Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Article Details
- CitationCopy to clipboard
Colabufo NA, Berardi F, Contino M, Inglese C, Niso M, Perrone R
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Bioorg Med Chem Lett. 2008 Jul 1;18(13):3741-4. doi: 10.1016/j.bmcl.2008.05.055. Epub 2008 May 20.
- PubMed ID
- 18524592 [ View in PubMed]
- Abstract
Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC(50)=14.7 microM), Cyclosporin A and Tamoxifen displayed EC(50)=25.2 and 39.4 microM, respectively.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Cyclosporine P-glycoprotein 1 EC 50 (nM) 45500 N/A N/A Details Tamoxifen P-glycoprotein 1 EC 50 (nM) 56500 N/A N/A Details Verapamil P-glycoprotein 1 EC 50 (nM) 20000 N/A N/A Details