Prejunctional muscarinic receptors regulating neurotransmitter release in airways.
Article Details
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Kilbinger H, von Bardeleben RS, Siefken H, Wolf D
Prejunctional muscarinic receptors regulating neurotransmitter release in airways.
Life Sci. 1995;56(11-12):981-7. doi: 10.1016/0024-3205(95)00037-7.
- PubMed ID
- 10188802 [ View in PubMed]
- Abstract
Prejunctional pA2 values of five muscarinic antagonists were determined in the guinea-pig trachea under stimulation conditions in which the antagonists alone did not enhance acetylcholine release. The antagonists were partly selective at M1 (pirenzepine), M2 (AQ-RA 741, himbacine) and M3 receptors (hexahydrosiladifenidol, dicyclomine). The profile of the antagonist affinities was different from that obtained at cardiac M2 receptors but resembled the profile reported in the literature for the cloned m4 receptor. This suggests that autoinhibition of acetylcholine release in the trachea is mediated via M4 receptors.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Dicyclomine Muscarinic acetylcholine receptor M3 Protein Humans UnknownAntagonistDetails