Molecular Targets of the Phytocannabinoids: A Complex Picture.
Article Details
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Morales P, Hurst DP, Reggio PH
Molecular Targets of the Phytocannabinoids: A Complex Picture.
Prog Chem Org Nat Prod. 2017;103:103-131. doi: 10.1007/978-3-319-45541-9_4.
- PubMed ID
- 28120232 [ View in PubMed]
- Abstract
For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. These effects are associated with the phytocannabinoids which are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis. For many years, it was assumed that the beneficial effects of the phytocannabinoids were mediated by the cannabinoid receptors, CB1 and CB2. However, today we know that the picture is much more complex, with the same phytocannabinoid acting at multiple targets. This contribution focuses on the molecular pharmacology of the phytocannabinoids, including Delta(9)-THC and CBD, from the prospective of the targets at which these important compounds act.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tetrahydrocannabivarin 5-hydroxytryptamine receptor 1A Protein Humans YesAgonistDetails Tetrahydrocannabivarin Cannabinoid receptor 1 Protein Humans YesAntagonistDetails Tetrahydrocannabivarin Cannabinoid receptor 2 Protein Humans UnknownPartial agonistDetails Tetrahydrocannabivarin G-protein coupled receptor 55 Protein Humans YesPartial agonistDetails Tetrahydrocannabivarin Transient receptor potential cation channel subfamily A member 1 Protein Humans YesAgonistDetails Tetrahydrocannabivarin Transient receptor potential cation channel subfamily M member 8 Protein Humans YesAntagonistDetails Tetrahydrocannabivarin Transient receptor potential cation channel subfamily V member 2 Protein Humans YesAgonistDetails