Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1).
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Cryle MJ, De Voss JJ
Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1).
Chem Commun (Camb). 2004 Jan 7;(1):86-7. Epub 2003 Nov 17.
- PubMed ID
- 14737344 [ View in PubMed]
- Abstract
Cytochrome p450(BioI)(CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional p450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.