Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
Article Details
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Barbey S, Goossens L, Taverne T, Cornet J, Choesmel V, Rouaud C, Gimeno G, Yannic-Arnoult S, Michaux C, Charlier C, Houssin R, Henichart JP
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
Bioorg Med Chem Lett. 2002 Mar 11;12(5):779-82.
- PubMed ID
- 11859001 [ View in PubMed]
- Abstract
Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Rofecoxib Prostaglandin G/H synthase 2 IC 50 (nM) 1 N/A N/A Details Zileuton Arachidonate 5-lipoxygenase IC 50 (nM) 2900 N/A N/A Details