Identification

Name
Dipyridamole
Accession Number
DB00975  (APRD00360)
Type
Small Molecule
Groups
Approved
Description

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

Structure
Thumb
Synonyms
  • Cleridium 150
  • Curantyl
  • Dipiridamol
  • Dipyridamine
  • Dipyridamolum
  • Dipyudamine
  • Dypyridamol
  • Persantin
External IDs
B01AC07 / NSC-515776 / USAF GE-12
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DipyridamoleTablet50 mg/1OralRoxane Laboratories2012-02-15Not applicableUs
DipyridamoleTablet25 mg/1OralCarilion Materials Management2012-02-15Not applicableUs
DipyridamoleTablet75 mg/1OralRoxane Laboratories2012-02-15Not applicableUs
DipyridamoleTablet25 mg/1OralRoxane Laboratories2012-02-15Not applicableUs
DipyridamoleTablet75 mg/1OralAvera Mc Kennan Hospital2015-10-28Not applicableUs
Dipyridamole 25 Tab 25mgTablet25 mgOralPro Doc Limitee1983-12-312002-08-02Canada
Dipyridamole 50 Tab 50mgTablet50 mgOralPro Doc Limitee1983-12-312002-08-02Canada
Dipyridamole 75 TabTablet75 mgOralPro Doc Limitee1984-12-312002-08-02Canada
Dipyridamole for InjectionSolution5 mgIntravenousNovopharm Limited2002-04-30Not applicableCanada
Dipyridamole Injection, USPLiquid5 mgIntravenousFresenius Kabi2002-04-23Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-dipyridamole-FC Tab 25mgTablet25 mgOralApotex Corporation1990-12-31Not applicableCanada
Apo-dipyridamole-FC Tab 50mgTablet50 mgOralApotex Corporation1990-12-31Not applicableCanada
Apo-dipyridamole-FC Tab 75mgTablet75 mgOralApotex Corporation1990-12-31Not applicableCanada
Apo-dipyridamole-SC Tab 25mgTablet25 mgOralApotex Corporation1982-12-31Not applicableCanada
Apo-dipyridamole-SC Tab 50mgTablet50 mgOralApotex Corporation1982-12-31Not applicableCanada
Apo-dipyridamole-SC Tab 75mgTablet75 mgOralApotex Corporation1984-12-31Not applicableCanada
DipyridamoleTablet, film coated75 mg/1OralZydus Pharmaceuticals Usa, Inc.2008-05-22Not applicableUs
DipyridamoleTablet, film coated50 mg/1OralLannett Company, Inc.2008-04-23Not applicableUs
DipyridamoleTablet, film coated75 mg/1OralAv Pak2011-08-052016-01-15Us
DipyridamoleTablet, film coated75 mg/1OralTeva1982-01-01Not applicableUs00555 0286 02 nlmimage10 f92b7ceb
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DipyridamoleSolution5 mg/mLIntravenousAnazao Health Corporation2012-05-23Not applicableUs
International/Other Brands
Agilease (lsei) / Cardoxin (Rafa) / Cleridium 150 (Millot) / Curantyl (Arzneimittelwerk) / Persantin
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AggrenoxDipyridamole (200 mg) + Acetylsalicylic acid (25 mg)Capsule; Capsule, extended releaseOralBoehringer Ingelheim (Canada) Ltd Ltee2000-04-17Not applicableCanada
AggrenoxDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)Capsule, extended releaseOralCarilion Materials Management1999-12-19Not applicableUs00597 0001 60 nlmimage10 7303b9ed
AggrenoxDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)CapsuleOralRebel Distributors1999-12-19Not applicableUs
AggrenoxDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)CapsuleOralPhysicians Total Care, Inc.2004-08-24Not applicableUs
AggrenoxDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)Capsule, extended releaseOralBoehringer Ingelheim1999-12-19Not applicableUs
Asasantine CapDipyridamole (75 mg) + Acetylsalicylic acid (330 mg)CapsuleOralBoehringer Ingelheim (Canada) Ltd Ltee1983-12-312000-07-31Canada
Aspirin and DipyridamoleDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)CapsuleOralRoxane Laboratories2015-06-24Not applicableUs
Aspirin and DipyridamoleDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)Capsule, extended releaseOralImpax Generics2016-08-29Not applicableUs
Aspirin and DipyridamoleDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)Capsule, extended releaseOralTeva2015-07-01Not applicableUs00093 3040 06 nlmimage10 f343f9ef
Aspirin and Extended - Release Dipyridamole Capsules, 25 mg / 200 mgDipyridamole (200 mg/1) + Acetylsalicylic acid (25 mg/1)CapsuleOralPar Pharmaceutical2017-01-30Not applicableUs
Categories
UNII
64ALC7F90C
CAS number
58-32-2
Weight
Average: 504.6256
Monoisotopic: 504.317251808
Chemical Formula
C24H40N8O4
InChI Key
IZEKFCXSFNUWAM-UHFFFAOYSA-N
InChI
InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
IUPAC Name
2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)-[1,3]diazino[5,4-d]pyrimidin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol
SMILES
OCCN(CCO)C1=NC2=C(N=C(N=C2N2CCCCC2)N(CCO)CCO)C(=N1)N1CCCCC1

Pharmacology

Indication

For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.

Structured Indications
Pharmacodynamics

Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.

Mechanism of action

Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

TargetActionsOrganism
AcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
inhibitor
Human
AcGMP-specific 3',5'-cyclic phosphodiesterase
inhibitor
Human
AcAMP-specific 3',5'-cyclic phosphodiesterase 4A
inhibitor
Human
AAdenosine deaminase
inhibitor
Human
UCalcipressin-1Not AvailableHuman
UAlpha-1-acid glycoprotein 1Not AvailableHuman
Absorption

70%

Volume of distribution
  • 1 to 2.5 L/kg
Protein binding

99%

Metabolism

hepatic

Route of elimination

Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile.

Half life

40 minutes

Clearance
  • 2.3-3.5 mL/min/kg
Toxicity

Hypotension, if it occurs, is likely to be of short duration, but a vasopressor drug may be used if necessary. The oral LD50 in rats is greater than 6,000 mg/kg while in the dogs, the oral LD50 is approximately 400 mg/kg. LD50=8.4g/kg (orally in rat)

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Dipyridamole (Antiplatelet) Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Dipyridamole.Experimental
AbciximabDipyridamole may increase the anticoagulant activities of Abciximab.Approved
AcebutololDipyridamole may increase the bradycardic activities of Acebutolol.Approved
AcenocoumarolDipyridamole may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Dipyridamole.Approved
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Acetylsalicylic acid.Approved, Vet Approved
AdenosineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Adenosine.Approved, Investigational
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Dipyridamole.Approved
AlbendazoleThe serum concentration of Dipyridamole can be increased when it is combined with Albendazole.Approved, Vet Approved
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Dipyridamole.Approved
AldosteroneThe serum concentration of Dipyridamole can be decreased when it is combined with Aldosterone.Experimental, Investigational
AlectinibThe serum concentration of Dipyridamole can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Dipyridamole can be increased when it is combined with Alfentanil.Approved, Illicit
AliskirenThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Aliskiren.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Dipyridamole.Approved, Investigational
AloxiprinThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Aloxiprin.Experimental
AlprenololDipyridamole may increase the bradycardic activities of Alprenolol.Approved, Withdrawn
AlprostadilAlprostadil may increase the anticoagulant activities of Dipyridamole.Approved, Investigational
AlteplaseDipyridamole may increase the anticoagulant activities of Alteplase.Approved
ALX-0081Dipyridamole may increase the anticoagulant activities of ALX-0081.Investigational
AmantadineThe serum concentration of Dipyridamole can be increased when it is combined with Amantadine.Approved
AmbenoniumThe therapeutic efficacy of Ambenonium can be decreased when used in combination with Dipyridamole.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Dipyridamole.Approved, Investigational
AmifostineThe risk or severity of adverse effects can be increased when Amifostine is combined with Dipyridamole.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Dipyridamole.Approved
Aminohippuric acidThe serum concentration of Dipyridamole can be increased when it is combined with Aminohippuric acid.Approved, Investigational
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Aminosalicylic Acid.Approved
AmiodaroneThe serum concentration of Dipyridamole can be decreased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Dipyridamole.Approved
AmlodipineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Dipyridamole.Approved
AmobarbitalAmobarbital may increase the hypotensive activities of Dipyridamole.Approved, Illicit
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Dipyridamole.Approved, Investigational
AmprenavirThe serum concentration of Dipyridamole can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Dipyridamole can be increased when it is combined with Amsacrine.Approved
Amyl NitriteThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Amyl Nitrite.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Dipyridamole.Approved
AncrodDipyridamole may increase the anticoagulant activities of Ancrod.Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Dipyridamole.Investigational
AnistreplaseDipyridamole may increase the anticoagulant activities of Anistreplase.Approved
Antithrombin III humanDipyridamole may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Apixaban.Approved
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Dipyridamole.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Apraclonidine is combined with Dipyridamole.Approved
AprotininThe therapeutic efficacy of Dipyridamole can be decreased when used in combination with Aprotinin.Approved, Withdrawn
ArdeparinDipyridamole may increase the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanDipyridamole may increase the anticoagulant activities of Argatroban.Approved, Investigational
AripiprazoleAripiprazole may increase the hypotensive activities of Dipyridamole.Approved, Investigational
ArotinololDipyridamole may increase the bradycardic activities of Arotinolol.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Dipyridamole.Approved, Investigational
AstaxanthinDipyridamole may increase the anticoagulant activities of Astaxanthin.Investigational
AstemizoleThe serum concentration of Dipyridamole can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Dipyridamole.Approved, Investigational
AtenololDipyridamole may increase the bradycardic activities of Atenolol.Approved
AtorvastatinThe serum concentration of Dipyridamole can be increased when it is combined with Atorvastatin.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Dipyridamole.Approved, Investigational
AzelastineThe serum concentration of Dipyridamole can be increased when it is combined with Azelastine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Azilsartan medoxomil.Approved
AzithromycinThe serum concentration of Dipyridamole can be increased when it is combined with Azithromycin.Approved
BalsalazideThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Balsalazide.Approved, Investigational
BarbexacloneBarbexaclone may increase the hypotensive activities of Dipyridamole.Experimental
BarbitalBarbital may increase the hypotensive activities of Dipyridamole.Illicit
BarnidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Dipyridamole.Approved
BatroxobinDipyridamole may increase the anticoagulant activities of Batroxobin.Experimental
BecaplerminDipyridamole may increase the anticoagulant activities of Becaplermin.Approved, Investigational
BefunololDipyridamole may increase the bradycardic activities of Befunolol.Experimental
BelinostatThe serum concentration of Belinostat can be increased when it is combined with Dipyridamole.Approved, Investigational
BemiparinDipyridamole may increase the anticoagulant activities of Bemiparin.Approved, Investigational
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Dipyridamole.Approved, Investigational
BendroflumethiazideThe risk or severity of adverse effects can be increased when Bendroflumethiazide is combined with Dipyridamole.Approved
BenzocaineThe serum concentration of Dipyridamole can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Dipyridamole can be increased when it is combined with Bepridil.Approved, Withdrawn
BeraprostDipyridamole may increase the anticoagulant activities of Beraprost.Investigational
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Dipyridamole.Approved, Vet Approved
BetaxololDipyridamole may increase the bradycardic activities of Betaxolol.Approved
BevantololDipyridamole may increase the bradycardic activities of Bevantolol.Approved
BiperidenThe serum concentration of Dipyridamole can be increased when it is combined with Biperiden.Approved, Investigational
BisoprololDipyridamole may increase the bradycardic activities of Bisoprolol.Approved
BivalirudinDipyridamole may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Dipyridamole.Approved, Withdrawn
BopindololDipyridamole may increase the bradycardic activities of Bopindolol.Approved
BortezomibThe risk or severity of adverse effects can be increased when Bortezomib is combined with Dipyridamole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Dipyridamole.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Dipyridamole.Approved
BretyliumThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Bretylium.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Brimonidine is combined with Dipyridamole.Approved
BrinaseDipyridamole may increase the anticoagulant activities of Brinase.Experimental
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Dipyridamole.Approved, Investigational
BucindololDipyridamole may increase the bradycardic activities of Bucindolol.Investigational
BuflomedilBuflomedil may increase the anticoagulant activities of Dipyridamole.Experimental
BufuralolDipyridamole may increase the bradycardic activities of Bufuralol.Experimental, Investigational
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Dipyridamole.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dipyridamole.Approved, Investigational
BupranololDipyridamole may increase the bradycardic activities of Bupranolol.Approved
BuprenorphineThe serum concentration of Dipyridamole can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Dipyridamole can be increased when it is combined with Buspirone.Approved, Investigational
ButylphthalideButylphthalide may increase the anticoagulant activities of Dipyridamole.Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Dipyridamole.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Dipyridamole.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Dipyridamole.Experimental
CanagliflozinThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Canagliflozin.Approved
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Candesartan is combined with Dipyridamole.Approved
CangrelorDipyridamole may increase the anticoagulant activities of Cangrelor.Approved
CaptoprilThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Captopril.Approved
CarbamazepineThe serum concentration of Dipyridamole can be decreased when it is combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Carbaspirin calcium.Experimental, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Dipyridamole.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Dipyridamole.Approved
CarteololDipyridamole may increase the bradycardic activities of Carteolol.Approved
CarvedilolDipyridamole may increase the bradycardic activities of Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Dipyridamole can be increased when it is combined with Caspofungin.Approved
CeliprololDipyridamole may increase the bradycardic activities of Celiprolol.Approved, Investigational
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Dipyridamole.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Dipyridamole.Withdrawn
CertoparinDipyridamole may increase the anticoagulant activities of Certoparin.Approved, Investigational
ChloroquineThe serum concentration of Dipyridamole can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Chlorothiazide is combined with Dipyridamole.Approved, Vet Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Dipyridamole.Approved, Vet Approved
ChlorpropamideThe serum concentration of Dipyridamole can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Dipyridamole can be increased when it is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Dipyridamole.Approved
CholesterolThe serum concentration of Dipyridamole can be increased when it is combined with Cholesterol.Experimental, Investigational
Cholic AcidThe serum concentration of Dipyridamole can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Cilnidipine is combined with Dipyridamole.Approved, Investigational
CilostazolDipyridamole may increase the anticoagulant activities of Cilostazol.Approved
CimetidineThe serum concentration of Dipyridamole can be decreased when it is combined with Cimetidine.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Dipyridamole.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Dipyridamole.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Dipyridamole.Approved
Citric AcidDipyridamole may increase the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Dipyridamole.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Clevidipine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Dipyridamole.Approved, Illicit
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Dipyridamole.Approved, Investigational
ClofazimineThe serum concentration of Dipyridamole can be increased when it is combined with Clofazimine.Approved, Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Dipyridamole.Approved, Investigational
ClomipramineThe serum concentration of Dipyridamole can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Dipyridamole.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Dipyridamole.Approved, Nutraceutical
CloranololDipyridamole may increase the bradycardic activities of Cloranolol.Experimental
CloricromenDipyridamole may increase the anticoagulant activities of Cloricromen.Experimental
ClorindioneDipyridamole may increase the anticoagulant activities of Clorindione.Experimental
ClotrimazoleThe serum concentration of Dipyridamole can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Dipyridamole.Approved
CobicistatThe serum concentration of Dipyridamole can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Dipyridamole.Approved
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Dipyridamole.Approved
ColforsinThe serum concentration of Dipyridamole can be increased when it is combined with Colforsin.Experimental, Investigational
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Collagenase clostridium histolyticum.Approved, Investigational
ConivaptanThe risk or severity of adverse effects can be increased when Conivaptan is combined with Dipyridamole.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be increased when it is combined with Dipyridamole.Approved
CopanlisibThe serum concentration of Copanlisib can be increased when it is combined with Dipyridamole.Approved
CoumaphosThe therapeutic efficacy of Coumaphos can be decreased when used in combination with Dipyridamole.Vet Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Dipyridamole.Approved
CyclophosphamideThe serum concentration of Dipyridamole can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Dipyridamole can be decreased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateDipyridamole may increase the anticoagulant activities of Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Dipyridamole.Approved
DaclatasvirThe serum concentration of Dipyridamole can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Dipyridamole.Approved
DalteparinDipyridamole may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidDipyridamole may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DapagliflozinThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Dapagliflozin.Approved
DarexabanDipyridamole may increase the anticoagulant activities of Darexaban.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Dipyridamole.Approved, Investigational
DaunorubicinThe serum concentration of Dipyridamole can be decreased when it is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Dipyridamole.Approved, Investigational
DecamethoniumThe therapeutic efficacy of Decamethonium can be decreased when used in combination with Dipyridamole.Approved
DefibrotideDipyridamole may increase the anticoagulant activities of Defibrotide.Approved, Investigational
DemecariumThe therapeutic efficacy of Demecarium can be decreased when used in combination with Dipyridamole.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Deoxycholic Acid.Approved
dersalazineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with dersalazine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Dipyridamole.Approved
DesipramineThe serum concentration of Dipyridamole can be increased when it is combined with Desipramine.Approved
DesirudinDipyridamole may increase the anticoagulant activities of Desirudin.Approved
DesloratadineThe serum concentration of Dipyridamole can be increased when it is combined with Desloratadine.Approved, Investigational
DesmoteplaseDipyridamole may increase the anticoagulant activities of Desmoteplase.Investigational
DexamethasoneThe serum concentration of Dipyridamole can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Dipyridamole.Approved, Vet Approved
DextranDipyridamole may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Dipyridamole may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Dipyridamole may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Dipyridamole may increase the anticoagulant activities of Dextran 75.Approved
DextromethorphanThe serum concentration of Dipyridamole can be increased when it is combined with Dextromethorphan.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Dipyridamole.Approved, Illicit, Vet Approved
DichlorvosThe therapeutic efficacy of Dichlorvos can be decreased when used in combination with Dipyridamole.Vet Approved
DiclofenacThe serum concentration of Dipyridamole can be increased when it is combined with Diclofenac.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Diclofenamide.Approved
DicoumarolDipyridamole may increase the anticoagulant activities of Dicoumarol.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Dipyridamole.Approved, Investigational
DiflunisalThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Diflunisal.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Dipyridamole.Approved, Investigational
DigoxinThe serum concentration of Dipyridamole can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe serum concentration of Dipyridamole can be increased when it is combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dipyridamole.Illicit
DiltiazemThe risk or severity of adverse effects can be increased when Diltiazem is combined with Dipyridamole.Approved
DinutuximabThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Dinutuximab.Approved
DiphenadioneDipyridamole may increase the anticoagulant activities of Diphenadione.Experimental
DistigmineThe therapeutic efficacy of Distigmine can be decreased when used in combination with Dipyridamole.Experimental
DitazoleDipyridamole may increase the anticoagulant activities of Ditazole.Approved, Withdrawn
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Dipyridamole.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Dipyridamole.Approved, Investigational, Vet Approved
DonepezilThe therapeutic efficacy of Donepezil can be decreased when used in combination with Dipyridamole.Approved
DoxazosinThe risk or severity of adverse effects can be increased when Doxazosin is combined with Dipyridamole.Approved
DoxepinThe serum concentration of Dipyridamole can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Dipyridamole.Approved, Investigational
DoxorubicinThe serum concentration of Dipyridamole can be decreased when it is combined with Doxorubicin.Approved, Investigational
DronabinolThe serum concentration of Dipyridamole can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Dipyridamole can be increased when it is combined with Dronedarone.Approved
Drotrecogin alfaDipyridamole may increase the anticoagulant activities of Drotrecogin alfa.Approved, Investigational, Withdrawn
DuloxetineDipyridamole may increase the orthostatic hypotensive activities of Duloxetine.Approved
EchothiophateThe therapeutic efficacy of Echothiophate can be decreased when used in combination with Dipyridamole.Approved
Edetic AcidDipyridamole may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Dipyridamole.Approved
EdrophoniumThe therapeutic efficacy of Edrophonium can be decreased when used in combination with Dipyridamole.Approved
EfonidipineThe risk or severity of adverse effects can be increased when Efonidipine is combined with Dipyridamole.Approved
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Dipyridamole.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Dipyridamole.Approved, Investigational
EmpagliflozinThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Empagliflozin.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Dipyridamole.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Dipyridamole.Approved
EnasidenibThe serum concentration of Enasidenib can be increased when it is combined with Dipyridamole.Approved
EnoxaparinDipyridamole may increase the anticoagulant activities of Enoxaparin.Approved
EnzalutamideThe serum concentration of Dipyridamole can be increased when it is combined with Enzalutamide.Approved
EpanololDipyridamole may increase the bradycardic activities of Epanolol.Experimental
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Dipyridamole.Approved, Investigational
EplerenoneThe risk or severity of adverse effects can be increased when Eplerenone is combined with Dipyridamole.Approved
EplivanserinDipyridamole may increase the anticoagulant activities of Eplivanserin.Investigational
eplivanserineDipyridamole may increase the anticoagulant activities of eplivanserine.Investigational
EpoprostenolThe risk or severity of adverse effects can be increased when Epoprostenol is combined with Dipyridamole.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Dipyridamole.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Dipyridamole.Approved, Investigational
ErgonovineThe serum concentration of Dipyridamole can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Dipyridamole can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Dipyridamole.Approved, Investigational
ErythromycinThe serum concentration of Dipyridamole can be decreased when it is combined with Erythromycin.Approved, Vet Approved
EsmololDipyridamole may increase the bradycardic activities of Esmolol.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Dipyridamole.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Dipyridamole can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Dipyridamole can be decreased when it is combined with Estriol.Approved, Investigational, Vet Approved
EstroneThe serum concentration of Dipyridamole can be decreased when it is combined with Estrone.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Dipyridamole.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dipyridamole.Approved
Ethyl biscoumacetateDipyridamole may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtoposideThe serum concentration of Dipyridamole can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Dipyridamole can be increased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Dipyridamole.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Dipyridamole.Approved
FelodipineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Felodipine.Approved, Investigational
FenoldopamThe risk or severity of adverse effects can be increased when Fenoldopam is combined with Dipyridamole.Approved
FentanylThe serum concentration of Dipyridamole can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FenthionThe therapeutic efficacy of Fenthion can be decreased when used in combination with Dipyridamole.Vet Approved
Ferulic acidDipyridamole may increase the anticoagulant activities of Ferulic acid.Experimental
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Dipyridamole.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Dipyridamole.Approved
FibrinolysinDipyridamole may increase the anticoagulant activities of Fibrinolysin.Investigational
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Dipyridamole.Approved
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Dipyridamole.Approved, Investigational
FluconazoleThe serum concentration of Dipyridamole can be increased when it is combined with Fluconazole.Approved
FluindioneDipyridamole may increase the anticoagulant activities of Fluindione.Investigational
FluoxetineThe serum concentration of Dipyridamole can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Dipyridamole can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Dipyridamole can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Dipyridamole can be increased when it is combined with Flurazepam.Approved, Illicit
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Dipyridamole.Approved
FluvoxamineThe serum concentration of Dipyridamole can be increased when it is combined with Fluvoxamine.Approved, Investigational
FondaparinuxDipyridamole may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumDipyridamole may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Dipyridamole.Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Dipyridamole.Approved, Vet Approved
GabexateDipyridamole may increase the anticoagulant activities of Gabexate.Investigational
GalantamineThe therapeutic efficacy of Galantamine can be decreased when used in combination with Dipyridamole.Approved
Gallamine TriethiodideThe therapeutic efficacy of Gallamine Triethiodide can be decreased when used in combination with Dipyridamole.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Dipyridamole.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Dipyridamole.Approved
GenisteinThe serum concentration of Dipyridamole can be increased when it is combined with Genistein.Investigational
Ginkgo bilobaThe therapeutic efficacy of Ginkgo biloba can be decreased when used in combination with Dipyridamole.Approved, Investigational, Nutraceutical
GlecaprevirThe serum concentration of Glecaprevir can be increased when it is combined with Dipyridamole.Approved
GlucosamineGlucosamine may increase the antiplatelet activities of Dipyridamole.Approved
GlyburideThe serum concentration of Dipyridamole can be increased when it is combined with Glyburide.Approved
GlycerinThe serum concentration of Dipyridamole can be increased when it is combined with Glycerin.Approved, Investigational
Gramicidin DThe serum concentration of Dipyridamole can be increased when it is combined with Gramicidin D.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Dipyridamole.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Dipyridamole.Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Guacetisal.Experimental
GuanfacineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Guanfacine.Approved, Investigational
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Dipyridamole.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Dipyridamole.Approved, Vet Approved
Hemoglobin crosfumarilThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Hemoglobin crosfumaril.Experimental
HeparinDipyridamole may increase the anticoagulant activities of Heparin.Approved, Investigational
HexobarbitalHexobarbital may increase the hypotensive activities of Dipyridamole.Approved
HigenamineDipyridamole may increase the anticoagulant activities of Higenamine.Investigational
Huperzine AThe therapeutic efficacy of Huperzine A can be decreased when used in combination with Dipyridamole.Investigational
HydralazineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Hydralazine.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Dipyridamole.Approved, Vet Approved
HydroflumethiazideThe risk or severity of adverse effects can be increased when Hydroflumethiazide is combined with Dipyridamole.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Dipyridamole.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Dipyridamole.Approved
IbudilastIbudilast may increase the anticoagulant activities of Dipyridamole.Approved, Investigational
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Dipyridamole.Approved
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Dipyridamole.Approved, Nutraceutical
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Dipyridamole.Approved
IdraparinuxDipyridamole may increase the anticoagulant activities of Idraparinux.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Dipyridamole.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Dipyridamole.Investigational
IloprostThe risk or severity of adverse effects can be increased when Iloprost is combined with Dipyridamole.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Dipyridamole.Approved
ImidaprilThe risk or severity of adverse effects can be increased when Imidapril is combined with Dipyridamole.Investigational
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Dipyridamole.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Dipyridamole.Approved
IndapamideThe risk or severity of adverse effects can be increased when Indapamide is combined with Dipyridamole.Approved
IndenololDipyridamole may increase the bradycardic activities of Indenolol.Withdrawn
IndinavirThe serum concentration of Dipyridamole can be decreased when it is combined with Indinavir.Approved
IndobufenDipyridamole may increase the anticoagulant activities of Indobufen.Investigational
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Dipyridamole.Approved, Investigational
IndoraminThe risk or severity of adverse effects can be increased when Indoramin is combined with Dipyridamole.Withdrawn
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Dipyridamole.Approved
IpidacrineThe therapeutic efficacy of Ipidacrine can be decreased when used in combination with Dipyridamole.Experimental
IrbesartanThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Dipyridamole.Approved, Investigational
IsavuconazoniumThe serum concentration of Dipyridamole can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Dipyridamole.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Dipyridamole.Approved, Vet Approved
IsoflurophateThe therapeutic efficacy of Isoflurophate can be decreased when used in combination with Dipyridamole.Approved, Investigational, Withdrawn
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Isosorbide Dinitrate is combined with Dipyridamole.Approved
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Isosorbide Mononitrate.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Isoxsuprine.Approved, Withdrawn
IsradipineThe risk or severity of adverse effects can be increased when Isradipine is combined with Dipyridamole.Approved
ItraconazoleThe serum concentration of Dipyridamole can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Dipyridamole can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Dipyridamole.Approved, Vet Approved
KetamineThe serum concentration of Dipyridamole can be increased when it is combined with Ketamine.Approved, Vet Approved
KetanserinKetanserin may increase the anticoagulant activities of Dipyridamole.Investigational
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Dipyridamole.Approved
KetoconazoleThe serum concentration of Dipyridamole can be increased when it is combined with Ketoconazole.Approved, Investigational
LabetalolDipyridamole may increase the bradycardic activities of Labetalol.Approved
LacidipineThe risk or severity of adverse effects can be increased when Lacidipine is combined with Dipyridamole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Dipyridamole.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Dipyridamole.Approved, Investigational
LandiololDipyridamole may increase the bradycardic activities of Landiolol.Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Dipyridamole.Approved, Investigational
LapatinibThe serum concentration of Dipyridamole can be increased when it is combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Dipyridamole.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Dipyridamole.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Dipyridamole.Approved
LepirudinDipyridamole may increase the anticoagulant activities of Lepirudin.Approved
LercanidipineThe risk or severity of adverse effects can be increased when Lercanidipine is combined with Dipyridamole.Approved, Investigational
LetaxabanDipyridamole may increase the anticoagulant activities of Letaxaban.Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Dipyridamole.Approved, Investigational
LevobunololDipyridamole may increase the bradycardic activities of Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Dipyridamole.Approved, Investigational
LevodopaDipyridamole may increase the orthostatic hypotensive activities of Levodopa.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Dipyridamole.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Dipyridamole.Approved
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Dipyridamole.Approved, Investigational
LevothyroxineThe serum concentration of Dipyridamole can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Dipyridamole can be increased when it is combined with Lidocaine.Approved, Vet Approved
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Dipyridamole.Approved, Investigational
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Dipyridamole.Approved
LinsidomineLinsidomine may increase the anticoagulant activities of Dipyridamole.Experimental
LiothyronineThe serum concentration of Dipyridamole can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Dipyridamole can be decreased when it is combined with Liotrix.Approved
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Dipyridamole.Approved, Investigational
LofexidineThe risk or severity of adverse effects can be increased when Lofexidine is combined with Dipyridamole.Approved, Investigational
LomitapideThe serum concentration of Dipyridamole can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Dipyridamole.Approved
LopinavirThe serum concentration of Dipyridamole can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Dipyridamole can be increased when it is combined with Loratadine.Approved
LosartanThe risk or severity of adverse effects can be increased when Losartan is combined with Dipyridamole.Approved
LovastatinThe serum concentration of Dipyridamole can be increased when it is combined with Lovastatin.Approved, Investigational
LumacaftorThe serum concentration of Dipyridamole can be decreased when it is combined with Lumacaftor.Approved
MalathionThe therapeutic efficacy of Malathion can be decreased when used in combination with Dipyridamole.Approved, Investigational
MannitolThe risk or severity of adverse effects can be increased when Mannitol is combined with Dipyridamole.Approved, Investigational
MaprotilineThe serum concentration of Dipyridamole can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Dipyridamole can be increased when it is combined with Mebendazole.Approved, Vet Approved
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Dipyridamole.Approved
MefloquineThe therapeutic efficacy of Mefloquine can be decreased when used in combination with Dipyridamole.Approved
Megestrol acetateThe serum concentration of Dipyridamole can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelagatranDipyridamole may increase the anticoagulant activities of Melagatran.Experimental
MemantineThe therapeutic efficacy of Memantine can be decreased when used in combination with Dipyridamole.Approved, Investigational
MepindololDipyridamole may increase the bradycardic activities of Mepindolol.Experimental
MeprobamateThe serum concentration of Dipyridamole can be increased when it is combined with Meprobamate.Approved, Illicit
MesalazineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Mesalazine.Approved
MethadoneThe serum concentration of Dipyridamole can be increased when it is combined with Methadone.Approved
Methanesulfonyl FluorideThe therapeutic efficacy of Methanesulfonyl Fluoride can be decreased when used in combination with Dipyridamole.Investigational
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Dipyridamole.Approved
MethohexitalMethohexital may increase the hypotensive activities of Dipyridamole.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Dipyridamole.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Dipyridamole.Approved
Methyl salicylateThe therapeutic efficacy of Methyl salicylate can be decreased when used in combination with Dipyridamole.Approved, Vet Approved
MethyldopaThe risk or severity of adverse effects can be increased when Methyldopa is combined with Dipyridamole.Approved
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Dipyridamole.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Dipyridamole.Approved, Vet Approved
MetipranololDipyridamole may increase the bradycardic activities of Metipranolol.Approved
MetoclopramideThe therapeutic efficacy of Metoclopramide can be decreased when used in combination with Dipyridamole.Approved, Investigational
MetolazoneThe risk or severity of adverse effects can be increased when Metolazone is combined with Dipyridamole.Approved
MetoprololDipyridamole may increase the bradycardic activities of Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Dipyridamole can be increased when it is combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Dipyridamole can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Dipyridamole can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Dipyridamole can be decreased when it is combined with Mifepristone.Approved, Investigational
MilrinoneMilrinone may increase the anticoagulant activities of Dipyridamole.Approved
MinaprineThe therapeutic efficacy of Minaprine can be decreased when used in combination with Dipyridamole.Approved
MinoxidilThe risk or severity of adverse effects can be increased when Minoxidil is combined with Dipyridamole.Approved
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Dipyridamole.Approved
MitomycinThe serum concentration of Dipyridamole can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Dipyridamole can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Dipyridamole.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Dipyridamole.Approved, Investigational
MoxonidineThe risk or severity of adverse effects can be increased when Moxonidine is combined with Dipyridamole.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Dipyridamole.Approved, Investigational
NabiloneThe risk or severity of adverse effects can be increased when Nabilone is combined with Dipyridamole.Approved, Investigational
NadololDipyridamole may increase the bradycardic activities of Nadolol.Approved
NadroparinDipyridamole may increase the anticoagulant activities of Nadroparin.Approved
NafamostatDipyridamole may increase the anticoagulant activities of Nafamostat.Approved, Investigational
NaftopidilNaftopidil may increase the anticoagulant activities of Dipyridamole.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Dipyridamole.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Dipyridamole.Approved, Vet Approved
NaltrexoneThe serum concentration of Dipyridamole can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Dipyridamole can be increased when it is combined with Naringenin.Experimental
NebivololThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Nebivolol.Approved, Investigational
NefazodoneThe serum concentration of Dipyridamole can be decreased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Dipyridamole can be decreased when it is combined with Nelfinavir.Approved
NeostigmineThe therapeutic efficacy of Neostigmine can be decreased when used in combination with Dipyridamole.Approved, Vet Approved
NesiritideThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Nesiritide.Approved, Investigational
NicardipineThe risk or severity of adverse effects can be increased when Nicardipine is combined with Dipyridamole.Approved
NicorandilNicorandil may increase the hypotensive activities of Dipyridamole.Approved, Investigational
NifedipineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Nifedipine.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Dipyridamole.Approved, Investigational
NilvadipineThe risk or severity of adverse effects can be increased when Nilvadipine is combined with Dipyridamole.Approved, Investigational
NimesulideNimesulide may increase the anticoagulant activities of Dipyridamole.Approved, Investigational, Withdrawn
NimodipineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Dipyridamole.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Dipyridamole.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Nisoldipine is combined with Dipyridamole.Approved
NitrazepamThe serum concentration of Dipyridamole can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Dipyridamole can be increased when it is combined with Nitrendipine.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Dipyridamole.Approved
NitroaspirinThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Nitroaspirin.Investigational
NitroglycerinThe risk or severity of adverse effects can be increased when Nitroglycerin is combined with Dipyridamole.Approved, Investigational
NitroprussideThe risk or severity of adverse effects can be increased when Nitroprusside is combined with Dipyridamole.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Dipyridamole.Approved
NorethisteroneThe serum concentration of Dipyridamole can be decreased when it is combined with Norethisterone.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Obinutuzumab.Approved
OdanacatibThe serum concentration of Odanacatib can be increased when it is combined with Dipyridamole.Investigational
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Dipyridamole.Approved, Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Dipyridamole.Approved, Investigational
OlsalazineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Olsalazine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Dipyridamole.Approved
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Dipyridamole.Approved, Nutraceutical
OmeprazoleThe serum concentration of Dipyridamole can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Dipyridamole.Approved
OtamixabanDipyridamole may increase the anticoagulant activities of Otamixaban.Investigational
OxprenololDipyridamole may increase the bradycardic activities of Oxprenolol.Approved
OzagrelDipyridamole may increase the anticoagulant activities of Ozagrel.Investigational
P-NitrophenolThe serum concentration of Dipyridamole can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Dipyridamole can be increased when it is combined with Paclitaxel.Approved, Vet Approved
Palmitic AcidThe serum concentration of Dipyridamole can be increased when it is combined with Palmitic Acid.Approved, Experimental
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Dipyridamole.Approved, Investigational
PantoprazoleThe serum concentration of Dipyridamole can be increased when it is combined with Pantoprazole.Approved
PapaverineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Papaverine.Approved
ParaoxonThe therapeutic efficacy of Paraoxon can be decreased when used in combination with Dipyridamole.Experimental
ParnaparinDipyridamole may increase the anticoagulant activities of Parnaparin.Approved, Investigational
ParoxetineThe serum concentration of Dipyridamole can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Dipyridamole.Approved
PenbutololDipyridamole may increase the bradycardic activities of Penbutolol.Approved, Investigational
PentobarbitalPentobarbital may increase the hypotensive activities of Dipyridamole.Approved, Vet Approved
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Dipyridamole.Approved
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Dipyridamole.Approved, Investigational
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Dipyridamole.Approved
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Dipyridamole.Approved
PhenindioneDipyridamole may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenobarbitalThe serum concentration of Dipyridamole can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe risk or severity of adverse effects can be increased when Phenoxybenzamine is combined with Dipyridamole.Approved
PhenprocoumonDipyridamole may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhentolamineThe risk or severity of adverse effects can be increased when Phentolamine is combined with Dipyridamole.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Dipyridamole.Approved, Vet Approved
PhysostigmineThe therapeutic efficacy of Physostigmine can be decreased when used in combination with Dipyridamole.Approved
PibrentasvirThe serum concentration of Pibrentasvir can be increased when it is combined with Dipyridamole.Approved
PicotamideDipyridamole may increase the anticoagulant activities of Picotamide.Experimental
PimozideThe serum concentration of Dipyridamole can be increased when it is combined with Pimozide.Approved
PindololDipyridamole may increase the bradycardic activities of Pindolol.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Dipyridamole.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Dipyridamole.Approved
Platelet Activating FactorThe serum concentration of Dipyridamole can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Dipyridamole.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Dipyridamole.Approved
PosaconazoleThe serum concentration of Dipyridamole can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PractololDipyridamole may increase the bradycardic activities of Practolol.Approved
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Dipyridamole.Approved, Investigational
PrasugrelDipyridamole may increase the anticoagulant activities of Prasugrel.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Dipyridamole.Approved
PrazosinThe risk or severity of adverse effects can be increased when Prazosin is combined with Dipyridamole.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Dipyridamole.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Dipyridamole.Approved, Vet Approved
PrimidonePrimidone may increase the hypotensive activities of Dipyridamole.Approved, Vet Approved
ProbenecidThe serum concentration of Dipyridamole can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Dipyridamole can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Dipyridamole can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Dipyridamole can be increased when it is combined with Propafenone.Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Dipyridamole.Approved, Investigational, Vet Approved
PropranololDipyridamole may increase the bradycardic activities of Propranolol.Approved, Investigational
Protein CDipyridamole may increase the anticoagulant activities of Protein C.Approved
Protein S humanDipyridamole may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeDipyridamole may increase the anticoagulant activities of Protocatechualdehyde.Approved
ProtriptylineThe serum concentration of Dipyridamole can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Dipyridamole.Approved
PyridostigmineThe therapeutic efficacy of Pyridostigmine can be decreased when used in combination with Dipyridamole.Approved
QuercetinThe serum concentration of Dipyridamole can be increased when it is combined with Quercetin.Experimental, Investigational
QuetiapineThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Quetiapine.Approved
QuinacrineThe serum concentration of Dipyridamole can be increased when it is combined with Quinacrine.Approved, Investigational
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Dipyridamole.Approved, Investigational
QuinidineThe serum concentration of Dipyridamole can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Dipyridamole.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Dipyridamole.Investigational
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Dipyridamole.Approved
RanitidineThe serum concentration of Dipyridamole can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Dipyridamole.Approved, Investigational
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Dipyridamole.Approved
ReboxetineThe serum concentration of Dipyridamole can be increased when it is combined with Reboxetine.Approved, Investigational
RegadenosonThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Regadenoson.Approved
RegorafenibThe serum concentration of Dipyridamole can be increased when it is combined with Regorafenib.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Dipyridamole.Approved
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Dipyridamole.Approved, Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Dipyridamole.Approved, Experimental, Investigational
ReteplaseDipyridamole may increase the anticoagulant activities of Reteplase.Approved
ReviparinDipyridamole may increase the anticoagulant activities of Reviparin.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Dipyridamole.Approved
RifampicinThe serum concentration of Dipyridamole can be decreased when it is combined with Rifampicin.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Dipyridamole.Approved, Investigational
RilpivirineThe serum concentration of Dipyridamole can be increased when it is combined with Rilpivirine.Approved
RiociguatDipyridamole may increase the hypotensive activities of Riociguat.Approved
RisperidoneDipyridamole may increase the hypotensive activities of Risperidone.Approved, Investigational
RitonavirThe serum concentration of Dipyridamole can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanDipyridamole may increase the anticoagulant activities of Rivaroxaban.Approved
RivastigmineThe therapeutic efficacy of Rivastigmine can be decreased when used in combination with Dipyridamole.Approved, Investigational
RolapitantThe serum concentration of Dipyridamole can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Dipyridamole.Approved, Investigational
RopiniroleThe risk or severity of adverse effects can be increased when Ropinirole is combined with Dipyridamole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Dipyridamole.Approved
RosiglitazoneDipyridamole may increase the anticoagulant activities of Rosiglitazone.Approved, Investigational
RotigotineThe risk or severity of adverse effects can be increased when Rotigotine is combined with Dipyridamole.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Dipyridamole.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Salicylic acid.Approved, Vet Approved
SaquinavirThe serum concentration of Dipyridamole can be decreased when it is combined with Saquinavir.Approved, Investigational
SarpogrelateDipyridamole may increase the anticoagulant activities of Sarpogrelate.Investigational
SaruplaseDipyridamole may increase the anticoagulant activities of Saruplase.Experimental
ScopolamineThe serum concentration of Dipyridamole can be increased when it is combined with Scopolamine.Approved
SecobarbitalSecobarbital may increase the hypotensive activities of Dipyridamole.Approved, Vet Approved
SelegilineThe serum concentration of Dipyridamole can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Dipyridamole.Approved
SertralineThe serum concentration of Dipyridamole can be increased when it is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Dipyridamole.Approved, Vet Approved
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Dipyridamole.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Dipyridamole.Approved
SimvastatinThe serum concentration of Dipyridamole can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Dipyridamole can be decreased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Dipyridamole.Approved, Investigational
Sodium NitriteThe risk or severity of adverse effects can be increased when Sodium Nitrite is combined with Dipyridamole.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Dipyridamole.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Dipyridamole.Approved, Investigational
SotalolDipyridamole may increase the bradycardic activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Dipyridamole.Approved, Investigational
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Dipyridamole.Experimental
SpironolactoneThe risk or severity of adverse effects can be increased when Spironolactone is combined with Dipyridamole.Approved
SRT501SRT501 may increase the anticoagulant activities of Dipyridamole.Investigational
St. John's WortThe serum concentration of Dipyridamole can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StaurosporineThe serum concentration of Dipyridamole can be increased when it is combined with Staurosporine.Experimental
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Dipyridamole.Approved, Investigational
StreptozocinThe serum concentration of Dipyridamole can be decreased when it is combined with Streptozocin.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Dipyridamole.Approved, Investigational
SulfinpyrazoneThe serum concentration of Dipyridamole can be increased when it is combined with Sulfinpyrazone.Approved
SulodexideDipyridamole may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SumatriptanThe serum concentration of Dipyridamole can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Dipyridamole can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe therapeutic efficacy of Tacrine can be decreased when used in combination with Dipyridamole.Investigational, Withdrawn
TacrolimusThe serum concentration of Dipyridamole can be decreased when it is combined with Tacrolimus.Approved, Investigational
TalinololDipyridamole may increase the bradycardic activities of Talinolol.Investigational
TamoxifenThe serum concentration of Dipyridamole can be decreased when it is combined with Tamoxifen.Approved
TamsulosinThe risk or severity of adverse effects can be increased when Tamsulosin is combined with Dipyridamole.Approved, Investigational
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Dipyridamole.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dipyridamole.Approved
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Dipyridamole.Approved, Withdrawn
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Dipyridamole.Approved, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Dipyridamole.Approved
TenecteplaseDipyridamole may increase the anticoagulant activities of Tenecteplase.Approved
TerazosinThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Terazosin.Approved
TerfenadineThe serum concentration of Dipyridamole can be increased when it is combined with Terfenadine.Withdrawn
TertatololDipyridamole may increase the bradycardic activities of Tertatolol.Experimental
TesmilifeneThe serum concentration of Dipyridamole can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Dipyridamole can be increased when it is combined with Testosterone.Approved, Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Dipyridamole.Approved, Investigational, Withdrawn
ThiamylalThiamylal may increase the hypotensive activities of Dipyridamole.Approved, Vet Approved
ThiopentalThiopental may increase the hypotensive activities of Dipyridamole.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Dipyridamole.Approved, Withdrawn
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Dipyridamole.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Dipyridamole.Approved
TimololDipyridamole may increase the bradycardic activities of Timolol.Approved
TinzaparinDipyridamole may increase the anticoagulant activities of Tinzaparin.Approved
TioclomarolDipyridamole may increase the anticoagulant activities of Tioclomarol.Experimental
TipranavirTipranavir may increase the antiplatelet activities of Dipyridamole.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Dipyridamole.Approved
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Dipyridamole.Approved
TolazolineThe risk or severity of adverse effects can be increased when Tolazoline is combined with Dipyridamole.Approved, Vet Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Dipyridamole.Approved, Withdrawn
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Dipyridamole.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Dipyridamole.Approved, Investigational
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Dipyridamole.Approved
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Dipyridamole.Approved, Investigational
TositumomabThe risk or severity of adverse effects can be increased when Dipyridamole is combined with Tositumomab.Approved, Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Dipyridamole.Approved
TranilastTranilast may increase the anticoagulant activities of Dipyridamole.Approved, Investigational
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Dipyridamole.Approved
TrapidilTrapidil may increase the anticoagulant activities of Dipyridamole.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Dipyridamole.Approved
TrazodoneThe serum concentration of Dipyridamole can be decreased when it is combined with Trazodone.Approved, Investigational
TreprostinilTreprostinil may increase the antiplatelet activities of Dipyridamole.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Dipyridamole.Approved, Investigational, Nutraceutical
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Dipyridamole.Approved
TrichlorfonThe therapeutic efficacy of Trichlorfon can be decreased when used in combination with Dipyridamole.Vet Approved
TrifluoperazineThe serum concentration of Dipyridamole can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Dipyridamole can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TriflusalDipyridamole may increase the anticoagulant activities of Triflusal.Approved, Investigational
TrimethoprimThe serum concentration of Dipyridamole can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Dipyridamole can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Dipyridamole can be increased when it is combined with Troleandomycin.Approved
TroxerutinDipyridamole may increase the anticoagulant activities of Troxerutin.Investigational
TubocurarineThe therapeutic efficacy of Tubocurarine can be decreased when used in combination with Dipyridamole.Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Dipyridamole.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Dipyridamole.Approved
UrokinaseDipyridamole may increase the anticoagulant activities of Urokinase.Approved, Investigational, Withdrawn
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Dipyridamole.Approved, Investigational
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Dipyridamole.Approved
VelpatasvirThe serum concentration of Velpatasvir can be increased when it is combined with Dipyridamole.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Dipyridamole.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Dipyridamole.Approved
VerapamilThe risk or severity of adverse effects can be increased when Verapamil is combined with Dipyridamole.Approved
VinblastineThe serum concentration of Dipyridamole can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Dipyridamole.Approved, Investigational
VincristineThe serum concentration of Dipyridamole can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Dipyridamole can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Dipyridamole.Approved
Vitamin EVitamin E may increase the antiplatelet activities of Dipyridamole.Approved, Nutraceutical, Vet Approved
VorapaxarDipyridamole may increase the anticoagulant activities of Vorapaxar.Approved
VoxilaprevirThe serum concentration of Voxilaprevir can be increased when it is combined with Dipyridamole.Approved
WarfarinDipyridamole may increase the anticoagulant activities of Warfarin.Approved
XimelagatranDipyridamole may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Dipyridamole.Approved
ZimelidineThe serum concentration of Dipyridamole can be increased when it is combined with Zimelidine.Withdrawn
Food Interactions
  • Coffee and tea can decrease the effect of dipyridamole.
  • Take with food to reduce irritation.

References

Synthesis Reference

Minutza Leibovici, Itamar Kanari, Michael Fox, "Dipyridamole extended-release formulations and process for preparing same." U.S. Patent US20070184110, issued August 09, 2007.

US20070184110
General References
  1. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13. [PubMed:8981292]
External Links
Human Metabolome Database
HMDB15110
KEGG Drug
D00302
PubChem Compound
3108
PubChem Substance
46506292
ChemSpider
2997
BindingDB
23620
ChEBI
4653
ChEMBL
CHEMBL932
Therapeutic Targets Database
DNC001625
PharmGKB
PA449367
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Dipyridamole
ATC Codes
B01AC07 — Dipyridamole
AHFS Codes
  • 24:12.92 — Miscellaneous Vasodilatating Agents
FDA label
Download (48.7 KB)
MSDS
Download (73.3 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Unknown StatusNot AvailableCoronary Angiography1
1CompletedNot AvailableHealthy Volunteers1
1CompletedTreatmentHealthy Volunteers4
1CompletedTreatmentHypertensive1
1, 2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedPreventionCardiovascular Disease (CVD) / Carotid Stenosis / Cerebrovascular Disorders / Heart Diseases / Vascular Diseases1
2CompletedTreatmentMalignant Neoplasm of Pancreas1
2CompletedTreatmentRheumatoid Arthritis2
2Not Yet RecruitingTreatmentDry Eye Syndromes / Pterygium1
2RecruitingTreatmentIntracerebral Hemorrhage / Nonvalvular Atrial Fibrillation1
2TerminatedTreatmentMetastatic Breast Cancer (MBC)1
2Unknown StatusNot AvailableIschaemic Heart Diseases1
2Unknown StatusTreatmentCancer, Ovarian1
3CompletedPreventionAngina Pectoris / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia1
3CompletedPreventionCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia1
3CompletedPreventionCerebrovascular Accidents1
3CompletedPreventionRenal Failure1
3CompletedTreatmentCarotid Artery Dissection / Cervical Artery Dissection / Strokes / Vertebral Artery Dissection1
4CompletedNot AvailableDiabetes1
4CompletedPreventionArteriosclerosis / Ischemia, Brain / Transient Ischaemic Attack (TIA)1
4CompletedPreventionAtherosclerosis / Coronary Heart Disease (CHD) / Percutaneous Transluminal Coronary Angioplasty1
4CompletedPreventionCardiovascular Disease (CVD) / Ischaemic Heart Diseases1
4CompletedPreventionEndotoxaemia1
4CompletedPreventionStrokes1
4CompletedTreatmentAtherosclerosis / Ischemia-Reperfusion Injury1
4CompletedTreatmentCardiovascular Disease (CVD) / Ischemia-Reperfusion Injury1
4CompletedTreatmentHealthy Volunteers1
4CompletedTreatmentHypertensive / Liver Cirrhosis / Status;Splenectomy / Thrombosis, Venous1
4CompletedTreatmentMania1
4RecruitingPreventionHypertensive / Liver Cirrhosis / Status;Splenectomy / Thrombosis, Venous1
4TerminatedDiagnosticCoronary Artery Disease1
Not AvailableCompletedNot AvailableAtherosclerosis / Cardiovascular Disease (CVD) / Carotid Stenosis / Strokes1
Not AvailableCompletedBasic ScienceArterial hypoxia / Hyperemia1
Not AvailableCompletedTreatmentSchizoaffective Disorders / Schizophrenic Disorders / Schizophreniform Disorder1
Not AvailableRecruitingNot AvailableIgA Nephropathy / Immunosuppressive Treatment / Proteinuria in Nephrotic Range1
Not AvailableRecruitingTreatmentSystemic Lupus Erythematosus (SLE)1
Not AvailableTerminatedTreatmentPeripheral Arterial Disease (PAD)1

Pharmacoeconomics

Manufacturers
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Claris lifesciences ltd
  • Hospira inc
  • Teva parenteral medicines inc
  • Boehringer ingelheim pharmaceuticals inc
  • Actavis totowa llc
  • Barr laboratories inc
  • Glenmark generics inc usa
  • Impax laboratories inc
  • Lannett holdings inc
  • Murty pharmaceuticals inc
  • Purepac pharmaceutical co
  • Sandoz inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
  • Boehringer Ingelheim Pharmaceuticals, Inc
Packagers
Dosage forms
FormRouteStrength
Capsule, extended releaseOral
Capsule; capsule, extended releaseOral
TabletOral50 mg
CapsuleOral
InjectionIntravenous5 mg/mL
SolutionIntravenous5 mg/mL
TabletOral25 mg/1
TabletOral50 mg/1
TabletOral75 mg/1
Tablet, film coatedOral25 mg/1
Tablet, film coatedOral50 mg/1
Tablet, film coatedOral75 mg/1
LiquidIntravenous5 mg
TabletOral100 mg
SolutionIntravenous5 mg
Tablet, coatedOral25 mg/1
Tablet, coatedOral50 mg/1
Tablet, coatedOral75 mg/1
TabletOral25 mg
TabletOral75 mg
Prices
Unit descriptionCostUnit
Dipyridamole powder5.34USD g
Aggrenox capsule sa3.25USD capsule
Aggrenox 25-200 mg 12 Hour Capsule3.0USD capsule
Dipyridamole 5 mg/ml ampul1.5USD ml
Persantine 75 mg tablet1.46USD tablet
Dipyridamole 5 mg/ml vial1.32USD ml
Dipyridamole 75 mg tablet1.28USD tablet
Persantine 50 mg tablet1.09USD tablet
Dipyridamole 50 mg tablet0.96USD tablet
Persantine 25 mg tablet0.89USD tablet
Dipyridamole 25 mg tablet0.58USD tablet
Apo-Dipyridamole (Fc) 75 mg Tablet0.46USD tablet
Apo-Dipyridamole (Fc) 50 mg Tablet0.31USD tablet
Apo-Dipyridamole (Fc) 25 mg Tablet0.28USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6015577No1997-01-182017-01-18Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)163 °CPhysProp
water solubilitySlightlyNot Available
logP1.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.922 mg/mLALOGPS
logP1.52ALOGPS
logP1.81ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)14.97ChemAxon
pKa (Strongest Basic)6.59ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area145.44 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity142.78 m3·mol-1ChemAxon
Polarizability56.94 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9917
Blood Brain Barrier-0.6246
Caco-2 permeable-0.7261
P-glycoprotein substrateSubstrate0.7696
P-glycoprotein inhibitor INon-inhibitor0.5321
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterNon-inhibitor0.615
CYP450 2C9 substrateNon-substrate0.8345
CYP450 2D6 substrateNon-substrate0.6825
CYP450 3A4 substrateNon-substrate0.6849
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorInhibitor0.8045
CYP450 2D6 inhibitorInhibitor0.7201
CYP450 2C19 inhibitorNon-inhibitor0.957
CYP450 3A4 inhibitorInhibitor0.6789
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7806
Ames testNon AMES toxic0.7009
CarcinogenicityNon-carcinogens0.8884
BiodegradationNot ready biodegradable0.988
Rat acute toxicity2.1167 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.5271
hERG inhibition (predictor II)Non-inhibitor0.633
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udl-0291000000-2fc7956fe6ea13c73317
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-0001190000-346cf73a19cbefa2dc11
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-0013490000-839580758bc83767be8f
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udl-0291000000-caeb14eb3ea863e020a0
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-1348890000-aa1e3a113b8c2768cb08

Taxonomy

Description
This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
Kingdom
Organic compounds
Super Class
Organic nitrogen compounds
Class
Organonitrogen compounds
Sub Class
Amines
Direct Parent
Dialkylarylamines
Alternative Parents
Aminopyrimidines and derivatives / Piperidines / Imidolactams / Heteroaromatic compounds / Azacyclic compounds / Alkanolamines / Primary alcohols / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
Dialkylarylamine / Aminopyrimidine / Piperidine / Pyrimidine / Imidolactam / Heteroaromatic compound / Organoheterocyclic compound / Alkanolamine / Azacycle / Alcohol
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
piperidines, tertiary amino compound, tetrol, pyrimidopyrimidine (CHEBI:4653)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient wit...
Gene Name
PDE10A
Uniprot ID
Q9Y233
Uniprot Name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Molecular Weight
88411.71 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Fujishige K, Kotera J, Michibata H, Yuasa K, Takebayashi S, Okumura K, Omori K: Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J Biol Chem. 1999 Jun 25;274(26):18438-45. [PubMed:10373451]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, ...
Gene Name
PDE5A
Uniprot ID
O76074
Uniprot Name
cGMP-specific 3',5'-cyclic phosphodiesterase
Molecular Weight
99984.14 Da
References
  1. Kulkarni SK, Patil CS: Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects. Methods Find Exp Clin Pharmacol. 2004 Dec;26(10):789-99. [PubMed:15672122]
  2. Santini F, Casali G, Franchi G, Auriemma S, Lusini M, Barozzi L, Favaro A, Messina A, Mazzucco A: Hemodynamic effects of inhaled nitric oxide and phosphodiesterase inhibitor (dipyridamole) on secondary pulmonary hypertension following heart valve surgery in adults. Int J Cardiol. 2005 Aug 18;103(2):156-63. [PubMed:16080974]
  3. Kruuse C, Lassen LH, Iversen HK, Oestergaard S, Olesen J: Dipyridamole may induce migraine in patients with migraine without aura. Cephalalgia. 2006 Aug;26(8):925-33. [PubMed:16886928]
  4. Jackson EK, Ren J, Zacharia LC, Mi Z: Characterization of renal ecto-phosphodiesterase. J Pharmacol Exp Ther. 2007 May;321(2):810-5. Epub 2007 Feb 16. [PubMed:17308037]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Name
PDE4A
Uniprot ID
P27815
Uniprot Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Molecular Weight
98142.155 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Zinc ion binding
Specific Function
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, an...
Gene Name
ADA
Uniprot ID
P00813
Uniprot Name
Adenosine deaminase
Molecular Weight
40764.13 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Specific Function
Calcium-dependent protein serine/threonine phosphatase regulator activity
Gene Name
RCAN1
Uniprot ID
P53805
Uniprot Name
Calcipressin-1
Molecular Weight
28078.425 Da
References
  1. Mulero MC, Aubareda A, Orzaez M, Messeguer J, Serrano-Candelas E, Martinez-Hoyer S, Messeguer A, Perez-Paya E, Perez-Riba M: Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. J Biol Chem. 2009 Apr 3;284(14):9394-401. doi: 10.1074/jbc.M805889200. Epub 2009 Feb 3. [PubMed:19189965]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in...
Gene Name
ORM1
Uniprot ID
P02763
Uniprot Name
Alpha-1-acid glycoprotein 1
Molecular Weight
23511.38 Da
References
  1. Herve F, Duche JC, d'Athis P, Marche C, Barre J, Tillement JP: Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein. Pharmacogenetics. 1996 Oct;6(5):403-15. [PubMed:8946472]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Atpase activity, coupled to transmembrane movement of substances
Specific Function
May be an organic anion pump relevant to cellular detoxification.
Gene Name
ABCC4
Uniprot ID
O15439
Uniprot Name
Multidrug resistance-associated protein 4
Molecular Weight
149525.33 Da
References
  1. van Aubel RA, Smeets PH, Peters JG, Bindels RJ, Russel FG: The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002 Mar;13(3):595-603. [PubMed:11856762]
  2. Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. [PubMed:12695538]
  3. Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. [PubMed:12883481]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Organic anion transmembrane transporter activity
Specific Function
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene Name
ABCC5
Uniprot ID
O15440
Uniprot Name
Multidrug resistance-associated protein 5
Molecular Weight
160658.8 Da
References
  1. Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. [PubMed:12695538]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514]

Drug created on June 13, 2005 07:24 / Updated on November 13, 2017 21:49