Regulation of protein kinase cascades by protein phosphatase 2A.
Article Details
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Millward TA, Zolnierowicz S, Hemmings BA
Regulation of protein kinase cascades by protein phosphatase 2A.
Trends Biochem Sci. 1999 May;24(5):186-91. doi: 10.1016/s0968-0004(99)01375-4.
- PubMed ID
- 10322434 [ View in PubMed]
- Abstract
Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases are transiently phosphorylated and activated. Several of these protein kinases are substrates for protein phosphatase 2A (PP2A), and PP2A appears to be the major kinase phosphatase in eukaryotic cells that downregulates activated protein kinases. This idea is substantiated by the observation that some viral proteins and naturally occurring toxins target PP2A and modulate its activity. There is increasing evidence that PP2A activity is regulated by extracellular signals and during the cell cycle. Thus, PP2A is likely to play an important role in determining the activation kinetics of protein kinase cascades.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Vitamin E Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Protein Humans UnknownNot Available Details Vitamin E Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Protein Humans UnknownNot Available Details