recruiting	Treatment	Acute Lymphocytic Leukemia (ALL) / Adult Lymphoblastic Lymphoma	1
2	Recruiting	Treatment	Acute Myeloid Leukaemias (AML)	1
2	Recruiting	Treatment	Acute Myeloid Leukaemias (AML) / Myelodysplastic Syndromes	1
2	Recruiting	Treatment	Adrenal Hyperplasia, Congenital	1
2	Recruiting	Treatment	Apomorphine-induced Skin Reactions / Parkinson's Disease (PD)	1
2	Recruiting	Treatment	Malignant Neoplasm of Prostate	1
2	Recruiting	Treatment	Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood B-Lymphoblastic Lymphoma	1
2	Terminated	Treatment	Acute Lymphoblastic Leukaemias (ALL) / Lymphoma, Lymphoblastic	1
2	Terminated	Treatment	Acute Lymphocytic Leukemia (ALL) / Acute Myeloid Leukaemias (AML) / Mixed Lineage Acute Leukemia	1
2	Terminated	Treatment	Acute Myeloid Leukaemias (AML) / Myelodysplastic Syndromes (MDS)	1
2	Terminated	Treatment	Lymphoma, Lymphoblastic	1
2	Terminated	Treatment	Phobic Disorders	1
2	Unknown Status	Treatment	Addison's Disease	1
2	Unknown Status	Treatment	Cirrhosis With Ascites	1
2	Unknown Status	Treatment	Injuries, Whiplash	1
2	Unknown Status	Treatment	Leukemias	1
2	Unknown Status	Treatment	Lymphoblastic Leukemia, Acute	1
2, 3	Active Not Recruiting	Treatment	Childhood B Acute Lymphoblastic Leukemia / Childhood Burkitt Leukemia / Childhood Diffuse Large Cell Lymphoma / Mediastinal (Thymic) Large B-Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma	1
2, 3	Completed	Prevention	Injuries, Multiple	1
2, 3	Completed	Treatment	Addison's Disease	1
2, 3	Completed	Treatment	Adrenal Insufficiency	1
2, 3	Completed	Treatment	Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia	1
2, 3	Recruiting	Treatment	Asphyxia / Hypoxic-Ischaemic Encephalopathy	1
2, 3	Unknown Status	Treatment	Mortality / Ventilations, Mechanical	1
3	Active Not Recruiting	Treatment	Acute Undifferentiated Leukemia (AUL) / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia	1
3	Active Not Recruiting	Treatment	Cardiovascular Insufficiency / Infant, Newborn, Diseases	1
3	Completed	Supportive Care	Cardiac Toxicity / Leukemias / Malignant Lymphomas	1
3	Completed	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
3	Completed	Treatment	Alcohol Craving / Stress, Physiological / Stress, Psychological	1
3	Completed	Treatment	Alopecia Areata (AA)	1
3	Completed	Treatment	Cardiac Arrest	1
3	Completed	Treatment	Childhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Refractory Anemia With Ringed Sideroblasts / Secondary Myelodysplastic Syndromes / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies	1
3	Completed	Treatment	Chronic Lung Disease of Prematurity	1
3	Completed	Treatment	Coagulation Dysfunction in Septic Shock / Hemodynamic Improvement Induced by Hydrocortisone	1
3	Completed	Treatment	Healthy Volunteers	1
3	Completed	Treatment	Herpes Labialis	1
3	Completed	Treatment	Leukemias / Malignant Lymphomas	1
3	Completed	Treatment	Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms	1
3	Completed	Treatment	Malignant Neoplasm of Prostate	1
3	Completed	Treatment	Neonatal Hypotension	1
3	Completed	Treatment	Oral SubMucous Fibrosis	1
3	Completed	Treatment	Otitis Externa	1
3	Completed	Treatment	Patient Admitted in Reanimation	1
3	Completed	Treatment	Psoriasis Vulgaris	1
3	Completed	Treatment	Sepsis / Shock, Septic	1
3	Completed	Treatment	Severe Sepsis	1
3	Completed	Treatment	Shock, Septic	3
3	Not Yet Recruiting	Treatment	Acute Lymphoblastic Leukemia, Pediatric	1
3	Not Yet Recruiting	Treatment	B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / BCR-ABL1 Fusion Protein Expression / Minimal Residual Disease / Philadelphia Chromosome Positive / T Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia	1
3	Recruiting	Prevention	Chronic Lung Disease of Prematurity / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants / Very Low Birth Weight Infant	1
3	Recruiting	Treatment	Adult T Acute Lymphoblastic Leukemia / Childhood T Acute Lymphoblastic Leukemia / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia	1
3	Recruiting	Treatment	B Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain / Ph-Like Acute Lymphoblastic Leukemia / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia	1
3	Recruiting	Treatment	B Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia	1
3	Recruiting	Treatment	B Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia	1
3	Recruiting	Treatment	Community Acquired Pneumonia (CAP)	1
3	Recruiting	Treatment	Congenital Adrenal Hyperplasia (CAH)	2
3	Recruiting	Treatment	Liver Cirrhosis	1
3	Recruiting	Treatment	Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit	1
3	Terminated	Treatment	Evidence of Liver Transplantation / Transplantations	1
3	Terminated	Treatment	Influenza in Humans / Viral Pneumonia	1
3	Terminated	Treatment	Prostatic Neoplasms	1
3	Unknown Status	Treatment	Low Back Pain (LBP)	1
4	Active Not Recruiting	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
4	Active Not Recruiting	Treatment	Shock, Septic	1
4	Completed	Not Available	Minor burns	1
4	Completed	Basic Science	Feeling Anxious	1
4	Completed	Basic Science	Healthy Volunteers	1
4	Completed	Prevention	Postoperative Inflammatory Response	1
4	Completed	Prevention	Posttraumatic Stress Disorders / Systemic Inflammatory Response Syndrome (SIRS)	1
4	Completed	Treatment	Acute Lymphoblastic Leukaemias (ALL)	1
4	Completed	Treatment	Adrenal Insufficiency	1
4	Completed	Treatment	Asthma Bronchial	1
4	Completed	Treatment	Coronary Artery Disease / Mitral Valve Regurgitation	1
4	Completed	Treatment	Hip Injuries	1
4	Completed	Treatment	Knee Replacement Surgery	1
4	Completed	Treatment	Moderate, refractory Atopic dermatitis / Psoriasis	1
4	Completed	Treatment	Shock	1
4	Completed	Treatment	Snake Bites	1
4	Enrolling by Invitation	Treatment	Adrenal Insufficiency	1
4	Not Yet Recruiting	Treatment	Ulcerative Colitis (UC)	1
4	Recruiting	Prevention	Neoplasms, Pancreatic / Pancreatic Fistula	1
4	Recruiting	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
4	Recruiting	Treatment	Community Acquired Pneumonia (CAP)	1
4	Recruiting	Treatment	Function of Renal Transplant	1
4	Recruiting	Treatment	Granulomatous Mastitis	1
4	Recruiting	Treatment	Hyperglycemias	1
4	Recruiting	Treatment	Ulcerative Colitis (UC)	1
4	Terminated	Not Available	Asthma Bronchial	1
4	Terminated	Treatment	Partial Corticotrope Insufficiency	1
4	Terminated	Treatment	Shock, Septic	1
4	Unknown Status	Treatment	Acute Respiratory Distress Syndrome (ARDS) / Adrenal Insufficiency	1
4	Unknown Status	Treatment	Crohn's Disease (CD)	1
4	Unknown Status	Treatment	Pituitary Neoplasms / Postsurgical craniopharyngioma	1
4	Unknown Status	Treatment	Moderate, refractory Atopic dermatitis	1
4	Withdrawn	Treatment	Adrenal Insufficiency / Sepsis	1
4	Withdrawn	Treatment	Phimosis	1
4	Withdrawn	Treatment	Post-Traumatic Stress Disorder (PTSD)	1
4	Withdrawn	Treatment	Moderate, refractory Atopic dermatitis	1
Not Available	Active Not Recruiting	Basic Science	Stress Disorders, Posttraumatic	1
Not Available	Active Not Recruiting	Supportive Care	Sjögren's Syndrome	1
Not Available	Completed	Not Available	Anxiety Disorder / Major Depressive Disorder (MDD)	1
Not Available	Completed	Not Available	Dependence, Cocaine	1
Not Available	Completed	Not Available	Heroin Dependence / Learning and Memory	1
Not Available	Completed	Not Available	Osteoarthritis of the Knees	1
Not Available	Completed	Not Available	Sepsis	1
Not Available	Completed	Basic Science	Intrusive Memories	1
Not Available	Completed	Basic Science	Posttraumatic Stress Disorders	1
Not Available	Completed	Prevention	Fevers / Hemodynamics Instability / Hypothermia / Idiopathic orthostatic hypotension	1
Not Available	Completed	Screening	Other Diseases or Conditions	1
Not Available	Completed	Treatment	Acute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS) / Severe Sepsis / Shock, Septic	1
Not Available	Completed	Treatment	Addison's Disease	1
Not Available	Completed	Treatment	Addison's Disease / BMI >30 kg/m2	1
Not Available	Completed	Treatment	Adrenal Hyperplasia, Congenital	1
Not Available	Completed	Treatment	Heart Arrest	1
Not Available	Completed	Treatment	Heart Disease Congenital Complex	1
Not Available	Completed	Treatment	PTSD	1
Not Available	Completed	Treatment	Phobic Disorders	1
Not Available	Completed	Treatment	Pituitary Adenomas / Pituitary Diseases	1
Not Available	Completed	Treatment	Total Hip Replacement	1
Not Available	Completed	Treatment	Moderate, refractory Atopic dermatitis	1
Not Available	Enrolling by Invitation	Treatment	Granuloma / Tracheostomy care	1
Not Available	Not Yet Recruiting	Basic Science	BMI >30 kg/m2 / Hyperandrogenemia / Polycystic Ovaries Syndrome	2
Not Available	Recruiting	Basic Science	Borderline Personality Disorder (BPD) / PTSD	1
Not Available	Recruiting	Prevention	Post Traumatic Stress Disorder (PTSD)	1
Not Available	Recruiting	Treatment	Fatty Acids, Nonesterified / Hydrocortisone / Hypopituitarism / Insulin Sensitivity / Lipids	1
Not Available	Recruiting	Treatment	Intussusception	1
Not Available	Recruiting	Treatment	Plantar fascial fibromatosis	1
Not Available	Recruiting	Treatment	Shock, Septic	1
Not Available	Recruiting	Treatment	Moderate, refractory Atopic dermatitis	1
Not Available	Suspended	Not Available	Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver	1
Not Available	Terminated	Not Available	Nonvalvular Atrial Fibrillation	1
Not Available	Terminated	Prevention	Brain Death	1
Not Available	Terminated	Treatment	Necrotizing Enterocolitis	1
Not Available	Terminated	Treatment	Posttraumatic Stress Disorders	1
Not Available	Unknown Status	Prevention	Posttraumatic Stress Disorders	1
Not Available	Unknown Status	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
Not Available	Unknown Status	Treatment	Major Depressive Disorder (MDD)	1
Not Available	Unknown Status	Treatment	PTSD	1
Not Available	Withdrawn	Treatment	Post-Traumatic Stress Disorder (PTSD)	1

Pharmacoeconomics

Manufacturers

Hi tech pharmacal co inc
Allergan herbert div allergan inc
Del ray laboratories inc
Salix pharmaceuticals inc
Bayer pharmaceuticals corp
Monarch pharmaceuticals inc
Valeant pharmaceuticals international
Westwood squibb pharmaceuticals inc
C and m pharmacal inc
Pharmaceutical assoc inc div beach products
Actavis mid atlantic llc
Alpharma us pharmaceuticals division
Altana inc
Ambix laboratories div organics corp america
Everylife
E fougera div altana inc
G and w laboratories inc
Ingram pharmaceutical co
Ivax pharmaceuticals inc
Naska pharmacal co inc div rugby darby group cosmetics
Perrigo new york inc
Pharmaderm div altana inc
Pharmafair inc
Stiefel laboratories inc
Syosset laboratories inc
Taro pharmaceuticals usa inc
Teva pharmaceuticals usa inc
Topiderm inc
Usl pharma inc
Vintage pharmaceuticals inc
Whiteworth towne paulsen inc
Sanofi aventis us llc
Coria laboratories ltd
Medicis pharmaceutical corp
Paddock laboratories inc
Ani pharmaceuticals inc
Teva pharmaceuticals usa
Healthpoint ltd
Allergan herbert skin care div allergan inc
Pharmacia and upjohn co
Baker norton pharmaceuticals inc
Solvay pharmaceuticals
Beta dermaceuticals inc
Bluline laboratories inc
Heran pharmaceutical inc
Mericon industries inc
Perrigo co
Pfizer global research development
Carolina medical products co
Dermik laboratories div aventis pharmaceuticals inc
Torch laboratories inc
X gen pharmaceuticals inc
Jsj pharmaceuticals llc
Pfizer laboratories div pfizer inc
Barr laboratories inc
Elkins sinn div ah robins co inc
John j ferrante
Impax laboratories inc
Inwood laboratories inc sub forest laboratories inc
Lannett co inc
Nexgen pharma inc
Panray corp sub ormont drug and chemical co inc
Parke davis div warner lambert co
Purepac pharmaceutical co
Roxane laboratories inc
Sandoz inc
Stiefel a gsk co
Vintage pharmaceuticals llc
Watson laboratories inc
West ward pharmaceutical corp
Merck and co inc
Pfipharmecs div pfizer inc
Schwarz pharma inc
Able laboratories inc
Hr cenci laboratories inc
Ferndale laboratories inc
Akorn inc
Bel mar laboratories inc
Colgate oral pharmaceuticals inc
Taro pharmaceutical industries ltd
Triax pharmaceuticals llc
Yamanouchi europe bv
Savage laboratories inc div altana inc
Abbott laboratories pharmaceutical products div
Abbott laboratories hosp products div
Hospira inc
Abraxis pharmaceutical products
Baxter healthcare corp anesthesia and critical care
International medication systems ltd
Taro pharmaceuticals inc
Ranbaxy laboratories inc

Packagers

Actavis Group
Advanced Pharmaceutical Services Inc.
AG Marin Pharmaceuticals
Alaven Pharmaceutical
Alcon Laboratories
Amerisource Health Services Corp.
Ani Pharmaceuticals
Anip Acquisition Co.
Arbor Pharmaceuticals Incorporated
A-S Medication Solutions LLC
Avidas Pharmaceuticals
Bay Pharma Inc.
Bayer Healthcare
Bergen Brunswig
Beta Dermaceuticals
Bio Pharm Inc.
Bristol-Myers Squibb Co.
C.O. Truxton Inc.
Cardinal Health
Carlisle Laboratories Inc.
Carolina Medical Products Co.
Chattem Chemicals Inc.
Co Med Pharmaceuticals Inc.
Colgate Oral
Combe Inc.
Consolidated Midland Corp.
Contract Pharm
Crown Laboratories Inc.
Cutis Pharma Inc.
Cypress Pharmaceutical Inc.
Darby Dental Supply Co. Inc.
Del Ray Dermatology
Dermik Labs
DispenseXpress Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Dofs Laboratories
DPT Laboratories Ltd.
DSC Laboratories
E. Fougera and Co.
ECR Pharmaceuticals
Elkins-Sinn Inc.
Enterprises Importfab Inc.
Ferndale Labs
G & W Labs
Genesis Pharmaceutical Inc.
Gertz
H and H Laboratories
H.J. Harkins Co. Inc.
Harmony Laboratories Inc.
Hi Tech Pharmacal Co. Inc.
Hospira Inc.
Inyx Usa Ltd.
JHP Pharmaceuticals LLC
Johnson & Johnson Healthcare
JSJ Pharmaceuticals Inc.
Kaiser Foundation Hospital
Keltman Pharmaceuticals Inc.
Lake Erie Medical and Surgical Supply
Lehigh Valley Technologies Inc.
Lyne Laboratories Inc.
Major Pharmaceuticals
Mallinckrodt Inc.
Martin Surgical Supply
Meda AB
Mikart Inc.
Murfreesboro Pharmaceutical Nursing Supply
National Vitamin Company
Nexgen Pharma Inc.
Nycomed Inc.
Paddock Labs
Palmetto Pharmaceuticals Inc.
Patheon Inc.
Perrigo Co.
Person & Covey
Pfizer Inc.
Pharmacia Inc.
Pharmaderm
Pharmedix
Physician Partners Ltd.
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Professional Co.
Prometic Pharma Inc.
Qualitest
Ranbaxy Laboratories
Rebel Distributors Corp.
Redpharm Drug
Resource Optimization and Innovation LLC
Rising Pharmaceuticals
River's Edge Pharmaceuticals
Rouses Point Pharmaceuticals LLC
Salix Pharmaceuticals
Sandhills Packaging Inc.
Sandoz
Sanofi-Aventis Inc.
Schwarz Pharma Inc.
Solvay Pharmaceuticals
Southwood Pharmaceuticals
Stanley Pharmaceuticals Ltd.
Stat Rx Usa
Stat Scripts LLC
Summers Labs
Suppositoria Laboratories Inc.
Taro Pharmaceuticals USA
Teva Pharmaceutical Industries Ltd.
Topiderm Inc.
Triax Pharmaceuticals LLC
UCB Pharma
United Pharmaceuticals
United Research Laboratories Inc.
Universal Laboratories Inc.
Upsher Smith Laboratories
Veratex Corp.
Vertical Pharmaceuticals Inc.
Vintage Pharmaceuticals Inc.
West-Ward Pharmaceuticals
Wockhardt Ltd.
WraSer Pharmaceuticals
Wyeth Pharmaceuticals

Dosage forms

Form	Route	Strength
Injection, powder, lyophilized, for solution	Intramuscular; Intravenous	100 mg/2mL
Powder	Topical
Powder, for solution	Topical
Soap	Topical	1 g/100g
Lotion	Topical	20 mg/mL
Cream	Topical	1 %
Kit
Ointment	Rectal; Topical
Lotion	Topical	1 g/100g
Solution	Topical	1 g/100g
Ointment	Topical	1.02 g/100g
Cream; jelly	Topical	1 %
Lotion	Topical	.088 mL/88mL
Cream	Topical	.01 g/g
Cream	Topical	1 g/g
Suspension	Auricular (otic)
Suspension	Rectal	100 mg/60mL
Spray	Topical	1 g/100g
Cream	Topical	0.5 %
Spray	Topical	10 g/mL
Ointment	Ophthalmic	25 mg
Ointment	Topical	10 mg
Tablet	Oral	10 mg
Tablet	Oral	20 mg
Enema	Rectal	100 mg
Enema	Rectal	100 mg/60mL
Enema; suspension	Rectal	100 mg
Ointment	Topical	100 g/g
Cream	Topical	1 mg
Aerosol	Rectal	10 %
Aerosol, foam	Rectal	1500 mg/15g
Aerosol, foam	Topical	1500 mg/15g
Suppository	Rectal	10 mg
Suppository	Rectal	40 mg
Suspension	Topical
Gel	Topical	10 mg/g
Liquid	Topical	10 mg/mL
Lotion	Topical	10 mg/g
Solution / drops	Ophthalmic
Suspension / drops	Auricular (otic)
Gel	Topical	1 mg/g
Lotion	Topical	1.18 mL/118mL
Lotion	Topical	.75 g/100mL
Cream	Topical	.284 g/28.4g
Cream	Topical	.284 g/287.4g
Cream	Topical	1 g/100mL
Suppository	Rectal
Cream	Topical	2.5 %
Solution	Topical	2.5 %
Kit	Oral
Ointment	Topical	10 mg/mL
Ointment	Topical	1 mL/100mL
Cream	Topical	1 g/100g
Suppository	Rectal	.025 g/2g
Suppository	Rectal	25 mg/2g
Lotion / shampoo	Topical	5 mg/mL
Lotion	Topical	1 g/mL
Aerosol, spray	Topical	1.13 g/113g
Cream	Topical	.5 g/100g
Cream	Topical	1 h/100g
Cream	Topical	10 mg/g
Cream	Topical	10 mg/mL
Cream	Topical	25 mg/g
Cream	Topical	5 mg/g
Gel	Topical	1 g/100g
Lotion	Topical	25 mg/mL
Ointment	Topical	10 mg/g
Ointment	Topical	25 mg/1
Ointment	Topical	25 mg/g
Ointment	Topical	5 mg/g
Shampoo	Topical	1 g/100mL
Tablet	Oral	10 mg/1
Tablet	Oral	20 mg/1
Tablet	Oral	5 mg/1
Ointment	Topical	1.12 g/100g
Suppository	Rectal	25 mg/1
Suppository	Rectal	30 mg/1
Cream	Topical	500 mg
Cream	Topical	1 g
Cream	Topical	1.02 g/100g
Cream	Topical	5 mg
Cream	Topical	10 mg
Ointment	Topical	0.5 %
Ointment	Topical	1 %
Powder, for solution	Intramuscular; Intravenous	100 mg
Powder, for solution	Intramuscular; Intravenous	250 mg
Powder, for solution	Intramuscular; Intravenous	500 mg
Powder, for solution	Intramuscular; Intravenous	1 g
Cream	Topical	140 mg/14g
Cream	Topical	2 mg/g
Lotion	Topical	1 g/100mL
Cream	Topical	0.2 %
Ointment	Topical	0.2 %
Lotion	Topical	1 g/88mL
Ointment	Topical	1 g/100g
Cream	Topical	.5 %
Cream	Rectal; Topical
Cream	Rectal
Gel	Rectal
Cream	Topical	1 mg/g
Lotion	Topical	1 mg/mL
Ointment	Topical	1 mg/g
Solution	Topical	1 mg/mL
Liquid	Topical	5 mg/mL
Liquid	Topical	9 mg/mL
Spray	Topical	10 mg/mL
Cream	Topical	.009 g/1
Solution / drops	Auricular (otic)
Suspension	Ophthalmic
Ointment	Ophthalmic
Lotion	Topical	5 mg/g
Lotion	Topical	20 mg/g
Kit
Ointment	Auricular (otic); Ophthalmic
Suspension	Auricular (otic); Ophthalmic
Gel	Topical
Cream	Topical	7.5 g/100mL
Lotion	Topical
Ointment	Topical
Liquid	Topical	.28 mg/100mL
Aerosol	Rectal
Aerosol, foam	Topical
Ointment	Rectal; Topical	750 mg
Ointment	Rectal
Cream	Topical	.51 g/100g
Cream	Topical	1 mg/100mL
Lotion	Topical	2.5 %
Liquid	Topical	10 mg/g
Liquid	Topical
Liquid	Topical	1 g/100mL
Injection, powder, for solution	Intramuscular; Intravascular	100 mg/2mL
Injection, powder, for solution	Intramuscular; Intravenous	100 mg/2mL
Injection, powder, for solution	Intramuscular; Intravenous	1000 mg/8mL
Injection, powder, for solution	Intramuscular; Intravenous	250 mg/2mL
Injection, powder, for solution	Intramuscular; Intravenous	500 mg/4mL
Lotion	Topical	1 mL/100mL
Solution	Topical	25 mg/mL
Lotion	Topical	1 %
Cream	Topical	2 %
Cream	Topical	280 mg/28g
Cream	Topical	1.12 g/100g
Solution	Auricular (otic)
Ointment	Topical	2 mg/g
Cream	Topical
Cream	Topical	10 mg/L
Spray	Topical	10 g/L

Prices

Unit description	Cost	Unit
Locoid Lipocream 0.1% Cream 60 gm Tube	335.36USD	tube
Cortifoam 90 mg Foam 15 gm Can	239.99USD	can
Locoid 0.1% Solution 60ml Bottle	233.15USD	bottle
Locoid Lipocream 0.1% Cream 45 gm Tube	200.98USD	tube
Locoid 0.1% Cream 45 gm Tube	183.83USD	tube
Locoid 0.1% Ointment 45 gm Tube	174.86USD	tube
Pandel 0.1% Cream 45 gm Tube	161.37USD	tube
Pandel 0.1% Cream 15 gm Tube	138.56USD	tube
Proctocort 1% Cream 28.35 gm Tube	127.51USD	tube
Anusol-HC 2.5% Cream 30 gm Tube	106.45USD	tube
Locoid Lipocream 0.1% Cream 15 gm Tube	85.41USD	tube
Texacort 2.5% Solution 30ml Bottle	85.41USD	bottle
Cortisporin 3.5-10000-1 Solution 10ml Bottle	84.33USD	bottle
Proctofoam HC 1-1% Foam 10 gm Can	81.9USD	can
Cortisporin 3.5-10000-1 Suspension 10ml Bottle	79.55USD	bottle
Locoid 0.1% Solution 20ml Bottle	79.28USD	bottle
Cortisporin 1% Ointment 15 gm Tube	75.09USD	tube
Locoid 0.1% Cream 15 gm Tube	67.49USD	tube
Hydrocortisone Ace-Pramoxine 2.5-1% Cream 28.35 gm Tube	64.75USD	tube
Locoid 0.1% Ointment 15 gm Tube	62.04USD	tube
Hydrocortisone Valerate 0.2% Ointment 60 gm Tube	56.74USD	tube
Hydrocortisone 2.5% Lotion 59 gm Bottle	55.61USD	bottle
Westcort 0.2% Ointment 60 gm Tube	55.0USD	tube
Cortisporin 0.5-0.5-10000 Cream 7.5 gm Tube	54.37USD	tube
Westcort 0.2% Ointment 15 gm Tube	50.99USD	tube
Hydrocortisone Butyrate 0.1% Cream 45 gm Tube	49.43USD	tube
Hydrocortisone Valerate 0.2% Ointment 45 gm Tube	48.73USD	tube
Hydrocortisone 2.5% Lotion 59ml Bottle	47.47USD	bottle
Westcort 0.2% Ointment 45 gm Tube	46.97USD	tube
Hydrocortisone Valerate 0.2% Cream 60 gm Tube	44.99USD	tube
Hydrocortisone Valerate 0.2% Cream 45 gm Tube	33.99USD	tube
Ala Scalp 2% Lotion 29.6ml Bottle	30.99USD	bottle
Hydrocortisone Valerate 0.2% Ointment 15 gm Tube	30.56USD	tube
Westcort 0.2% Cream 15 gm Tube	25.99USD	tube
Hydrocortisone Valerate 0.2% Cream 15 gm Tube	19.99USD	tube
Cortisporin eye drops	19.74USD	ml
Solu-Cortef 1 g/vial	17.55USD	vial
Hydrocortisone 1% Lotion 118ml Bottle	15.99USD	bottle
Hydrocortisone Acetate 12 25 mg Suppository Box	15.01USD	box
Hydrocortisone 2.5% Ointment 28.35 gm Tube	13.68USD	tube
Hydrocortisone 2.5% Cream 30 gm Tube	13.67USD	tube
Colocort 100 mg/60ml Enema 60ml Bottle	13.15USD	bottle
Hydrocortisone 100 mg/60ml Enema 60ml Bottle	12.6USD	bottle
Hydrocortisone 0.5% Cream 28.35 gm Tube	11.99USD	tube
Hydrocortisone 1% Cream 15 gm Tube	11.99USD	tube
Hydrocortisone 1% Cream 28 gm Tube	11.99USD	tube
Hydrocortisone Acetate 1-1% Ointment 30 gm Tube	11.99USD	tube
Solu-Cortef 500 mg/vial	10.47USD	vial
Hydrocortisone hemisucc powder	9.9USD	g
Cortifoam 10% aerosol	9.35USD	g
Hydrocortisone Sod. Succinate 1 g/vial	9.01USD	vial
Solu-cortef (pf) 250 mg vial	8.58USD	vial
Cortisporin-tc ear susp	8.3USD	ml
Cortisporin ear suspension	7.86USD	ml
Solu-Cortef 250 mg/vial	7.05USD	vial
Cortenema (100 mg/60Ml) 100 mg/enm Enema	6.96USD	enema
Proctofoam-hc foam	6.77USD	g
Cortifoam 10 % Foam	6.14USD	g
Hycort (100 mg/60Ml) 100 mg/enm Enema	5.79USD	enema
Cortamed 2.5 % Ointment	5.67USD	g
Hydrocortisone Sod. Succinate 500 mg/vial	5.34USD	vial
Hydrocortisone powder	5.19USD	g
Solu-cortef (pf) 100 mg vial	4.85USD	vial
Solu-cortef 100 mg vial	4.63USD	vial
Proctocort 1% cream	4.37USD	g
Pandel 0.1% cream	4.34USD	g
Locoid 0.1% lipocream	4.3USD	g
Solu-Cortef 100 mg/vial	4.07USD	vial
Locoid 0.1% cream	3.92USD	g
Hydrocortisone Sod. Succinate 250 mg/vial	3.56USD	vial
Hydrocortisone ss 250 mg vial	3.5USD	vial
Anusol-hc 2.5% cream	3.45USD	g
Hydrocortisone acet powder	3.15USD	g
Proctofoam	2.89USD	g
A-hydrocort 100 mg vial	2.42USD	each
Proctocream-hc 2.5% cream	2.17USD	g
Hydrocortisone Sod. Succinate 100 mg/vial	2.1USD	vial
Hydrocortisone val 0.2% cream	2.07USD	g
Hytone 2.5% cream	1.46USD	g
Hydrocortisone buty 0.1% cream	1.31USD	g
First hydrocort 10% gel	1.18USD	g
Westcort 0.2% cream	1.17USD	g
Procto-kit 1% cream	1.08USD	g
Ala-scalp hp 2% lotion	1.03USD	ml
Cortef 20 mg tablet	0.9USD	tablet
Proctosol-hc 2.5% cream	0.89USD	g
Proctozone-hc 2.5% cream	0.83USD	g
Orabase plain paste	0.77USD	g
Hydrocortisone 2.5% lotion	0.6USD	ml
Cortef 10 mg tablet	0.55USD	tablet
Orabase-b 20% gel	0.55USD	g
Hydrocortisone 2.5% cream	0.53USD	g
Hydrocortisone 10 mg tablet	0.52USD	tablet
Cortef 5 mg tablet	0.45USD	tablet
Ala-cort 1% cream	0.43USD	g
Hydrocortisone 5 mg tablet	0.38USD	tablet
Corticaine 0.5% cream	0.37USD	g
Hydrocortisone 20 mg tablet	0.32USD	tablet
Prevex Hc 1 % Occlusive Cream	0.3USD	g
Emo-Cort 2.5 % Cream	0.26USD	g
Preparation h 1% cream	0.24USD	g
Tucks hydrocortisone ointment	0.24USD	g
Emo-Cort 2.5 % Lotion	0.23USD	g
Emo-Cort Scalp 2.5 % Lotion	0.22USD	g
Colocort 100 mg enema	0.21USD	ml
Cortenema 100 mg enema	0.21USD	ml
Sarna Hc 2.5 % Lotion	0.2USD	g
Emo-Cort 1 % Cream	0.19USD	g
Balneol lotion	0.18USD	ml
Emo-Cort 1 % Lotion	0.18USD	g
Lanacort 1% cool creme	0.18USD	g
Hyderm 0.5 % Cream	0.18USD	g
Hytone 1% cream	0.17USD	g
Cortoderm Mild 0.5 % Ointment	0.15USD	g
Beta hc 1% lotion	0.14USD	ml
Cortizone-10 1% spray	0.14USD	ml
Hydroval 0.2 % Cream	0.13USD	g
Hydroval 0.2 % Ointment	0.13USD	g
Aquanil hc 1% lotion	0.12USD	ml
Hydrocortisone plus 12 1% crm	0.12USD	g
Scalpicin 3% liquid	0.12USD	ml
Slender cortisol capsule	0.12USD	capsule
Cortaid 1% spray	0.1USD	ml
Sarna Hc 1 % Lotion	0.1USD	g
Hydrocortisone 0.5% cream	0.08USD	g
Hydrocortisone 1% cream	0.08USD	g
Uniderm moisturizer	0.05USD	ml
Cortoderm Regular 1 % Ointment	0.04USD	g
Hyderm 1 % Cream	0.04USD	g

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5635497	No	1994-06-03	2014-06-03	US
US6514980	No	1999-01-24	2019-01-24	US
US7223387	No	2001-07-24	2021-07-24	US
US7378405	No	2006-12-19	2026-12-19	US
US7981877	No	2005-01-23	2025-01-23	US
USRE39264	No	1996-08-02	2016-08-02	US

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	220 °C	PhysProp
water solubility	320 mg/L (at 25 °C)	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	1.61	HANSCH,C ET AL. (1995)
logS	-2.97	ADME Research, USCD
Caco2 permeability	-4.66	ADME Research, USCD

Predicted Properties

Property	Value	Source
Water Solubility	0.199 mg/mL	ALOGPS
logP	1.79	ALOGPS
logP	1.28	ChemAxon
logS	-3.3	ALOGPS
pKa (Strongest Acidic)	12.58	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	94.83 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	97.4 m³·mol^-1	ChemAxon
Polarizability	39.55 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9918
Blood Brain Barrier	+	0.9383
Caco-2 permeable	-	0.5096
P-glycoprotein substrate	Substrate	0.7861
P-glycoprotein inhibitor I	Non-inhibitor	0.7847
P-glycoprotein inhibitor II	Non-inhibitor	0.8383
Renal organic cation transporter	Non-inhibitor	0.7463
CYP450 2C9 substrate	Non-substrate	0.8496
CYP450 2D6 substrate	Non-substrate	0.9138
CYP450 3A4 substrate	Substrate	0.7407
CYP450 1A2 substrate	Non-inhibitor	0.9406
CYP450 2C9 inhibitor	Non-inhibitor	0.9072
CYP450 2D6 inhibitor	Non-inhibitor	0.9418
CYP450 2C19 inhibitor	Non-inhibitor	0.9253
CYP450 3A4 inhibitor	Non-inhibitor	0.8902
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9095
Ames test	Non AMES toxic	0.9132
Carcinogenicity	Non-carcinogens	0.9597
Biodegradation	Not ready biodegradable	0.925
Rat acute toxicity	1.8914 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.95
hERG inhibition (predictor II)	Non-inhibitor	0.584

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

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Spectra

Spectrum Type	Description	Splash Key
GC-MS	GC-MS Spectrum - GC-MS (2 MEOX; 3 TMS)	splash10-0f7o-3930000000-b7b43b2fc9f20acfd20b	View in MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF	splash10-052f-2910000000-2625335a031486ecb302	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT , negative	splash10-015a-0189000000-61afe49a8d4a96aae3f9	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , negative	splash10-00lu-0149000000-b95a11b27f7e7d44dd51	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , negative	splash10-001l-0019000000-4c4924e6ac472ad52886	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-TOF , negative	splash10-001j-0259000000-fda4e876e9ef04015946	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-03di-0009000000-cc8188e19dbdd6210b77	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-07r1-1985000000-b6d756bd554367393be3	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-00dj-1930000000-120dc8893cc4709c1f6b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-00dm-2910000000-d1f01e1bce5fe0108f40	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-05tf-3900000000-4ffd79c22013fe5479b6	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-054o-4900000000-fdbed869a0cadc21b64b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-002f-7900000000-dac7b2c5b3f8e8b85086	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-016u-7900000000-3a770c3819f82ea45841	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-016r-9800000000-d261cf7141fbf30715f5	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-056r-0289000000-9a48511b5c3d5fa404e9	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-03di-0759000000-b337a46ecfd6de91776b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-05fs-3940000000-2bf712a915c3a2c100a2	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Hydroxysteroids

Direct Parent

21-hydroxysteroids

Alternative Parents

Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 3-oxo delta-4-steroids / 17-hydroxysteroids / 11-beta-hydroxysteroids / Delta-4-steroids / Cyclohexenones / Tertiary alcohols / Alpha-hydroxy ketones / Secondary alcohols

Substituents

Progestogin-skeleton / 21-hydroxysteroid / 20-oxosteroid / Pregnane-skeleton / 3-oxo-delta-4-steroid / 3-oxosteroid / Oxosteroid / 11-beta-hydroxysteroid / 11-hydroxysteroid / 17-hydroxysteroid

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

3-oxo steroid, 11beta-hydroxy steroid, 17alpha-hydroxy steroid, glucocorticoid, 20-oxo steroid, 21-hydroxy steroid, C21-steroid (CHEBI:17650 ) / Pregnane and derivatives [Fig], Glucocorticoids, C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives (C00735 ) / C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030001 )

Targets

Details

1. Glucocorticoid receptor

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: Zinc ion binding
Specific Function:: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon grow...
Gene Name:: NR3C1
Uniprot ID:: P04150
Uniprot Name:: Glucocorticoid receptor
Molecular Weight:: 85658.57 Da

References

Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS: Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006 Jul;1071:410-21. [PubMed:16891588 ]
Rautanen A, Eriksson JG, Kere J, Andersson S, Osmond C, Tienari P, Sairanen H, Barker DJ, Phillips DI, Forsen T, Kajantie E: Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene. J Clin Endocrinol Metab. 2006 Nov;91(11):4544-51. Epub 2006 Aug 8. [PubMed:16895953 ]
Hammer F, Stewart PM: Cortisol metabolism in hypertension. Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):337-53. [PubMed:16980198 ]
Shaw JR, Gabor K, Hand E, Lankowski A, Durant L, Thibodeau R, Stanton CR, Barnaby R, Coutermarsh B, Karlson KH, Sato JD, Hamilton JW, Stanton BA: Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R1052-60. Epub 2006 Oct 12. [PubMed:17038445 ]
Sher L: Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. ScientificWorldJournal. 2006 Oct 31;6:1398-404. [PubMed:17086345 ]

Details

2. Annexin A1

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: agonist

General Function:: Structural molecule activity
Specific Function:: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions ...
Gene Name:: ANXA1
Uniprot ID:: P04083
Uniprot Name:: Annexin A1
Molecular Weight:: 38713.855 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Sato-Matsumura KC, Matsumura T, Nakamura H, Sawa H, Nagashima K, Koizumi H: Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes. Arch Dermatol Res. 2000 Oct;292(10):496-9. [PubMed:11142771 ]
White MV, Igarashi Y, Lundgren JD, Shelhamer J, Kaliner M: Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. J Immunol. 1991 Jul 15;147(2):667-73. [PubMed:1712816 ]
Serres M, Viac J, Comera C, Schmitt D: Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes. Arch Dermatol Res. 1994;286(5):268-72. [PubMed:8060156 ]

Details

3. Corticosteroid 11-beta-dehydrogenase isozyme 2

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Steroid binding
Specific Function:: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Gene Name:: HSD11B2
Uniprot ID:: P80365
Uniprot Name:: Corticosteroid 11-beta-dehydrogenase isozyme 2
Molecular Weight:: 44126.06 Da

References

Furstenberger C, Vuorinen A, Da Cunha T, Kratschmar DV, Saugy M, Schuster D, Odermatt A: The anabolic androgenic steroid fluoxymesterone inhibits 11beta-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicol Sci. 2012 Apr;126(2):353-61. doi: 10.1093/toxsci/kfs022. Epub 2012 Jan 23. [PubMed:22273746 ]

Details

4. 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Steroid delta-isomerase activity
Specific Function:: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxypr...
Gene Name:: HSD3B1
Uniprot ID:: P14060
Uniprot Name:: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Molecular Weight:: 42251.25 Da

References

Bhatia C, Oerum S, Bray J, Kavanagh KL, Shafqat N, Yue W, Oppermann U: Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chem Biol Interact. 2015 Jun 5;234:114-25. doi: 10.1016/j.cbi.2014.12.013. Epub 2014 Dec 16. [PubMed:25526675 ]

Enzymes

Details

1. Cytochrome P450 3A4

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitorinducer

General Function:: Vitamin d3 25-hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:: CYP3A4
Uniprot ID:: P08684
Uniprot Name:: Cytochrome P450 3A4
Molecular Weight:: 57342.67 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

2. Cytochrome P450 3A5

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Oxygen binding
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP3A5
Uniprot ID:: P20815
Uniprot Name:: Cytochrome P450 3A5
Molecular Weight:: 57108.065 Da

References

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

3. Cytochrome P450 3A7

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Oxygen binding
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP3A7
Uniprot ID:: P24462
Uniprot Name:: Cytochrome P450 3A7
Molecular Weight:: 57525.03 Da

References

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

4. Cytochrome P450 11B1, mitochondrial

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid 11-beta-monooxygenase activity
Specific Function:: Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:: CYP11B1
Uniprot ID:: P15538
Uniprot Name:: Cytochrome P450 11B1, mitochondrial
Molecular Weight:: 57572.44 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Details

5. Cytochrome P450 11B2, mitochondrial

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid 11-beta-monooxygenase activity
Specific Function:: Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
Gene Name:: CYP11B2
Uniprot ID:: P19099
Uniprot Name:: Cytochrome P450 11B2, mitochondrial
Molecular Weight:: 57559.62 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Details

6. Cytochrome P450 2C8

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inducer

General Function:: Steroid hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:: CYP2C8
Uniprot ID:: P10632
Uniprot Name:: Cytochrome P450 2C8
Molecular Weight:: 55824.275 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Details

1. Sex hormone-binding globulin

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Androgen binding
Specific Function:: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gene Name:: SHBG
Uniprot ID:: P04278
Uniprot Name:: Sex hormone-binding globulin
Molecular Weight:: 43778.755 Da

References

Khoromi S, Muniyappa R, Nackers L, Gray N, Baldwin H, Wong KA, Matheny LA, Moquin B, Rainer A, Hill S, Remaley A, Johnson LL, Max MB, Blackman MR: Effects of chronic osteoarthritis pain on neuroendocrine function in men. J Clin Endocrinol Metab. 2006 Nov;91(11):4313-8. Epub 2006 Aug 15. [PubMed:16912126 ]
Stroud LR, Solomon C, Shenassa E, Papandonatos G, Niaura R, Lipsitt LP, Lewinn K, Buka SL: Long-term stability of maternal prenatal steroid hormones from the National Collaborative Perinatal Project: still valid after all these years. Psychoneuroendocrinology. 2007 Feb;32(2):140-50. Epub 2007 Jan 31. [PubMed:17270355 ]
Lombardi G, Mondaini N, Macchiarella A, Del Popolo G: Female sexual dysfunction and hormonal status in spinal cord injured (SCI) patients. J Androl. 2007 Sep-Oct;28(5):722-6. Epub 2007 May 9. [PubMed:17494102 ]
Shifren JL, Desindes S, McIlwain M, Doros G, Mazer NA: A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. Menopause. 2007 Nov-Dec;14(6):985-94. [PubMed:17507833 ]
Rizzo L, Dobrovsky V, Danilowicz K, Kral M, Cross G, Serra HA, Bruno OD: Low-dose glucocorticoids in hyperandrogenism. Medicina (B Aires). 2007;67(3):247-52. [PubMed:17628912 ]

Details

2. Corticosteroid-binding globulin

Kind: Protein
Organism: Human
Pharmacological action: unknown

General Function:: Steroid binding
Specific Function:: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:: SERPINA6
Uniprot ID:: P08185
Uniprot Name:: Corticosteroid-binding globulin
Molecular Weight:: 45140.49 Da

References

Henley DE, Lightman SL: New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience. 2011 Apr 28;180:1-8. doi: 10.1016/j.neuroscience.2011.02.053. Epub 2011 Mar 1. [PubMed:21371536 ]

Transporters

Details

1. Multidrug resistance protein 1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Xenobiotic-transporting atpase activity
Specific Function:: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:: ABCB1
Uniprot ID:: P08183
Uniprot Name:: Multidrug resistance protein 1
Molecular Weight:: 141477.255 Da

References

Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. [PubMed:10213372 ]
Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924 ]
Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R: Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 1992 Dec 5;267(34):24248-52. [PubMed:1360010 ]
Orlowski S, Mir LM, Belehradek J Jr, Garrigos M: Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J. 1996 Jul 15;317 ( Pt 2):515-22. [PubMed:8713080 ]

Details

2. Solute carrier organic anion transporter family member 1A2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Sodium-independent organic anion transmembrane transporter activity
Specific Function:: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:: SLCO1A2
Uniprot ID:: P46721
Uniprot Name:: Solute carrier organic anion transporter family member 1A2
Molecular Weight:: 74144.105 Da

References

Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. [PubMed:8779893 ]
Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566 ]

Details

3. ATP-binding cassette sub-family G member 2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Xenobiotic-transporting atpase activity
Specific Function:: High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:: ABCG2
Uniprot ID:: Q9UNQ0
Uniprot Name:: ATP-binding cassette sub-family G member 2
Molecular Weight:: 72313.47 Da

References

Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. [PubMed:12920197 ]

Drug created on June 13, 2005 07:24 / Updated on July 25, 2017 12:02

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Structure for DB00741 (Hydrocortisone)

Targets

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Enzymes

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Carriers

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Transporters

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