Ticagrelor Removal From Human Blood.

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Angheloiu GO, Gugiu GB, Ruse C, Pandey R, Dasari RR, Whatling C

Ticagrelor Removal From Human Blood.

JACC Basic Transl Sci. 2017 Apr 24;2(2):135-145. doi: 10.1016/j.jacbts.2017.01.007. eCollection 2017 Apr.

PubMed ID

30167561 [ View in PubMed

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Abstract

The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples.

DrugBank Data that Cites this Article

Drugs

Ticagrelor

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Ticagrelor	Serum albumin	Protein	Humans	Unknown	Binder	Details