Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.

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Jeong HW, Kim MR, Son KH, Han MY, Ha JH, Garnier M, Meijer L, Kwon BM

Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1819-22.

PubMed ID
10969976 [ View in PubMed
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Abstract

A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 microM.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
AlvocidibCyclin-dependent kinase 4IC 50 (nM)1007.230Details