Identification of a novel HLA-DQB1*06 allele, DQB1*0618.
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Casamitjana N, Gil J, Campos E, Santos M, Nogues N, Ribera A, Palou E
Identification of a novel HLA-DQB1*06 allele, DQB1*0618.
Tissue Antigens. 2001 Oct;58(4):269-71.
- PubMed ID
- 11782280 [ View in PubMed]
- Abstract
We report here the identification of a novel DQB1*06 allele, DQB1*0618, found in a bone marrow donor. The new allele was detected during routine DNA-based HLA typing by an ambiguous pattern of probe hybridization, obtained by polymerase chain reaction using sequence-specific oligonucleotides (PCR-SSO). Molecular cloning and sequencing confirmed that the new allele is identical to DQB1*0609 at exon 2 except for 3 nucleotide substitutions at positions 353, 356 and 367, also found in other alleles. These nucleotide changes may explain its anomalous reactivity.