The fumarate reductase system as a site of anthelmintic attack in Ascaris suum.

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Barrowman MM, Marriner SE, Bogan JA

The fumarate reductase system as a site of anthelmintic attack in Ascaris suum.

Biosci Rep. 1984 Oct;4(10):879-83.

PubMed ID

6518278 [ View in PubMed

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Abstract

Various benzimidazole compounds have been shown to be highly effective as inhibitors (up to 50% reduction of activity) in vitro of the helminth-specific enzyme, fumarate reductase, of Ascaris suum. Anthelmintically active and inactive benzimidazoles were similarly effective as inhibitors of enzyme activity. Albendazole-induced inhibition of fumarate reductase was not observed when the enzyme was preincubated with NADH.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Albendazole	Fumarate reductase flavoprotein subunit	Protein	Shewanella oneidensis (strain MR-1)	Unknown	Inhibitor	Details