The role of transporters in the pharmacokinetics of orally administered drugs.
Article Details
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Shugarts S, Benet LZ
The role of transporters in the pharmacokinetics of orally administered drugs.
Pharm Res. 2009 Sep;26(9):2039-54. doi: 10.1007/s11095-009-9924-0. Epub 2009 Jun 30.
- PubMed ID
- 19568696 [ View in PubMed]
- Abstract
Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives transporter proteins a unique gatekeeper function in controlling drug access to metabolizing enzymes and excretory pathways. This review seeks to discuss the influence intestinal and hepatic drug transporters have on pharmacokinetic parameters, including bioavailability, exposure, clearance, volume of distribution, and half-life, for orally dosed drugs. This review also describes in detail the Biopharmaceutics Drug Disposition Classification System (BDDCS) and explains how many of the effects drug transporters exert on oral drug pharmacokinetic parameters can be predicted by this classification scheme.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Acyclovir Solute carrier family 22 member 1 Protein Humans UnknownSubstrateInhibitorDetails Ganciclovir Solute carrier family 22 member 1 Protein Humans UnknownSubstrateInhibitorDetails