Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).

Article Details

Citation

Copy to clipboard

Mulamba GB, Hu A, Azad RF, Anderson KP, Coen DM

Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).

Antimicrob Agents Chemother. 1998 Apr;42(4):971-3.

PubMed ID

9559825 [ View in PubMed

]

Abstract

A human cytomegalovirus mutant that was isolated for resistance (10-fold) to the antisense oligonucleotide fomivirsen (ISIS 2922) exhibited cross-resistance to a modified derivative of fomivirsen with an identical base sequence but little or no resistance to an oligonucleotide with an unrelated sequence. No changes in the mutant's DNA corresponding to the fomivirsen target sequence were found.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fomivirsen	30 kDa immediate-early protein 2	Protein	Human cytomegalovirus (strain Towne)	Yes	Antisense oligonucleotide	Details
Fomivirsen	45 kDa immediate-early protein 2	Protein	Human cytomegalovirus (strain Towne)	Yes	Antisense oligonucleotide	Details