Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.

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Wang Z, Woolverton WL

Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.

Eur J Pharmacol. 2007 Feb 28;557(2-3):159-60. Epub 2006 Dec 1.

PubMed ID

17196194 [ View in PubMed

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Abstract

Histamine H1 receptor antagonists have some behavioral effects that predict abuse liability. In the present study, diphenhydramine and cocaine each maintained i.v. self-administration under a progressive-ratio schedule in rhesus monkeys. When cocaine and DPH were combined in a 1:1 ratio of the ED50s, the combination was super-additive in all monkeys. The data predict that the combination of cocaine and histamine H1 receptor antagonists would have enhanced potential for abuse relative to either drug alone.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Diphenhydramine	Histamine H1 receptor	Protein	Humans	Yes	Antagonist	Details