Novel alleles at the HLA-DRB1 and -DQB1 loci.
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Lazaro AM, Xiao Y, Masaberg C, Lebeck L, Ng J, Hurley CK, Posch PE
Novel alleles at the HLA-DRB1 and -DQB1 loci.
Tissue Antigens. 2008 Jul;72(1):72-4. doi: 10.1111/j.1399-0039.2008.01070.x.
- PubMed ID
- 18588576 [ View in PubMed]
- Abstract
Twelve novel human leukocyte antigen class II alleles are described; eight DRB1 alleles and four DQB1 alleles. Nine of the variants are single nucleotide substitutions from their most homologous allele, of which six result in amino acid changes (DRB1*0459, *1156 and *1522; DQB1*0205, *0320 and *0321) and three are silent substitutions (DRB1*030105 and *040304, and DQB1*030104). The remaining alleles (DRB1*0906, *1464 and *1468) differ from their most similar alleles by two to three nucleotide substitutions which alter one to two amino acids.