Inhibition of theophylline clearance by troleandomycin.
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Weinberger M, Hudgel D, Spector S, Chidsey C
Inhibition of theophylline clearance by troleandomycin.
J Allergy Clin Immunol. 1977 Mar;59(3):228-31.
- PubMed ID
- 300083 [ View in PubMed]
- Abstract
The effect of troleandomycin, a macrolide antibiotic, on theophylline elimination was examined in eight patients with chronic asthma. Clearance from serum was reduced by 50 +/- 6% (mean +/- SD) during administration of 250 mg troleandomycin four times daily. Reduction of clearance persisted to a lesser degree in one of these patients examined while receiving 250 mg troleandomycin daily. An increase in serum theophylline concentration can thus result from initiating troleandomycin in asthmatic patients receiving continuous treatment with theophylline. This may be at least a partial explanation for the apparent benefit of troleandomycin in chronic asthma and also suggests that possibility of inducing theophylline toxicity, including seizures, as was observed in one of the patients in this study.
DrugBank Data that Cites this Article
- Drugs
- Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAminophyllineTylvalosin The metabolism of Aminophylline can be decreased when combined with Tylvalosin. AminophyllineJosamycin The metabolism of Aminophylline can be decreased when combined with Josamycin. AminophyllineSirolimus The metabolism of Aminophylline can be decreased when combined with Sirolimus. AminophyllineEverolimus The metabolism of Aminophylline can be decreased when combined with Everolimus. AminophyllineTemsirolimus The metabolism of Aminophylline can be decreased when combined with Temsirolimus.