Food components inhibiting recombinant human histidine decarboxylase activity.

Article Details

Citation
Copy to clipboard

Nitta Y, Kikuzaki H, Ueno H

Food components inhibiting recombinant human histidine decarboxylase activity.

J Agric Food Chem. 2007 Jan 24;55(2):299-304.

PubMed ID
17227057 [ View in PubMed
]
Abstract

Histidine decarboxylase (HDC) catalyzes histamine formation from histidine. Histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator. Phenolic food components have been tested for their ability to inhibit recombinant human HDC. Epicatechin gallate (ECG) was found to be a potent inhibitor as it inhibited HDC activity in a competitive manner with Ki = 10 muM against l-histidine. Epigallocatechin gallate (EGCG) showed time-dependent inhibition which disappeared under anaerobic conditions. It is probable that time-dependent inhibition could be due to the result of autoxidation of EGCG. The initial burst observed for EGCG suggests that EGCG itself is involved in HDC inhibition as observed for ECG. Our present results have shown that the tested food components can inhibit HDC activity. This inhibition likely affects histamine biosynthesis and possibly leads to controlling the biological action induced by histamine. Therefore, those food components exhibiting HDC inhibitory activity might be potentially useful in controlling histamine-induced biological actions.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
HistidineHistidine decarboxylaseProteinHumans
Unknown
Not AvailableDetails