Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application.

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Wachter SB, Gilbert EM

Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application.

Cardiology. 2012;122(2):104-12. doi: 10.1159/000339271. Epub 2012 Jul 3.

PubMed ID
22759389 [ View in PubMed
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Abstract

beta-Adrenergic receptors (beta-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical beta-blocker trials beta-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of beta-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways.

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