Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver.

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Sidorova YA, Grishanova AY

Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver.

Bull Exp Biol Med. 2004 Mar;137(3):231-4. doi: 10.1023/b:bebm.0000031556.47763.04.

PubMed ID

15232626 [ View in PubMed

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Abstract

We studied the effect of synthetic vitamin K analogue menadione on enzymes of xenobiotic metabolism in rat liver (total content of cytochrome P450 and catalytic activities of CYP1A1/2, CYP2B1, CYP2C, NADPH-cytochrome P450 reductase, and glutathione S-transferase). Menadione induced phase I and II enzymes for metabolism of xenobiotics, drugs, and procarcinogens. The effect of menadione depended on its dose and duration of treatment.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Menadione	Cytochrome P450 1A1	Protein	Humans	Unknown	Inhibitor Inducer	Details