Serum albumin

Details

Name
Serum albumin
Synonyms
  • Serum albumin precursor
Gene Name
ALB
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001058|Serum albumin
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
Number of residues
609
Molecular Weight
69365.94
Theoretical pI
6.21
GO Classification
Functions
antioxidant activity / chaperone binding / copper ion binding / DNA binding / drug binding / fatty acid binding / pyridoxal phosphate binding / toxic substance binding
Processes
bile acid and bile salt transport / bile acid metabolic process / blood coagulation / cellular response to starvation / hemolysis by symbiont of host erythrocytes / lipoprotein metabolic process / maintenance of mitochondrion location / negative regulation of apoptotic process / negative regulation of programmed cell death / platelet activation / platelet degranulation / receptor-mediated endocytosis / retina homeostasis / small molecule metabolic process / sodium-independent organic anion transport / transmembrane transport / transport
Components
blood microparticle / endoplasmic reticulum / extracellular exosome / extracellular region / extracellular space / Golgi apparatus / myelin sheath / nucleus / platelet alpha granule lumen / protein complex
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010372|Serum albumin (ALB)
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GAGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCCTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTATTAGTTCGTTACACCAAGAAAGTACCC
CAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCAGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA
Chromosome Location
4
Locus
4q11-q13
External Identifiers
ResourceLink
UniProtKB IDP02768
UniProtKB Entry NameALBU_HUMAN
GenBank Protein ID28590
GenBank Gene IDV00494
GenAtlas IDALB
HGNC IDHGNC:399
General References
  1. Lawn RM, Adelman J, Bock SC, Franke AE, Houck CM, Najarian RC, Seeburg PH, Wion KL: The sequence of human serum albumin cDNA and its expression in E. coli. Nucleic Acids Res. 1981 Nov 25;9(22):6103-114. [PubMed:6171778]
  2. Dugaiczyk A, Law SW, Dennison OE: Nucleotide sequence and the encoded amino acids of human serum albumin mRNA. Proc Natl Acad Sci U S A. 1982 Jan;79(1):71-5. [PubMed:6275391]
  3. Minghetti PP, Ruffner DE, Kuang WJ, Dennison OE, Hawkins JW, Beattie WG, Dugaiczyk A: Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4. J Biol Chem. 1986 May 25;261(15):6747-57. [PubMed:3009475]
  4. Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y, Wan J, Ouyang S, Li L, Zhang S, Zhou K, Zhang Y, Wu C, He F: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. Genome Res. 2001 Aug;11(8):1392-403. [PubMed:11483580]
  5. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005]
  6. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621]
  7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334]
  8. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309]
  9. Urano Y, Watanabe K, Sakai M, Tamaoki T: The human albumin gene. Characterization of the 5' and 3' flanking regions and the polymorphic gene transcripts. J Biol Chem. 1986 Mar 5;261(7):3244-51. [PubMed:2419329]
  10. Meloun B, Moravek L, Kostka V: Complete amino acid sequence of human serum albumin. FEBS Lett. 1975 Oct 15;58(1):134-7. [PubMed:1225573]
  11. Corbett JM, Wheeler CH, Baker CS, Yacoub MH, Dunn MJ: The human myocardial two-dimensional gel protein database: update 1994. Electrophoresis. 1994 Nov;15(11):1459-65. [PubMed:7895732]
  12. Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed:12665801]
  13. Mogard MH, Kobayashi R, Chen CF, Lee TD, Reeve JR Jr, Shively JE, Walsh JH: The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8. [PubMed:3087352]
  14. Carraway RE, Mitra SP, Cochrane DE: Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s). J Biol Chem. 1987 May 5;262(13):5968-73. [PubMed:2437111]
  15. Walker JE: Lysine residue 199 of human serum albumin is modified by acetylsalicyclic acid. FEBS Lett. 1976 Jul 15;66(2):173-5. [PubMed:955075]
  16. Lapolla A, Fedele D, Reitano R, Arico NC, Seraglia R, Traldi P, Marotta E, Tonani R: Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides. J Am Soc Mass Spectrom. 2004 Apr;15(4):496-509. [PubMed:15047055]
  17. Jacobsen C: Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin. Biochem J. 1978 May 1;171(2):453-9. [PubMed:656055]
  18. Garlick RL, Mazer JS: The principal site of nonenzymatic glycosylation of human serum albumin in vivo. J Biol Chem. 1983 May 25;258(10):6142-6. [PubMed:6853480]
  19. Shaklai N, Garlick RL, Bunn HF: Nonenzymatic glycosylation of human serum albumin alters its conformation and function. J Biol Chem. 1984 Mar 25;259(6):3812-7. [PubMed:6706980]
  20. Iberg N, Fluckiger R: Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites. J Biol Chem. 1986 Oct 15;261(29):13542-5. [PubMed:3759977]
  21. Watkins S, Madison J, Galliano M, Minchiotti L, Putnam FW: A nucleotide insertion and frameshift cause analbuminemia in an Italian family. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2275-9. [PubMed:8134387]
  22. Lu J, Stewart AJ, Sadler PJ, Pinheiro TJ, Blindauer CA: Albumin as a zinc carrier: properties of its high-affinity zinc-binding site. Biochem Soc Trans. 2008 Dec;36(Pt 6):1317-21. doi: 10.1042/BST0361317. [PubMed:19021548]
  23. Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. Proteomics. 2008 Apr;8(7):1346-61. doi: 10.1002/pmic.200700884. [PubMed:18318008]
  24. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332]
  25. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [PubMed:21269460]
  26. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
  27. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE: A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell. 2015 Jun 18;161(7):1619-32. doi: 10.1016/j.cell.2015.05.028. [PubMed:26091039]
  28. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [PubMed:25944712]
  29. Carter DC, He XM, Munson SH, Twigg PD, Gernert KM, Broom MB, Miller TY: Three-dimensional structure of human serum albumin. Science. 1989 Jun 9;244(4909):1195-8. [PubMed:2727704]
  30. Carter DC, He XM: Structure of human serum albumin. Science. 1990 Jul 20;249(4966):302-3. [PubMed:2374930]
  31. He XM, Carter DC: Atomic structure and chemistry of human serum albumin. Nature. 1992 Jul 16;358(6383):209-15. [PubMed:1630489]
  32. Curry S, Mandelkow H, Brick P, Franks N: Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat Struct Biol. 1998 Sep;5(9):827-35. [PubMed:9731778]
  33. Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K: Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng. 1999 Jun;12(6):439-46. [PubMed:10388840]
  34. Bhattacharya AA, Curry S, Franks NP: Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem. 2000 Dec 8;275(49):38731-8. [PubMed:10940303]
  35. Petitpas I, Grune T, Bhattacharya AA, Curry S: Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. J Mol Biol. 2001 Dec 14;314(5):955-60. [PubMed:11743713]
  36. Brennan SO, Herbert P: Albumin Canterbury (313 Lys----Asn). A point mutation in the second domain of serum albumin. Biochim Biophys Acta. 1987 Apr 8;912(2):191-7. [PubMed:3828358]
  37. Takahashi N, Takahashi Y, Blumberg BS, Putnam FW: Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4413-7. [PubMed:3474609]
  38. Takahashi N, Takahashi Y, Isobe T, Putnam FW, Fujita M, Satoh C, Neel JV: Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8001-5. [PubMed:3479777]
  39. Arai K, Ishioka N, Huss K, Madison J, Putnam FW: Identical structural changes in inherited albumin variants from different populations. Proc Natl Acad Sci U S A. 1989 Jan;86(2):434-8. [PubMed:2911589]
  40. Arai K, Madison J, Huss K, Ishioka N, Satoh C, Fujita M, Neel JV, Sakurabayashi I, Putnam FW: Point substitutions in Japanese alloalbumins. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6092-6. [PubMed:2762316]
  41. Arai K, Madison J, Shimizu A, Putnam FW: Point substitutions in albumin genetic variants from Asia. Proc Natl Acad Sci U S A. 1990 Jan;87(1):497-501. [PubMed:2404284]
  42. Brennan SO, Myles T, Peach RJ, Donaldson D, George PM: Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site. Proc Natl Acad Sci U S A. 1990 Jan;87(1):26-30. [PubMed:2104980]
  43. Galliano M, Minchiotti L, Porta F, Rossi A, Ferri G, Madison J, Watkins S, Putnam FW: Mutations in genetic variants of human serum albumin found in Italy. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8721-5. [PubMed:2247440]
  44. Watkins S, Madison J, Davis E, Sakamoto Y, Galliano M, Minchiotti L, Putnam FW: A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):5959-63. [PubMed:2068071]
  45. Madison J, Arai K, Sakamoto Y, Feld RD, Kyle RA, Watkins S, Davis E, Matsuda Y, Amaki I, Putnam FW: Genetic variants of serum albumin in Americans and Japanese. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9853-7. [PubMed:1946412]
  46. Peach RJ, Brennan SO: Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp----Asn). Biochim Biophys Acta. 1991 Jul 26;1097(1):49-54. [PubMed:1859851]
  47. Minchiotti L, Galliano M, Stoppini M, Ferri G, Crespeau H, Rochu D, Porta F: Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions. Biochim Biophys Acta. 1992 Mar 12;1119(3):232-8. [PubMed:1347703]
  48. Carlson J, Sakamoto Y, Laurell CB, Madison J, Watkins S, Putnam FW: Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8225-9. [PubMed:1518850]
  49. Minchiotti L, Galliano M, Zapponi MC, Tenni R: The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240-->Glu] albumin mutant. Eur J Biochem. 1993 Jun 1;214(2):437-44. [PubMed:8513793]
  50. Brennan SO, Fellowes AP: Albumin Hawkes Bay; a low level variant caused by loss of a sulphydryl group at position 177. Biochim Biophys Acta. 1993 Aug 4;1182(1):46-50. [PubMed:8347685]
  51. Galliano M, Minchiotti L, Iadarola P, Stoppini M, Giagnoni P, Watkins S, Madison J, Putnam FW: Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys). Biochim Biophys Acta. 1993 Nov 25;1225(1):27-32. [PubMed:7902134]
  52. Madison J, Galliano M, Watkins S, Minchiotti L, Porta F, Rossi A, Putnam FW: Genetic variants of human serum albumin in Italy: point mutants and a carboxyl-terminal variant. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6476-80. [PubMed:8022807]
  53. Sunthornthepvarakul T, Angkeow P, Weiss RE, Hayashi Y, Refetoff S: An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. Biochem Biophys Res Commun. 1994 Jul 29;202(2):781-7. [PubMed:8048949]
  54. Rushbrook JI, Becker E, Schussler GC, Divino CM: Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. J Clin Endocrinol Metab. 1995 Feb;80(2):461-7. [PubMed:7852505]
  55. Wada N, Chiba H, Shimizu C, Kijima H, Kubo M, Koike T: A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. J Clin Endocrinol Metab. 1997 Oct;82(10):3246-50. [PubMed:9329347]
  56. Sunthornthepvarakul T, Likitmaskul S, Ngowngarmratana S, Angsusingha K, Kitvitayasak S, Scherberg NH, Refetoff S: Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect. J Clin Endocrinol Metab. 1998 May;83(5):1448-54. [PubMed:9589637]
  57. Spahr CS, Davis MT, McGinley MD, Robinson JH, Bures EJ, Beierle J, Mort J, Courchesne PL, Chen K, Wahl RC, Yu W, Luethy R, Patterson SD: Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry. I. Profiling an unfractionated tryptic digest. Proteomics. 2001 Jan;1(1):93-107. [PubMed:11680902]
  58. Minchiotti L, Campagnoli M, Rossi A, Cosulich ME, Monti M, Pucci P, Kragh-Hansen U, Granel B, Disdier P, Weiller PJ, Galliano M: A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. Eur J Biochem. 2001 Jan;268(2):344-52. [PubMed:11168369]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00070Hyaluronidase (ovine)approved, investigationalunknowninhibitorDetails
DB00137Luteinapproved, investigational, nutraceuticalunknownDetails
DB00459AcitretinapprovedunknownDetails
DB00576Sulfamethizoleapproved, investigational, vet_approvedunknownDetails
DB00743Gadobenic acidapproved, investigationalunknownbinderDetails
DB00815Sodium lauryl sulfateapprovedunknownbinderDetails
DB00936Salicylic acidapproved, investigational, vet_approvednoother/unknownDetails
DB00946Phenprocoumonapproved, investigationalnoDetails
DB00995Auranofinapproved, investigationalunknownDetails
DB01120GliclazideapprovedunknownDetails
DB01328Cefonicidapproved, investigationalnoother/unknownDetails
DB01329Cefoperazoneapproved, investigationalnoother/unknownDetails
DB01396Digitoxinapproved, investigationalnoDetails
DB03017Lauric acidapproved, experimentalunknownDetails
DB03193Stearic acidapproved, experimentalunknownDetails
DB03600Capric acidexperimentalnoDetails
DB03796Palmitic AcidapprovedunknownDetails
DB04224Oleic Acidapproved, investigational, vet_approvedunknownDetails
DB04557Arachidonic AcidexperimentalnoDetails
DB04711IodipamideapprovedunknownbinderDetails
DB06412Oxymetholoneapproved, illicitunknownDetails
DB01197Captoprilapprovednoother/unknownDetails
DB01050IbuprofenapprovednobinderDetails
DB00563MethotrexateapprovednoDetails
DB00451LevothyroxineapprovednoDetails
DB00279Liothyronineapproved, vet_approvedunknownDetails
DB00605Sulindacapproved, investigationalunknownDetails
DB00749Etodolacapproved, investigational, vet_approvedunknownDetails
DB00861Diflunisalapproved, investigationalunknownDetails
DB01009Ketoprofenapproved, vet_approvedunknownDetails
DB00586Diclofenacapproved, vet_approvedunknownDetails
DB00783Estradiolapproved, investigational, vet_approvednoDetails
DB00655EstroneapprovednoDetails
DB00624Testosteroneapproved, investigationalnoother/unknownDetails
DB01307Insulin Detemirapprovednoother/unknownDetails
DB01418Acenocoumarolapproved, investigationalnoDetails
DB00802Alfentanilapproved, illicitunknownDetails
DB00818Propofolapproved, investigational, vet_approvednoDetails
DB00228Enfluraneapproved, investigational, vet_approvedunknownDetails
DB00753Isofluraneapproved, vet_approvedunknownDetails
DB01189DesfluraneapprovedunknownDetails
DB01159Halothaneapproved, vet_approvedunknownDetails
DB01236Sevofluraneapproved, vet_approvedunknownDetails
DB00252Phenytoinapproved, vet_approvedunknownDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownDetails
DB00540NortriptylineapprovednoDetails
DB00321AmitriptylineapprovednoDetails
DB00903Etacrynic acidapproved, investigationalunknownDetails
DB00695Furosemideapproved, vet_approvedunknownDetails
DB00829Diazepamapproved, illicit, investigational, vet_approvednoDetails
DB00682WarfarinapprovednoDetails
DB00554Piroxicamapproved, investigationalunknownDetails
DB00573FenoprofenapprovedunknownDetails
DB00328Indometacinapproved, investigationalunknownDetails
DB03585Oxyphenbutazoneapproved, withdrawnunknownDetails
DB00544FluorouracilapprovednoDetails
DB01232Saquinavirapproved, investigationalunknownDetails
DB01032Probenecidapproved, investigationalnoDetails
DB01044Gatifloxacinapproved, investigationalunknownother/unknownDetails
DB01068Clonazepamapproved, illicitnoDetails
DB01147Cloxacillinapproved, investigational, vet_approvedunknownDetails
DB01327Cefazolinapprovedunknownother/unknownDetails
DB00931Metacyclineapproved, investigationalnoDetails
DB01015SulfamethoxazoleapprovednoDetails
DB00415Ampicillinapproved, vet_approvednoother/unknownDetails
DB00567Cephalexinapproved, investigational, vet_approvednoother/unknownDetails
DB00759Tetracyclineapproved, vet_approvednoDetails
DB01212Ceftriaxoneapprovednoother/unknownDetails
DB01330CefotetanapprovednoDetails
DB00274Cefmetazoleapproved, investigationalnoDetails
DB00495ZidovudineapprovednoDetails
DB01397Magnesium salicylateexperimentalnoDetails
DB00788Naproxenapproved, vet_approvednoDetails
DB00334Olanzapineapproved, investigationalnobinderDetails
DB01056Tocainideapprovednoother/unknownDetails
DB01320Fosphenytoinapproved, investigationalnoother/unknownDetails
DB00712Flurbiprofenapproved, investigationalnoother/unknownDetails
DB07402AzapropazonewithdrawnunknownDetails
DB075173-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONICexperimentalunknownDetails
DB079923-SULFOOXY-1H-INDOLEexperimentalunknownDetails
DB08231Myristic acidexperimentalunknownDetails
DB08496(R)-warfarinexperimentalunknownDetails
DB08735R,S-Warfarin alcoholexperimentalunknownDetails
DB08736S,R-Warfarin alcoholexperimentalunknownDetails
DB00430CefpiramideapprovedunknownDetails
DB01583LiotrixapprovedunknownDetails
DB01294Bismuth subsalicylateapproved, vet_approvedunknownbinderDetails
DB00456Cefalotinapproved, investigational, vet_approvedunknownbinderDetails
DB01581Sulfamerazineapproved, vet_approvedunknownDetails
DB01582Sulfamethazineapproved, investigational, vet_approvedunknownDetails
DB01587KetazolamapprovedunknownDetails
DB01614Acepromazineexperimental, vet_approvedunknownDetails
DB01621Pipotiazineapproved, investigationalunknownDetails
DB04574Estrone sulfateapprovedunknownDetails
DB06710MethyltestosteroneapprovedunknownDetails
DB01622ThioproperazineexperimentalunknownDetails
DB01623ThiothixeneapprovedunknownDetails
DB06705Gadofosveset trisodiumapprovedunknownsubstrateDetails
DB00454MeperidineapprovedunknownDetails
DB01016GlyburideapprovedunknownDetails
DB00912Repaglinideapproved, investigationalunknownDetails
DB00731Nateglinideapproved, investigationalunknownDetails
DB08867UlipristalapprovednosubstrateDetails
DB05294VandetanibapprovedunknownbinderDetails
DB05521Telaprevirapproved, withdrawnnosubstrateDetails
DB05812AbirateroneapprovedunknownsubstrateDetails
DB08881VemurafenibapprovedunknownsubstrateDetails
DB08828Vismodegibapproved, investigationalunknownsubstrateDetails
DB08893MirabegronapprovednosubstrateDetails
DB00635Prednisoneapproved, vet_approvedunknownsubstrateDetails
DB08899EnzalutamideapprovedunknownsubstrateDetails
DB08820IvacaftorapprovednocarrierDetails
DB00776OxcarbazepineapprovedunknownsubstrateDetails
DB06201RufinamideapprovedunknownsubstrateDetails
DB06716Fospropofolapproved, illicit, investigationalunknownsubstrateDetails
DB04855DronedaroneapprovedunknownsubstrateDetails
DB06209PrasugrelapprovedunknownsubstrateDetails
DB08860PitavastatinapprovedunknownsubstrateDetails
DB01183Naloxoneapproved, vet_approvedunknownsubstrateDetails
DB01242Clomipramineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateDetails
DB00619ImatinibapprovedunknownsubstrateDetails
DB00762Irinotecanapproved, investigationalunknownsubstrateDetails
DB00678LosartanapprovedunknownsubstrateDetails
DB00688Mycophenolate mofetilapproved, investigationalunknownsubstrateDetails
DB00412Rosiglitazoneapproved, investigationalunknownsubstrateDetails
DB01098RosuvastatinapprovedunknownsubstrateDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateDetails
DB00717NorethisteroneapprovedunknownsubstrateDetails
DB08931RiociguatapprovedunknownsubstrateDetails
DB08895Tofacitinibapproved, investigationalunknownDetails
DB08932MacitentanapprovednobinderDetails
DB06290SimeprevirapprovednobinderDetails
DB00493CefotaximeapprovedunknownDetails
DB01045RifampicinapprovedunknownDetails
DB06205Vorhyaluronidase alfaapproved, investigationalunknowninhibitorDetails
DB09280LumacaftorapprovednocarrierDetails
DB09130Copperapproved, investigationalnobinderDetails
DB11093Calcium Citrateapproved, investigationalnosubstrateDetails
DB11348Calcium PhosphateapprovednosubstrateDetails
DB11575GrazoprevirapprovednosubstrateDetails
DB11943Delafloxacinapproved, investigationalnosubstrateDetails
DB01685TopiroxostatexperimentalunknownbinderDetails
DB09093Chlortetracyclineapproved, investigational, vet_approvednoDetails
DB06796Mangafodipirapproved, investigational, withdrawnunknownbinderDetails
DB09262ImidafenacininvestigationalnosubstrateDetails
DB00276Amsacrineapproved, investigationalunknownDetails
DB11359GuaiacolapprovedunknownDetails
DB03255Phenolapproved, experimentalunknownDetails
DB06728AnilineexperimentalunknownDetails
DB00545Pyridostigmineapproved, investigationalunknownDetails
DB06713Norelgestrominapproved, investigationalunknownDetails
DB01370Aluminiumapproved, investigationalunknownDetails
DB13014HypericininvestigationalunknownDetails
DB01057EchothiophateapprovedunknownDetails
DB11397Dichlorvosvet_approvedunknownDetails
DB00677Isoflurophateapproved, investigational, withdrawnunknownDetails
DB00943Zalcitabineapproved, investigationalunknownDetails
DB01072Atazanavirapproved, investigationalunknownDetails
DB00649Stavudineapproved, investigationalunknownDetails
DB00900DidanosineapprovedunknownDetails
DB00625Efavirenzapproved, investigationalunknownDetails
DB00879Emtricitabineapproved, investigationalunknownDetails
DB00220NelfinavirapprovedunknownDetails
DB00238NevirapineapprovedunknownDetails
DB00503Ritonavirapproved, investigationalunknownDetails
DB00709Lamivudineapproved, investigationalunknownDetails
DB04216Quercetinexperimental, investigationalunknownDetails
DB00997Doxorubicinapproved, investigationalunknownDetails
DB04816Dantronapproved, investigational, withdrawnunknownDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownDetails
DB00515CisplatinapprovedunknownDetails
DB00162Vitamin Aapproved, nutraceutical, vet_approvedunknownDetails
DB04690CamptothecinexperimentalunknownDetails
DB02709Resveratrolapproved, experimental, investigationalunknownDetails
DB00744Zileutonapproved, investigational, withdrawnunknownDetails
DB04539GlyphosateexperimentalunknownDetails
DB11590ThimerosalapprovedunknownDetails
DB05134TanespimycininvestigationalunknownDetails
DB01124Tolbutamideapproved, investigationalunknownDetails
DB01276Exenatideapproved, investigationalunknownDetails
DB00414Acetohexamideapproved, investigational, withdrawnunknownDetails
DB00458ImipramineapprovedunknownDetails
DB00159Icosapentapproved, nutraceuticalunknownDetails
DB00951Isoniazidapproved, investigationalunknownDetails
DB01104SertralineapprovedunknownDetails
DB09383Meprednisoneapproved, investigationalunknownDetails
DB00266DicoumarolapprovedunknownDetails
DB04828ZomepiracwithdrawnunknownDetails
DB00500TolmetinapprovedunknownDetails
DB11217ArbutinapprovedunknownDetails
DB09526Hydroquinoneapproved, investigationalunknownDetails
DB00784Mefenamic acidapprovedunknownDetails
DB00313Valproic Acidapproved, investigationalunknownDetails
DB01169Arsenic trioxideapproved, investigationalnosubstrateDetails
DB11828Neratinibapproved, investigationalnosubstrateDetails
DB00607Nafcillinapproved, investigationalunknownDetails
DB12483Copanlisibapproved, investigationalunknownsubstrateDetails
DB00512VancomycinapprovednosubstrateDetails
DB12001Abemaciclibapproved, investigationalunknownbinderDetails
DB08864Rilpivirineapprovednoother/unknownDetails
DB13928Semaglutideapproved, investigationalnosubstrateDetails
DB09087Potassium alumapprovedunknownbinderDetails
DB09223BlonanserininvestigationalnosubstrateDetails
DB09236Lacidipineapproved, investigationalunknownbinderDetails
DB09124MedrogestoneapprovednobinderDetails
DB11827Ertugliflozinapproved, investigationalnobinderDetails
DB09139Technetium Tc-99m oxidronateapprovednobinderDetails
DB13943Testosterone cypionateapprovednoother/unknownDetails
DB13944Testosterone enanthateapprovednoother/unknownDetails
DB13946Testosterone undecanoateapproved, investigationalnoother/unknownDetails
DB13952Estradiol acetateapproved, investigational, vet_approvednoDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvednoDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvednoDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvednoDetails
DB13956Estradiol valerateapproved, investigational, vet_approvednoDetails
DB11638Artenimolexperimental, investigationalunknownligandDetails
DB01420Testosterone propionateapproved, investigational, vet_approved, withdrawnnosubstrateDetails
DB09195LorpiprazoleapprovednosubstrateDetails
DB09204ArotinololinvestigationalnosubstrateDetails
DB08814Triflusalapproved, investigationalnosubstrateDetails
DB09229AranidipineexperimentalnobinderDetails
DB09333Iopodic acidapproved, investigational, withdrawnnosubstrateDetails
DB11712Tezacaftorapproved, investigationalnosubstrateDetails
DB09347Acetrizoic acidwithdrawnnobinderDetails
DB09348Propiolactoneapproved, withdrawnnobinderDetails
DB11130Opiumapproved, illicitnobinderDetails
DB06778Cupric sulfateapprovedunknownDetails
DB09053IbrutinibapprovednosubstrateDetails
DB11182Rose bengal free acidapproved, investigationalunknownbinderDetails
DB13967Patent BlueapprovedyesbinderDetails
DB13909Bismuth subgallateapprovedunknowncarrierDetails
DB09418Potassium perchlorateapproved, investigationalunknownbinderDetails
DB11641Vinflunineapproved, investigationalnosubstrateDetails
DB13421Edoxudineapproved, investigational, withdrawnnobinderDetails
DB11134Cupric oxideapprovedunknownbinderDetails
DB11148Butambenapproved, withdrawnnosubstrateDetails
DB11637Delamanidapproved, investigationalunknownsubstrateDetails
DB13751Glycyrrhizic acidapproved, experimentalyessubstrateDetails
DB12965Silverapproved, investigationalunknownbinderDetails
DB14185Aripiprazole lauroxilapproved, investigationalunknownbinderDetails
DB14481Calcium phosphate dihydrateapprovednoDetails
DB14517Aluminium phosphateapproved, investigationalunknownDetails
DB14518Aluminum acetateapproved, investigationalunknownDetails
DB00432Trifluridineapproved, investigationalunknownbinderDetails
DB14582Patisiranapproved, investigationalunknownligandDetails
DB09213Dexibuprofenapproved, investigationalnoDetails
DB12455Omadacyclineapproved, investigationalunknownDetails
DB12836Grapiprantinvestigational, vet_approvednosubstrateDetails
DB11753Rifamycinapproved, investigationalnosubstrateDetails
DB11963Dacomitinibapproved, investigationalnobinderDetails
DB11855Revefenacinapproved, investigationalnobinderDetails
DB12141Gilteritinibapproved, investigationalnobinderDetails
DB06480PrucaloprideapprovedunknownbinderDetails
DB11978Glasdegibapproved, investigationalnosubstrateDetails
DB00214TorasemideapprovedunknownsubstrateDetails
DB00227Lovastatinapproved, investigationalnosubstrateDetails
DB09564Insulin DegludecapprovedunknownDetails
DB00243Ranolazineapproved, investigationalnobinderDetails
DB00245BenzatropineapprovednobinderDetails
DB00264Metoprololapproved, investigationalnobinderDetails
DB00275Olmesartanapproved, investigationalnobinderDetails
DB00286Conjugated estrogensapprovednobinderDetails
DB00289AtomoxetineapprovednobinderDetails
DB00294Etonogestrelapproved, investigationalnocarrierDetails
DB00295Morphineapproved, investigationalnobinderDetails
DB00310ChlorthalidoneapprovednoDetails
DB00304DesogestrelapprovednobinderDetails
DB00327Hydromorphoneapproved, illicitnobinderDetails
DB09073Palbociclibapproved, investigationalnobinderDetails
DB00332Ipratropiumapproved, experimentalnobinderDetails
DB01142Doxepinapproved, investigationalnobinderDetails
DB01076AtorvastatinapprovednobinderDetails
DB06655LiraglutideapprovedunknownbinderDetails
DB01235LevodopaapprovedunknownbinderDetails
DB01238Aripiprazoleapproved, investigationalunknownbinderDetails
DB00404Alprazolamapproved, illicit, investigationalunknownbinderDetails
DB00421SpironolactoneapprovedunknownDetails
DB00335AtenololapprovednosubstrateDetails
DB01126Dutasterideapproved, investigationalnobinderDetails
DB09299Tenofovir alafenamideapprovednobinderDetails
DB00343Diltiazemapproved, investigationalnobinderDetails
DB14126Tenofovirapproved, experimental, investigationalnobinderDetails
DB00476DuloxetineapprovedunknownligandDetails
DB00497Oxycodoneapproved, illicit, investigationalunknownbinderDetails
DB00481Raloxifeneapproved, investigationalnobinderDetails
DB00537Ciprofloxacinapproved, investigationalunknownbinderDetails
DB00461NabumetoneapprovedunknownDetails