A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1.
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Banfi B, Maturana A, Jaconi S, Arnaudeau S, Laforge T, Sinha B, Ligeti E, Demaurex N, Krause KH
A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1.
Science. 2000 Jan 7;287(5450):138-42.
- PubMed ID
- 10615049 [ View in PubMed]
- Abstract
Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).