Identification

Name
Hydrocortisone
Accession Number
DB00741  (APRD01019, DB07886)
Type
Small Molecule
Groups
Approved, Vet approved
Description

The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Structure
Thumb
Synonyms
  • (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione
  • 11beta-hydrocortisone
  • 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
  • 11β-hydrocortisone
  • 17-Hydroxycorticosterone
  • 4-pregnen-11β,17α,21-triol-3,20-dione
  • Cortisol
  • Hidrocortisona
  • Hydrocortisonum
  • Kendall's compound F
  • Reichstein's substance M
External IDs
NSC-10483
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
A-hydrocort Inj 1000mg/8mlPowder, for solution1 gIntramuscular; IntravenousHospira, Inc.1993-12-312012-08-03Canada
A-hydrocort Inj 100mg/2mlPowder, for solution100 mgIntramuscular; IntravenousHospira, Inc.1992-12-312012-08-03Canada
A-hydrocort Inj 250mg/2mlPowder, for solution250 mgIntramuscular; IntravenousHospira, Inc.1992-12-312012-08-03Canada
A-hydrocort Inj 500mg/4mlPowder, for solution500 mgIntramuscular; IntravenousHospira, Inc.1992-12-312012-08-03Canada
Aquacort Lotion 2.5%Lotion2.5 %TopicalMerit Industries Inc.1992-12-312002-05-14Canada
Barriere HC 1%Cream; Jelly1 %TopicalAllen & Hanburys A Glaxo Canada Ltd. Co.1979-12-311998-07-29Canada
Cortate Crm 1%Cream10 mgTopicalSchering Plough1980-12-312013-07-31Canada
Cortate Ont 1%Ointment10 mgTopicalSchering Plough1980-12-312013-07-31Canada
CortefTablet10 mg/1OralPharmacia and Upjohn Company LLC1952-12-15Not applicableUs
CortefTablet5 mg/1OralPharmacia and Upjohn Company LLC1952-12-15Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AlacortCream10 mg/1gTopicalCrown Laboratories1973-03-09Not applicableUs
AlacortCream25 mg/1gTopicalCrown Laboratories2016-01-06Not applicableUs
Anusol HCCream25 mg/1gTopicalSalix Pharmaceuticals1984-06-06Not applicableUs
ColocortSuspension100 mg/60mLRectalPaddock Laboratories, Inc.1999-12-31Not applicableUs
Home PapKitCream25 mg/1gTopicalInternational Brand Management, Llc2016-09-15Not applicableUs
HydrocortisoneCream25 mg/1gTopicalRemedy Repack2016-02-092016-02-10Us
HydrocortisoneOintment10 mg/1gTopicalCmp Pharma, Inc.1985-07-30Not applicableUs
HydrocortisoneCream25 mg/1gTopicalAidarex Pharmaceuticals LLC2005-04-28Not applicableUs
HydrocortisoneTablet20 mg/1OralWest-Ward Pharmaceuticals Corp1973-06-18Not applicableUs0143 125420180907 15195 efk541
HydrocortisoneCream25 mg/1gTopicalActavis Pharma Company2002-09-30Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
1% HydrocortisoneCream1 g/100gTopicalYuyao Jessie Commodity Co.,Ltd.2015-12-01Not applicableUs
999 Itch RelievingOintment1 g/100gTopicalGuangdong CR. Shunfeng Pharmaceutical Co Ltd1989-07-20Not applicableUs
999 Itch RelievingOintment1 g/100gTopicalGuangdong CR. Shunfeng Pharmaceutical Co Ltd1989-07-20Not applicableUs
Advanced HydrocortisoneCream10 mg/1gTopicalUltra Seal Corporation2011-04-05Not applicableUs
Ana Cool Rapid Soothing Cooling FormulaCream10 mg/1gTopicalAna-Cool, LLC2015-11-25Not applicableUs
Anti ItchCream1 g/100gTopicalRite Aid2013-09-11Not applicableUs
Anti itchCream1 g/100gTopicalRite Aid2009-02-092011-02-03Us
Anti ItchLotion1 g/100gTopicalWalgreen2012-03-27Not applicableUs
Anti ItchOintment1 g/100gTopicalRite Aid2005-07-25Not applicableUs
Anti ItchCream1 g/100gTopicalSafeway2005-08-24Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Acetasol HCHydrocortisone (1.1 g/100mL) + Acetic acid (2.41 g/100mL)SolutionAuricular (otic)Physicians Total Care, Inc.1994-12-152012-06-30Us
Acetasol HCHydrocortisone (1.1 g/100mL) + Acetic acid (2.41 g/100mL)SolutionAuricular (otic)Actavis Pharma Company2002-09-10Not applicableUs
Antibiotic Ear (Neo/Polym/HC)Hydrocortisone (10 mg/1mL) + Neomycin sulfate (3.5 mg/1mL) + Polymyxin B Sulfate (10000 [USP'U]/1mL)Solution / dropsAuricular (otic)Physicians Total Care, Inc.1995-12-29Not applicableUs
Calmurid HC CrmHydrocortisone (10 mg) + Urea (100 mg)CreamTopicalGalderma1994-12-312000-08-02Canada
CiproHydrocortisone (10 mg/1mL) + Benzyl alcohol (9 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL)SuspensionAuricular (otic)Physicians Total Care, Inc.2009-02-12Not applicableUs
Cipro HCHydrocortisone (10 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL)SuspensionAuricular (otic)Alcon, Inc.1999-03-15Not applicableUs
Cipro HCHydrocortisone (10 mg/1mL) + Benzyl alcohol (9 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL)SuspensionAuricular (otic)Stat Rx USA1998-02-10Not applicableUs
Cipro HCHydrocortisone (10 mg/1mL) + Ciprofloxacin hydrochloride (2 mg/1mL)SuspensionAuricular (otic)A-S Medication Solutions1999-03-15Not applicableUs
Cipro HC Otic SuspensionHydrocortisone (10 mg) + Ciprofloxacin (2 mg)SuspensionAuricular (otic)Alcon, Inc.1999-06-222008-12-08Canada
CortisporinHydrocortisone (10 mg) + Neomycin (3.5 mg) + Polymyxin B Sulfate (10000 unit)SuspensionTopicalGlaxosmithkline Inc1994-12-312006-11-21Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Ala QuinHydrocortisone (5 mg/1g) + Clioquinol (30 mg/1g)CreamTopicalCrown Laboratories1970-08-19Not applicableUs
AlcortinHydrocortisone (2 g/100g) + Diiodohydroxyquinoline (1 g/100g)GelTopicalPrimus Pharmaceuticals2003-07-25Not applicableUs
BencortHydrocortisone (5 mg/1g) + Benzoyl peroxide (350 mg/1g) + Benzoyl peroxide (50 mg/1g)KitRiver's Edge Pharmaceuticals, LLC2009-10-012011-01-13Us
Cortaine -B AqueousHydrocortisone (10 mg/1mL) + Chloroxylenol (1 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)Solution / dropsAuricular (otic)Physicians Total Care, Inc.2010-09-092013-01-15Us
Cortane-BHydrocortisone (10 mg/1mL) + Chloroxylenol (1 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)LotionTopicalBlansett Pharmacal Co2017-03-20Not applicableUs
Dermasorb AF Complete KitHydrocortisone (5 mg/1g) + Clioquinol (30 mg/1g)KitTopicalCrown Laboratories2013-11-142018-01-02Us
DermazeneHydrocortisone (10 mg/1g) + Diiodohydroxyquinoline (10 mg/1g)CreamTopicalStratus Pharmaceuticals2001-06-11Not applicableUs
Dr. Throwers HydrotetHydrocortisone (1 g/100g) + Tretinoin (0.05 g/100g)CreamTopicalDr. Thrower's Skincare, Inc.2015-05-15Not applicableUs
FIRST Dukes Mouthwash CompoundingHydrocortisone (0.06 g/0.06g) + Diphenhydramine hydrochloride (0.525 g/0.525g) + Nystatin (0.6 g/0.6g)KitOralCutisPharma, Inc.2010-12-15Not applicableUs
FIRST Marys Mouthwash CompoundingHydrocortisone (0.06 g/0.06g) + Diphenhydramine hydrochloride (0.45 g/0.45g) + Nystatin (1.2 g/1.2g) + Tetracycline hydrochloride (1.5 g/1.5g)KitOralCutisPharma, Inc.2010-12-15Not applicableUs
International/Other Brands
Acticort / Aeroseb HC / Ala-Scalp / Algicirtis / Aquanil HC / Beta-HC / Cetacort / Cortaid / Delacort / Ficortril / Genacort / Glycort / Komed HC / Lacticare HC / Lubricort / Medicort / Meusicort / Micort-HC / Mildison / Nogenic HC / Nutracort / Nystaform-HC / Otocort / Penecort / Permicort / Polcort H / Preparation H Hydrocortisone Cream / Prepcort / Prevex HC / Proctocort / Proctocream / Protocort / Remederm HC / Sanatison / Scalpicin Capilar / Schericur / Sigmacort / Synacort / Systral Hydrocort / Timocort
Categories
UNII
WI4X0X7BPJ
CAS number
50-23-7
Weight
Average: 362.4599
Monoisotopic: 362.20932407
Chemical Formula
C21H30O5
InChI Key
JYGXADMDTFJGBT-VWUMJDOOSA-N
InChI
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
IUPAC Name
(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
SMILES
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Pharmacology

Indication

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Associated Conditions
Pharmacodynamics

Hydrocortisone is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

Mechanism of action

Hydrocortisone binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In other words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

TargetActionsOrganism
AGlucocorticoid receptor
agonist
Human
AAnnexin A1
agonist
Human
UCorticosteroid 11-beta-dehydrogenase isozyme 2Not AvailableHuman
U3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1Not AvailableHuman
Absorption

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Volume of distribution
Not Available
Protein binding

95%

Metabolism

Primarily hepatic via CYP3A4

Route of elimination

Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Half life

6-8 hours

Clearance
Not Available
Toxicity

Side effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Corticosterone Methyl Oxidase II Deficiency (CMO II)Disease
Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase DeficiencyDisease
17-alpha-Hydroxylase Deficiency (CYP17)Disease
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase DeficiencyDisease
Corticosterone Methyl Oxidase I Deficiency (CMO I)Disease
11-beta-Hydroxylase Deficiency (CYP11B1)Disease
21-Hydroxylase Deficiency (CYP21)Disease
3-beta-Hydroxysteroid Dehydrogenase DeficiencyDisease
SteroidogenesisMetabolic
Corticotropin Activation of Cortisol ProductionSignaling
Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAHDisease
Apparent Mineralocorticoid Excess SyndromeDisease
SteroidogenesisMetabolic
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be increased when combined with Hydrocortisone.
(S)-WarfarinThe metabolism of (S)-Warfarin can be increased when combined with Hydrocortisone.
1-TestosteroneThe risk or severity of edema formation can be increased when 1-Testosterone is combined with Hydrocortisone.
1,10-PhenanthrolineThe therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Hydrocortisone.
16-BromoepiandrosteroneThe risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Hydrocortisone.
19-norandrostenedioneThe risk or severity of edema formation can be increased when 19-norandrostenedione is combined with Hydrocortisone.
1alpha-Hydroxyvitamin D5The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Hydrocortisone.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Hydrocortisone is combined with 2-Methoxyethanol.
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Hydrocortisone.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Hydrocortisone.
Food Interactions
  • Take with food to reduce irritation. Calcium, phosphorous, potassium, Vitamin A, C, D and zinc needs increased with long term use.

References

Synthesis Reference

Manfred Baumgarth, Dieter Orth, Jurgen Harting, Hans Schaefer, Achim Zesch, "Hydrocortisone orthoesters, pharmaceutical formulations thereof and processes for the preparation thereof." U.S. Patent US4264584, issued March, 1974.

US4264584
General References
  1. de Weerth C, Zijl RH, Buitelaar JK: Development of cortisol circadian rhythm in infancy. Early Hum Dev. 2003 Aug;73(1-2):39-52. [PubMed:12932892]
  2. Palacios R, Sugawara I: Hydrocortisone abrogates proliferation of T cells in autologous mixed lymphocyte reaction by rendering the interleukin-2 Producer T cells unresponsive to interleukin-1 and unable to synthesize the T-cell growth factor. Scand J Immunol. 1982 Jan;15(1):25-31. [PubMed:6461917]
  3. KNIGHT RP Jr, KORNFELD DS, GLASER GH, BONDY PK: Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176-81. [PubMed:13233328]
External Links
Human Metabolome Database
HMDB0000063
KEGG Drug
D00088
KEGG Compound
C00735
PubChem Compound
5754
PubChem Substance
46505089
ChemSpider
5551
BindingDB
13775
ChEBI
17650
ChEMBL
CHEMBL389621
Therapeutic Targets Database
DAP000718
PharmGKB
PA449905
IUPHAR
2868
Guide to Pharmacology
GtP Drug Page
HET
HCY
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Hydrocortisone
ATC Codes
S03CA04 — Hydrocortisone and antiinfectivesS01CA03 — Hydrocortisone and antiinfectivesS01CB03 — HydrocortisoneS02BA01 — HydrocortisoneS02CA03 — Hydrocortisone and antiinfectivesD07AA02 — HydrocortisoneC05AA01 — HydrocortisoneD07BA04 — Hydrocortisone and antisepticsS01BA02 — HydrocortisoneD07CA01 — Hydrocortisone and antibioticsA01AC03 — HydrocortisoneS01BB01 — Hydrocortisone and mydriaticsA07EA02 — HydrocortisoneR01AD60 — Hydrocortisone, combinationsH02AB09 — HydrocortisoneD07XA01 — Hydrocortisone
AHFS Codes
  • 68:04.00 — Adrenals
  • 84:06.00 — Anti-inflammatory Agents
  • 56:36.00 — Anti-inflammatory Agents
PDB Entries
2v95 / 2vdy / 4c49 / 4p6x / 5hgc
FDA label
Download (30 KB)
MSDS
Download (73.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingOtherInsulin Resistance1
0CompletedTreatmentFibromyalgia1
0RecruitingBasic ScienceDepression1
0RecruitingBasic ScienceHealthy Volunteers1
0RecruitingBasic ScienceHuman Immunodeficiency Virus (HIV)1
0WithdrawnBasic ScienceBMI >30 kg/m2 / Hyperandrogenemia / Polycystic Ovaries Syndrome2
1Active Not RecruitingBasic ScienceBMI >30 kg/m21
1Active Not RecruitingTreatmentRotator Cuff Tear - Partial Thickness1
1CompletedNot AvailableInfection NOS1
1CompletedNot AvailableRelative Adrenal Insufficiency / Sepsis1
1CompletedBasic ScienceHealthy Volunteers2
1CompletedBasic ScienceHealthy Volunteers / Inflammatory Reaction / Pain1
1CompletedBasic ScienceSmoking, Cigarette1
1CompletedOtherAdrenal Insufficiency1
1CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Mixed Phenotype Acute Leukemia (MPAL) / Myelodysplastic Syndromes (MDS)1
1CompletedTreatmentAdrenal Insufficiency2
1CompletedTreatmentAdrenal Insufficiency / Congenital Adrenal Hyperplasia (CAH)1
1CompletedTreatmentArterial Hypotension / Blood Pressures / Infant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants1
1CompletedTreatmentErythemas / Pain1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentKnee Osteoarthritis (Knee OA)1
1CompletedTreatmentLeukemia Acute Myeloid Leukemia (AML)1
1CompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
1RecruitingBasic ScienceSleep Restriction1
1RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1RecruitingTreatmentAcute Lymphoblastic Leukemia With Failed Remission / Acute Lymphoblastic Leukemia, in Relapse1
1RecruitingTreatmentHeroin Dependence / Opioid Use Disorders1
1RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
1RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome1
1RecruitingTreatmentLymphoblastic Leukemia, Acute, Childhood / Lymphoma, Lymphoblastic / Peripheral T-Cell Lymphoma (PTCL)1
1Unknown StatusTreatmentOvarian Epithelial Cancer1
1WithdrawnBasic ScienceDiabetes, Diabetes Mellitus Type 11
1, 2CompletedDiagnosticSystemic Lupus Erythematosus (SLE)1
1, 2CompletedTreatment21-Hydroxylase Deficiency / Adrenogenital Syndrome / Congenital Adrenal Hyperplasia (CAH)1
1, 2CompletedTreatmentCardiac Arrest1
1, 2CompletedTreatmentInhospital Cardiac Arrest1
1, 2CompletedTreatmentRecurrent Childhood Acute Lymphoblastic Leukemia1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1, 2RecruitingTreatmentAddison's Disease / Adrenal Hyperplasia Congenital1
1, 2RecruitingTreatmentAdult Burkitt Lymphoma / B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma / Lymphoma, Large B-Cell, Diffuse (DLBCL) / MYC Gene Mutation / Plasmablastic Lymphoma1
1, 2TerminatedBasic ScienceRenin Angiotensin1
1, 2TerminatedTreatmentAdenocarcinoma, Prostate / Recurrent Prostate Carcinoma / Stage III Prostate Cancer / Stage IV Prostate Cancer1
1, 2TerminatedTreatmentAnaplastic Large Cell Lymphoma / Recurrent Childhood Anaplastic Large Cell Lymphoma1
1, 2TerminatedTreatmentProstate Cancer1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)2
2Active Not RecruitingTreatmentLymphoma, Lymphoblastic1
2Active Not RecruitingTreatmentProstate Cancer1
2Active Not RecruitingTreatmentPulmonary Arterial Hypertension (PAH)1
2CompletedNot AvailablePostoperative Complications / Postoperative Pancreatitis1
2CompletedPreventionChronic Lung Disease of Prematurity1
2CompletedPreventionChronic Lung Disease of Prematurity / Encephalomalacia / Premature Births1
2CompletedPreventionMemory Disturbances1
2CompletedSupportive CareAdvanced Malignant Neoplasm / Dermatologic Complication / Dermatologic Complications / Neoplasms, Malignant1
2CompletedTreatmentAcute Lymphocytic Leukemia (ALL)1
2CompletedTreatmentAcute Respiratory Distress Syndrome (ARDS) / Multiple Organ Failure1
2CompletedTreatmentAdenocarcinoma, Prostate / Prostate Cancer1
2CompletedTreatmentAdrenal Hyperplasia, Congenital1
2CompletedTreatmentAdrenal Insufficiency / Congenital Adrenal Hyperplasia (CAH) / Excess Androgen1
2CompletedTreatmentAngioedema1
2CompletedTreatmentB-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentBlood Cancers / Chronic Lymphocytic Leukaemia (CLL) / Graft Versus Host Disease (GVHD) / Hodgkins Disease (HD) / Leukemias / Malignancies / NHL / Smith-Magenis Syndrome1
2CompletedTreatmentBlood and Marrow Transplant (BMT) / Multiple Myeloma (MM) / Transplantation, Autologous / Transplantation, Homologous1
2CompletedTreatmentCardiac Output, Low1
2CompletedTreatmentChildhood Burkitt Lymphoma / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Small Noncleaved Cell Lymphoma / Stage II Childhood Large Cell Lymphoma / Stage II Childhood Small Noncleaved Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Small Noncleaved Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Untreated Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentHemorrhoids1
2CompletedTreatmentJet Lag Syndrome1
2CompletedTreatmentLeukemia, Mast-Cell / Mantle Cell Lymphoma (MCL)1
2CompletedTreatmentLeukemias1
2CompletedTreatmentLeukemias / Malignant Lymphomas1
2CompletedTreatmentLymphohistiocytosis, Hemophagocytic1
2CompletedTreatmentOpioid Dependence1
2CompletedTreatmentPaediatric Sepsis / Pediatric Sepsis / Sepsis1
2CompletedTreatmentProstate Cancer1
2CompletedTreatmentPrurigo Nodularis1
2CompletedTreatmentRash1
2CompletedTreatmentRecurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma / T-cell Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentRheumatoid Arthritis1
2Not Yet RecruitingBasic ScienceAdolescent Development / Borderline Personality Disorder (BPD)1
2Not Yet RecruitingTreatmentCongenital Adrenal Hyperplasia (CAH)1
2RecruitingTreatmentAcute Leukemias of Ambiguous Lineage / Childhood B Acute Lymphoblastic Leukemia / KMT2A Gene Rearrangement / Mixed Phenotype Acute Leukemia (MPAL)1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Childhood Cancers / Down Syndrome (DS)1
2RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Adult Lymphoblastic Lymphoma1
2RecruitingTreatmentAdrenal Hyperplasia, Congenital1
2RecruitingTreatmentApomorphine-induced Skin Reactions / Parkinson's Disease (PD)1
2RecruitingTreatmentColorectal Cancers / Head and Neck Carcinoma1
2RecruitingTreatmentCritically Ill / Sepsis / Shock, Septic / Vasoplegic Syndrome1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes1
2RecruitingTreatmentProstate Cancer1
2RecruitingTreatmentRecurrent B-Cell Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood B-Lymphoblastic Lymphoma1
2RecruitingTreatmentSevere Sepsis / Shock, Septic1
2RecruitingTreatmentSickle Cell Disorders1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemia, B-Cell / Leukemia, T-Cell / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Lymphoma, Lymphoblastic1
2TerminatedTreatmentAcute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Mixed Lineage Acute Leukemia1
2TerminatedTreatmentBlood and Marrow Transplant (BMT) / Diffuse Large B-Cell / Lymphoma, B-Cell / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Lymphomas: Non-Hodgkin / Malignant Lymphoma, Non-Hodgkin / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentCastration-Resistant Prostate Cancer (CRPC)1
2TerminatedTreatmentLeukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndromes (MDS)1
2TerminatedTreatmentPhobic Disorders1
2Unknown StatusTreatmentAcute Lymphoblastic Leukaemias (ALL)1
2Unknown StatusTreatmentAddison's Disease1
2Unknown StatusTreatmentCirrhosis With Ascites1
2Unknown StatusTreatmentInjuries, Whiplash1
2Unknown StatusTreatmentLeukemias1
2, 3Active Not RecruitingTreatmentAsphyxia / Hypoxic-Ischaemic Encephalopathy1
2, 3Active Not RecruitingTreatmentChildhood B Acute Lymphoblastic Leukemia / Childhood Burkitt Leukemia / Childhood Diffuse Large Cell Lymphoma / Mediastinal (Thymic) Large B-Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma1
2, 3CompletedPreventionInjuries, Multiple1
2, 3CompletedTreatmentAddison's Disease1
2, 3CompletedTreatmentAdrenal Insufficiency1
2, 3CompletedTreatmentAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
2, 3Not Yet RecruitingPreventionNonvalvular Atrial Fibrillation1
2, 3RecruitingTreatmentLeft Ventricular Remodeling / ST Segment Elevation Myocardial Infarction (STEMI)1
2, 3RecruitingTreatmentOsteoarthritis, Shoulder1
2, 3Unknown StatusTreatmentMortality / Ventilations, Mechanical1
3CompletedSupportive CareCardiac Toxicity / Leukemias / Malignant Lymphomas1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Undifferentiated Leukemia (AUL) / Childhood T Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentAlcohol Craving / Stress, Physiological / Stress, Psychological1
3CompletedTreatmentAlopecia Areata (AA)1
3CompletedTreatmentCardiac Arrest1
3CompletedTreatmentCardiovascular Insufficiency / Infant, Newborn, Diseases1
3CompletedTreatmentChildhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Refractory Anemia With Ringed Sideroblasts / Secondary Myelodysplastic Syndromes / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
3CompletedTreatmentChronic Lung Disease of Prematurity1
3CompletedTreatmentCoagulation Dysfunction in Septic Shock / Hemodynamic Improvement Induced by Hydrocortisone1
3CompletedTreatmentCongenital Adrenal Hyperplasia (CAH)1
3CompletedTreatmentHealthy Volunteers1
3CompletedTreatmentHerpes Labialis1
3CompletedTreatmentLeukemias / Malignant Lymphomas1
3CompletedTreatmentLeukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
3CompletedTreatmentNeonatal Hypotension1
3CompletedTreatmentOral Submucous Fibrosis1
3CompletedTreatmentOtitis Externa1
3CompletedTreatmentPatient Admitted in Reanimation1
3CompletedTreatmentProstate Cancer1
3CompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
3CompletedTreatmentSepsis / Shock, Septic1
3CompletedTreatmentSevere Sepsis1
3CompletedTreatmentShock, Septic3
3Not Yet RecruitingTreatmentCongenital Adrenal Hyperplasia (CAH)1
3Not Yet RecruitingTreatmentImmune Thrombocytopenia / Purpura, Thrombocytopenic, Idiopathic1
3RecruitingPreventionChronic Lung Disease of Prematurity / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants / Very Low Birth Weight Infant1
3RecruitingSupportive CareSepsis1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / BCR-ABL1 Fusion Protein Expression / Minimal Residual Disease / Philadelphia Chromosome Positive / T Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain / Ph-Like Acute Lymphoblastic Leukemia / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAcute Lymphoblastic Leukemia, Pediatric1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentCommunity Acquired Pneumonia (CAP)1
3RecruitingTreatmentCongenital Adrenal Hyperplasia (CAH)1
3RecruitingTreatmentLiver Cirrhosis1
3RecruitingTreatmentSevere Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit1
3SuspendedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult T Acute Lymphoblastic Leukemia / Ann Arbor Stage II Adult Lymphoblastic Lymphoma / Ann Arbor Stage II Childhood Lymphoblastic Lymphoma / Ann Arbor Stage III Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Childhood Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult Lymphoblastic Lymphoma / Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma / Childhood T Acute Lymphoblastic Leukemia / Stage II Adult Lymphoblastic Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3TerminatedTreatmentEvidence of Liver Transplantation / Transplantations1
3TerminatedTreatmentInfluenza in Humans / Viral Pneumonia1
3TerminatedTreatmentProstatic Neoplasms1
3Unknown StatusTreatmentLow Back Pain (LBP)1
4Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
4CompletedNot AvailableMinor burns1
4CompletedBasic ScienceFeeling Anxious1
4CompletedBasic ScienceHealthy Volunteers1
4CompletedBasic ScienceStress Disorders, Posttraumatic1
4CompletedPreventionPostoperative Inflammatory Response1
4CompletedPreventionPosttraumatic Stress Disorders / Systemic Inflammatory Response Syndrome (SIRS)1
4CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)1
4CompletedTreatmentAdrenal Insufficiency1
4CompletedTreatmentAsthma Bronchial1
4CompletedTreatmentAtopic Dermatitis (AD)1
4CompletedTreatmentAtopic Dermatitis (AD) / Psoriasis1
4CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4CompletedTreatmentCoronary Artery Disease / Mitral Valve Regurgitation1
4CompletedTreatmentHip Injuries1
4CompletedTreatmentHyperglycemias1
4CompletedTreatmentKnee Replacement Surgery1
4CompletedTreatmentRheumatic Diseases1
4CompletedTreatmentShock1
4CompletedTreatmentShock, Septic1
4CompletedTreatmentSnake Bites1
4Enrolling by InvitationTreatmentAdrenal Insufficiency1
4Enrolling by InvitationTreatmentCorticotropin Deficiency / Fasting1
4Enrolling by InvitationTreatmentGranuloma / Tracheostomy care1
4RecruitingPreventionNeoplasms, Pancreatic / Pancreatic Fistula1
4RecruitingSupportive CareRheumatoid Arthritis1
4RecruitingTreatmentAtopic Dermatitis (AD)1
4RecruitingTreatmentCommunity Acquired Pneumonia (CAP)1
4RecruitingTreatmentCritical Illness / Fluid Overload / Sepsis / Shock, Septic1
4RecruitingTreatmentFunction of Renal Transplant1
4RecruitingTreatmentGranulomatous Mastitis1
4RecruitingTreatmentUlcerative Colitis (UC)2
4TerminatedNot AvailableAsthma Bronchial1
4TerminatedTreatmentPartial Corticotrope Insufficiency1
4TerminatedTreatmentShock, Septic1
4Unknown StatusTreatmentAcute Respiratory Distress Syndrome (ARDS) / Adrenal Insufficiency1
4Unknown StatusTreatmentCrohn's Disease (CD)1
4Unknown StatusTreatmentPituitary Neoplasms / Postsurgical craniopharyngioma1
4WithdrawnTreatmentAdrenal Insufficiency / Sepsis1
4WithdrawnTreatmentAtopic Dermatitis (AD)1
4WithdrawnTreatmentPhimosis1
4WithdrawnTreatmentPost-Traumatic Stress Disorder (PTSD)1
Not AvailableActive Not RecruitingPreventionDialysis Hypotension1
Not AvailableActive Not RecruitingSupportive CareSjögren's Syndrome1
Not AvailableCompletedNot AvailableAnxiety Disorders / Major Depressive Disorder (MDD)1
Not AvailableCompletedNot AvailableDependence, Cocaine1
Not AvailableCompletedNot AvailableHeroin Dependence / Learning and Memory1
Not AvailableCompletedNot AvailableKnee Osteoarthritis (Knee OA)1
Not AvailableCompletedNot AvailableSepsis1
Not AvailableCompletedBasic ScienceIntrusive Memories1
Not AvailableCompletedBasic SciencePosttraumatic Stress Disorders1
Not AvailableCompletedPreventionFevers / Hemodynamics Instability / Hypothermia / Idiopathic orthostatic hypotension1
Not AvailableCompletedScreeningOther Diseases or Conditions1
Not AvailableCompletedTreatmentAcute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS) / Severe Sepsis / Shock, Septic1
Not AvailableCompletedTreatmentAddison's Disease1
Not AvailableCompletedTreatmentAddison's Disease / BMI >30 kg/m21
Not AvailableCompletedTreatmentAdrenal Hyperplasia, Congenital1
Not AvailableCompletedTreatmentAtopic Dermatitis (AD)1
Not AvailableCompletedTreatmentHeart Arrest1
Not AvailableCompletedTreatmentHeart Disease Congenital Complex1
Not AvailableCompletedTreatmentPTSD1
Not AvailableCompletedTreatmentPhobic Disorders1
Not AvailableCompletedTreatmentPituitary Adenomas / Pituitary Diseases1
Not AvailableCompletedTreatmentTotal Hip Replacement1
Not AvailableRecruitingBasic ScienceBorderline Personality Disorder (BPD) / PTSD1
Not AvailableRecruitingPreventionHyperlactacidaemia1
Not AvailableRecruitingPreventionPost Traumatic Stress Disorder (PTSD)1
Not AvailableRecruitingTreatmentAtopic Dermatitis (AD)1
Not AvailableRecruitingTreatmentIntussusception1
Not AvailableRecruitingTreatmentPlantar fascial fibromatosis1
Not AvailableRecruitingTreatmentShock, Septic1
Not AvailableSuspendedNot AvailableSome Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver1
Not AvailableTerminatedNot AvailableNonvalvular Atrial Fibrillation1
Not AvailableTerminatedPreventionBrain Death1
Not AvailableTerminatedTreatmentFatty Acids, Nonesterified / Hydrocortisone / Hypopituitarism / Insulin Sensitivity / Lipids1
Not AvailableTerminatedTreatmentNecrotizing Enterocolitis1
Not AvailableTerminatedTreatmentPosttraumatic Stress Disorders1
Not AvailableUnknown StatusPreventionPosttraumatic Stress Disorders1
Not AvailableUnknown StatusTreatmentChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableUnknown StatusTreatmentMajor Depressive Disorder (MDD)1
Not AvailableUnknown StatusTreatmentPTSD1
Not AvailableWithdrawnTreatmentPost-Traumatic Stress Disorder (PTSD)1

Pharmacoeconomics

Manufacturers
  • Hi tech pharmacal co inc
  • Allergan herbert div allergan inc
  • Del ray laboratories inc
  • Salix pharmaceuticals inc
  • Bayer pharmaceuticals corp
  • Monarch pharmaceuticals inc
  • Valeant pharmaceuticals international
  • Westwood squibb pharmaceuticals inc
  • C and m pharmacal inc
  • Pharmaceutical assoc inc div beach products
  • Actavis mid atlantic llc
  • Alpharma us pharmaceuticals division
  • Altana inc
  • Ambix laboratories div organics corp america
  • Everylife
  • E fougera div altana inc
  • G and w laboratories inc
  • Ingram pharmaceutical co
  • Ivax pharmaceuticals inc
  • Naska pharmacal co inc div rugby darby group cosmetics
  • Perrigo new york inc
  • Pharmaderm div altana inc
  • Pharmafair inc
  • Stiefel laboratories inc
  • Syosset laboratories inc
  • Taro pharmaceuticals usa inc
  • Teva pharmaceuticals usa inc
  • Topiderm inc
  • Usl pharma inc
  • Vintage pharmaceuticals inc
  • Whiteworth towne paulsen inc
  • Sanofi aventis us llc
  • Coria laboratories ltd
  • Medicis pharmaceutical corp
  • Paddock laboratories inc
  • Ani pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Healthpoint ltd
  • Allergan herbert skin care div allergan inc
  • Pharmacia and upjohn co
  • Baker norton pharmaceuticals inc
  • Solvay pharmaceuticals
  • Beta dermaceuticals inc
  • Bluline laboratories inc
  • Heran pharmaceutical inc
  • Mericon industries inc
  • Perrigo co
  • Pfizer global research development
  • Carolina medical products co
  • Dermik laboratories div aventis pharmaceuticals inc
  • Torch laboratories inc
  • X gen pharmaceuticals inc
  • Jsj pharmaceuticals llc
  • Pfizer laboratories div pfizer inc
  • Barr laboratories inc
  • Elkins sinn div ah robins co inc
  • John j ferrante
  • Impax laboratories inc
  • Inwood laboratories inc sub forest laboratories inc
  • Lannett co inc
  • Nexgen pharma inc
  • Panray corp sub ormont drug and chemical co inc
  • Parke davis div warner lambert co
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Stiefel a gsk co
  • Vintage pharmaceuticals llc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Merck and co inc
  • Pfipharmecs div pfizer inc
  • Schwarz pharma inc
  • Able laboratories inc
  • Hr cenci laboratories inc
  • Ferndale laboratories inc
  • Akorn inc
  • Bel mar laboratories inc
  • Colgate oral pharmaceuticals inc
  • Taro pharmaceutical industries ltd
  • Triax pharmaceuticals llc
  • Yamanouchi europe bv
  • Savage laboratories inc div altana inc
  • Abbott laboratories pharmaceutical products div
  • Abbott laboratories hosp products div
  • Hospira inc
  • Abraxis pharmaceutical products
  • Baxter healthcare corp anesthesia and critical care
  • International medication systems ltd
  • Taro pharmaceuticals inc
  • Ranbaxy laboratories inc
Packagers
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • AG Marin Pharmaceuticals
  • Alaven Pharmaceutical
  • Alcon Laboratories
  • Amerisource Health Services Corp.
  • Ani Pharmaceuticals
  • Anip Acquisition Co.
  • Arbor Pharmaceuticals Incorporated
  • A-S Medication Solutions LLC
  • Avidas Pharmaceuticals
  • Bay Pharma Inc.
  • Bayer Healthcare
  • Bergen Brunswig
  • Beta Dermaceuticals
  • Bio Pharm Inc.
  • Bristol-Myers Squibb Co.
  • C.O. Truxton Inc.
  • Cardinal Health
  • Carlisle Laboratories Inc.
  • Carolina Medical Products Co.
  • Chattem Chemicals Inc.
  • Co Med Pharmaceuticals Inc.
  • Colgate Oral
  • Combe Inc.
  • Consolidated Midland Corp.
  • Contract Pharm
  • Crown Laboratories Inc.
  • Cutis Pharma Inc.
  • Cypress Pharmaceutical Inc.
  • Darby Dental Supply Co. Inc.
  • Del Ray Dermatology
  • Dermik Labs
  • DispenseXpress Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Dofs Laboratories
  • DPT Laboratories Ltd.
  • DSC Laboratories
  • E. Fougera and Co.
  • ECR Pharmaceuticals
  • Elkins-Sinn Inc.
  • Enterprises Importfab Inc.
  • Ferndale Labs
  • G & W Labs
  • Genesis Pharmaceutical Inc.
  • Gertz
  • H and H Laboratories
  • H.J. Harkins Co. Inc.
  • Harmony Laboratories Inc.
  • Hi Tech Pharmacal Co. Inc.
  • Hospira Inc.
  • Inyx Usa Ltd.
  • JHP Pharmaceuticals LLC
  • Johnson & Johnson Healthcare
  • JSJ Pharmaceuticals Inc.
  • Kaiser Foundation Hospital
  • Keltman Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Lehigh Valley Technologies Inc.
  • Lyne Laboratories Inc.
  • Major Pharmaceuticals
  • Mallinckrodt Inc.
  • Martin Surgical Supply
  • Meda AB
  • Mikart Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • National Vitamin Company
  • Nexgen Pharma Inc.
  • Nycomed Inc.
  • Paddock Labs
  • Palmetto Pharmaceuticals Inc.
  • Patheon Inc.
  • Perrigo Co.
  • Person & Covey
  • Pfizer Inc.
  • Pharmacia Inc.
  • Pharmaderm
  • Pharmedix
  • Physician Partners Ltd.
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Professional Co.
  • Prometic Pharma Inc.
  • Qualitest
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Resource Optimization and Innovation LLC
  • Rising Pharmaceuticals
  • River's Edge Pharmaceuticals
  • Rouses Point Pharmaceuticals LLC
  • Salix Pharmaceuticals
  • Sandhills Packaging Inc.
  • Sandoz
  • Sanofi-Aventis Inc.
  • Schwarz Pharma Inc.
  • Solvay Pharmaceuticals
  • Southwood Pharmaceuticals
  • Stanley Pharmaceuticals Ltd.
  • Stat Rx Usa
  • Stat Scripts LLC
  • Summers Labs
  • Suppositoria Laboratories Inc.
  • Taro Pharmaceuticals USA
  • Teva Pharmaceutical Industries Ltd.
  • Topiderm Inc.
  • Triax Pharmaceuticals LLC
  • UCB Pharma
  • United Pharmaceuticals
  • United Research Laboratories Inc.
  • Universal Laboratories Inc.
  • Upsher Smith Laboratories
  • Veratex Corp.
  • Vertical Pharmaceuticals Inc.
  • Vintage Pharmaceuticals Inc.
  • West-Ward Pharmaceuticals
  • Wockhardt Ltd.
  • WraSer Pharmaceuticals
  • Wyeth Pharmaceuticals
Dosage forms
FormRouteStrength
GelTopical
SolutionTopical1 g/100g
CreamTopical.05 mg/1g
LotionTopical0.01 g/1g
OintmentTopical1 g/100g
Cream; jellyTopical1 %
CreamTopical0.01 g/1g
CreamTopical0.284 g/28.4g
SprayTopical10 g/1mL
OintmentTopical10 mg
TabletOral10 mg
TabletOral20 mg
EnemaRectal100 mg
Enema; suspensionRectal100 mg
OintmentTopical100 g/1g
OintmentOphthalmic
OintmentTopical
SolutionAuricular (otic)
SuspensionTopical
GelTopical10 mg/1g
LiquidTopical10 mg/1mL
LotionTopical1 g/100g
LotionTopical10 mg/1g
GelTopical1 g/100g
Solution / dropsOphthalmic
GelTopical1 mg/1g
LotionTopical1 mg/1mL
KitTopical
LotionTopical0.75 g/100mL
CreamTopical.284 g/28.4g
CreamTopical.284 g/287.4g
CreamTopical1 g/100mL
CreamTopical2.5 %
SolutionTopical2.5 %
KitOral
OintmentTopical1 mL/100mL
OintmentTopical10 mg/1mL
CreamTopical0.5 g/100g
LotionTopical1 g/1mL
Aerosol, sprayTopical1.13 g/113g
CreamTopical1 h/100g
CreamTopical10 mg/1g
CreamTopical10 mg/1mL
CreamTopical25 mg/1g
CreamTopical5 mg/1g
EnemaRectal100 mg/60mL
LiquidTopical10 mg/1g
LotionTopical1 g/100.65mL
LotionTopical10 mg/1mL
LotionTopical25 mg/1mL
OintmentTopical10 mg/1g
OintmentTopical25 mg/1g
OintmentTopical5 mg/1g
PowderNot applicable1 g/1g
ShampooTopical1 g/100mL
SuspensionRectal100 mg/60mL
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral5 mg/1
CreamTopical500 mg
CreamTopical1 g
CreamTopical1.02 g/100g
CreamTopical0.5 %
CreamTopical5 mg
CreamTopical10 mg
OintmentTopical0.5 %
OintmentTopical1 %
Powder, for solutionIntramuscular; Intravenous100 mg
Powder, for solutionIntramuscular; Intravenous250 mg
Powder, for solutionIntramuscular; Intravenous500 mg
Powder, for solutionIntramuscular; Intravenous1 g
CreamTopical140 mg/14g
LotionTopical1 g/100mL
SprayTopical1 g/100g
LotionTopical1.02 g/100g
Kit
LiquidTopical5 mg/1mL
LiquidTopical9 mg/1mL
SprayTopical10 mg/1mL
OintmentTopical1.02 g/100g
CreamTopical1 g/100g
CreamTopical0.009 g/1
Solution / dropsAuricular (otic)
SuspensionOphthalmic
Suspension / dropsAuricular (otic)
LotionTopical5 mg/1g
LiquidAuricular (otic)
SuspensionAuricular (otic)
Kit20 mg/1mL
LipstickTopical0.005 g/1g
LotionTopical0.025 mg/2.5mL
CreamTopical7.5 g/100mL
CreamTopical1 mg/1g
LiquidTopical0.28 mg/100mL
OintmentRectal
SuppositoryRectal
OintmentRectal; Topical750 mg
SuppositoryRectal10 mg
CreamTopical.01 mg/1g
CreamTopical0.51 g/100g
SprayTopical500 g/1g
CreamTopical1 mg/100mL
LotionTopical2.5 %
LiquidTopical1 g/100mL
LiquidTopical
SolutionTopical25 mg/1mL
LotionTopical1 %
LotionTopical1 mL/100mL
LotionTopical
CreamTopical
CreamTopical10 mg/1L
SprayTopical10 g/1L
Prices
Unit descriptionCostUnit
Locoid Lipocream 0.1% Cream 60 gm Tube335.36USD tube
Cortifoam 90 mg Foam 15 gm Can239.99USD can
Locoid 0.1% Solution 60ml Bottle233.15USD bottle
Locoid Lipocream 0.1% Cream 45 gm Tube200.98USD tube
Locoid 0.1% Cream 45 gm Tube183.83USD tube
Locoid 0.1% Ointment 45 gm Tube174.86USD tube
Pandel 0.1% Cream 45 gm Tube161.37USD tube
Pandel 0.1% Cream 15 gm Tube138.56USD tube
Proctocort 1% Cream 28.35 gm Tube127.51USD tube
Anusol-HC 2.5% Cream 30 gm Tube106.45USD tube
Locoid Lipocream 0.1% Cream 15 gm Tube85.41USD tube
Texacort 2.5% Solution 30ml Bottle85.41USD bottle
Cortisporin 3.5-10000-1 Solution 10ml Bottle84.33USD bottle
Proctofoam HC 1-1% Foam 10 gm Can81.9USD can
Cortisporin 3.5-10000-1 Suspension 10ml Bottle79.55USD bottle
Locoid 0.1% Solution 20ml Bottle79.28USD bottle
Cortisporin 1% Ointment 15 gm Tube75.09USD tube
Locoid 0.1% Cream 15 gm Tube67.49USD tube
Hydrocortisone Ace-Pramoxine 2.5-1% Cream 28.35 gm Tube64.75USD tube
Locoid 0.1% Ointment 15 gm Tube62.04USD tube
Hydrocortisone Valerate 0.2% Ointment 60 gm Tube56.74USD tube
Hydrocortisone 2.5% Lotion 59 gm Bottle55.61USD bottle
Westcort 0.2% Ointment 60 gm Tube55.0USD tube
Cortisporin 0.5-0.5-10000 Cream 7.5 gm Tube54.37USD tube
Westcort 0.2% Ointment 15 gm Tube50.99USD tube
Hydrocortisone Butyrate 0.1% Cream 45 gm Tube49.43USD tube
Hydrocortisone Valerate 0.2% Ointment 45 gm Tube48.73USD tube
Hydrocortisone 2.5% Lotion 59ml Bottle47.47USD bottle
Westcort 0.2% Ointment 45 gm Tube46.97USD tube
Hydrocortisone Valerate 0.2% Cream 60 gm Tube44.99USD tube
Hydrocortisone Valerate 0.2% Cream 45 gm Tube33.99USD tube
Ala Scalp 2% Lotion 29.6ml Bottle30.99USD bottle
Hydrocortisone Valerate 0.2% Ointment 15 gm Tube30.56USD tube
Westcort 0.2% Cream 15 gm Tube25.99USD tube
Hydrocortisone Valerate 0.2% Cream 15 gm Tube19.99USD tube
Cortisporin eye drops19.74USD ml
Solu-Cortef 1 g/vial17.55USD vial
Hydrocortisone 1% Lotion 118ml Bottle15.99USD bottle
Hydrocortisone Acetate 12 25 mg Suppository Box15.01USD box
Hydrocortisone 2.5% Ointment 28.35 gm Tube13.68USD tube
Hydrocortisone 2.5% Cream 30 gm Tube13.67USD tube
Colocort 100 mg/60ml Enema 60ml Bottle13.15USD bottle
Hydrocortisone 100 mg/60ml Enema 60ml Bottle12.6USD bottle
Hydrocortisone 0.5% Cream 28.35 gm Tube11.99USD tube
Hydrocortisone 1% Cream 15 gm Tube11.99USD tube
Hydrocortisone 1% Cream 28 gm Tube11.99USD tube
Hydrocortisone Acetate 1-1% Ointment 30 gm Tube11.99USD tube
Solu-Cortef 500 mg/vial10.47USD vial
Hydrocortisone hemisucc powder9.9USD g
Cortifoam 10% aerosol9.35USD g
Hydrocortisone Sod. Succinate 1 g/vial9.01USD vial
Solu-cortef (pf) 250 mg vial8.58USD vial
Cortisporin-tc ear susp8.3USD ml
Cortisporin ear suspension7.86USD ml
Solu-Cortef 250 mg/vial7.05USD vial
Cortenema (100 mg/60Ml) 100 mg/enm Enema6.96USD enema
Proctofoam-hc foam6.77USD g
Cortifoam 10 % Foam6.14USD g
Hycort (100 mg/60Ml) 100 mg/enm Enema5.79USD enema
Cortamed 2.5 % Ointment5.67USD g
Hydrocortisone Sod. Succinate 500 mg/vial5.34USD vial
Hydrocortisone powder5.19USD g
Solu-cortef (pf) 100 mg vial4.85USD vial
Solu-cortef 100 mg vial4.63USD vial
Proctocort 1% cream4.37USD g
Pandel 0.1% cream4.34USD g
Locoid 0.1% lipocream4.3USD g
Solu-Cortef 100 mg/vial4.07USD vial
Locoid 0.1% cream3.92USD g
Hydrocortisone Sod. Succinate 250 mg/vial3.56USD vial
Hydrocortisone ss 250 mg vial3.5USD vial
Anusol-hc 2.5% cream3.45USD g
Hydrocortisone acet powder3.15USD g
Proctofoam2.89USD g
A-hydrocort 100 mg vial2.42USD each
Proctocream-hc 2.5% cream2.17USD g
Hydrocortisone Sod. Succinate 100 mg/vial2.1USD vial
Hydrocortisone val 0.2% cream2.07USD g
Hytone 2.5% cream1.46USD g
Hydrocortisone buty 0.1% cream1.31USD g
First hydrocort 10% gel1.18USD g
Westcort 0.2% cream1.17USD g
Procto-kit 1% cream1.08USD g
Ala-scalp hp 2% lotion1.03USD ml
Cortef 20 mg tablet0.9USD tablet
Proctosol-hc 2.5% cream0.89USD g
Proctozone-hc 2.5% cream0.83USD g
Orabase plain paste0.77USD g
Hydrocortisone 2.5% lotion0.6USD ml
Cortef 10 mg tablet0.55USD tablet
Orabase-b 20% gel0.55USD g
Hydrocortisone 2.5% cream0.53USD g
Hydrocortisone 10 mg tablet0.52USD tablet
Cortef 5 mg tablet0.45USD tablet
Ala-cort 1% cream0.43USD g
Hydrocortisone 5 mg tablet0.38USD tablet
Corticaine 0.5% cream0.37USD g
Hydrocortisone 20 mg tablet0.32USD tablet
Prevex Hc 1 % Occlusive Cream0.3USD g
Emo-Cort 2.5 % Cream0.26USD g
Preparation h 1% cream0.24USD g
Tucks hydrocortisone ointment0.24USD g
Emo-Cort 2.5 % Lotion0.23USD g
Emo-Cort Scalp 2.5 % Lotion0.22USD g
Colocort 100 mg enema0.21USD ml
Cortenema 100 mg enema0.21USD ml
Sarna Hc 2.5 % Lotion0.2USD g
Emo-Cort 1 % Cream0.19USD g
Balneol lotion0.18USD ml
Emo-Cort 1 % Lotion0.18USD g
Lanacort 1% cool creme0.18USD g
Hyderm 0.5 % Cream0.18USD g
Hytone 1% cream0.17USD g
Cortoderm Mild 0.5 % Ointment0.15USD g
Beta hc 1% lotion0.14USD ml
Cortizone-10 1% spray0.14USD ml
Hydroval 0.2 % Cream0.13USD g
Hydroval 0.2 % Ointment0.13USD g
Aquanil hc 1% lotion0.12USD ml
Hydrocortisone plus 12 1% crm0.12USD g
Scalpicin 3% liquid0.12USD ml
Slender cortisol capsule0.12USD capsule
Cortaid 1% spray0.1USD ml
Sarna Hc 1 % Lotion0.1USD g
Hydrocortisone 0.5% cream0.08USD g
Hydrocortisone 1% cream0.08USD g
Uniderm moisturizer0.05USD ml
Cortoderm Regular 1 % Ointment0.04USD g
Hyderm 1 % Cream0.04USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5635497No1994-06-032014-06-03Us
US7378405No2006-12-192026-12-19Us
US7981877No2005-01-232025-01-23Us
USRE39264No1996-08-022016-08-02Us
US6514980No1999-01-242019-01-24Us
US7223387No2001-07-242021-07-24Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)220 °CPhysProp
water solubility320 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.61HANSCH,C ET AL. (1995)
logS-2.97ADME Research, USCD
Caco2 permeability-4.66ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.199 mg/mLALOGPS
logP1.79ALOGPS
logP1.28ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)12.59ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.83 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity97.4 m3·mol-1ChemAxon
Polarizability39.45 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9918
Blood Brain Barrier+0.9383
Caco-2 permeable-0.5096
P-glycoprotein substrateSubstrate0.7861
P-glycoprotein inhibitor INon-inhibitor0.7847
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterNon-inhibitor0.7463
CYP450 2C9 substrateNon-substrate0.8496
CYP450 2D6 substrateNon-substrate0.9138
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9406
CYP450 2C9 inhibitorNon-inhibitor0.9072
CYP450 2D6 inhibitorNon-inhibitor0.9418
CYP450 2C19 inhibitorNon-inhibitor0.9253
CYP450 3A4 inhibitorNon-inhibitor0.8902
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9095
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9597
BiodegradationNot ready biodegradable0.925
Rat acute toxicity1.8914 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.95
hERG inhibition (predictor II)Non-inhibitor0.584
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (2.96 KB)
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (2 MEOX; 3 TMS)GC-MSsplash10-0f7o-3930000000-b7b43b2fc9f20acfd20b
GC-MS Spectrum - GC-MSGC-MSsplash10-0f7o-3930000000-b7b43b2fc9f20acfd20b
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-052f-2910000000-2625335a031486ecb302
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-IT , negativeLC-MS/MSsplash10-015a-0189000000-61afe49a8d4a96aae3f9
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-00lu-0149000000-b95a11b27f7e7d44dd51
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-001l-0019000000-4c4924e6ac472ad52886
MS/MS Spectrum - , negativeLC-MS/MSsplash10-001j-0259000000-fda4e876e9ef04015946
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-03di-0009000000-cc8188e19dbdd6210b77
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-07r1-1985000000-b6d756bd554367393be3
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-00dj-1930000000-120dc8893cc4709c1f6b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-00dm-2910000000-d1f01e1bce5fe0108f40
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-05tf-3900000000-4ffd79c22013fe5479b6
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-054o-4900000000-fdbed869a0cadc21b64b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-002f-7900000000-dac7b2c5b3f8e8b85086
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-016u-7900000000-3a770c3819f82ea45841
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-016r-9800000000-d261cf7141fbf30715f5
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-056r-0289000000-9a48511b5c3d5fa404e9
MS/MS Spectrum - , positiveLC-MS/MSsplash10-03di-0759000000-b337a46ecfd6de91776b
MS/MS Spectrum - , positiveLC-MS/MSsplash10-05fs-3940000000-2bf712a915c3a2c100a2

Taxonomy

Description
This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Hydroxysteroids
Direct Parent
21-hydroxysteroids
Alternative Parents
Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 3-oxo delta-4-steroids / 17-hydroxysteroids / 11-beta-hydroxysteroids / Delta-4-steroids / Cyclohexenones / Tertiary alcohols / Alpha-hydroxy ketones / Secondary alcohols
show 4 more
Substituents
Progestogin-skeleton / 21-hydroxysteroid / 20-oxosteroid / Pregnane-skeleton / 3-oxo-delta-4-steroid / 3-oxosteroid / Oxosteroid / 11-beta-hydroxysteroid / 11-hydroxysteroid / 17-hydroxysteroid
show 16 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
3-oxo steroid, 11beta-hydroxy steroid, 17alpha-hydroxy steroid, glucocorticoid, 20-oxo steroid, 21-hydroxy steroid, C21-steroid (CHEBI:17650) / Pregnane and derivatives [Fig], Glucocorticoids, C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives (C00735) / C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030001)

Targets

Details
1. Glucocorticoid receptor
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name
NR3C1
Uniprot ID
P04150
Uniprot Name
Glucocorticoid receptor
Molecular Weight
85658.57 Da
References
  1. Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS: Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006 Jul;1071:410-21. [PubMed:16891588]
  2. Rautanen A, Eriksson JG, Kere J, Andersson S, Osmond C, Tienari P, Sairanen H, Barker DJ, Phillips DI, Forsen T, Kajantie E: Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene. J Clin Endocrinol Metab. 2006 Nov;91(11):4544-51. Epub 2006 Aug 8. [PubMed:16895953]
  3. Hammer F, Stewart PM: Cortisol metabolism in hypertension. Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):337-53. [PubMed:16980198]
  4. Shaw JR, Gabor K, Hand E, Lankowski A, Durant L, Thibodeau R, Stanton CR, Barnaby R, Coutermarsh B, Karlson KH, Sato JD, Hamilton JW, Stanton BA: Role of glucocorticoid receptor in acclimation of killifish (Fundulus heteroclitus) to seawater and effects of arsenic. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R1052-60. Epub 2006 Oct 12. [PubMed:17038445]
  5. Sher L: Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior. ScientificWorldJournal. 2006 Oct 31;6:1398-404. [PubMed:17086345]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Structural molecule activity
Specific Function
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Play...
Gene Name
ANXA1
Uniprot ID
P04083
Uniprot Name
Annexin A1
Molecular Weight
38713.855 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Sato-Matsumura KC, Matsumura T, Nakamura H, Sawa H, Nagashima K, Koizumi H: Membrane expression of annexin I is enhanced by calcium and TPA in cultured human keratinocytes. Arch Dermatol Res. 2000 Oct;292(10):496-9. [PubMed:11142771]
  4. White MV, Igarashi Y, Lundgren JD, Shelhamer J, Kaliner M: Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. J Immunol. 1991 Jul 15;147(2):667-73. [PubMed:1712816]
  5. Serres M, Viac J, Comera C, Schmitt D: Expression of annexin I in freshly isolated human epidermal cells and in cultured keratinocytes. Arch Dermatol Res. 1994;286(5):268-72. [PubMed:8060156]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Steroid binding
Specific Function
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation...
Gene Name
HSD11B2
Uniprot ID
P80365
Uniprot Name
Corticosteroid 11-beta-dehydrogenase isozyme 2
Molecular Weight
44126.06 Da
References
  1. Furstenberger C, Vuorinen A, Da Cunha T, Kratschmar DV, Saugy M, Schuster D, Odermatt A: The anabolic androgenic steroid fluoxymesterone inhibits 11beta-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicol Sci. 2012 Apr;126(2):353-61. doi: 10.1093/toxsci/kfs022. Epub 2012 Jan 23. [PubMed:22273746]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Steroid delta-isomerase activity
Specific Function
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system pl...
Gene Name
HSD3B1
Uniprot ID
P14060
Uniprot Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
Molecular Weight
42251.25 Da
References
  1. Bhatia C, Oerum S, Bray J, Kavanagh KL, Shafqat N, Yue W, Oppermann U: Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chem Biol Interact. 2015 Jun 5;234:114-25. doi: 10.1016/j.cbi.2014.12.013. Epub 2014 Dec 16. [PubMed:25526675]

Enzymes

Details
1. Cytochrome P450 3A4
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochro...
Gene Name
CYP11B1
Uniprot ID
P15538
Uniprot Name
Cytochrome P450 11B1, mitochondrial
Molecular Weight
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
Gene Name
CYP11B2
Uniprot ID
P19099
Uniprot Name
Cytochrome P450 11B2, mitochondrial
Molecular Weight
57559.62 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Bauersachs J, Christ M, Ertl G, Michaelis UR, Fisslthaler B, Busse R, Fleming I: Cytochrome P450 2C expression and EDHF-mediated relaxation in porcine coronary arteries is increased by cortisol. Cardiovasc Res. 2002 Jun;54(3):669-75. [PubMed:12031713]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Androgen binding
Specific Function
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone...
Gene Name
SHBG
Uniprot ID
P04278
Uniprot Name
Sex hormone-binding globulin
Molecular Weight
43778.755 Da
References
  1. Khoromi S, Muniyappa R, Nackers L, Gray N, Baldwin H, Wong KA, Matheny LA, Moquin B, Rainer A, Hill S, Remaley A, Johnson LL, Max MB, Blackman MR: Effects of chronic osteoarthritis pain on neuroendocrine function in men. J Clin Endocrinol Metab. 2006 Nov;91(11):4313-8. Epub 2006 Aug 15. [PubMed:16912126]
  2. Stroud LR, Solomon C, Shenassa E, Papandonatos G, Niaura R, Lipsitt LP, Lewinn K, Buka SL: Long-term stability of maternal prenatal steroid hormones from the National Collaborative Perinatal Project: still valid after all these years. Psychoneuroendocrinology. 2007 Feb;32(2):140-50. Epub 2007 Jan 31. [PubMed:17270355]
  3. Lombardi G, Mondaini N, Macchiarella A, Del Popolo G: Female sexual dysfunction and hormonal status in spinal cord injured (SCI) patients. J Androl. 2007 Sep-Oct;28(5):722-6. Epub 2007 May 9. [PubMed:17494102]
  4. Shifren JL, Desindes S, McIlwain M, Doros G, Mazer NA: A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. Menopause. 2007 Nov-Dec;14(6):985-94. [PubMed:17507833]
  5. Rizzo L, Dobrovsky V, Danilowicz K, Kral M, Cross G, Serra HA, Bruno OD: Low-dose glucocorticoids in hyperandrogenism. Medicina (B Aires). 2007;67(3):247-52. [PubMed:17628912]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Steroid binding
Specific Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name
SERPINA6
Uniprot ID
P08185
Uniprot Name
Corticosteroid-binding globulin
Molecular Weight
45140.49 Da
References
  1. Henley DE, Lightman SL: New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience. 2011 Apr 28;180:1-8. doi: 10.1016/j.neuroscience.2011.02.053. Epub 2011 Mar 1. [PubMed:21371536]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389]
  2. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. [PubMed:10213372]
  3. Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924]
  4. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R: Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 1992 Dec 5;267(34):24248-52. [PubMed:1360010]
  5. Orlowski S, Mir LM, Belehradek J Jr, Garrigos M: Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J. 1996 Jul 15;317 ( Pt 2):515-22. [PubMed:8713080]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both fro...
Gene Name
ABCG2
Uniprot ID
Q9UNQ0
Uniprot Name
ATP-binding cassette sub-family G member 2
Molecular Weight
72313.47 Da
References
  1. Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. [PubMed:12920197]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibit...
Gene Name
SLCO1A2
Uniprot ID
P46721
Uniprot Name
Solute carrier organic anion transporter family member 1A2
Molecular Weight
74144.105 Da
References
  1. Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. [PubMed:8779893]
  2. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Curator comments
Cortisol demonstrated substrate activity in vitro using human OAT3 expressed on Xenopus Laevis.
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenad...
Gene Name
SLC22A8
Uniprot ID
Q8TCC7
Uniprot Name
Solute carrier family 22 member 8
Molecular Weight
59855.585 Da
References
  1. VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos. 2010 Jan;31(1):1-71. doi: 10.1002/bdd.693. [PubMed:19953504]

Drug created on June 13, 2005 07:24 / Updated on October 16, 2018 08:30