Molecular and cellular mechanisms of general anaesthesia.
Article Details
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Franks NP, Lieb WR
Molecular and cellular mechanisms of general anaesthesia.
Nature. 1994 Feb 17;367(6464):607-14. doi: 10.1038/367607a0.
- PubMed ID
- 7509043 [ View in PubMed]
- Abstract
General anaesthetics are much more selective than is usually appreciated and may act by binding to only a small number of targets in the central nervous system. At surgical concentrations their principal effects are on ligand-gated (rather than voltage-gated) ion channels, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia. Although the role of second messengers remains uncertain, it is now clear that anaesthetics act directly on proteins rather than on lipids.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Sevoflurane Calcium transporting ATPases (Protein Group) Protein group Humans YesInhibitorDetails Sevoflurane GABA(A) Receptor (Protein Group) Protein group Humans YesAgonistDetails Sevoflurane Glutamate receptor 1 Protein Humans YesAntagonistDetails Sevoflurane Glycine receptor subunit alpha-1 Protein Humans YesAgonistDetails