Breath hydrogen concentrations after oral lactose and lactulose in tropical malabsorption and adult hypolactasia.

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Breath hydrogen concentrations after oral lactose and lactulose in tropical malabsorption and adult hypolactasia.

Trans R Soc Trop Med Hyg. 1978;72(3):277-81.

PubMed ID

97820 [ View in PubMed

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Abstract

Thirty-six hospital in-patients in London had breath-hydrogen concentrations measured after 50 g lactose were given orally; in 23 or them serial blood glucose concentrations were also estimated. Eight had tropical malabsorption (TM), 14 were Europeans with no detectable disease (normal group) and 14 who also had no detectable disease, were from ethnic groups known to have a very high incidence of genetically determined adult hypolactasia (hl). In 21 of them breath-hydrogen concentrations were also measured after 33.5 g of lactulose were given orally. There was a good inverse correlation between breath-hydrogen production and blood-glucose rise after lactose. Correlations between the first appearance of hydrogen (T) and the area under the hydrogen curve between 0 and 120 min (A) were inversely significant both for lactose and lactulose. Mean T was earlier and mean A greater for lactose compared with lactulose. Correlation between individual values for A after lactase and after lactulose was significant. Indirect measurements of lactase are of no value in either detecting or assessing the severity of TM; that is largely due to the very high incidence of HL in individuals exposed to that disease.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Lactulose	Evolved beta-galactosidase subunit alpha	Protein	Escherichia coli (strain K12)	Unknown	Other	Details