Identification of two novel HLA class II alleles, DQB1*0311 and DQB1*0620.
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Hogbin JP, Greville W, Chapman G, Kennedy A, Velickovic ZM, Dunckley H
Identification of two novel HLA class II alleles, DQB1*0311 and DQB1*0620.
Tissue Antigens. 2004 Oct;64(4):515-7.
- PubMed ID
- 15361133 [ View in PubMed]
- Abstract
Two novel HLA class II alleles have been identified in routine typing of a kidney transplant patient and a cord blood unit from the Australian Cord Blood Bank in Sydney. Sequence analysis of exon 2 of the DQB1 genes revealed the novel polymorphism. A substitution of A to C at nucleotide position 136 has been identified for the DQB1*0311 allele when compared to the closest-matched allele, DQB1*030201. An identical substitution has also been identified for the DQB1*0620 allele when compared to the closest-matched allele, DQB1*0602. The substitution results in an amino acid change from methionine to leucine at position 46 implicating different specificity and affinity of antigen binding.