Nitrofurantoin

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Squadrito FJ, del Portal D

Nitrofurantoin

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PubMed ID
29262089 [ View in PubMed
]
Abstract

Nitrofurantoin is an antibiotic medication that is used for the treatment of uncomplicated lower urinary tract infection. It is effective against most gram-positive and gram-negative organisms. Nitrofurantoin was approved by the FDA in 1953 for treatment of lower urinary tract infection. Nitrofurantoin is a synthetic antimicrobial created from furan and an added nitro group and a side change containing hydantoin. Nitrofurantoin was widely used the for treatment of lower urinary tract infections until the 1970s when trimethoprim-sulfamethoxazole and newer beta-lactam antibiotics became available. More recently, several major guidelines have declared nitrofurantoin as the first-line therapy for treatment of uncomplicated lower urinary tract infections. Increasing resistance to newer antibiotics coinciding with increasing prevalence of extended-spectrum beta-lactamase (ESBL) producing bacteria has led to a resurgence in use of nitrofurantoin.[1][2][3][4][5]

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Nitrofurantoin30S ribosomal protein S10ProteinEscherichia coli (strain K12)
Unknown
Inhibitor
Details