Clofarabine: emerging role in leukemias.
Article Details
- CitationCopy to clipboard
Sampat K, Kantarjian H, Borthakur G
Clofarabine: emerging role in leukemias.
Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. doi: 10.1517/13543780903173222.
- PubMed ID
- 19715446 [ View in PubMed]
- Abstract
Clofarabine is a second-generation purine nucleoside analogue. It works mainly by inhibiting ribonucleotide reductase and incorporating into DNA. Clofarabine has shown efficacy in selected pediatric leukemias. It has also shown significant efficacy alone and in combination with other drugs in treating adult myeloid leukemias and high-risk myelodysplastic syndromes. Further, there is significant promise for clofarabine in the treatment of older patients with acute myeloid leukemia who are unlikely to benefit from standard induction chemotherapy due to unfavorable baseline prognostic factors. An oral formulation of clofarabine is also currently under development.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cladribine DNA Nucleotide Humans YesOther/unknownDetails Cladribine Ribonucleoside-diphosphate reductase large subunit Protein Humans YesInhibitorDetails Cladribine Ribonucleoside-diphosphate reductase subunit M2 Protein Humans YesInhibitorDetails Cladribine Ribonucleoside-diphosphate reductase subunit M2 B Protein Humans YesInhibitorDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Cladribine Deoxycytidine kinase Protein Humans UnknownSubstrateDetails