Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens.
Article Details
- CitationCopy to clipboard
McKenzie GJ, Rosenberg SM
Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens.
Curr Opin Microbiol. 2001 Oct;4(5):586-94. doi: 10.1016/s1369-5274(00)00255-1.
- PubMed ID
- 11587937 [ View in PubMed]
- Abstract
"Adaptive" or "stationary-phase" mutation is a collection of stress responses promoting mutations, some of which are advantageous. In 2000 and 2001, in Escherichia coli, adaptive gene amplification was documented, and a parallel adaptive point-mutation mechanism was linked to the error-prone DNA polymerase, DinB (pol IV). We suggest that DinB homologues may contribute to adaptive strategies of pathogens, including antigenic variation.