Analytical and functional determination of polymyxin B protein binding in serum.

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Abodakpi H, Gohlke J, Chang KT, Chow DS, Tam VH

Analytical and functional determination of polymyxin B protein binding in serum.

Antimicrob Agents Chemother. 2015 Nov;59(11):7121-3. doi: 10.1128/AAC.01815-15. Epub 2015 Aug 31.

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26324262 [ View in PubMed
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Abstract

To enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin B1 was evaluated. Using equilibrium dialysis and ultrafiltration, comparable protein binding was found in all 4 components of polymyxin B (92% to 99%). Protein binding in human serum was further assessed using a functional assay, the results of which were in general agreement with previous findings (approximately 90%).

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