[Effect of sulpiride on immobility reflex and pinch-induced catalepsy in CBA/Lac male mice with various social status].

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Lipina TV, Vishnivetskaia GB

[Effect of sulpiride on immobility reflex and pinch-induced catalepsy in CBA/Lac male mice with various social status].

Zh Vyssh Nerv Deiat Im I P Pavlova. 2009 Jul-Aug;59(4):482-7.

PubMed ID

19795811 [ View in PubMed

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Abstract

This study was aimed to determine the effect of D2/D3 receptor antagonist sulpiride on the expression of immobility reflex ("pinch-test") and pinch-induced catalepsy ("bar-test") of CBA/Lac male mice depending on their social status ("aggressors" with repeated experience of victories or a "losers" with repeated experience of social defeats). Sulpiride (20 mg/kg, i.p.) was acutely administered to "aggressors" and "losers" after 10 and 20 daily social contacts (victories or social defeats) and to a control group of male mice. Repeated experience of social victories and defeats altered the immobility duration in both tests and modified the expression of the sulpiride effect. In the pinch-tets, the duration of immobility was longer in "loosers" than in "aggressors". In the bar-test, the pinch-induced catalepsy was more expressed in "losers" and "aggressors" as compared to control. Sulpiride was more effective in increasing immobility of"aggressors" and had a weaker effect on the control and "losers". Therefore, the effect of sulpiride is affected by the social status of the animals.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Sulpiride	Dopamine D3 receptor	Protein	Humans	Unknown	Antagonist	Details