SUMOylation of RORalpha potentiates transcriptional activation function.
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Hwang EJ, Lee JM, Jeong J, Park JH, Yang Y, Lim JS, Kim JH, Baek SH, Kim KI
SUMOylation of RORalpha potentiates transcriptional activation function.
Biochem Biophys Res Commun. 2009 Jan 16;378(3):513-7. doi: 10.1016/j.bbrc.2008.11.072. Epub 2008 Nov 28.
- PubMed ID
- 19041634 [ View in PubMed]
- Abstract
SUMOylation regulates a variety of cellular processes, including control of transcriptional activities of nuclear receptors. Here, we present SUMOylation of orphan nuclear receptor, RORalpha by both SUMO-1 and SUMO-2. SUMOylation of RORalpha occurred on the 240th lysine residue at the hinge region of human protein. PIAS family members, PIASxalpha, PIAS3, and PIASy, increased SUMOylation of RORalpha, whereas SENP2 specifically removed SUMO from RORalpha. SUMOylation-defective mutant form of RORalpha exhibited decreased transcriptional activity on RORalpha-responsive promoters indicating that SUMOylation may positively regulate transcriptional function of RORalpha.