The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

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Manallack DT, Hughes RA, Thompson PE

The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

J Med Chem. 2005 May 19;48(10):3449-62.

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15887951 [ View in PubMed

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Dipyridamole	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Ki (nM)	1000	N/A	N/A	Details
Tadalafil	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	IC 50 (nM)	60000	N/A	N/A	Details