Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions.
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Liao WS, Hamilton RW, Taylor JM
Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions.
J Biol Chem. 1980 Sep 10;255(17):8046-9.
- PubMed ID
- 6157681 [ View in PubMed]
- Abstract
The nucleotide sequence of the 3'-terminal untranslated region and a portion of the coding region of rat alpha-fetoprotein mRNA has been determined from a cloned double-stranded cDNA. the amino acid sequence of the COOH-terminal portion of alpha-fetoprotein was inferred from the nucleotide sequence and compared to the amino acid sequence of the corresponding portion of rat, bovine, and human albumin. A striking homology in amino acid sequence between alpha-fetoprotein and albumin was observed. These results confirm earlier suggestions that the two proteins are closely related in structure and probably arose from a common ancestral gene.