You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameDiphenhydramine
Accession NumberDB01075  (APRD00587, DB06975)
TypeSmall Molecule
GroupsApproved
DescriptionA histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Structure
Thumb
Synonyms
2-(Benzhydryloxy)-N,N-dimethylethylamine
2-diphenylmethoxy-N,N-demthylethanamine
alpha-(2-Dimethylaminoethoxy)diphenylmethane
beta-Dimethylaminoethanol diphenylmethyl ether
beta-Dimethylaminoethyl benzhydryl ether
Difenhidramina
Diphenhydraminum
N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine
O-benzhydryldimethylaminoethanol
β-dimethylaminoethyl benzhydryl ether
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Benadryl Inj. 50mg/mlLiquid50 mgIntramuscular; IntravenousWarner Lambert Canada Inc.1994-12-312000-11-27Canada
Diphenhydramine HCl Inj USP 50mg/mlLiquid50 mgIntravenousInternational Medication Systems Ltd.1974-12-311997-08-15Canada
Diphenhydramine HCl Injection, USPSolution50 mgIntramuscular; IntravenousSterimax Inc1994-12-31Not applicableCanada
Diphenhydramine Hydrochloride InjectionSolution50 mgIntramuscular; IntravenousFresenius Kabi Canada Ltd2012-02-17Not applicableCanada
Diphenhydramine Hydrochloride Injection USPLiquid50 mgIntramuscular; IntravenousSandoz Canada Incorporated1983-12-31Not applicableCanada
Diphenist 50mg/mlLiquid50 mgIntramuscular; IntravenousOmega Laboratories Ltd1997-10-28Not applicableCanada
PMS-diphenhydramine Hydrochloride Inj 50mg/mlLiquid50 mgIntramuscular; IntravenousPharmascience Inc1991-12-31Not applicableCanada
Scheinpharm Diphenhydramine Inj.50mg/mlSolution50 mgIntramuscular; IntravenousSchein Pharmaceutical Canada Inc.1996-09-302004-07-26Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Diphendydramine HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2010-12-17Not applicableUs
DiphenhydramineInjection, solution50 mg/mLIntramuscular; IntravenousFresenius Kabi USA, LLC2002-08-01Not applicableUs
DiphenhydramineInjection, solution50 mg/mLIntravenousREMEDYREPACK INC.2013-06-13Not applicableUs
Diphenhydramine HydrochlorideInjection, solution50 mg/mLIntramuscular; IntravenousGeneral Injectables & Vaccines, Inc2010-07-01Not applicableUs
Diphenhydramine HydrochlorideInjection, solution50 mg/mLIntramuscular; IntravenousGeneral Injectables and Vaccines2010-03-01Not applicableUs
Diphenhydramine HydrochlorideSolution12.5 mg/5mLOralPharmaceutical Associates, Inc.1982-02-10Not applicableUs
Diphenhydramine HydrochlorideElixir12.5 mg/5mLOralCardinal Health1982-02-10Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousCardinal Health2011-06-28Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralREMEDYREPACK INC.2013-03-252016-04-05Us
Diphenhydramine HydrochlorideInjection, solution50 mg/mLIntramuscular; IntravenousMylan Institutional LLC2013-05-09Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Diphenhydramine HydrochlorideInjection, solution50 mg/mLIntramuscular; IntravenousBd Rx2013-03-26Not applicableUs
Diphenhydramine HydrochlorideInjection, solution50 mg/mLIntramuscular; IntravenousHospira, Inc.1988-11-20Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralCardinal Health2011-01-20Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousSina Health Inc1972-11-27Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousDispensing Solutions, Inc.1972-11-27Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscularREMEDYREPACK INC.2013-06-132016-12-15Us
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousTYA Pharmaceuticals1972-11-27Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousWest Ward Pharmaceutical Corp.1972-11-27Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousCardinal Health2002-05-28Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscularREMEDYREPACK INC.2013-06-10Not applicableUs
Diphenhydramine HydrochlorideInjection, solution50 mg/mLIntramuscular; IntravenousCardinal Health1988-11-20Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousA S Medication Solutions1972-11-27Not applicableUs
Diphenhydramine HydrochlorideInjection50 mg/mLIntramuscular; IntravenousRebel Distributors Corp1972-11-27Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralContract Pharmacy Services Pa2010-08-05Not applicableUs
Diphenhydramine HydrochlorideElixir25 mg/10mLOralCardinal Health1982-02-10Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select AllergyTablet25 mg/1Oral7 Eleven2014-04-22Not applicableUs
7 Select Allergy ChildrensSolution12.5 mg/5mLOral7 Eleven2014-08-05Not applicableUs
7 Select Night Time Sleep AidLiquid50 mg/30mLOral7 Eleven2014-04-22Not applicableUs
Adult AllergySolution50 mg/20mLOralChain Drug Consortium, LLC2015-05-04Not applicableUs
After Bite OutdoorGel20 mg/mLTopicalTender Corporation2016-11-01Not applicableUs
After Bite PlusCream20 mg/mLTopicalTender Corporation2012-07-03Not applicableUs
After Bite XtraGel20 mg/mLTopicalTender Corporation2016-11-01Not applicableUs
Afterbite With AntihistimineCream2 mL/100mLTopicalTender Corporation2012-07-032016-11-03Us
Alka-seltzer Plus AllergyTablet25 mg/1OralBayer Health Care Llc, Consumer Care2011-11-07Not applicableUs
Aller-aideTablet25 mgOralTeva Canada Limited1996-05-02Not applicableCanada
Aller-aide ElixirElixir12.5 mgOralTeva Canada Limited1995-12-31Not applicableCanada
Aller-aide PlusTablet50 mgOralTeva Canada Limited1997-02-21Not applicableCanada
Aller-aide Plus Capsules 50mgCapsule50 mgOralTechnilab Pharma Inc.1996-12-311997-08-22Canada
Aller-G-timeTablet, film coated25 mg/1OralTIME CAP LABORATORIES, INC2012-05-01Not applicableUs
Allerdryl Cap 25mgCapsule25 mgOralValeant Canada Lp Valeant Canada S.E.C.1976-12-312014-07-30Canada
Allerdryl Cap 50mgCapsule50 mgOralValeant Canada Lp Valeant Canada S.E.C.1973-12-312014-07-30Canada
Allergies ReliefTablet, film coated25 mg/1OralMedex Merchandising, Llc2015-10-01Not applicableUs
AllergyCapsule25 mg/1OralCVS Pharmacy1987-12-15Not applicableUs
AllergyCapsule25 mg/1OralMeijer Distribution Inc1991-01-15Not applicableUs
AllergyLiquid12.5 mg/5mLOralAccudial Pharmaceutical, Inc.2013-02-01Not applicableUs
AllergyCapsule25 mg/1OralWestern Family Foods Inc2003-04-09Not applicableUs
AllergyCapsule25 mg/1OralTOP CARE (Topco Associates LLC)2016-07-15Not applicableUs
AllergyCapsule25 mg/1OralKroger Company1990-08-15Not applicableUs
AllergyTablet25 mg/1OralMc Kesson2012-05-17Not applicableUs
AllergyTablet25 mg/1OralCVS Pharmacy1991-08-14Not applicableUs
AllergyTablet25 mg/1OralHy Vee Inc2016-03-01Not applicableUs
AllergyCapsule25 mg/1OralPublix Super Markets Inc1993-08-31Not applicableUs
AllergySolution12.5 mg/5mLOralHy Vee Inc1992-11-11Not applicableUs
AllergyTablet, coated25 mg/1OralFRED'S, INC.1990-03-02Not applicableUs
AllergyCapsule25 mg/1OralMedicine Shoppe International Inc1990-03-15Not applicableUs
AllergyTablet25 mg/1OralVelocity Pharma2012-05-12Not applicableUs
AllergyLiquid12.5 mgOralAccudial Pharmaceutical Inc2010-01-11Not applicableCanada
AllergyTablet25 mg/1OralMeijer Distribution Inc1991-09-06Not applicableUs
AllergyTablet25 mg/1OralPublix Super Markets Inc1998-05-07Not applicableUs
AllergyTablet25 mg/1OralWestern Family Foods Inc2003-02-25Not applicableUs
AllergyTablet, coated25 mg/1OralDiscount Drug Mart2016-09-30Not applicableUs
AllergyCapsule25 mg/1OralTOP CARE (Topco Associates LLC)2013-11-30Not applicableUs
AllergyCapsule25 mg/1OralCardinal Health (Leader) 497812016-01-31Not applicableUs
AllergyTablet25 mg/1OralAllegiant Health2014-12-15Not applicableUs
AllergySolution12.5 mg/5mLOralH E B1987-07-15Not applicableUs
AllergyLiquid12.5 mg/5mLOralKroger Company1987-07-15Not applicableUs
AllergyTablet25 mg/1OralKroger Company1987-09-15Not applicableUs
AllergyTablet25 mg/1OralGreenbrier International, Inc.1990-03-02Not applicableUs
AllergyLiquid12.5 mg/5mLOralAccudial Pharmaceutical, Inc.2009-10-26Not applicableUs
AllergyCapsule25 mg/1OralHy Vee Inc1988-12-15Not applicableUs
AllergyCapsule25 mg/1OralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED1990-03-15Not applicableUs
Allergy AntihistamineTablet25 mg/1OralP & L Development, LLC2013-08-27Not applicableUs
Allergy AntihistamineTablet25 mg/1OralBest Choice (Valu Merchandisers Company)2010-08-27Not applicableUs
Allergy AntihistamineTablet25 mg/1OralSuper Valu (Equaline)2010-07-22Not applicableUs
Allergy AntihistamineCapsule25 mg/1OralBest Choice (Valu Merchandisers Company)2010-08-10Not applicableUs
Allergy AntihistamineTablet25 mg/1OralEqualine (Super Valu)2010-07-22Not applicableUs
Allergy AntihistamineCapsule25 mg/1OralCardinal Health (Leader)2012-08-30Not applicableUs
Allergy AntihistamineTablet25 mg/1OralCardinal Health (Leader)2012-10-30Not applicableUs
Allergy AntihistamineTablet25 mg/1OralSelect Corporation2012-10-15Not applicableUs
Allergy Attack Relief To GoPowder25 mg/1OralBreakthrough Products Inc.2012-10-01Not applicableUs
Allergy Capsules Extra StrengthCapsule50 mgOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Allergy ChildrensLiquid12.5 mg/5mLOralH E B2016-02-29Not applicableUs
Allergy ChildrensLiquid12.5 mg/5mLOralCVS Pharmacy1987-07-15Not applicableUs
Allergy ChildrensSolution12.5 mg/5mLOralMeijer Distribution Inc1987-11-15Not applicableUs
Allergy ChildrensLiquid12.5 mg/5mLOralWe Care Distributors Inc.2016-06-21Not applicableUs
Allergy Childrens AllergyLiquid12.5 mg/5mLOralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2015-06-30Not applicableUs
Allergy Complete ReliefCapsule, liquid filled25 mg/1OralNash Finch Company2001-09-13Not applicableUs
Allergy Complete ReliefCapsule25 mg/1OralNash Finch Company1990-03-15Not applicableUs
Allergy Complete ReliefTablet25 mg/1OralNash Finch Company1990-03-02Not applicableUs
Allergy Dye-freeSolution12.5 mgOralAccudial Pharmaceutical Inc2012-06-01Not applicableCanada
Allergy ElixirElixir12.5 mgOralTanta Pharmaceuticals Inc1991-12-31Not applicableCanada
Allergy FormulaTablet25 mgOralVita Health Products Inc1997-04-01Not applicableCanada
Allergy FormulaTablet25 mgOralPharmetics (2011) Inc2009-05-08Not applicableCanada
Allergy FormulaTablet25 mgOralLaboratoires Trianon Inc2016-09-15Not applicableCanada
Allergy FormulaTablet25 mgOralPharmascience IncNot applicableNot applicableCanada
Allergy FormulaTablet25 mgOralGenvion CorporationNot applicableNot applicableCanada
Allergy FormulaTablet25 mgOralActavis Pharma Company2010-07-21Not applicableCanada
Allergy Formula CapletsTablet25 mgOralPerrigo International1997-09-29Not applicableCanada
Allergy Formula ElixirSolution12.5 mgOralActavis Pharma Company2016-10-19Not applicableCanada
Allergy Formula Junior StrengthTablet, chewable12.5 mgOralPharmetics (2011) IncNot applicableNot applicableCanada
Allergy Formula LiquidLiquid12.5 mgOralPerrigo International1997-09-29Not applicableCanada
Allergy Formula Liquid CapsulesCapsule25 mgOralVita Health Products Inc2008-07-11Not applicableCanada
Allergy Formula Liquid GelsCapsule25 mgOralAccucaps Industries LimitedNot applicableNot applicableCanada
Allergy Get ReliefTablet25 mg/1OralEagle Distributors,Inc.2012-06-30Not applicableUs
Allergy Liquid Gel CapsulesCapsule25 mgOralApotex IncNot applicableNot applicableCanada
Allergy MedicineTablet25 mg/1OralCostco Wholesale Corporation1990-03-02Not applicableUs
Allergy MedicineTablet, film coated25 mg/1OralL&R Distributors, Inc.1990-03-02Not applicableUs
Allergy MedicineCapsule25 mg/1OralL&R Distributors, Inc.1990-03-15Not applicableUs
Allergy Rapid Melts ChildrensTablet, chewable12.5 mg/1OralChain Drug Consortium2011-04-25Not applicableUs
Allergy ReilefCapsule25 mg/1OralChain Drug Consortium1990-03-15Not applicableUs
Allergy ReliefTablet25 mg/1OralTOP CARE (Topco Associates LLC)2013-03-31Not applicableUs
Allergy ReliefTablet25 mg/1OralWe Care Distributor Inc2016-01-11Not applicableUs
Allergy ReliefTablet25 mg/1OralKareway Product, Inc.2011-08-18Not applicableUs
Allergy ReliefCapsule25 mg/1OralMcKesson (Sunmark)2011-08-26Not applicableUs
Allergy ReliefTablet25 mg/1OralArmy and Air Force Exchange Service1990-03-02Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralCVS Pharmacy2014-11-21Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralSpirit Pharmaceutical Llc2016-08-18Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralTarget Corporation1990-03-02Not applicableUs
Allergy ReliefCapsule25 mg/1OralMEIJER, INC.2014-10-31Not applicableUs
Allergy ReliefTablet25 mg/1OralHealth Life Of Usa2012-05-12Not applicableUs
Allergy ReliefCapsule25 mg/1OralFamily Dollar1990-03-15Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralMeijer Distribution Inc1990-03-02Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralRite Aid2001-09-13Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralPreferred Plus (Kinray)2013-11-25Not applicableUs
Allergy ReliefTablet25 mg/1OralInternational Laboratories, Inc.2016-05-27Not applicableUs
Allergy ReliefCapsule25 mg/1OralMc Kesson (Sunmark)1990-03-15Not applicableUs
Allergy ReliefCapsule25 mg/1OralArmy and Air Force Exchange Service1990-03-15Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralHy Vee2015-11-30Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralFoodhold U.S.A., Llc2016-10-03Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralDolgencorp, LLC1990-03-02Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralPura Cap Pharmaceutical Llc2016-07-14Not applicableUs
Allergy ReliefCapsule25 mg/1OralSUPERVALU INC.1990-03-15Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralRite Aid Corporation1990-03-02Not applicableUs
Allergy ReliefCapsule25 mg/1OralMEIJER, INC.2015-10-31Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralP & L Development, LLC2015-09-30Not applicableUs
Allergy ReliefTablet, coated25 mg/1OralChain Drug Marketing Association2014-06-13Not applicableUs
Allergy ReliefTablet, coated24 mg/1OralMc Kesson (Sunmark)1990-03-02Not applicableUs
Allergy ReliefTablet25 mg/1OralHealthy Accents (DZA Brands, LLC)2013-12-30Not applicableUs
Allergy ReliefCapsule25 mg/1OralH E B2016-02-29Not applicableUs
Allergy ReliefCapsule25 mg/1OralMc Kesson (Health Mart)1990-03-15Not applicableUs
Allergy ReliefTablet, coated25 mg/1OralCardinal Health1990-03-02Not applicableUs
Allergy ReliefSolution12.5 mg/5mLOralBio Pharm, Inc.2007-12-06Not applicableUs
Allergy ReliefTablet25 mg/1OralCVS Pharmacy2015-07-212018-04-30Us
Allergy ReliefCapsule25 mg/1OralMc Kesson (Health Mart)2015-10-31Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralArmy and Air Force Exchange Service2001-09-13Not applicableUs
Allergy ReliefTablet25 mg/1OralFamily Dollar1990-03-02Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralL.N.K. International, Inc.1990-03-02Not applicableUs
Allergy ReliefCapsule25 mg/1OralWal Mart Stores Inc1990-03-15Not applicableUs
Allergy ReliefTablet25 mg/1OralBetter Living Brands, Llc1990-03-02Not applicableUs
Allergy ReliefTablet25 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2015-03-31Not applicableUs
Allergy ReliefCapsule25 mg/1OralBetter Living Brands, Llc1990-03-15Not applicableUs
Allergy ReliefCapsule25 mg/1OralFamily Dollar (FAMILY WELLNESS)2016-06-30Not applicableUs
Allergy ReliefCapsule25 mg/1OralAldi Inc.1990-03-15Not applicableUs
Allergy ReliefCapsule25 mg/1OralSuper Valu (Equaline)2011-08-15Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralSUPERVALU INC.1990-03-02Not applicableUs
Allergy ReliefCapsule25 mg/1OralRite Aid1990-03-15Not applicableUs
Allergy ReliefCapsule, liquid filled25 mg/1OralTarget Corporation2015-06-30Not applicableUs
Allergy ReliefTablet25 mg/1OralNavarro Discount Pharmacies,LLC2013-01-01Not applicableUs
Allergy ReliefTablet25 mg/1OralMc Kesson (Health Mart)1990-03-02Not applicableUs
Allergy ReliefTablet25 mg/1OralCVS Pharmacy2016-08-19Not applicableUs
Allergy ReliefTablet25 mg/1OralL.N.K. International, Inc.1990-03-02Not applicableUs
Allergy ReliefCapsule25 mg/1OralChain Drug Marketing Association2008-11-10Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralHarmon Store Inc.1990-03-02Not applicableUs
Allergy ReliefTablet25 mg/1OralShopko Stores Operating Co., LLC2013-09-09Not applicableUs
Allergy ReliefTablet, coated25 mg/1OralWal Mart Stores Inc1990-03-02Not applicableUs
Allergy ReliefCapsule25 mg/1OralBest Choice (Valu Merchandisers Company)2015-09-30Not applicableUs
Allergy ReliefCapsule25 mg/1OralMc Kesson (Sunmark)2015-09-30Not applicableUs
Allergy ReliefCapsule25 mg/1OralShopko Stores Operating Co., LLC2016-10-07Not applicableUs
Allergy ReliefCapsule25 mg/1OralL.N.K. International, Inc.1990-03-15Not applicableUs
Allergy ReliefCapsule25 mg/1OralFreds Inc2015-12-18Not applicableUs
Allergy ReliefTablet, film coated25 mg/1OralCVS Pharmacy1990-03-02Not applicableUs
Allergy Relief AntihistamineTablet25 mg/1OralFreds Inc2010-07-22Not applicableUs
Allergy Relief AntihistamineCapsule, liquid filled25 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2013-05-30Not applicableUs
Allergy Relief AntihistamineCapsule, liquid filled25 mg/1OralTOP CARE (Topco Associates LLC)2013-05-30Not applicableUs
Allergy Relief AntihistamineTablet25 mg/1OralMcKesson (Sunmark)2011-09-28Not applicableUs
Allergy Relief AntihistamineCapsule, liquid filled25 mg/1OralFreds Inc2013-04-08Not applicableUs
Allergy Relief AntihistamineTablet25 mg/1OralSIMPLY RIGHT (Sam's West, Inc.)2011-10-30Not applicableUs
Allergy Relief AntihistamineTablet25 mg/1OralPreferred Plus (Kinray)2010-10-26Not applicableUs
Allergy Relief AntihistamineCapsule, liquid filled25 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2013-06-06Not applicableUs
Allergy Relief AntihistamineCapsule, liquid filled25 mg/1OralP And L Development Of New York Corporation (Ready In Case)2013-02-07Not applicableUs
Allergy Relief AntihistamineCapsule, liquid filled25 mg/1OralSMART SENSE (Kmart)2013-04-01Not applicableUs
Allergy Relief AntihistamineTablet25 mg/1OralCardinal Health (Leader) 497812011-09-28Not applicableUs
Allergy Relief ChildrensSolution12.5 mg/5mLOralCVS Pharmacy2015-09-03Not applicableUs
Allergy Relief ChildrensLiquid12.5 mg/5mLOralASSURED / DOLLAR TREE (Greenbrier International, Inc.)2016-06-30Not applicableUs
Allergy Relief ChildrensTablet, chewable12.5 mg/1OralMeijer2011-04-25Not applicableUs
Allergy Relief ChildrensTablet, chewable12.5 mg/1OralSUPERVALU INC.2009-03-20Not applicableUs
Allergy Relief CompleteTablet25 mg/1OralWin Co Foods, Llc1990-03-02Not applicableUs
Allergy Relief CompleteCapsule25 mg/1OralWin Co Foods, Llc1990-03-15Not applicableUs
Allergy Relief Dye FreeCapsule, liquid filled25 mg/1OralTOP CARE (Topco Associates LLC)2016-02-29Not applicableUs
Allergy Relief Dye FreeCapsule, liquid filled25 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2015-10-31Not applicableUs
Allergy Relief Dye FreeCapsule, liquid filled25 mg/1OralSMART SENSE (Kmart)2016-07-31Not applicableUs
Allergy Relief Dye FreeCapsule, liquid filled25 mg/1OralWestern Family Foods, Inc.2015-09-30Not applicableUs
Allergy Relief Dye FreeCapsule, liquid filled25 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2016-03-31Not applicableUs
Allergy Relief Dye-freeCapsule, liquid filled25 mg/1OralChain Drug Marketing Association Inc2015-03-01Not applicableUs
Allergy Relief Dye-freeTablet25 mg/1OralCVS Pharmacy2013-02-07Not applicableUs
Allergy Relief Dye-freeCapsule, liquid filled25 mg/1OralHarmon Store Inc.2015-03-01Not applicableUs
Allergy Relief Dye-freeCapsule, liquid filled25 mg/1OralCVS Pharmacy2015-03-01Not applicableUs
Allergy Relief Dye-freeCapsule, liquid filled25 mg/1OralCardinal Health2015-03-01Not applicableUs
Allergy Relief Dye-freeCapsule, liquid filled25 mg/1OralWal Mart Stores Inc2015-03-01Not applicableUs
Allergy Relief Dye-free Liquid GelsCapsule, liquid filled25 mg/1OralArmy and Air Force Exchange Service2015-03-01Not applicableUs
Allergy Relief ElixirElixir12.5 mgOralPharmetics (2011) IncNot applicableNot applicableCanada
Allergy Relief Extra Strength NighttimeTablet50 mg/1OralHy Vee2014-11-30Not applicableUs
Allergy Relief Extra Strength NighttimeTablet50 mg/1OralP & L Development, LLC2015-09-30Not applicableUs
Allergy Relief NighttimeTablet, film coated25 mg/1OralWALGREEN CO.2015-01-20Not applicableUs
Allergy Relief NighttimeTablet25 mg/1OralMeijer2015-01-20Not applicableUs
Allergy SoftgelCapsule, liquid filled25 mg/1OralAi Ping Pharmaceutical Inc.2015-01-31Not applicableUs
Allergy SoftgelCapsule, liquid filled25 mg/1OralAllegiant Health2014-12-15Not applicableUs
Allergy Tablets 25mgTablet25 mgOralTanta Pharmaceuticals Inc1992-12-31Not applicableCanada
Allergy Tablets Extra StrengthTablet50 mgOralTanta Pharmaceuticals Inc1997-04-21Not applicableCanada
AllernixTablet25 mgOralTeva Canada Limited1995-12-31Not applicableCanada
Allernix Cap 50mg UCapsule50 mgOralTechnilab Pharma Inc.1991-12-311997-08-22Canada
Allernix ElixirSolution12.5 mgOralTeva Canada Limited1991-12-31Not applicableCanada
Allernix Extra StrengthTablet50 mgOralTeva Canada Limited1995-12-31Not applicableCanada
Allernix HCl Cap 25mg UCapsule25 mgOralTechnilab Pharma Inc.1991-12-311997-08-22Canada
Anti-itchGel2 g/100gTopicalNavarro Discount Pharmacies,LLC2013-01-18Not applicableUs
Anti-itch CreamCream2 %TopicalTaro Pharmaceuticals Inc2007-12-20Not applicableCanada
Anti-itch Diphenhydramine Hydrochloride CreamCream2.0 %TopicalCrlsNot applicableNot applicableCanada
Antihistamine AllergyCapsule25 mg/1OralH E B2011-03-23Not applicableUs
Antihistamine AllergyCapsule25 mg/1OralH E B1989-07-15Not applicableUs
Antihistamine AllergyTablet, coated25 mg/1OralH E B1990-03-02Not applicableUs
Antihistamine AllergyTablet25 mg/1OralH E B1989-08-15Not applicableUs
Antihistamine AllergyTablet25 mg/1OralH E B2011-12-01Not applicableUs
Antihistimine AllergyTablet, coated25 mg/1OralAvema Pharma Solutions2012-04-30Not applicableUs
AphenapTablet25 mg/1OralA P J Laboratories Limited2013-03-01Not applicableUs
Assured Allergy ReliefTablet, film coated25 mg/1OralSpirit Pharmaceutical Llc2016-07-01Not applicableUs
Aurodryl Childrens AllergySolution12.5 mg/5mLOralAurohealth LLC2015-05-13Not applicableUs
Aurodryl Childrens AllergySolution12.5 mg/5mLOralAurohealth LLC2014-09-10Not applicableUs
Aurozzil Nighttime Sleep-aidSolution50 mg/30mLOralAurohealth LLC2015-05-15Not applicableUs
Bactimicina Childrens AllergyLiquid12.5 mg/5mLOralDLC Laboratories, Inc.2015-06-17Not applicableUs
BanophenLiquid12.5 mg/5mLOralMajor Pharmaceuticals2012-08-24Not applicableUs
BanophenLiquid12.5 mg/5mLOralProficient Rx LP2006-11-20Not applicableUs
BanophenTablet25 mg/1OralCardinal Health1990-03-02Not applicableUs
BanophenLiquid12.5 mg/5mLOralMajor Pharmaceuticals2006-11-20Not applicableUs
BanophenCapsule50 mg/1OralMajor Pharmaceuticals2009-11-02Not applicableUs
BanophenCapsule25 mg/1OralMajor Pharmaceuticals1990-03-15Not applicableUs
BanophenCapsule50 mg/1OralUnit Dose Services2009-01-02Not applicableUs
BanophenTablet25 mg/1OralMajor Pharmaceuticals1990-03-02Not applicableUs
BanophenCapsule50 mg/1OralREMEDYREPACK INC.2015-12-23Not applicableUs
BanophenTablet25 mg/1OralCarilion Materials Management1990-03-02Not applicableUs
BenadrylTablet, film coated25 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-09-01Not applicableUs
BenadrylTablet, film coated25 mg/1OralMechanical Servants, Llc2008-09-01Not applicableUs
BenadrylTablet, film coated25 mg/1OralREMEDYREPACK INC.2016-08-31Not applicableUs
BenadrylTablet, film coated25 mg/1OralLil' Drug Store Products, Inc.2010-09-16Not applicableUs
Benadryl 25mg CapletsTablet25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1993-12-31Not applicableCanada
Benadryl AllergyTablet, coated25 mg/1OralRebel Distributors Corp2009-01-01Not applicableUs
Benadryl AllergySolution12.5 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benadryl Allergy Liqui-gelsCapsule, liquid filled25 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2009-03-01Not applicableUs
Benadryl Allergy LiquigelsCapsule25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2008-05-05Not applicableCanada
Benadryl Allergy Quick Dissolve StripsStrip25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benadryl Allergy TabletsTablet, chewable12.5 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1998-03-06Not applicableCanada
Benadryl Capsules 50mgCapsule50 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1994-12-312016-01-22Canada
Benadryl Childrens Liquid 6.25mg/5mlLiquid6.25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1991-12-31Not applicableCanada
Benadryl Cream 2%Cream2 %TopicalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1993-12-31Not applicableCanada
Benadryl ElixirElixir12.5 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1994-12-31Not applicableCanada
Benadryl Extra Strength CapletsTablet50 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1999-04-06Not applicableCanada
Benadryl Extra Strength Itch StoppingGel20 mg/mLTopicalJohnson & Johnson Consumer Inc.2013-02-132019-09-01Us
Benadryl Extra Strength Itch StoppingGel20 mg/mLTopicalJohnson & Johnson Consumer Inc.2013-10-01Not applicableUs
Benadryl Fast MeltsTablet, chewable25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benadryl Itch Stopping GelGel2 %TopicalMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benadryl UltratabsTablet25 mg/1OralNavajo Manufacturing Company Inc.2016-09-22Not applicableUs
BenaldrylTablet25 mg/250mgOralAjes Pharmaceuticals,LLC2012-09-01Not applicableUs
Benylin Cough and Cold Night StripsStrip25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Benylin Night CoughCapsule25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-10-012009-08-06Canada
Benylin Night for ChildrenLiquid6.25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2013-01-28Not applicableCanada
Benylin Sleep TimeLiquid12.5 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2012-08-31Not applicableCanada
Berkley and Jensen AllergyTablet25 mg/1OralBJWC2008-10-31Not applicableUs
Berkley and Jensen Allergy ReliefTablet25 mg/1OralBJWC2013-12-10Not applicableUs
Calmex Tab 25mgTablet25 mgOralNovopharm Limited1981-12-312015-10-26Canada
Careall DiphenhydramineTablet, coated25 mg/1OralNew World Imports, Inc2016-04-28Not applicableUs
Careone AllergyCapsule25 mg/1OralAmerican Sales Company2004-07-27Not applicableUs
Careone Allergy MedicationTablet25 mg/1OralAmerican Sales Company2004-05-24Not applicableUs
Careone Allergy ReliefCapsule25 mg/1OralAmerican Sales Company2016-10-28Not applicableUs
Careone Childrens AllergySolution12.5 mg/5mLOralAmerican Sales Company2015-10-28Not applicableUs
Careone Childrens Allergy ReliefSolution12.5 mg/5mLOralAmerican Sales Company2016-04-12Not applicableUs
Careone Nighttime Sleep AidCapsule, liquid filled25 mg/1OralAmerican Sales Company2014-01-28Not applicableUs
Careone Nighttime Sleep AidTablet25 mg/1OralAmerican Sales Company2004-04-13Not applicableUs
Children's Allergy FormulaLiquid6.25 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.2000-05-022002-07-31Canada
Children's Allergy FormulaSyrup6.25 mgOralPharmascience Inc2004-11-01Not applicableCanada
Children's Allergy Relief LiquidLiquid6.25 mgOralPharmetics (2011) IncNot applicableNot applicableCanada
Children's Benadryl Allergy FastmeltTablet19 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Children's Benadryl Allergy StripsStrip12.5 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Children's Cough, Cold & Allergy StripsStrip19 mgOralVita Health Products Inc2007-09-072011-07-20Canada
Children's Liquid Allergy FormulaLiquid6.25 mgOralJamp Pharma Corporation2004-06-25Not applicableCanada
Childrens AllergySolution12.5 mg/5mLOralChain Drug Consortium, LLC2015-05-04Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralH.E.B2010-03-02Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralDe Moulas Market Basket2012-09-11Not applicableUs
Childrens AllergySyrup12.5 mg/5mLOralTarget Corporation2016-07-31Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralChain Drug Consortium, LLC2012-09-24Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralSelect Brand Dist.2015-12-31Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralChain Drug Consortium, LLC2012-09-11Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralQUALITY CHOICE (Chain Drug Marketing Association)2014-05-30Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralAmerican Sales Company2009-08-29Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralFreds Inc2015-04-30Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralAaron Industries, Inc.2009-07-29Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralSafeway, Inc.2009-02-03Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralAafes/Your Military Exchanges2015-09-30Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralP & L Development, LLC2015-03-31Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralBest Choice2009-04-28Not applicableUs
Childrens AllergyTablet, chewable12.5 mg/1OralL&R Distributors, Inc.2009-03-20Not applicableUs
Childrens AllergySolution12.5 mg/5mLOralPublix Super Markets Inc2014-02-11Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralQUALITY CHOICE (Chain Drug Marketing Association)2014-06-30Not applicableUs
Childrens AllergySolution12.5 mg/5mLOralC.D.M.A., Inc.2014-09-10Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralDiscount Drug Mart2015-01-12Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralDollar General2000-01-01Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralRite Aid2009-07-30Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralFamily Dollar2009-06-30Not applicableUs
Childrens AllergySolution12.5 mg/5mLOralAmerisource Bergen2016-05-20Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralBest Choice (Valu Merchandisers Company)2015-03-31Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralHarris Teeter2010-01-19Not applicableUs
Childrens AllergyTablet12.5 mg/1OralCapricorn Pharma Inc.2010-09-29Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralNash Finch Company2000-01-01Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralFamily Dollar (FAMILY WELLNESS)2015-02-28Not applicableUs
Childrens AllergyLiquid12.5 mg/5mLOralRite Aid2009-09-04Not applicableUs
Childrens Allergy MeltsTablet, chewable12.5 mg/1OralTarget Corporation2011-04-25Not applicableUs
Childrens Allergy MeltsTablet, chewable12.5 mg/1OralTarget Corporation2009-03-20Not applicableUs
Childrens Allergy ReliefTablet, chewable12.5 mg/1OralRite Aid2011-04-25Not applicableUs
Childrens Allergy ReliefSolution12.5 mg/5mLOralKroger Company2014-02-04Not applicableUs
Childrens Allergy ReliefLiquid12.5 mg/5mLOralMarc Glassman, Inc.2014-12-02Not applicableUs
Childrens Allergy ReliefSolution12.5 mg/5mLOralShopko Stores Operating Co., LLC2013-09-12Not applicableUs
Childrens Allergy ReliefLiquid12.5 mg/5mLOralMcKesson2013-08-08Not applicableUs
Childrens Allergy ReliefTablet, chewable12.5 mg/1OralWal Mart Stores Inc2011-04-25Not applicableUs
Childrens Allergy ReliefTablet, chewable12.5 mg/1OralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2009-03-20Not applicableUs
Childrens Allergy ReliefLiquid12.5 mg/5mLOralApta Pharma Inc.2013-08-21Not applicableUs
Childrens Allergy ReliefLiquid12.5 mg/5mLOralRite Aid2013-11-18Not applicableUs
Childrens Allergy Relief Dye FreeTablet, chewable12.5 mg/1OralCVS Pharmacy2015-03-01Not applicableUs
Childrens Allergy Relief Dye Free CherryLiquid12.5 mg/5mLOralWin Co Foods, Llc2014-12-12Not applicableUs
Childrens Benadryl AllergySolution12.5 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-07-01Not applicableUs
Childrens Benadryl ChewablesTablet, chewable12.5 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-07-11Not applicableUs
Childrens Benadryl Dye-free AllergySolution12.5 mg/5mLOralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2008-07-01Not applicableUs
Childrens Complete AllergySolution12.5 mg/5mLOralWestern Family Foods Inc1993-09-08Not applicableUs
Childrens Dye Free AllergyLiquid12.5 mg/5mLOralP & L Development, LLC2015-02-28Not applicableUs
Childrens Wal-dryl AllergyTablet, chewable12.5 mg/1OralWALGREEN CO.2009-03-20Not applicableUs
Childrens Wal-dryl AllergyTablet, chewable12.5 mg/1OralWALGREEN CO.2011-04-25Not applicableUs
Childrens Wal-dryl Single-use AllergyLiquid12.5 mg/5mLOralWalgreen Company2011-08-25Not applicableUs
Circle K Allergy AntihistamineTablet25 mg/1OralLil' Drug Store Products, Inc2014-11-01Not applicableUs
Circle K Allergy AntihistamineTablet25 mg/1OralLil' Drug Store Products, Inc2014-11-01Not applicableUs
Circle K Allergy AntihistamineTablet25 mg/1OralLil' Drug Store Products, Inc2014-11-01Not applicableUs
Clear Allergy Formula for Children and AdultsLiquid6.25 mgOralPerrigo International1997-09-292001-03-09Canada
Clear TimeTablet, film coated25 mg/1OralHy Vee Inc2015-02-16Not applicableUs
CleartimeTablet, film coated25 mg/1OralWestern Family Foods Inc2015-03-04Not applicableUs
Complete AllergyCapsule, liquid filled25 mg/1OralWestern Family Foods, Inc.2013-12-30Not applicableUs
Complete AllergyTablet, film coated25 mg/1OralChain Drug Consortium1990-03-02Not applicableUs
Complete AllergyTablet25 mg/1OralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.1990-03-02Not applicableUs
Complete Allergy AntihistamineTablet25 mg/1OralChain Drug Consortium, LLC2010-07-13Not applicableUs
Complete Allergy MedicineCapsule25 mg/1OralSalado Sales, Inc.1990-03-15Not applicableUs
Complete Allergy MedicineTablet25 mg/1OralSave A Lot Food Stores, Ltd.1990-03-02Not applicableUs
Complete Allergy MedicineCapsule25 mg/1OralChain Drug Consortium, LLC2011-03-23Not applicableUs
Complete Allergy MedicineCapsule25 mg/1OralChain Drug Consortium, LLC2011-03-23Not applicableUs
Complete Allergy ReliefTablet, coated25 mg/1OralNew World Imports, Inc2010-11-11Not applicableUs
Complete Allergy SoftgelCapsule, liquid filled25 mg/1OralChain Drug Consortium2014-12-29Not applicableUs
Compoz Maximum Strength Nighttime Sleep AidCapsule, liquid filled50 mg/1OralMedtech Products Inc.2016-01-15Not applicableUs
Conrx AllergyTablet25 mg/1OralEagle Distributors,Inc.2013-02-15Not applicableUs
Correct Dose Childrens Allergy ReliefLiquid12.5 mg/5mLOralBfs Pharma, Inc.2011-06-15Not applicableUs
Cvs Health Childrens Allergy ReliefLiquid12.5 mg/5mLOralCvs Pharmacy,inc.2015-09-07Not applicableUs
Cvs Health Nighttime Sleep-aidLiquid50 mg/30mLOralCvs Pharmacy,inc.2015-02-11Not applicableUs
Cvs Maximum Strength Itch ReliefGel20.5 mg/mLTopicalCVS Pharmacy2011-08-10Not applicableUs
Cvs Pharmacy Pre-measured Spoon Childrens Allergy MedicationLiquid12.5 mg/5mLOralCVS Pharmacy, Inc.2011-08-25Not applicableUs
Dalay Maximum StrengthTablet25 mg/1OralGenomma Labs Usa2015-04-21Not applicableUs
Dg Health AllergyCapsule25 mg/1OralDolgencorp, LLC2010-02-22Not applicableUs
Dg Health AllergyTablet25 mg/1OralDolgencorp, LLC2010-01-30Not applicableUs
Dg Health Allergy ChildrensSolution12.5 mg/5mLOralDolgencorp, LLC2010-01-29Not applicableUs
Dg Health Maximum Strength Sleep AidCapsule, liquid filled50 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2012-11-29Not applicableUs
Dg Health Sleep AidTablet25 mg/1OralDolgencorp Inc2009-12-04Not applicableUs
Dg Health Sleep AidTablet25 mg/1OralDolgencorp Inc2010-01-24Not applicableUs
Dg Health Sleep AidSolution50 mg/30mLOralDolgencorp, LLC2015-05-11Not applicableUs
Dimetane Allergy TabletsTablet38.0 mgOralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2009-01-20Not applicableCanada
Diphendydramine HydrochlorideCapsule25 mg/1OralContract Pharmacy Services Pa2010-08-05Not applicableUs
Diphendydramine HydrochlorideCapsule50 mg/1OralContract Pharmacy Services Pa2010-08-05Not applicableUs
Diphendydramine HydrochlorideCapsule50 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-01-02Not applicableUs
DiphenhistLiquid12.5 mg/5mLOralRugby Laboratories Inc.2009-09-26Not applicableUs
DiphenhistTablet25 mg/1OralRugby Laboratories Inc.2006-09-26Not applicableUs
DiphenhistCapsule25 mg/1OralRugby Laboratories2014-03-17Not applicableUs
DiphenhistLiquid12.5 mg/5mLOralRebel Distributors Corp2009-09-26Not applicableUs
DiphenhistCapsule25 mg/1OralRugby Laboratories Inc.2006-05-30Not applicableUs
DiphenhydramineCapsule25 mg/1OralAAA Pharmaceutical, Inc.2012-12-22Not applicableUs
DiphenhydramineTablet, coated25 mg/1OralSam's West Inc1990-03-02Not applicableUs
DiphenhydramineCapsule50 mg/1OralH.J. Harkins Company, Inc.2011-08-17Not applicableUs
DiphenhydramineTablet, coated25 mg/1OralAAA Pharmaceutical, Inc.2012-12-22Not applicableUs
DiphenhydramineCapsule25 mg/1OralRebel Distributors Corp2007-01-01Not applicableUs
DiphenhydramineCapsule25 mg/1OralPURINEPHARMA LLC2014-07-31Not applicableUs
DiphenhydramineTablet25 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
DiphenhydramineCapsule25 mg/1OralRebel Distributors Corp2007-01-01Not applicableUs
DiphenhydramineCapsule, coated25 mg/1OralSam's West Inc1990-03-02Not applicableUs
DiphenhydramineTablet, coated25 mg/1OralNew World Imports, Inc2010-09-09Not applicableUs
DiphenhydramineCapsule50 mg/1OralPURINEPHARMA LLC2014-07-31Not applicableUs
Diphenhydramine HClCapsule, liquid filled20 mg/1OralAi Ping Pharmaceutical Inc.2015-01-31Not applicableUs
Diphenhydramine HClCapsule25 mg/1OralBlenheim Pharmacal, Inc.2010-05-12Not applicableUs
Diphenhydramine HClCapsule50 mg/1OralPreferred Pharmaceuticals, Inc.2010-01-27Not applicableUs
Diphenhydramine HClCapsule25 mg/1OralSDA Laboratories, Inc.2010-01-27Not applicableUs
Diphenhydramine HClCapsule, liquid filled25 mg/1OralSoftech Pharma Pvt. Ltd2013-01-01Not applicableUs
Diphenhydramine HClCapsule50 mg/1OralCardinal Health2009-01-02Not applicableUs
Diphenhydramine HClCapsule25 mg/1OralPhysicians Total Care, Inc.2010-01-27Not applicableUs
Diphenhydramine HClTablet50 mg/1OralRugby Laboratories Inc.2007-07-13Not applicableUs
Diphenhydramine HClCapsule50 mg/1OralSDA Laboratories, Inc.2010-01-27Not applicableUs
Diphenhydramine HClCapsule25 mg/1OralNu Care Pharmaceuticals, Inc.2010-01-27Not applicableUs
Diphenhydramine HClCapsule25 mg/1OralCardinal Health2011-06-03Not applicableUs
Diphenhydramine HClTablet25 mg/1OralContract Pharmacal Corp2004-01-01Not applicableUs
Diphenhydramine HClCapsule, liquid filled25 mg/1OralAgile Pharmachem2013-10-15Not applicableUs
Diphenhydramine HClCapsule50 mg/1OralNu Care Pharmaceuticals, Inc.2010-01-27Not applicableUs
Diphenhydramine HClCapsule25 mg/1OralPreferred Pharmaceuticals, Inc.2013-03-27Not applicableUs
Diphenhydramine HClTablet50 mg/1OralContract Pharmacal Corp2004-01-01Not applicableUs
Diphenhydramine HCl 25 mgTablet25 mg/1OralReliable 1 Laboratories Llc2015-11-01Not applicableUs
Diphenhydramine HCl 25 mgCapsule25 mg/1OralReliable 1 Laboratories Llc2015-11-01Not applicableUs
Diphenhydramine HCl 25mg 24ct BlisterCapsule, gelatin coated25 mg/1OralAccucaps Industries Limited2016-09-21Not applicableUs
Diphenhydramine HCl Allergy AntihistamineTablet25 mg/1OralMedline Industries2013-03-30Not applicableUs
Diphenhydramine HCl Children's LiquidSyrup6.25 mgOralLaboratoires Confab Inc2002-06-19Not applicableCanada
Diphenhydramine HydrochlorideSolution50 mg/20mLOralAhold U.S.A., Inc,2015-08-10Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1Oralbryant ranch prepack2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralDIRECT RX2014-01-01Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralA S Medication Solutions Llc2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralAdvance Pharmaceutical Inc.1989-09-12Not applicableUs
Diphenhydramine HydrochlorideCapsule, liquid filled25 mg/1OralRite Aid Corporation2016-09-30Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralTYA Pharmaceuticals2007-05-24Not applicableUs
Diphenhydramine HydrochlorideLiquid12.5 mg/5mLOralPhysicians Total Care, Inc.2006-06-29Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralQualitest Pharmaceuticals2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralLake Erie Medical DBA Quality Care Products LLC2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2015-03-26Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralClinical Solutions Wholesale2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralLake Erie Medical DBA Quality Care Products LLC2000-05-01Not applicableUs
Diphenhydramine HydrochlorideCapsule, liquid filled50 mg/1OralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2014-08-13Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralA S Medication Solutions Llc2007-05-24Not applicableUs
Diphenhydramine HydrochlorideTablet25 mg/1OralAAA Pharmaceutical, Inc.2012-12-15Not applicableUs
Diphenhydramine HydrochlorideSolution50 mg/20mLOralAurohealth LLC2014-11-26Not applicableUs
Diphenhydramine HydrochlorideTablet, coated25 mg/1OralAvema Pharma Solutions2010-01-02Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-05Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralAdvance Pharmaceutical Inc.1989-10-05Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralA S Medication Solutions Llc2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule, liquid filled25 mg/1OralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2013-04-15Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralRichmond Pharmaceuticals Inc.2000-02-15Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralMajor Pharmaceuticals2009-01-02Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralProficient Rx LP2007-05-24Not applicableUs
Diphenhydramine HydrochlorideTablet, film coated25 mg/1OralHIMPRIT PHARMACHEM PVT LTD2010-03-01Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralQualitest Pharmaceuticals2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule, liquid filled25 mg/1OralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2014-10-14Not applicableUs
Diphenhydramine HydrochlorideSolution50 mg/30mLOralFRED'S, INC.2015-01-31Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralREMEDYREPACK INC.2015-03-24Not applicableUs
Diphenhydramine HydrochlorideSolution50 mg/20mLOralDiscount Drug Mart2016-02-11Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralUnit Dose Services2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralPreferred Pharmaceuticals, Inc.2013-03-19Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralA S Medication Solutions Llc2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralREMEDYREPACK INC.2012-06-07Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralMajor Pharmaceuticals2009-01-02Not applicableUs
Diphenhydramine HydrochlorideSolution50 mg/20mLOralAurohealth LLC2015-08-01Not applicableUs
Diphenhydramine HydrochlorideTablet25 mg/1OralAdvance Pharmaceutical Inc.2006-09-26Not applicableUs
Diphenhydramine HydrochlorideSolution50 mg/20mLOralAmerisource Bergen2016-05-18Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralA S Medication Solutions Llc2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule, liquid filled50 mg/1OralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2013-04-15Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralRichmond Pharmaceuticals Inc.2000-02-15Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralEon Labs, Inc.2000-05-01Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-01-02Not applicableUs
Diphenhydramine HydrochlorideTablet, film coated25 mg/1OralHIMPRIT PHARMACHEM PVT LTD2010-03-01Not applicableUs
Diphenhydramine HydrochlorideCapsule, liquid filled50 mg/1OralSPIRIT PHARMACEUTICALS,LLC2010-06-01Not applicableUs
Diphenhydramine HydrochlorideTablet, coated25 mg/1OralBonita Pharmaceuticals LLC2013-05-21Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralAventura Pharmaceuticals, Llc2015-10-14Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralPhysicians Total Care, Inc.2000-05-01Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralA S Medication Solutions Llc2007-05-24Not applicableUs
Diphenhydramine HydrochlorideTablet, film coated25 mg/1OralAurohealth LLC2016-03-01Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralPreferred Pharmaceuticals, Inc.2013-03-19Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralA S Medication Solutions Llc2007-05-24Not applicableUs
Diphenhydramine HydrochlorideTablet, coated25 mg/1OralAAA Pharmaceutical, Inc.2012-12-15Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1Oralbryant ranch prepack2000-05-01Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralClinical Solutions Wholesale2007-05-24Not applicableUs
Diphenhydramine HydrochlorideSolution50 mg/20mLOralDolgencorp, LLC2016-02-22Not applicableUs
Diphenhydramine HydrochlorideCapsule, liquid filled25 mg/1OralHumanwell Pura Cap Pharmaceutical (Wuhan), Ltd.2013-09-15Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralCentral Texas Community Health Centers1990-03-15Not applicableUs
Diphenhydramine HydrochlorideTablet, coated25 mg/1OralTime Cap Labs, Inc2010-03-01Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralEon Labs, Inc.2000-05-01Not applicableUs
Diphenhydramine HydrochlorideTablet25 mg/1OralSimpex Pharma Pvt. Ltd2012-11-15Not applicableUs
Diphenhydramine HydrochlorideTablet25 mg/1OralAAA Pharmaceutical, Inc.2012-12-15Not applicableUs
Diphenhydramine HydrochlorideSolution25 mg/10mLOralAurohealth LLC2014-11-26Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralLake Erie Medical DBA Quality Care Products LLC2007-05-24Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralContract Pharmacy Services Pa2010-08-30Not applicableUs
Diphenhydramine HydrochlorideLiquid12.5 mg/5mLOralPhysicians Total Care, Inc.2002-10-22Not applicableUs
Diphenhydramine HydrochlorideSolution50 mg/20mLOralCVS Pharmacy, Inc.2015-11-02Not applicableUs
Diphenhydramine HydrochlorideCapsule25 mg/1OralDIRECT RX2015-01-01Not applicableUs
Diphenhydramine HydrochlorideCapsule50 mg/1OralProficient Rx LP2007-05-24Not applicableUs
Diphenhydramine Hydrochloride 25 Mg CapletTablet25 mgOralJamp Pharma Corporation2005-09-12Not applicableCanada
Diphenhydramine Hydrochloride 25 Mg TabletTablet25 mgOralNobel Pharm Enr.2000-02-012014-05-27Canada
Diphenhydramine Hydrochloride 25mgCapsule25 mgOralPharma Strides Canada CorporationNot applicableNot applicableCanada
Diphenhydramine Hydrochloride 50 Mg CapletTablet50 mgOralNobel Pharm Enr.2000-02-012014-05-27Canada
Diphenhydramine Hydrochloride 50 Mg CapsuleCapsule50 mgOralNobel Pharm Enr.1983-12-312016-08-25Canada
Diphenhydramine Hydrochloride 50 Mg Capsules USP Extra Strength Sleep AidCapsule50 mgOralPharmetics (2011) Inc2008-07-022010-07-12Canada
Diphenhydramine Hydrochloride 50mg CapletTablet50 mgOralJamp Pharma Corporation2005-09-12Not applicableCanada
Diphenhydramine Hydrochloride 50mg USPCapsule50 mgOralPharma Strides Canada CorporationNot applicableNot applicableCanada
Diphenhydramine Hydrochloride Caplets 25mgTablet25 mgOralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Diphenhydramine Hydrochloride Caplets 50mgTablet50 mgOralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Diphenhydramine Hydrochloride Elixir U.S.P.Elixir12.5 mgOralLaboratoires Confab Inc2004-04-01Not applicableCanada
Diphenhydramine Hydrochloride Elixir USPElixir12.5 mgOralJamp Pharma Corporation2009-01-30Not applicableCanada
Diphenhydramine Oral LiquidLiquid12.5 mg/5mLOralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Dorm-L Tab 25mgTablet25 mgOralNutribon (1986) Inc.1995-12-311996-09-30Canada
DormaxTablet50 mgOralNobel Pharm Enr.2004-06-112013-07-18Canada
Dormiphen ComprimeTablet25 mgOralLaboratoire Lalco Inc.1998-06-05Not applicableCanada
Dormiphen Extra-fort CapsuleCapsule50 mgOralLaboratoire Lalco Inc.1980-12-31Not applicableCanada
Dormiphen Extra-fort ComprimeTablet50 mgOralLaboratoire Lalco Inc.1998-06-05Not applicableCanada
Dormirax 25Tablet25 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
Dormirax 50Tablet50 mgOralLaboratoire Riva IncNot applicableNot applicableCanada
Dreamol Extra StrengthTablet50 mgOralGenvion Corporation2016-04-12Not applicableCanada
Dye Free Allergy ChildrensLiquid12.5 mg/5mLOralQUALITY CHOICE (Chain Drug Marketing Association)2016-02-29Not applicableUs
Dye Free Wal Dryl Allergy ChildrensLiquid12.5 mg/5mLOralWalgreens2015-03-31Not applicableUs
Dye-free Adult AllergySolution50 mg/20mLOralCVS Pharmacy, Inc.2014-11-26Not applicableUs
Dye-free AllergyCapsule, liquid filled25 mg/1OralPura Cap Pharmaceutical Llc2016-06-27Not applicableUs
Dye-free AllergyCapsule, liquid filled25 mg/1OralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2001-09-13Not applicableUs
Dye-free AllergySolution25 mg/10mLOralCVS Pharmacy, Inc.2014-11-26Not applicableUs
Dye-free Allergy ReliefCapsule, liquid filled25 mg/1OralChain Drug Marketing Association Inc2001-09-13Not applicableUs
Dye-free Allergy ReliefCapsule, liquid filled25 mg/1OralPura Vation Pharmaceuticals Inc2013-09-12Not applicableUs
Dye-free Wal-drylCapsule, liquid filled25 mg/1OralWALGREEN CO.2001-09-13Not applicableUs
Equaline AllergySolution12.5 mg/5mLOralSupervalu Inc2004-08-10Not applicableUs
Equaline AllergyCapsule25 mg/1OralSupervalu Inc2004-08-10Not applicableUs
Equaline AllergyTablet25 mg/1OralSupervalu Inc2004-08-30Not applicableUs
Equaline Night Time Sleep AidCapsule, liquid filled25 mg/1OralSupervalu Inc2014-03-07Not applicableUs
Equaline Night Time Sleep AidSolution50 mg/30mLOralSupervalu Inc2013-06-28Not applicableUs
Equate Allergy ReliefSolution12.5 mg/5mLOralWal Mart Stores Inc1990-08-15Not applicableUs
Equate Allergy ReliefTablet25 mg/1OralWal Mart Stores Inc1999-07-30Not applicableUs
Equate Nighttime Sleep AidTablet25 mg/1OralWal Mart Stores Inc2000-05-16Not applicableUs
Extra Strength Allergy Formula Liquid CapsulesCapsule50 mgOralVita Health Products Inc2009-11-05Not applicableCanada
Extra Strength Allergy Formula NighttimeCapsule50 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Extra Strength Benadryl Allergy NighttimeCapsule50 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2008-05-05Not applicableCanada
Extra Strength Dormex CapletsTablet50 mgOralVita Health Products Inc2013-11-06Not applicableCanada
Extra Strength Dormex CapsulesCapsule50 mgOralVita Health Products Inc2013-11-06Not applicableCanada
Extra Strength Nighttime Allergy Liquid Gel CapsulesCapsule50 mgOralApotex IncNot applicableNot applicableCanada
Extra Strength Nytol QuickgelsCapsule50 mgOralMedtech Products Inc1999-01-08Not applicableCanada
Extra Strength Nytol Tab 50mgTablet50 mgOralMedtech Products Inc1983-12-31Not applicableCanada
Extra Strength Simply Sleep Liqui-gelsCapsule50 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Extra Strength Sleep AidTablet50 mgOralPendopharm Division Of De Pharmascience Inc2007-06-01Not applicableCanada
Extra Strength Sleep AidTablet50 mgOralVita Health Products IncNot applicableNot applicableCanada
Extra Strength Sleep Aid FastCapsule50 mgOralBanner Pharmacaps (Canada) Ltd.2003-11-072014-09-10Canada
Extra Strength Sleep Aid Liquid GelsCapsule50 mgOralAccucaps Industries LimitedNot applicableNot applicableCanada
Ez Nite SleepLiquid50 mg/30mLOralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2013-01-01Not applicableUs
Ez Nite SleepLiquid50 mg/30mLOralAaron Industries, Inc.2013-01-01Not applicableUs
Ez Nite SleepLiquid50 mg/30mLOralSafeway, Inc.2015-06-30Not applicableUs
Ez Nite SleepCapsule, liquid filled25 mg/1OralP and L Development of New York Corporation2013-11-30Not applicableUs
Ez Nite SleepLiquid50 mg/30mLOralThe Kroger Co.2015-03-31Not applicableUs
Ez Nite SleepCapsule, liquid filled25 mg/1OralThe Kroger Co.2014-12-31Not applicableUs
Ez Nite SleepCapsule, liquid filled25 mg/1OralPreferred Plus (Kinray)2014-02-12Not applicableUs
Ez Nite SleepLiquid50 mg/30mLOralQUALITY CHOICE (Chain Drug Marketing Association)2015-06-30Not applicableUs
Ez Nite Sleep AidLiquid50 mg/30mLOralEQUATE (Walmart Stores, Inc.)2015-10-31Not applicableUs
Ez Nite Sleep AidLiquid50 mg/30mLOralAafes/Your Military Exchanges2015-08-31Not applicableUs
Ez Nite Sleep BerryLiquid50 mg/30mLOralExchange Select2013-11-21Not applicableUs
Ez Nite Sleep Nighttime Sleep AidCapsule, liquid filled25 mg/1OralFamily Dollar (FAMILY WELLNESS)2013-10-30Not applicableUs
Ez Nite Sleep Nighttime Sleep AidCapsule, liquid filled25 mg/1OralFamily Dollar (FAMILY WELLNESS)2014-07-31Not applicableUs
Ez Nite Sleep Nighttime Sleep-aidCapsule, liquid filled25 mg/1OralQUALITY CHOICE (Chain Drug Marketing Association)2014-07-31Not applicableUs
Ez Nite Sleep Nighttime Sleep-aidCapsule, liquid filled25 mg/1OralQUALITY CHOICE (Chain Drug Marketing Association)2013-03-11Not applicableUs
Ez Nite Sleep Nighttime Sleep-aidCapsule, liquid filled25 mg/1OralThe Kroger Co.2013-04-11Not applicableUs
First Aid Shot Therapy Allergy ReliefSolution50 mg/40mLOralFirst Aid Beverages, Inc.2016-07-01Not applicableUs
First Aid Shot Therapy Sleep AidSolution50 mg/40mLOralFirst Aid Beverages, Inc.2016-07-01Not applicableUs
Formule Allergie LiquideElixir12.5 mgOralProdemdis Enr.Not applicableNot applicableCanada
Geri-dryl Allergy ReliefTablet, coated25 mg/1OralGeri Care Pharmaceutical Corp2011-09-01Not applicableUs
Good Neighbor Pharmacy AllergyCapsule25 mg/1OralRebel Distributors Corp1989-10-15Not applicableUs
Good Neighbor Pharmacy AllergyTablet25 mg/1OralAmerisource Bergen1991-08-30Not applicableUs
Good Neighbor Pharmacy AllergyCapsule25 mg/1OralAmerisource Bergen1989-10-15Not applicableUs
Good Neighbor Pharmacy Childrens AllergySolution12.5 mg/5mLOralAmerisource Bergen1989-08-15Not applicableUs
Good Neighbor Pharmacy CleartimeTablet, film coated25 mg/1OralAmerisource Bergen2015-03-25Not applicableUs
Good Neighbor Pharmacy Sleep AidTablet25 mg/1OralAmerisource Bergen2001-04-14Not applicableUs
Good Neighbor Pharmacy Sleep TimeSolution50 mg/30mLOralAmerisource Bergen2013-07-22Not applicableUs
Good Neighbor Pharmacy Sleep TimeCapsule, liquid filled25 mg/1OralAmerisource Bergen2014-01-30Not applicableUs
Good Sense AllergySolution12.5 mg/5mLOralL. Perrigo Company1989-09-15Not applicableUs
Good Sense Allergy ReliefCapsule25 mg/1OralL Perrigo Company1989-09-15Not applicableUs
Good Sense Allergy ReliefTablet25 mg/1OralL. Perrigo Company1991-08-20Not applicableUs
Good Sense Allergy ReliefCapsule25 mg/1OralProficient Rx LP1989-09-15Not applicableUs
Good Sense Nighttime Sleep AidTablet25 mg/1OralL. Perrigo Company2001-04-25Not applicableUs
Good Sense Nighttime Sleep AidTablet25 mg/1OralL Perrigo Company2009-09-02Not applicableUs
Good Sense Sleep TimeCapsule, liquid filled25 mg/1OralL. Perrigo Company2014-02-06Not applicableUs
Good Sense Sleep TimeSolution50 mg/30mLOralL. Perrigo Company2013-07-02Not applicableUs
Handy Solutions Allergy ReliefTablet25 mg/1OralNavajo Manufacturing Company Inc.2016-10-22Not applicableUs
Harris Teeter Childrens AllergySolution12.5 mg/5mLOralHarris Teeter, LLC2015-06-24Not applicableUs
Health Mart Allergy ChildrensLiquid12.5 mg/5mLOralMc Kesson2012-01-11Not applicableUs
Health Mart Childrens Allergy ReliefSolution12.5 mg/5mLOralMcKesson2016-03-15Not applicableUs
Health Mart Maximum Strength Sleep AidCapsule, liquid filled50 mg/1OralMc Kesson2012-04-06Not applicableUs
Health Mart Nighttime Sleep AidTablet25 mg/1OralMc Kesson2013-08-13Not applicableUs
Health Mart Z SleepSolution50 mg/30mLOralMc Kesson2013-07-16Not applicableUs
Health Mart Z-sleepCapsule, liquid filled25 mg/1OralMc Kesson2014-01-31Not applicableUs
Healthy Accents AllergySolution12.5 mg/5mLOralDZA Brands LLC2008-04-01Not applicableUs
Healthy Accents Allergy ReliefCapsule25 mg/1OralDZA Brands LLC2008-01-29Not applicableUs
Healthy Accents Allergy ReliefTablet25 mg/1OralDZA Brands LLC2008-01-29Not applicableUs
Healthy Accents Nighttime Sleep AidTablet25 mg/1OralDZA Brands LLC2008-02-24Not applicableUs
Healthy Accents SleeptimeCapsule, liquid filled25 mg/1OralDZA Brands LLC2016-05-11Not applicableUs
Healthy Accents SleeptimeSolution50 mg/30mLOralDZA Brands LLC2014-05-09Not applicableUs
Helath Mart Childrens Allergy Relief Dye FreeLiquid12.5 mg/5mLOralMc Kesson2014-09-09Not applicableUs
Help I Can't SleepTablet25 mgOralHelp Remedies IncNot applicableNot applicableCanada
Help I Cant SleepTablet25 mg/1OralHelp Remedies, Inc.2009-07-01Not applicableUs
HistaprinTablet25 mg/1OralNor Med2009-01-01Not applicableUs
InsomnalTablet50 mgOralTeva Canada Limited2011-02-14Not applicableCanada
Insomnal Cap 25mgCapsule25 mgOralWelcker Lyster Ltd., Division Of Technilab Inc.1979-12-312004-08-03Canada
Insomnal DSCapsule50 mgOralRougier Pharma Division Of Ratiopharm Inc1996-12-312015-10-01Canada
Itch ReliefLiquid20.3 g/LTopicalCintas First Aid & Safety2013-05-13Not applicableUs
Itch ReliefLiquid20.3 g/LTopicalSafetec of America, Inc.2013-05-02Not applicableUs
Itch ReliefSpray2 g/100mLTopicalWater Jel Technologies2010-09-25Not applicableUs
Itch Relief CreamCream2 %TopicalPharmetics (2011) IncNot applicableNot applicableCanada
Itch Relif CvsGel2 g/100mLTopicalCVS2014-02-14Not applicableUs
Jack & Jill BedtimeLiquid6.25 mgOralThe Buckley's Company2000-08-082016-08-02Canada
Jack & Jill Thin Strips Cough & ColdStrip12.5 mgOralThe Buckley's Company2005-08-082010-06-21Canada
Jamp Diphenhydramine Children's SyrupSyrup6.25 mgOralJamp Pharma CorporationNot applicableNot applicableCanada
Junior Strength Allergy FormulaTablet12.5 mgOralActavis Pharma Company2010-12-10Not applicableCanada
Junior Strength Allergy TabletsTablet12.5 mgOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Kids-eeze AllergyTablet, orally disintegrating12.5 mg/1OralPro Phase Labs, Inc.2010-09-01Not applicableUs
Leader AllergyCapsule25 mg/1OralCardinal Health2015-01-02Not applicableUs
Leader AllergyTablet25 mg/1OralCardinal Health1992-05-11Not applicableUs
Leader AllergyTablet25 mg/1OralCardinal Health2014-12-22Not applicableUs
Leader AllergyCapsule25 mg/1OralCardinal Health1990-04-15Not applicableUs
Leader Childrens AllergySolution12.5 mg/5mLOralCardinal Health1990-05-15Not applicableUs
Leader Maximum Strength Sleep AidCapsule, liquid filled50 mg/1OralCardinal Health2012-06-05Not applicableUs
Leader Restfully SleepTablet25 mg/1OralCardinal Health2000-09-15Not applicableUs
Leader SleeptimeSolution50 mg/30mLOralCardinal Health2013-10-11Not applicableUs
Leader SleeptimeCapsule, liquid filled25 mg/1OralCardinal Health2013-12-02Not applicableUs
Lil Drug Store Nighttime Sleep-aidTablet25 mg/1OralLil' Drug Store Products, Inc.2011-06-02Not applicableUs
Lil Drug Store Nighttime Sleep-aidTablet25 mg/1OralLil' Drug Store Products, Inc.2011-06-02Not applicableUs
Lil Drug Store Products Allergy AntihistamineTablet25 mg/1OralLil Drug Store Products, Inc2015-01-10Not applicableUs
Lil Drug Store Products Allergy AntihistamineTablet25 mg/1OralLil Drug Store Products, Inc2015-01-10Not applicableUs
Lil Drug Store Products Allergy AntihistamineTablet25 mg/1OralLil Drug Store Products, Inc2015-01-10Not applicableUs
Maximum Strength Nighttime Sleep AidCapsule, liquid filled50 mg/1OralPura Cap Pharmaceutical Llc2016-07-12Not applicableUs
Medique DiphenTablet, film coated25 mg/1OralUnifirst First Aid Corporation2012-01-01Not applicableUs
Medique DiphenTablet, film coated25 mg/1OralUnifirst First Aid Corporation2012-01-01Not applicableUs
Multi-symptom AllergyCapsule25 mg/1OralMc Kesson (Health Mart)2012-02-14Not applicableUs
Nadryl 25mgTablet25 mgOralLaboratoire Riva Inc2002-02-14Not applicableCanada
Nadryl 50mgTablet50 mgOralLaboratoire Riva Inc2002-02-14Not applicableCanada
NaraminSolution12.5 mg/5mLOralNational Pharma Industries Inc2014-05-28Not applicableUs
Neocitran Thin Strips Nighttime CoughLozenge25 mgOralNovartis Consumer Health Canada Inc.2004-11-192013-07-31Canada
Night Cough Liquid FastgelsCapsule25 mgOralVita Health Products Inc2008-10-14Not applicableCanada
Night Time Sleep AidCapsule, liquid filled25 mg/1OralPura Cap Pharmaceutical Llc2016-05-05Not applicableUs
Night Time Sleep AidCapsule50 mg/1OralHy Vee2014-02-01Not applicableUs
Night Time Sleep AidLiquid50 mg/30mLOralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2015-03-31Not applicableUs
Night Time Sleep AidCapsule, liquid filled25 mg/1OralHarmon Stores2015-02-28Not applicableUs
Night Time Sleep AidSolution50 mg/30mLOralHy Vee Inc2013-07-08Not applicableUs
Night Time Sleep-aidLiquid50 mg/30mLOralDiscount Drug Mart2013-12-10Not applicableUs
Nightime Sleep AidCapsule, liquid filled50 mg/1OralAgile Pharmachem2014-03-31Not applicableUs
Nightime Sleep AidCapsule, liquid filled50 mg/1OralVelocity Pharma2014-03-31Not applicableUs
NighttimeTablet25 mg/1OralWestern Family Foods Inc2001-01-28Not applicableUs
Nighttime AllergyTablet50 mgOralPharmetics (2011) IncNot applicableNot applicableCanada
Nighttime Allergy Relief Extra StrengthTablet50 mg/1OralMEIJER, INC.2014-06-30Not applicableUs
Nighttime Allergy Relief Extra StrengthTablet50 mg/1OralTOP CARE (Topco Associates LLC)2014-07-31Not applicableUs
Nighttime Liquigel Sleep-aidCapsule25 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Nighttime SleepTablet, film coated25 mg/1OralSafeway2000-06-10Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralPura Cap Pharmaceutical Llc2016-06-27Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralH E B2013-09-30Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralSuper Valu (Equaline)2012-10-31Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralWin Co Foods, Llc2014-12-31Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralMeijer Distribution Inc2016-02-07Not applicableUs
Nighttime Sleep AidCapsule50 mg/1OralChain Drug Consortium, LLC2010-07-08Not applicableUs
Nighttime Sleep AidCapsule, liquid filled50 mg/1OralPura Vation Pharmaceuticals Inc2013-04-15Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralWe Care Distributor Inc2016-02-04Not applicableUs
Nighttime Sleep AidCapsule50 mg/1OralEqualine (Super Valu)2012-01-03Not applicableUs
Nighttime Sleep AidSolution50 mg/30mLOralMeijer Distribution Inc2014-12-04Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralH E B2014-12-31Not applicableUs
Nighttime Sleep AidCapsule50 mg/1OralValu Merchandisers Company (Best Choice)2010-07-26Not applicableUs
Nighttime Sleep AidLiquid50 mg/30mLOralFRED'S, INC.2013-10-23Not applicableUs
Nighttime Sleep AidTablet, film coated25 mg/1OralCVS Pharmacy2000-06-10Not applicableUs
Nighttime Sleep AidCapsule, liquid filled50 mg/1OralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2015-03-01Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralOUR FAMILY (Nash Finch Company)2013-11-30Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralKroger Company2001-02-05Not applicableUs
Nighttime Sleep AidCapsule25 mgOralApotex Inc2014-01-24Not applicableCanada
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralPura Cap Pharmaceutical Llc2016-07-26Not applicableUs
Nighttime Sleep AidSolution50 mg/30mLOralH E B2013-10-30Not applicableUs
Nighttime Sleep AidCapsule, liquid filled50 mg/1OralBest Choice (Valu Merchandisers Company)2014-02-01Not applicableUs
Nighttime Sleep AidTablet, film coated25 mg/1OralTarget Corporation2000-06-10Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralAvema Pharma Solutions2011-01-16Not applicableUs
Nighttime Sleep AidTablet, film coated25 mg/1OralSUPERVALU INC.2000-06-10Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralWin Co Foods, Llc2000-06-10Not applicableUs
Nighttime Sleep AidLiquid50 mg/30mLOralCare One (American Sales Company)2015-06-30Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralChain Drug Consortium, LLC2010-07-08Not applicableUs
Nighttime Sleep AidTablet, coated25 mg/1OralHealth Life Of Usa2012-05-12Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralWestern Family Foods, Inc.2010-07-12Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralFreds Inc2014-11-30Not applicableUs
Nighttime Sleep AidCapsule, liquid filled50 mg/1OralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2004-04-08Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralChain Drug Marketing Association2007-06-25Not applicableUs
Nighttime Sleep AidCapsule50 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2013-04-15Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralEQUATE (Walmart Stores, Inc.)2013-09-30Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralH E B2009-10-09Not applicableUs
Nighttime Sleep AidCapsule, liquid filled50 mg/1OralTopco Associates LLC2016-07-19Not applicableUs
Nighttime Sleep AidCapsule, liquid filled50 mg/1OralPura Cap Pharmaceutical Llc2016-06-01Not applicableUs
Nighttime Sleep AidTablet25 mg/1OralThe Kroger Co.2012-11-02Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralHy Vee Inc2014-11-24Not applicableUs
Nighttime Sleep AidCapsule50 mg/1OralWestern Family Foods, Inc.2010-07-01Not applicableUs
Nighttime Sleep AidCapsule, liquid filled25 mg/1OralSafeway, Inc.2013-05-31Not applicableUs
Nighttime Sleep Aid LiquidSolution50 mgOralPerrigo International2015-05-13Not applicableCanada
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralMc Kesson (Health Mart)2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralWestern Family Foods, Inc.2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralWalgreens2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralEQUATE (Walmart Stores, Inc.)2013-10-31Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralCVS Pharmacy2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralChain Drug Consortium, LLC2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2010-07-26Not applicableUs
Nighttime Sleep Aid Maximum StrengthTablet, film coated50 mg/1OralWalgreen Company2016-07-31Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralEQUATE (Walmart Stores, Inc.)2010-07-06Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule50 mg/1OralOUR FAMILY (Nash Finch Company)2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2014-02-01Not applicableUs
Nighttime Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralP & L Development, LLC2011-09-02Not applicableUs
Nighttime Sleep Aid Non Habit FormingCapsule, liquid filled25 mg/1OralFreds Inc2013-04-11Not applicableUs
Nighttime Sleep EasyTablet25 mg/1OralP And L Development Of New York Corporation (Ready In Case)2012-12-04Not applicableUs
Nighttime Sleep-aidCapsule, liquid filled25 mg/1OralPura Cap Pharmaceutical Llc2015-05-26Not applicableUs
Nighttime Sleep-aidLiquid50 mg/30mLOralDe Moulas Market Basket2013-09-19Not applicableUs
Nighttime Sleep-aidTablet25 mg/1OralGeri Care Pharmaceutical Corp2004-01-01Not applicableUs
Nighttime Sleep-aidCapsule, liquid filled25 mg/1OralLil' Drug Store Products, Inc2014-09-05Not applicableUs
Nighttime Sleep-aidLiquid50 mgOralActavis Pharma Company2015-02-12Not applicableCanada
Nighttime Sleep-aidCapsule25 mg/1OralSafeway, Inc.2014-12-31Not applicableUs
Nighttime Sleep-aidTablet25 mg/1OralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2013-05-07Not applicableUs
Nighttime Sleep-aid Maximum StrengthCapsule50 mg/1OralSMART SENSE (Kmart)2013-03-31Not applicableUs
Nighttime Sleep-aid SoftgelCapsule, liquid filled50 mg/21OralAi Ping Pharmaceutical Inc.2015-01-31Not applicableUs
Nighttime SleepaidCapsule, gelatin coated50 mg/21OralKareway Product, Inc.2014-10-22Not applicableUs
Nighttime SnoozeCapsule25 mgOralVita Health Products IncNot applicableNot applicableCanada
Nite Time Sleep Aid LiquidgelsCapsule, liquid filled25 mg/1OralDolgencorp, Inc. (Dollar General)2013-04-11Not applicableUs
North AntihistamineTablet25 mg/1OralNorth Safety Products2011-12-02Not applicableUs
NytolTablet25 mg/1OralMedtech Products Inc.2012-06-01Not applicableUs
Nytol Extra Strength Sleep Aid Caplet 50mgTablet50 mgOralMedtech Products Inc1991-12-31Not applicableCanada
Nytol QuickcapsTablet, film coated25 mg/1OralGlaxo Smith Kline Consumer Healthcare Lp2011-08-12Not applicableUs
Nytol Tablet 25mgTablet25 mgOralMedtech Products Inc1979-12-31Not applicableCanada
Pdp-diphenhydramineCapsule25 mgOralPendopharm Division Of De Pharmascience Inc1990-12-31Not applicableCanada
Pdp-diphenhydramineCapsule50 mgOralPendopharm Division Of De Pharmascience Inc1990-12-31Not applicableCanada
Pediacare Childrens AllergyLiquid12.5 mg/5mLOralBlacksmith Brands, Inc.2009-10-29Not applicableUs
Pediacare Childrens AllergyLiquid12.5 mg/5mLOralBlacksmith Brands, Inc.2010-02-01Not applicableUs
PharbedrylCapsule50 mg/1OralPharbest Pharmaceuticals, Inc.2006-10-11Not applicableUs
PharbedrylCapsule25 mg/1OralPharbest Pharmaceuticals, Inc.2006-10-11Not applicableUs
Plus PharmaTablet, film coated25 mg/1OralGemini Pharmaceuticals, Inc. dba Plus Pharma2015-06-12Not applicableUs
PMS-diphenhydramine Elixir 2.5mg/mlElixir2.5 mgOralPharmascience Inc1990-12-31Not applicableCanada
Preferred Plus Complete Allergy MedicineCapsule25 mg/1OralKinray Inc.2013-05-07Not applicableUs
Premier Value Nighttime Sleep Aid SoftgelsCapsule, gelatin coated50 mg/21OralChain Drug Consortium2014-11-14Not applicableUs
Premier Value Nighttime Sleep-aid Liquid Sleep-aidLiquid50 mg/30mLOralChain Drug Consortium2012-12-10Not applicableUs
Premier Value Sleep-aidCapsule50 mg/1OralChain Drug Consortium LLC2013-05-31Not applicableUs
Q-drylCapsule25 mg/1OralQualitest Pharmaceuticals2007-05-24Not applicableUs
Qdryl AllergySolution12.5 mg/5mLOralA S Medication Solutions Llc1997-12-01Not applicableUs
Qdryl AllergySolution12.5 mg/5mLOralAtlantic Biologicals Corp1997-12-01Not applicableUs
Qdryl AllergySolution12.5 mg/5mLOralPreferred Pharmaceuticals, Inc1997-12-01Not applicableUs
Qdryl AllergySolution12.5 mg/5mLOralLake Erie Medical DBA Quality Care Products LLC1997-12-01Not applicableUs
Qdryl AllergySolution12.5 mg/5mLOralREMEDYREPACK INC.2015-03-04Not applicableUs
Qdryl AllergySolution12.5 mg/5mLOralQualitest Pharmaceuticals1997-12-012019-10-31Us
Quenalin CoughSyrup12.5 mg/5mLOralQualitest Pharmaceuticals, Inc1993-12-032016-11-15Us
Regular Strength Dormex CapsulesCapsule25 mgOralVita Health Products Inc2013-11-06Not applicableCanada
Regular Strength Sleep AidCapsule25 mgOralVita Health Products Inc2011-03-31Not applicableCanada
Rest SimplyTablet, coated25 mg/1OralChain Drug Marketing Association2014-06-13Not applicableUs
Rest SimplyTablet, film coated25 mg/1OralChain Drug Consortium2000-06-10Not applicableUs
Rest SimplyTablet, film coated25 mg/1OralNash Finch Company2000-06-10Not applicableUs
Rest SimplyTablet, film coated25 mg/1OralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.2000-06-10Not applicableUs
Restfully SleepTablet, film coated25 mg/1OralCardinal Health2000-06-10Not applicableUs
Rexall Childrens AllergyLiquid12.5 mg/5mLOralDolgencorp, LLC2013-07-26Not applicableUs
Rexall Sleep AidTablet25 mg/1OralDolgencorp, LLC2010-09-29Not applicableUs
Rite Aid Maximum Strength Itch ReliefGel20.5 mg/mLTopicalRite Aid Corporation2011-08-10Not applicableUs
Rugby DiphenhistTablet, film coated25 mg/1OralRugby Laboratories2014-12-13Not applicableUs
SedamoTablet25 mgOralViva Pharmaceutical Inc.Not applicableNot applicableCanada
Sedicin Tablets 25mgTablet25 mgOralCrombie Kennedy Nasmark Inc.1960-12-312000-07-19Canada
Select Brand Extra Strength Itch StoppingGel.2 g/10mLTopicalSelect Brand2012-07-11Not applicableUs
Select Health Allergy Relief CherryLiquid12.5 mg/5mLOralAxcentria Pharmaceuticals, LLC.2011-09-01Not applicableUs
Shoprite Allergy ReliefCapsule25 mg/1OralWakefern Food Corporation2016-09-12Not applicableUs
Shoprite Allergy ReliefTablet25 mg/1OralWakefern Food Corporation2016-09-13Not applicableUs
Shoprite Childrens AllergySolution12.5 mg/5mLOralWakefern Food Corporation2016-01-11Not applicableUs
Shoprite Sleep AidSolution50 mg/30mLOralWakefern Food Corporation2013-07-17Not applicableUs
Siladryl Allergy MedicineLiquid12.5 mg/5mLOralRebel Distributors Corp1997-01-01Not applicableUs
Siladryl Allergy MedicineLiquid12.5 mg/5mLOralSilarx Pharmaceuticals, Inc1997-01-01Not applicableUs
SilphenSyrup12.5 mg/5mLOralSilarx Pharmaceutical, Inc1993-12-03Not applicableUs
Simply Right Diphenhydramine Hydrochloride Allergy ReliefTablet25 mg/1OralSam's West Inc2012-01-27Not applicableUs
Simply SleepTablet, film coated25 mg/1OralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2004-02-01Not applicableUs
Simply SleepTablet25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-03-292016-01-22Canada
Simply Sleep Liqui-gelsCapsule25 mgOralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
SleepTablet25 mg/1OralSalado Sales, Inc.1990-04-10Not applicableUs
Sleep AidTablet, film coated25 mg/1OralHarmon Store Inc.2000-06-10Not applicableUs
Sleep AidTablet, film coated25 mg/1OralL.N.K. International, Inc.2000-06-10Not applicableUs
Sleep AidTablet, film coated25 mg/1OralRite Aid2015-07-24Not applicableUs
Sleep AidTablet25 mg/1OralRite Aid Corporation1990-04-10Not applicableUs
Sleep AidCapsule50 mg/1OralFreds Inc2014-02-01Not applicableUs
Sleep AidTablet25 mg/1OralAllegiant Health2015-03-03Not applicableUs
Sleep AidTablet, film coated25 mg/1OralHarmon Store Inc.2013-07-01Not applicableUs
Sleep AidTablet25 mg/1OralKareway Product, Inc.2011-08-18Not applicableUs
Sleep AidTablet, film coated25 mg/1OralMeijer Distribution Inc2000-06-10Not applicableUs
Sleep AidCapsule, liquid filled25 mg/1OralPura Vation Pharmaceuticals Inc2013-04-15Not applicableUs
Sleep AidTablet50 mgOralVita Health Products Inc1997-06-10Not applicableCanada
Sleep AidTablet25 mg/1OralNavarro Discount Pharmacies,LLC2013-02-01Not applicableUs
Sleep AidTablet25 mg/1OralChain Drug Consortium1998-11-07Not applicableUs
Sleep AidCapsule, liquid filled25 mg/1OralPura Cap Pharmaceutical Llc2016-07-20Not applicableUs
Sleep AidTablet25 mg/1OralHy Vee Inc2001-02-23Not applicableUs
Sleep AidTablet, film coated25 mg/1OralRite Aid Corporation2000-06-10Not applicableUs
Sleep AidTablet25 mg/1OralMedicine Shoppe International Inc2001-06-19Not applicableUs
Sleep AidTablet25 mg/1OralBest Choice (Valu Merchandisers Company)2014-04-30Not applicableUs
Sleep AidTablet25 mg/1OralCVS Pharmacy2000-10-03Not applicableUs
Sleep AidTablet25 mg/1OralMeijer Distribution Inc2004-10-17Not applicableUs
Sleep AidCapsule, liquid filled50 mg/1OralL.N.K. International, Inc.2004-04-08Not applicableUs
Sleep AidTablet25 mg/1OralSMART SENSE (Kmart)2014-03-31Not applicableUs
Sleep AidTablet25 mg/1OralPublix Super Markets Inc2001-07-24Not applicableUs
Sleep AidCapsule, liquid filled50 mg/1OralL.N.K. International, Inc.2015-03-01Not applicableUs
Sleep AidTablet25 mg/1OralChain Drug Consortium, LLC2010-07-12Not applicableUs
Sleep AidSolution50 mg/30mLOralRite Aid Corporation2016-07-07Not applicableUs
Sleep AidCapsule50 mg/1OralThe Kroger Co2010-07-12Not applicableUs
Sleep Aid (extra Strength) Tab 50mgTablet50 mgOralTanta Pharmaceuticals Inc1997-03-04Not applicableCanada
Sleep Aid (regular Strength) Tab 25mgTablet25 mgOralTanta Pharmaceuticals Inc1993-12-31Not applicableCanada
Sleep Aid CapletsTablet25 mgOralPharmetics (2011) IncNot applicableNot applicableCanada
Sleep Aid Dye-free NighttimeTablet, film coated25 mg/1OralWalgreen Company2013-07-01Not applicableUs
Sleep Aid Extra StrengthCapsule50 mgOralApotex IncNot applicableNot applicableCanada
Sleep Aid Extra StrengthCapsule50 mgOralPharmetics (2011) IncNot applicableNot applicableCanada
Sleep Aid Liquid FastgelsCapsule50 mgOralVita Health Products Inc2001-09-01Not applicableCanada
Sleep Aid Liquid GelsCapsule50 mgOralPerrigo International2001-08-222006-05-15Canada
Sleep Aid Liquid GelsCapsule25 mgOralAccucaps Industries LimitedNot applicableNot applicableCanada
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralMEIJER, INC.2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralSafeway, Inc.2013-04-30Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralThe Kroger Co.2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralTOP CARE (Topco Associates LLC)2013-05-31Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralCardinal Health (Leader) 497812014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralSelect Brand Dist.2014-04-30Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralCare One (American Sales Company)2010-07-01Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralGreenbrier International, Inc.2015-03-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralTarget Corporation2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralSafeway, Inc.2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralTOP CARE (Topco Associates LLC)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralCare One (American Sales Company)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralGreenbrier International, Inc.2004-04-08Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralEqualine (Super Valu)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralSam's West, Inc2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralMcKesson (Sunmark)2010-07-09Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralSMART SENSE (Kmart)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralMc Kesson (Sunmark)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralP & L Development, LLC2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralASSURED / DOLLAR TREE (Greenbrier International, Inc.)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralH E B2014-05-30Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralEQUATE (Walmart Stores, Inc.)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule, liquid filled50 mg/1OralQUALITY CHOICE (Chain Drug Marketing Association)2014-02-01Not applicableUs
Sleep Aid Maximum StrengthCapsule50 mg/1OralHarris Teeter, LLC2015-02-28Not applicableUs
Sleep Aid Maximum Strength NighttimeCapsule, liquid filled50 mg/1OralWin Co Foods, Llc2014-12-31Not applicableUs
Sleep Aid NighttimeTablet, film coated25 mg/1OralGreenbrier International, Inc.2000-06-10Not applicableUs
Sleep Aid NighttimeLiquid50 mg/30mLOralP & L Development, LLC2016-08-31Not applicableUs
Sleep Aid NighttimeLiquid50 mg/30mLOralWin Co Foods, Llc2016-06-30Not applicableUs
Sleep Aid NighttimeTablet25 mg/1OralH E B2014-08-31Not applicableUs
Sleep Aid NighttimeTablet, film coated25 mg/1OralBetter Living Brands, Llc2000-06-10Not applicableUs
Sleep Aid NighttimeCapsule50 mg/1OralFamily Dollar (FAMILY WELLNESS)2014-02-01Not applicableUs
Sleep Aid NighttimeLiquid50 mg/30mLOralTarget Corporation2016-07-31Not applicableUs
Sleep Aid NighttimeTablet, film coated25 mg/1OralWal Mart Stores Inc2015-07-24Not applicableUs
Sleep Aid NighttimeTablet, film coated25 mg/1OralWal Mart Stores Inc2000-06-10Not applicableUs
Sleep Aid NighttimeCapsule, liquid filled25 mg/1OralTarget Corporation2015-02-28Not applicableUs
Sleep Aid NighttimeTablet, film coated25 mg/1OralWalgreen Company2000-06-10Not applicableUs
Sleep Aid NighttimeCapsule, liquid filled25 mg/1OralWal Mart Stores Inc2015-02-28Not applicableUs
Sleep Aid NighttimeCapsule, liquid filled25 mg/1OralP & L Development, LLC2016-03-31Not applicableUs
Sleep Aid NighttimeTablet25 mg/1OralTarget Corporation2016-07-31Not applicableUs
Sleep Aid NighttimeTablet25 mg/1OralCVS Pharmacy2013-08-15Not applicableUs
Sleep Aid NighttimeTablet, film coated25 mg/1OralL&R Distributors, Inc.2000-06-10Not applicableUs
Sleep Aid NighttimeTablet, film coated25 mg/1OralFamily Dollar Services Inc2000-06-10Not applicableUs
Sleep Aid NighttimeTablet25 mg/1OralFamily Dollar (FAMILY WELLNESS)2016-07-31Not applicableUs
Sleep Aid Nite TimeTablet, film coated25 mg/1OralDolgencorp, LLC2000-06-10Not applicableUs
Sleep Aid Regular StrengthTablet25 mg/1OralGood Sense (Geiss, Destin & Dunn, Inc.)2014-02-28Not applicableUs
Sleep Aid Regular StrengthTablet25 mg/1OralGeiss, Destin & Dunn, Inc (Goodsense)2010-08-03Not applicableUs
Sleep EasyTablet, coated25 mg/1OralAvema Pharma Solutions2010-01-02Not applicableUs
Sleep Eze D Caplet 25mgTablet25 mgOralWhitehall Robins Inc.1993-12-311997-08-07Canada
Sleep Eze D Extra Strength Cap 50mgCapsule50 mgOralWhitehall Robins Inc.1993-12-311997-08-07Canada
Sleep Eze D Extra Strength Caplet 50mgTablet50 mgOralWhitehall Robins Inc.1993-12-311997-08-07Canada
Sleep II Nighttime Sleep AidTablet25 mg/1OralWalgreen Company1990-04-10Not applicableUs
Sleep Nighttime Sleep AidTablet25 mg/1OralWestern Family Foods, Inc.2014-02-28Not applicableUs
Sleep Original FormulaTablet25 mg/1OralBest Choice (Valu Merchandisers Company)2010-07-16Not applicableUs
Sleep TabsTablet25 mg/1OralL&R Distributors, Inc.1992-12-25Not applicableUs
Sleep TabsTablet25 mg/1OralMajor Pharmaceuticals1992-12-25Not applicableUs
Sleep Tabs for Nighttime UseTablet25 mg/1OralAllegiant Health2015-04-28Not applicableUs
Sleep TimeLiquid50 mg/30mLOralHy Vee Inc2013-07-08Not applicableUs
Sleep TimeCapsule, liquid filled25 mg/1OralHy Vee Inc2014-02-01Not applicableUs
Sleep- Aid NighttimeCapsule25 mg/1OralCVS Pharmacy2016-07-31Not applicableUs
Sleep-aidTablet25 mg/1OralInternational Laboratories, Inc.2016-05-27Not applicableUs
Sleep-aidTablet25 mg/1OralArmy and Air Force Exchange Service1992-12-25Not applicableUs
Sleep-aid Extra StrengthTablet50 mgOralTeva Canada Limited1997-02-06Not applicableCanada
Sleep-aid Maximum StrengthCapsule50 mg/1OralASSURED / DOLLAR TREE (Greenbrier International, Inc.)2010-07-06Not applicableUs
Sleep-aid Maximum StrengthCapsule50 mg/1OralFreds Inc2013-03-15Not applicableUs
Sleep-aid NighttimeTablet, film coated25 mg/1OralCVS Pharmacy2015-07-24Not applicableUs
Sleep-aid Regular StrengthTablet25 mg/1OralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED1992-12-25Not applicableUs
Sleep-ezeTablet25 mgOralPrestige Brands Inc2010-08-03Not applicableCanada
Sleep-eze D Extra Strength CapsulesCapsule50 mgOralMedtech Products Inc1998-08-072014-03-20Canada
Sleep-eze Extra Strength CapletsTablet50 mgOralMedtech Products Inc1997-11-12Not applicableCanada
Sleep-eze Extra Strength GelcapsCapsule50 mgOralMedtech Products Inc1999-12-14Not applicableCanada
Sleep-eze Eze-liquidSolution50 mgOralMedtech Products Inc2015-03-30Not applicableCanada
Sleep-eze Regular Strength CapletsTablet25 mgOralMedtech Products Inc1997-11-12Not applicableCanada
Sleepaid Extra Strength CapsulesCapsule50 mgOralTanta Pharmaceuticals IncNot applicableNot applicableCanada
SleepinalCapsule50 mg/1OralBlairex Laboratories, Inc.1999-10-01Not applicableUs
SleeptimeCapsule, liquid filled25 mg/1OralShopko Stores Operating Co., LLC2016-07-27Not applicableUs
SleeptimeSolution50 mg/30mLOralShopko Stores Operating Co., LLC2016-07-27Not applicableUs
Sleeptime Dry CoughSolution12.5 mgOralPerrigo InternationalNot applicableNot applicableCanada
SleepwellTablet25 mgOralStella Pharmaceutical Canada Inc.2001-11-202008-06-26Canada
Smart Sense AllergyLiquid12.5 mg/5mLOralKmart Corporation2011-01-13Not applicableUs
Smart Sense AllergyTablet25 mg/1OralKmart Corporation2011-01-06Not applicableUs
Smart Sense AllergyCapsule25 mg/1OralKmart Corporation1996-01-23Not applicableUs
Smart Sense Allergy ReliefCapsule25 mg/1OralKmart Corporation2014-02-10Not applicableUs
Smart Sense Allergy ReliefTablet25 mg/1OralKmart Corporation2014-02-20Not applicableUs
Smart Sense Childrens Allergy ReliefSolution12.5 mg/5mLOralKmart Corporation2014-02-21Not applicableUs
Smart Sense Nightime Sleep AidTablet25 mg/1OralKmart Corporation2007-06-29Not applicableUs
Smart Sense Nighttime Sleep AidSolution50 mg/30mLOralKmart Corporation2015-10-21Not applicableUs
Smart Sense Nighttime Sleep AidCapsule, liquid filled25 mg/1OralKmart Corporation2015-10-21Not applicableUs
Smart Sense Sleep AidTablet25 mg/1OralKmart Corporation2014-04-18Not applicableUs
Snoozease Nighttime Sleep-aidCapsule, liquid filled25 mg/1OralP and L Development of New York Corporation2013-04-11Not applicableUs
Sohmed AllergyTablet25 mg/1OralSOHM Inc.2013-08-25Not applicableUs
SominexTablet25 mg/1OralMedtech Products Inc.2012-06-01Not applicableUs
SominexTablet25 mg/1OralGlaxo Smith Kline Consumer Healthcare Lp2010-11-08Not applicableUs
SominexTablet25 mg/1OralNavajo Manufacturing Company Inc.2016-09-22Not applicableUs
Sominex Extra Strength Caplet 50mgTablet50 mgOralGlaxosmithkline Consumer Healthcare Inc.1992-12-312012-06-13Canada
Sominex MaxTablet50 mg/1OralMedtech Products Inc.2012-06-01Not applicableUs
Sominex Tablets 25mgTablet25 mgOralGlaxosmithkline Consumer Healthcare Inc.1992-12-312012-06-13Canada
Somnapure Clinical StrengthTablet, coated50 mg/1OralNutra Click, Llc2015-04-09Not applicableUs
Somnapure Clinical StrengthTablet, coated50 mg/1OralNutra Click, Llc2015-05-26Not applicableUs
SomnitabsTablet25 mg/1OralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.1992-12-25Not applicableUs
SomnitabsTablet25 mg/1OralFRED'S, INC.1990-04-10Not applicableUs
Sound Body Childrens Allergy ReliefSolution12.5 mg/5mLOralBig Lots Stores, Inc.2016-01-12Not applicableUs
Sound Body Nighttime Sleep AidSolution50 mg/30mLOralBig Lots Stores, Inc.2015-04-21Not applicableUs
Sound Body Sleep AidCapsule25 mg/1OralAllegiant Health2015-03-03Not applicableUs
Sun Mark Allergy ReliefCapsule25 mg/1OralMc Kesson2003-07-03Not applicableUs
Sunmark Allergy ReliefTablet25 mg/1OralMc Kesson2003-08-21Not applicableUs
Sunmark Allergy Relief AntihistamineSolution12.5 mg/5mLOralMc Kesson2003-08-21Not applicableUs
Sunmark Night Time Sleep AidTablet25 mg/1OralMc Kesson2003-08-21Not applicableUs
Sunmark Z SleepSolution50 mg/30mLOralMc Kesson2013-07-16Not applicableUs
Sunmark Z-sleepCapsule, liquid filled25 mg/1OralMcKesson2014-01-31Not applicableUs
The Itch Eraser Max StrengthGel20 mg/gTopicalTender Corporation2015-11-17Not applicableUs
The Itch Eraser Max StrengthSpray20 mg/mLTopicalTender Corporation2015-12-04Not applicableUs
The Itch Eraser With AntihistamineCream2 %TopicalTender CorporationNot applicableNot applicableCanada
Topcare AllergyTablet25 mg/1OralTopco Associates LLC1993-12-142016-10-29Us
Topcare AllergyCapsule25 mg/1OralTopco Associates LLC1988-01-15Not applicableUs
Topcare Childrens AllergySolution12.5 mg/5mLOralTopco Associates LLC1987-12-15Not applicableUs
Topcare Clear TimeTablet, film coated25 mg/1OralTopco Associates LLC2015-01-14Not applicableUs
Topcare Sleep AidTablet25 mg/1OralTopco Associates LLC2010-11-03Not applicableUs
Topcare Sleep Aid NighttimeTablet25 mg/1OralTopco Associates LLC2001-09-11Not applicableUs
Topcare Zzz SleepCapsule, liquid filled25 mg/1OralTopco Associates LLC2014-01-28Not applicableUs
Topcare Zzz SleepSolution50 mg/30mLOralTopco Associates LLC2013-08-20Not applicableUs
Tranquil NighttimeTablet25 mg/1OralAlva Amco Pharmacal Companies, Inc.2010-08-30Not applicableUs
Triaminic Thin Strips Cough & Runny NoseStrip12.5 mgOralNovartis Consumer Health Canada Inc.2004-11-19Not applicableCanada
UnisomTablet50 mgOralPaladin Labs Inc1982-12-31Not applicableCanada
Unisom C Nightime Sleep Aid Cap 50mgCapsule50 mgOralPfizer Canada Inc., Consumer Healthcare Division1989-12-311998-08-12Canada
Unisom Sleep GelsCapsule25 mgOralPaladin Labs Inc2012-03-20Not applicableCanada
Unisom Sleep Gels Extra StrengthCapsule50 mgOralPaladin Labs Inc1996-09-05Not applicableCanada
Unisom Sleepgels Nighttime Sleep-aidCapsule, liquid filled50 mg/1OralChattem, Inc.2007-01-01Not applicableUs
Unisom Sleepmelts Nighttime Sleep-aidTablet, chewable25 mg/1OralChattem, Inc.2008-01-01Not applicableUs
Unisom Sleepminis Nighttime Sleep-aidCapsule25 mg/1OralChattem, Inc.2015-04-01Not applicableUs
Unisom Warming CherryLiquid50 mg/30mLOralChattem, Inc.2013-12-02Not applicableUs
Up and Up Allergy ReliefCapsule25 mg/1OralTarget Corporation2009-06-10Not applicableUs
Up and Up Allergy ReliefTablet25 mg/1OralTarget Corporation2009-06-12Not applicableUs
Up and Up Childrens Allergy MedicationLiquid12.5 mg/5mLOralTarget Corporation2009-07-08Not applicableUs
Up and Up Childrens Allergy MeltsTablet, chewable12.5 mg/1OralTarget Corporation2015-08-03Not applicableUs
Up and Up Dye-free Childrens AllergySyrup12.5 mg/5mLOralTarget Corporation2015-02-12Not applicableUs
Up and Up Nighttime Sleep-aidLiquid50 mg/30mLOralTarget Corporation2015-10-20Not applicableUs
Vanamine PdLiquid6.25 mg/mLOralGm Pharmaceuticals2016-04-04Not applicableUs
Vicks Qlearquil Nighttime Allergy ReliefTablet25 mg/1OralThe Procter & Gamble Manufacturing Company2014-03-01Not applicableUs
Vicks Zzzquil Liquid and Liquicaps ComboKitOralThe Procter & Gamble Manufacturing Company2013-05-01Not applicableUs
Wal DrylSolution50 mg/20mLOralWALGREEN CO.2016-04-25Not applicableUs
Wal Dryl Allergy ChildrensSolution12.5 mg/5mLOralWalgreen Company1989-07-15Not applicableUs
Wal Dryl Childrens AllergyLiquid12.5 mg/5mLOralWalgreens2015-04-30Not applicableUs
Wal Som Nighttime Sleep AidCapsule25 mg/1OralWalgreen Company2016-04-04Not applicableUs
Wal-drylCapsule25 mg/1OralWalgreen Company1990-03-15Not applicableUs
Wal-dryl AllergyLiquid25 mg/10mLOralWalgreens2014-08-31Not applicableUs
Wal-dryl AllergyTablet25 mg/1OralWALGREEN CO.1990-03-02Not applicableUs
Wal-dryl Allergy Dye-freeCapsule, liquid filled25 mg/1OralWALGREEN CO.2015-03-01Not applicableUs
Wal-sleep ZCapsule, liquid filled25 mg/1OralWalgreen Company2015-02-28Not applicableUs
Wal-sleep ZTablet, film coated25 mg/1OralWalgreen Company2015-07-24Not applicableUs
Wal-sleep Z Diphenhydramine HCl / Sleep AidCapsule, gelatin coated50 mg/21OralWalgreen Company2011-12-08Not applicableUs
Wal-sleep Z NighttimeLiquid50 mg/30mLOralWalgreen Company2016-09-12Not applicableUs
Wal-somTablet25 mg/1OralWalgreen2012-08-22Not applicableUs
X3 On-the-GO First Aid Topical Analgesic Itch Relief SpraySpray2.0 %TopicalNatural Essentials Inc2012-04-24Not applicableCanada
Zzz SleepCapsule, liquid filled25 mg/1OralWestern Family Foods Inc2014-01-28Not applicableUs
Zzz SleepSolution50 mg/30mLOralWestern Family Foods Inc2013-08-29Not applicableUs
Zzz TimeCapsule, liquid filled25 mg/1OralMeijer Distribution Inc2014-02-07Not applicableUs
ZzzquilCapsule, liquid filled50 mg/21OralLil' Drug Store Products, Inc.2015-12-23Not applicableUs
ZzzquilCapsule25 mgOralProcter & Gamble Inc2013-02-12Not applicableCanada
Zzzquil Alcohol FreeLiquid50 mgOralProcter & Gamble IncNot applicableNot applicableCanada
Zzzquil Alcohol Free Nighttime Sleep-aidSolution50 mg/30mLOralProcter & Gamble Manufacturing Company2015-02-03Not applicableUs
Zzzquil LiquidLiquid50 mgOralProcter & Gamble Inc2014-08-15Not applicableCanada
Zzzquil Nightime Sleep-aidCapsule, gelatin coated25 mg/1OralNavajo Manufacturing Company Inc.2016-09-29Not applicableUs
Zzzquil Nighttime Sleep-aidSolution50 mg/30mLOralProcter & Gamble Manufacturing Company2015-02-03Not applicableUs
Zzzquil Nighttime Sleep-aidLiquid50 mg/30mLOralProcter & Gamble Manufacruing Company2011-12-08Not applicableUs
Zzzquil Nighttime Sleep-aidCapsule, gelatin coated50 mg/21OralProcter & Gamble Manufacturing Company2011-12-08Not applicableUs
ZzzsleepCapsule, liquid filled25 mg/1OralVelocity Pharma2013-10-15Not applicableUs
ZzztimeLiquid50 mg/30mLOralMeijer Distribution Inc2013-07-08Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DicopanolKitOralFusion Pharmaceuticals LLC2010-02-08Not applicableUs
DicopanolKitOralCalifornia Pharmaceuticals Llc2016-01-01Not applicableUs
Diphenhydramine HClCapsule25 mg/1OralCardinal Health2011-06-03Not applicableUs
Diphenhydramine HClTablet25 mg/1OralCardinal Health2011-06-03Not applicableUs
International Brands
NameCompany
AlerylNot Available
AlledrylNot Available
AllerdrylValeant
BaramineNot Available
BeldinNot Available
BelixNot Available
BenylanBiogen
DermodrinMontavit
DesentolMeda
DibondrinMontavit
DimedrolZdorovie
DiphenWockhardt
Dormarex 2Not Available
GenahistNot Available
HistaxinMeda
HyrexinHyrex
Nytol QuickgelsGlaxoSmithKline
RestaminKowa Souyaku
SiladrylNot Available
Silphen CoughNot Available
Brand mixtures
NameLabellerIngredients
7 Select Ibuprofen PM7 Eleven
7 Select Night Time Severe Cold, Cough and Flu7 Eleven
7 Select Pain Relief PM7 Eleven
7-select Advil PMLil' Drug Store Products, Inc
Aceta-gesicRugby Laboratories
AcetadrylPhysicians Science & Nature Inc.
Acetaminophen / Diphenhydramine 500/25 mgReliable 1 Laboratories Llc
Acetaminophen and Diphenhydramine HClRugby Laboratories Inc.
Acetaminophen and Diphenhydramine HydrochlorideWalmart stores Inc
Acetaminophen Extra StrengthSave A Lot Food Stores, Ltd.
Acetaminophen PMTarget Corporation
Acetaminophen PM Extra StrengthSafeway, Inc.
Acetaminophen PM Rapid ReleaseAAA Pharmaceutical, Inc.
Acetaminophen Pmextra Strength Extra StrengthMc Kesson (Health Mart)
Acetaminophen With Antihistamine NighttimeLaboratoires Trianon Inc
Acetaminophen, Diphenhydramine HydrochlorideAAA Pharmaceutical, Inc.
Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Acetaminophen, Diphenhydramine Hyhrochloride, Phenylephrine HydrochlorideAAA Pharmaceutical, Inc.
Added Strength PMWestern Family Foods Inc
Advil Cold & FluPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold, Cough & Flu NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Day/night Convenience PackPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Pain & Head Cold NightPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil PMLil' Drug Store Products, Inc.
AiracofCenturion Labs, Llc
Alahist LqPoly Pharmaceuticals, Inc.
Aleve NighttimeBayer Inc Consumer Care
Aleve PMBayer Health Care Consumer Care
Alka-seltzer Plus Night Severe Cold, Cough and FluBayer Health Care Llc Consumer Care
Allegra Cooling Relief Anti-itchChattem, Inc.
Allegra Intensive Relief Anti-itchChattem, Inc.
Allergic Itch ReliefValu Merchandisers, Co.
AllergyFRED'S, INC.
Allergy and ColdWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Allergy and Cold PESelect Brand
Allergy and Cold ReliefTarget Corporation
Allergy and Sinus HeadacheWal Mart Stores Inc
Allergy and Sinus Headache Relief CompleteWin Co Foods, Llc
Allergy CreamG&W Laboratories Inc.
Allergy Cream 2% Anti-itchPharmacy Value Alliance Llc
Allergy DCVS Pharmacy
Allergy Plus Severe Sinus HeadacheAmeri Source Bergen
Allergy Plus Sinus HeadacheTop Care
Allergy Plus Sinus ReliefRite Aid
Allergy Relief Plus Sinus HeadacheChain Drug Marketing Association
Allergy SevereL&R Distributors, Inc.
Allergy Sinus Headache CapletsTanta Pharmaceuticals Inc
Allergy Sinus Nighttime ReliefVita Health Products Inc
Allergy, Sinus and Headache Relief MedicationPharmetics (2011) Inc
Allergy/sinus HeadacheDolgencorp, LLC
Anti ItchMeijer Distribution Inc
Anti Itch and Skin ProtectantRite Aid Corporation
Anti Itch CreamNeo Pharm Co., Ltd.
Anti Itch SprayH.J. Sutton Industries Ltd.
Anti Itch Topical AnalgesicChain Drug Marketing Associations Inc
Anti-itchAmerisource Bergen
Anti-itch Extra StrengthStephen L. La France Pharmacy, Inc.
Anti-itch Maximum StrengthFred's Inc.
Anti-itch Plus CreamTaro Pharmaceuticals Inc
Anti-itch Wal-drylWalgreen's Co
Antiphlamine Coin PlasterHanul Trading Co., Ltd.
Army and Airforce Exchange Ibuprofen PMArmy & Air Force Exchange Service
Assured Headache PM (aspirin Free)Spirit Pharmaceutical Llc
Assured Night Time Cold and CoughBio Pharm, Inc.
Atopalm Itch ReliefNeopharm Co, Ltd
Auroflu Flu and Sore Throat Warming ReliefAurohealth LLC
Auroflu Night Time Severe Cold and CoughAurohealth LLC
Auroflu Night Time Severe Cold and Cough Warming ReliefAurohealth LLC
Aurophen Daytime NighttimeAurohealth LLC
Aurophen Pain Away Plus Sleep AidAurohealth LLC
Aurophen PM Extra StrengthAurohealth LLC
Balminil Codeine Night Time + ExpectorantRougier Pharma Division Of Ratiopharm Inc
Balminil Night-timeTeva Canada Limited
BanophenMajor Pharmaceuticals
Bayer PMBayer Health Care Llc, Consumer Care
Benadryl Allergy & Cold CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Allergy & SinusMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Allergy Rapid ReleaseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Allergy Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Allergy Sinus HeadacheMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Bug Bite ReliefMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Decongestant TabletsWarner Lambert Canada Inc.
Benadryl Extra Strength Itch CoolingJohnson & Johnson Consumer Inc.
Benadryl Extra Strength Itch ReliefJohnson & Johnson Consumer Inc.
Benadryl Extra Strength Itch StoppingJohnson & Johnson Consumer Inc.
Benadryl Original Strength Itch StoppingJohnson & Johnson Consumer Inc.
Benadryl PE Total Extra StrengthMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl PE Total Regular StrengthMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl Readymist Itch StoppingJohnson & Johnson Consumer Inc.
Benadryl SprayMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benadryl TotalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Night Extra StrengthMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin All-IN-one Cold and Flu Night PE CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin Cold and Sinus Night CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Benylin for Children All-IN-one Cold & Fever NightimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Berkley and Jensen Ibuprofen PMBJWC
Best Choice Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Bi Electro Extra StrengthGenomma Lab Usa
Bite and ItchWeeks & Leo Co., Inc.
Buckley's Complete PM - NighttimeThe Buckley's Company
Buckley's Night Time MixtureThe Buckley's Company
Bye Bye Bite LotDavid D. Daniels Ltd.
CalmylinTeva Canada Limited
Calmylin #4 SyrTechnilab Pharma Inc.
Care One Flu and Severe Cold and Cough NighttimeAmerican Sales Company
Care One Ibuprofen PMAmerican Sales Company
Care One Pain Relief and Pain Relief PMAmerican Sales Company
Care One Pain Relief PM Extra StrengthAmerican Sales Company
Careall Non-aspirin PM Extra StrengthNew World Imports, Inc
Careone Acetaminophen PMAmerican Sales Company
Careone AllergyAmerican Sales Company
Careone Day Time Severe Cold Night Time Cold and FluAmerican Sales Company
Careone Ibuprofen PMAmerican Sales Company
Careone Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Careone Pain Relief Pain Relief PMAmerican Sales Company
Careone Pain Relief PMAmerican Sales Company
Careone Triacting Night Time Cold and Cough ChildrensAmerican Sales Company
Children's Allergy and Sinus Medication Liquid SuspensionPharmetics (2011) Inc
Children's Benadryl-D Allergy & SinusMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Benadryl-D SyrupMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Allergy - D Chewable TabletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Allergy-D SuspensionMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Cold and Cough NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Children's Tylenol Complete Cold, Cough & Fever NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Childrens Allergy Plus CongestionWalgreens
Childrens Benadryl Allergy Plus CongestionJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Childrens Benadryl-D Allergy and SinusJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Childrens Cold and Cough NighttimeWalgreens
Childrens Cough and Cold NighttimeCVS Pharmacy
Childrens Delsym Cough Plus Cold Night TimeReckitt Benckiser LLC
Childrens Dimetapp Multi-symptom Cold and FluRichmond Division of Wyeth
Childrens Dimetapp Nighttime Cold and CongestionRichmond Division Of Wyeth Llc, A Subsidiary Of Pfizer Inc.
Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom ColdReckitt Benckiser LLC
Childrens Mucinex Night Time Multi-symptom ColdReckitt Benckiser LLC
Childrens Night Time Cold and CoughBest Choice (Valu Merchandisers Company)
Childrens Night Time Cough and Cold ReliefChain Drug Consortium, LLC
Childrens Nighttime Cold and CoughFamily Dollar (FAMILY WELLNESS)
Childrens TriactingWestern Family Foods Inc
Childrens Triacting Night Time Cold and CoughAmerisource Bergen (Good Neighbor Pharmacy) 46122
Childrens Triacting Nighttime Cold and CoughQUALITY CHOICE (Chain Drug Marketing Association)
Childrens Triacting Nighttime Cold and Cough ReadyincaseP & L Development, LLC
Cold & Flu-IN-oneVita Health Products Inc
Cold and Congestion Childrens NighttimeWalgreens
Cold and CoughMeijer Distribution Inc
Cold and Cough Multi-symptom Daytime / NighttimeWALGREEN CO.
Cold and FluHy Vee Inc
Cold and Flu NighttimeWestern Family Foods Inc
Cold and Flu ReliefPharmetics (2011) Inc
Cold-eeze Childrens Nighttime Cold and Cough ReliefPro Phase Labs, Inc.
Cold-eeze Nighttime Cold and FluPro Phase Labs, Inc.
Complete One Cold and Flu Nightime Extra Strength TabletsTanta Pharmaceuticals Inc
Complete One Cold and Flu PE NightPharmetics (2011) Inc
Conrx PMEagle Distributors,Inc.
Contac ColdGlaxosmithkline Consumer Healthcare Inc.
Contac Cold and Fever CapletsGlaxosmithkline Consumer Healthcare Inc.
Contac Day & Night Sinus/allergy CapletSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contac Night CapletsGlaxosmithkline Consumer Healthcare Inc.
Contac-C Ext.stren.night Time Cough,cold&fluSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.
Contrast Allergy Premed PackShertech Laboratories, Llc
Coricidin II Night Time Cold and FluSchering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
Cough Syr W Codeine Diphenhyd HCl & Ammon ClStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Cough SyrupTeva Canada Limited
Cough, Cold & FluVita Health Products Inc
Cough, Cold and Flu Nightime CapletsVita Health Products Inc
Cough, Cold and Flu Relief Complete Night Super StrengthPharmetics (2011) Inc
Counteract NightMelaleuca, Inc.
Counteract PMMelaleuca, Inc.
Cvs Cough and Severe Cold Night Time Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Cvs Effervescent Pain Relief PMCVS Pharmacy
Cvs Extra Strength Itch ReliefCVS Pharmacy
Cvs Health Nighttime Severe Cough and Cold Nighttime Severe Cold and CoughCvs Pharmacy,inc.
Cvs Pharmacy Nighttime Severe Cough and Cold Honey Lemon Infused With Chamomile and White Tea FlavorsCVS Pharmacy
Damylin Avec Codeine SiropLaboratoire Atlas Inc
Damylin With Codeine SyrupLaboratoire Riva Inc
Day and Night ColdAAA Pharmaceutical, Inc.
Day and Night Cold PEMeijer
Day and Night Sinus Maximum StrengthWal Mart Stores Inc
Daytime and Nighttime Pain ReliefCVS Pharmacy, Inc.
Daytime Cold and Cough and Nighttime Cold and Congestion ChildrensTarget Corporation
Daytime Mucus Relief Nighttime Cold and FluHy Vee Inc
Daytime Nighttime Cold and Cough ChildrensWalgreens
Daytime Nighttime Severe Cough and ColdCVS Pharmacy
Delsym Childrens Night Time Cough and ColdReckitt Benckiser LLC
Delsym Cough Plus Cold Night TimeReckitt Benckiser LLC
Delsym Night Time Cough and ColdReckitt Benckiser LLC
Dermamine Extra Strength Itch StoppingNatureplex LLC
Dermarest Plus - GelDel Pharmaceutics (Canada) Inc.
Dg Health Anti ItchDolgencorp Inc
Dg Health Flu and Severe Cold and CoughDolgencorp, LLC
Dg Health Headache Relief PMDolgencorp, LLC
Dg Health Ibuprofen PMDolgencorp Inc
Dg Health Pain Relief PMDolgencorp Inc
Dg Health Pain Relief PM Extra StrengthDolgencorp, LLC
Dg Health Triacting Night Time Cold and CoughDolgencorp, LLC
Dg Health TussinDolgencorp, LLC
Diabetic Tussin Nighttime Cold and FluHealth Care Products
DiphenhydraminePhysicians Total Care, Inc.
Diphenhydramine DNex Med (Usa), Inc.
Diphenhydramine HCl and Zinc AcetatePerrigo New York Inc
Diphenhydramine Hydrochloride and Zinc AcetateTaro Pharmaceuticals U.S.A., Inc.
DM Cough SyrProdemdis Enr.
DM Cough SyrupProdemdis Enr.
DM Plus Cough SyrupTechnilab Pharma Inc.
DM SyrupTechnilab Pharma Inc.
Doctor Manzanilla Cough Suppressant and Nasal DecongestantMid Valley Pharmaceuticals Llc
Dr. Cocoa for Children Nighttime Cough + ColdInfirst Healthcare Inc
Dr. Cocoa Nighttime Cough and ColdInfirst Healthcare
Dr. Sheffield Anti Itch CreamFaria LLC dba Sheffield Pharmaceuticals
Equaline Anti ItchSupervalu Inc
Equaline Anti-itchSupervalu Inc
Equaline Flu and Severe Cold and CoughSupervalu Inc
Equaline Ibuprofen PMSupervalu Inc
Equaline Night Time Cold and Cough ChildrensSupervalu Inc
Equaline Pain Relief PMSupervalu Inc
Equaline Pain Relief PM Extra StrengthSupervalu Inc
Equate Anti ItchWal Mart Stores Inc
Equate Flu and Severe Cold and CoughWal Mart Stores Inc
Equate Ibuprofen PMWal Mart Stores Inc
Equate Night Time Cold and Cough ChildrensWal Mart Stores Inc
Ergodryl CapErfa Canada 2012 Inc
Excedrin PMNovartis Consumer Health, Inc.
Excedrin PM Triple Action CapletsNovartis Consumer Health, Inc.
Extra Strength Acetaminophen PMMc Kesson
Extra Strength Allergy TotalVita Health Products Inc
Extra Strength Flu Relief NightimeVita Health Products Inc
Extra Strength Mapap PMMajor Pharmaceuticals
Extra Strength Multi-symptom Relief Sugar FreePharmetics (2011) Inc
Extra Strength Neocitran Flu SyrupNovartis Consumer Health Canada Inc.
Extra Strength Neocitran Total Symptom Relief - Sugar FreeNovartis Consumer Health Canada Inc.
Extra Strength Night Time Pain MedicineGeri Care Pharmaceutical Corp
Extra Strength Non-aspirin PMSave A Lot Food Stores, Ltd.
Extra Strength Pain Relief PMDiscount Drug Mart
Extra Strength Pain Reliever PMCardinal Health
Extra Strength PM Pain ReliefDolgencorp, LLC
Extra Strength Sinus Relief NighttimeVita Health Products Inc
Extra Strength Total Symptom Relief Sugar-freePharmetics (2011) Inc
Extra Strength Tylenol Allergy and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Allergy Sinus Nighttime CapletMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Complete Cold, Cough & Flu NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Flu Nighttime GelcapMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Pain and Head Cold NightMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Tylenol Pain and Head Cold Night Rapid ReleaseMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Extra Strength Wal-dryl Itch ReliefWalgreen Co
Facol Cold and Flu Day and NightJw Holdings
Facol Cold and Flu NightJw Holdings
Family Care Anti-itchUNITED EXCHANGE CORP.
Family Dollar Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Family WellnessZhejiang Jingwei Pharmaceutical Co., Ltd.
Fast Maximum Night Time Cold and FluAmerisource Bergen
First Dukes Mouthwash CompoundingCutis Pharma, Inc.
First Marys Mouthwash CompoundingCutis Pharma, Inc.
Flu and Severe Cold and CoughSafeway
Flu and Severe Cold and Cough Night TimeMeijer Distribution Inc
Flu and Severe Cold and Cough NighttimeSafeway
Flu and Severe Cold and Cough Nite TimeKroger Company
Flu and Severe Cold Nighttime ReliefCVS Pharmacy
Flu and Sore ThroatSelect Brand Dist.
Flu and Sore Throat ReliefChain Drug Consortium, LLC
Flu ReliefVita Health Products Inc
Flu Relief TherapyWalgreens
Flu Relief Therapy Night TimeGood Neighbor Pharmacy
Flu Relief Therapy NighttimeTOP CARE (Topco Associates LLC)
Flu Relief Therapy Nighttime Severe ColdSelect Brand Dist.
Flu Relief Therapy Severe Cough and Cold NighttimeFreds Inc
Flu, Cough & Cold Complete Day and NightVita Health Products Inc
Flu, Cough and Sore ThroatCVS Pharmacy
Formu Care Flu and Severe Cold and Cough Night TimeAccess Business Group International LLC
Fulton Street Market Nighttime Flu and Severe Cold and CoughAccess Business Group LLC
Good Neighbor Pharmacy Cold and Flu Night TimeAmerisource Bergen
Good Neighbor Pharmacy Flu and Severe Cold and CoughAmerisource Bergen
Good Neighbor Pharmacy Flu and Severe Cold and Cough NighttimeAmerisource Bergen
Good Neighbor Pharmacy Headache PMAmerisource Bergen
Good Neighbor Pharmacy Ibuprofen PMAmerisource Bergen
Good Neighbor Pharmacy Itch Relief Extra StrengthAmerisource Bergen Drug Corporation
Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night TimeAmerisource Bergen
Good Neighbor Pharmacy Pain Relief and Pain Relief PMAmerisource Bergen
Good Neighbor Pharmacy Pain Relief PMAmerisource Bergen
Good Neighbor Pharmacy Sinus Relief Day Time Night TimeAmerisource Bergen
Good Sense Flu and Severe Cold and CoughL. Perrigo Company
Good Sense Flu and Severe Cold and Cough NighttimeL. Perrigo Company
Good Sense Headache PML Perrigo Company
Good Sense Ibuprofen PML Perrigo Company
Good Sense Itch ReliefL. Perrigo Company
Good Sense Pain Relief PML. Perrigo Company
Good Sense Pain Relief PM Extra StrengthL. Perrigo Company
Goodys PM Pain RelieverMedtech Products Inc.
Harris Teeter Acetaminophen PMHarris Teeter, LLC
Harris Teeter Ibuprofen PMHarris Teeter, LLC
Harris Teeter Sinus ReliefHarris Teeter, LLC
Headache Formula PMSUPERVALU INC.
Headache PMHy Vee Inc
Headache PM Aspirin FreeGreenbrier International, Inc.
Headache PM FormulaHy Vee Inc
Headache Relief PMDolgencorp, LLC
Health Mart Severe Cold Cough and FluMcKesson
Healthy Accents Anti ItchDZA Brands LLC
Healthy Accents Ibuprofen PMDZA Brands LLC
Healthy Accents Pain Relief PMDZA Brands LLC
Healthy Accents Pain Relief PM Extra StrengthDZA Brands LLC
Healthy Accents Severe ColdDZA Brands LLC
Healthy Accents Sinus ReliefDZA Brands LLC
Healthy Mama Eazzze The PainMATERNAL SCIENCE, LLC
Ibuprofen and Diphenhydramine CitrateDr. Reddy's Laboratories Limited
Ibuprofen and Diphenhydramine HClP and L Development of New York Corporation
Ibuprofen Daytime, Ibuprofen NighttimeVita Health Products Inc
Ibuprofen NighttimeVita Health Products Inc
Ibuprofen PMWalgreen Company
Instant Itch Relief CvsCVS
Itch Rel Spr CvsCVS
Itch ReliefH E B
Itch Relief Extra StrengthSafeway
Itch Relief SprayTender Corporation
Itch Relief StickTender Corporation
Itch StoppingHy Vee Inc
IvarestBlistex Inc
Jack & Jill Bedtime Cough & ColdThe Buckley's Company
Kinkan CoolKinkando Co., Ltd.
Kmart - Pain Relief PMKmart Corporation
Kroger Nitetime Cold and FluThe Kroger Co
Kroger Nitetime Flu Plus Severe Cold and CoughKroger Company
Leader Anti Itch Maximum StrengthCardinal Health
Leader Cold and FluCardinal Health
Leader Flu and Severe Cold and CoughCardinal Health
Leader Headache PM FormulaCardinal Health
Leader Ibuprofen PMCardinal Health
Leader Night Time Cough and Cold Childrens TriactingCardinal Health
Leader Pain Reliever PMCardinal Health
Legatrin PMChurch & Dwight Co., Inc.
Live Better Anti-itchThe Great Atlantic & Pacific Tea Company
Lucky Itch StoppingDelta Brands Inc
Meijer Anti-itchMeijer Distribution Inc
Meijer Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Midol PMBayer Health Care Llc
Motrin PMJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Mountain Series Weekender MedicalTender Corporation Dba Adventure Medical Kits
Mucinex Fast-max Day Time Severe Cold and Mucinex Fast-max Night Time Cold and Flu Maximum StrengthReckitt Benckiser LLC
Mucinex Fast-max Day Time Severe Congestion and Cough - Mucinex Fast-max Night Time Cold and Flu Maximum StrengthReckitt Benckiser LLC
Mucinex Fast-max Day Time Severe Congestion and Cough and Mucinex Fast-max Night Time Cold and Flu Maximum StrengthReckitt Benckiser LLC
Mucinex Fast-max Night Time Cold and FluReckitt Benckiser LLC
Mucinex Fast-max Night Time Cold and Flu Clear and CoolReckitt Benckiser LLC
Mucinex Fast-max Severe Congestion and Cough Clear and Cool and Mucinex Fast-max Night Time Cold and Flu Clear and CoolReckitt Benckiser LLC
Mucinex Sinus-max Day Night Maximum StrengthReckitt Benckiser LLC
Mucinex Sinus-max Day Time Severe Congestion Relief and Mucinex Sinus-max Night Time Congestion and Cough Maximum StrengthReckitt Benckiser LLC
Mucinex Sinus-max Night Time Congestion and CoughReckitt Benckiser LLC
Mucus Relief Day Time and Night TimeHEB
Mucus Relief Daytime/nighttimeWalgreen Company
Mucus Relief Daytime/nighttime/maximum StrengthWalgreen Company
Mucus Relief Sinus Congestion Daytime Nighttime Maximum StrengthWalgreen Company
Mucus Relief Sinus Day and NightHEB
Multi Symptom Severe ColdCVS Pharmacy
Multi Symptom Severe Cold and Nighttime Severe Cold and CoughCvs Pharmacy,inc.
Multi-symptom Cold and Cough Daytime NighttimeRite Aid
Multi-symptom Wal-phed PEWalgreen Company
Neocitran Extra Strength Total Cold NightGlaxosmithkline Consumer Healthcare Inc.
Neocitran Thin Strips Nighttime Cough and ColdNovartis Consumer Health Canada Inc.
Neocitran Total Cold NightGlaxosmithkline Consumer Healthcare Inc.
Night Time Cold & Flu LiquidReckitt Benckiser (Canada) Inc
Night Time Cold and Cough ChildrensBest Choice (Valu Merchandisers Company)
Night Time Cough and Cold ReliefChain Drug Consortium, LLC
Night Time Severe Cold and CoughFamily Dollar, Inc.
Night Time Severe Cold and Cough ReliefChain Drug Consortium, LLC
Nighttime Cold and Flu Maximum StrengthWalgreens
Nighttime Cold and Flu Relief TherapyQUALITY CHOICE (Chain Drug Marketing Association)
Nighttime Cold and Flu-IN-one Extra StrengthVita Health Products Inc
Nighttime Cold, Cough & FluApotex Inc
Nighttime Flu and SevereTaro Pharmaceuticals U.S.A. Inc.
Nighttime Flu Relief Therapy Severe ColdAmerisource Bergen (Good Neighbor Pharmacy) 46122
Nighttime Flu, Cough & Cold Complete Relief Extra StrengthVita Health Products Inc
Nighttime Pain Plus SleepChain Drug Consortium, LLC
Nighttime Pain ReliefApotex Inc
Nighttime Pain RelieverMarcan Pharmaceuticals Inc
Nighttime Pain Reliever PMWALGREEN CO.
Nighttime Super Strength Contac CompleteGlaxosmithkline Consumer Healthcare Inc.
Nighttime Symptom Relief Extra Strength for Symptoms Of Cold and CoughPharmetics (2011) Inc
Nighttime Total Cold and FluVita Health Products Inc
Nite Time Cold and CoughAccudial Pharmaceutical, Inc.
Nite Time Cold and Cough ChildrensKroger Company
Non Aspirin PM Extra StrengthFreds Inc
Non-aspirin PM Extra StrengthNew World Imports, Inc
Our Family Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Pain Away Plus Sleep AidChain Drug Consortium, LLC
Pain Plus SleepAmerisource Bergen
Pain Relief Acetaminophen PM Extra StrengthRite Aid
Pain Relief and Pain Relief PMMeijer Distribution Inc
Pain Relief Medicine PMArmy and Air Force Exchange Service
Pain Relief Pain Relief PMMeijer Distribution Inc
Pain Relief Plus Sleep AidDolgencorp, LLC
Pain Relief PMTarget Corporation
Pain Relief PM Extra ReliefGreenbrier International, Inc.
Pain Relief PM Extra StrengthWalgreens
Pain Relief PM Extra Strength Aspirin FreeSafeway, Inc.
Pain Relief PM Nightime Sleep AidSelect Corporation
Pain Relief PM Rapid ReleaseMeijer Distribution Inc
Pain Reliever Extra Strength PML&R Distributors, Inc.
Pain Reliever PMNash Finch Company
Pain Reliever PM Extra StrengthWalgreens
Pain Reliever Sleep Aid Extra StrengthFamily Dollar (FAMILY WELLNESS)
Panadol PMGlaxo Smith Kline Consumer Healthcare Holdings (Us) Llc
Pediacare Childrens Allergy and ColdBlacksmith Brands, Inc.
Pediacare Childrens Nighttime Multi Symptom ColdMedtech Products Inc
Percogesic Extra StrengthMedtech Products Inc.
Percogesic Original StrengthMedtech Products Inc.
Plus Pharma Extra Strength Acetaminophen PMGemini Pharmaceuticals, Inc. dba Plus Pharma
PM AcetaminophenNew World Imports, Inc
PM Get ReliefEagle Distributors,Inc.
PM Pain RelieverRite Aid
Preferred Plus Cold and Flu Night TimeKinray
Preferred Plus Severe Cold Cough and FluKinray
Preferred Plus Severe Cold Day Time Cold and Flu Night TimeKinray
Preferred Plus Sinus Relief Day Tiime Night TimeKinray
Premier Value AllergyTAI GUK PHARM. CO., LTD.
Premier Value Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Publix AllergyPublix Super Markets Inc
Pulmorex Expectorant LiqNutribon (1986) Inc.
Quality Choice Extra Strength Anti ItchChain Drug Marketing Association Inc
Quality Choice Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Quality Choice Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsChain Drug Marketing Association
Rapid Release Acetaminophen PM Extra StrengthCostco Wholesale Corporation
Rapid Release Pain Relief PMMeijer
Reeses Onetab Allergy and SinusReese Pharmaceutical Co.
Reeses Onetab Cold and FluReese Pharmaceutical Co.
Regular Strength Flu Relief NightimeVita Health Products Inc
Rite Aid Maximum Strength Itch ReliefRite Aid Corporation
Rite Aid Night Time Severe Cold and Cough Honey Lemon With Chamomile and White Tea FlavorsQuality Home Products
Rite Aid Nighttime Severe Cold and Cough ReliefRite Aid Corporation
Robitussin Night Time Cough and ColdRichmond Division of Wyeth
Robitussin Peak Cold Nighttime Multi-symptom ColdRichmond Division of Wyeth
Robitussin Severe Multi-symptom Cough Cold Flu NighttimeRichmond Division of Wyeth
Rugby Acetaminophen 500 Mg and Diphenhydramine HCl 25 Mg Pain Reliever/sleep AidRugby Laboratories
Rx Act Flu and Severe Cold and Cough NighttimeH E B
Rx Act Ibuprofen PMH E B
Rx Act Pain Relief PMH E B
Rx Act Pain Relief PM Extra Strengh Rapid ReleaseH E B
Salonpas Medicated PlasterHisamitsu Pharmaceutical Co., Inc.
Sanatos Severe Cold and Cough NighttimePharmadel LLC
Select Brand Itch ReliefSelect Brand
Severe AllergyWALGREEN CO.
Severe Allergy and Sinus HeadacheRite Aid
Severe Allergy and Sinus Headache Maximum StrengthCVS Pharmacy
Severe Allergy Plus Sinus HeadacheTop Care
Severe Allergy Plus Sinus Headache Maximum StrengthMeijer
Severe Allergy Relief Plus Sinus HeadacheChain Drug Marketing Association
Severe ColdChain Drug Marketing Association
Severe Cold and Cough Night TimeDolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Severe Cold and Cough Relief NighttimeH E B
Severe Cold and Sinus Relief PERite Aid Corporation
Severe Cold Cough and FluHy Vee Inc
Severe Cold Cough and Flu Relief NighttimeRite Aid Corporation
Severe Cold Daytime Cold and Flu NighttimeWestern Family Foods Inc
Severe Cold PESelect Brand
Severe Cold PE Multi-symptomSUPERVALU INC.
Severe Cold Relief PEWoonsocket Prescription Center, Incorporated
Severe Congestion and Cough/ Cold and Flu Daytime/nighttimeRite Aid Corporation
Severe Congestion and Cough/cold and Flu Daytime/nighttime/maximum StrengthCVS Pharmacy
Shopko Anti-itchShopko Stores Operating Co., LLC
Shopright Childrens Nighttime Cold and CoughWakefern Food Corporation
Shoprite Anti ItchWakefern Food Corporation
Shoprite Ibuprofen PMWakefern Food Corporation
Shoprite Nighttime Flu Plus Severe Cold and CoughWakefern Food Corporation
Shoprite Non AspirinWakefern Food Corporation
Shoprite Pain Relief PMWakefern Food Corporation
Signature Care Ibuprofen PMSafeway
Signature Care Itch ReliefSafeway
Signature Care Severe Cold Cough and Flu NighttimeSafeway
Sinus ReliefKroger Company
Sinus Relief Congestion and Cough Maximum StrengthWalgreens
Sinus Relief Maximum Strength Daytime and Nighttime Sinus PainWOONSOCKET PRESCRIPTION CENTER,INCORPORATED
Sinus Relief Nightime CapletsPharmetics (2011) Inc
Sinutab Daytime/nightime Extra Strength Caplets (combo Pack)Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab N.T. Extra Strength CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sinutab N.T. Regular Strength CapletsWarner Lambert Canada Inc.
Sinutab PE Sinus and AllergyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Smart Sense Anti Itch Extra StrengthKmart Corporation
Smart Sense Childrens Nighttime Cold and CoughKmart Corporation
Smart Sense Flu and Severe Cold and Cough NighttimeKmart Corporation
Smart Sense Ibuprofen PMKmart Corporation
Smart Sense Itch StoppingKmart Corporation
Smart Sense Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Smart Sense Pain Relief PM Extra StrengthKmart Corporation
Smart Sense Sinus ReliefKmart Corporation
Smart Sense Topical Analgesic Skin ProtectantKmart Corporation
Smart Sense TriactingKmart Corporation
Sohmed Pain Relief PMSOHM Inc.
Sound Body Pain Relief PMAllegiant Health
Sting Kure - LiqWisconsin Pharmacal Co. Llc
Sting-eze-liqWisconsin Pharmacal Co. Llc
Sudafed PE Cold and CoughMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sudafed Sinus NighttimeMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Sunmark Anti-itchMc Kesson
Sunmark Ibuprofen PMMc Kesson
Sunmark Pain Reliever PM Extra StrengthMc Kesson
Suphedrine PETarget Corporation
Suppress Cough Syr W.cod.diphen.hcl Amm.chl.Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.
TactSato Pharmaceutical Inc., Ltd.
Tact Cool JellySato Pharmaceutical Co., Ltd.
Tecnu CalagelTec Laboratories, Inc.
Texaclear Kids Cold ReliefGm Pharmaceuticals, Inc.
Texaclear Night Time Cough Cold/fluGm Pharmaceuticals, Inc.
Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and CoughGlaxo Smith Kline Consumer Healthcare Holdings (Us) Llc
Theraflu Expressmax Flu, Cough, and Sore ThroatNovartis Consumer Health, Inc.
Theraflu Expressmax Nighttime Severe Cold and CoughNovartis Consumer Health, Inc.
Theraflu Nighttime Multi-symptom Severe Cold PowderGlaxo Smith Kline Consumer Healthcare Holdings (Us) Llc
Theraflu Nighttime Severe Cold and CoughNovartis Consumer Health
Theraflu Sugar Free Nightime Severe Cold and CoughNovartis Consumer Health, Inc.
Theraflu Warming Relief Flu and Sore ThroatNovartis Consumer Health
Theraflu Warming Relief Nighttime Severe Cold and CoughNovartis Consumer Health
Time-gesicTime Cap Labs, Inc
Topcare Anti-itchTopco Associates LLC
Topcare Childrens Triacting Nightime Cold and CoughTopco Associates LLC
Topcare Flu and Severe Cold and CoughTopco Associates LLC
Topcare Headache PM FormulaTopco Associates LLC
Topcare Ibuprofen PMTopco Associates LLC
Topcare Mucus Relief and Cold and FluTopco Associates LLC
Topcare Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Topcare Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsTOP CARE (Topco Associates LLC)
Topcare Pain Relief PMTopco Associates LLC
Topcare Pain Relief PM Extra StrengthTopco Associates LLC
Topcare Pain Relief PM Extra Strength Non Habit FormingTopco Associates LLC
Topcare Sinus Relief Day Time Night TimeTopco Associates LLC
Total Cold & Flu ComboVita Health Products Inc
Triacting Night TimeSafeway
Triacting Night Time Cold and CoughGood Neighbor Pharmacy
Trialyn SyrupLaboratoires Trianon Inc
Triaminic Childrens Night Time Cold and CoughNovartis Consumer Health, Inc.
Triaminic Day - Night Club PackNovartis Consumer Health, Inc.
Triaminic Night Time Cold and CoughNovartis Consumer Health, Inc.
Triaminic Nighttime Cough and ColdNovartis Consumer Health Canada Inc.
Triaminic Thin Strips Nighttime Cold & CoughGlaxosmithkline Consumer Healthcare Inc.
Tussin CF Nighttime Cough and ColdCVS Pharmacy
Tylenol PMNavajo Manufacturing Company Inc.
Tylenol PM Extra StrengthJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Unisom PM Pain Nighttime Sleep Aid and Pain RelieverChattem, Inc.
Up and Up Acetaminophen PMTarget Corporation
Up and Up Acetaminophen PM Extra StrengthTarget Corporation
Up and Up Childrens Cold and Cough ReliefTarget Corporation
Up and Up Daytime Severe Cold Nighttime Cold and FluTarget Corporation
Up and Up Flu and Severe Cold and Cough ReliefTarget Corporation
Up and Up Ibuprofen PMTarget Corporation
Up and Up Itch ReliefTarget Corporation
Up and Up Nighttime Flu and Severe Cold and CoughTarget Corporation
Vanapain PMGm Pharmaceuticals, Inc.
Wal Flu Severe Cold and CoughWalgreen Company
Wal-drylWalgreen Company
Wal-dryl Allergy Plus ColdWALGREEN CO.
Wal-dryl Itch ReliefWalgreen Company
Wal-dryl Maximum StrengthWalgreen Company
Wal-dryl PE Allergy and SinusWALGREEN CO.
Wal-dryl-DWALGREEN CO.
Wal-nadol PMWalgreen Company
Wal-phed PEWALGREEN CO.
Wal-phed PE Pressure Plus Pain Plus Cold Daytime, Nighttime, Multi-symptomWalgreen Company
Walgreens Anti ItchWalgreen Company
Walgreens Night Time Wal-flu Severe Cold and Cough Honey Lemon Flavor Infused With Chamomile and White Tea FlavorsWALGREEN CO.
Walgreens Original Strength Anti ItchWalgreen Company
Walgreens Sugar Free Nighttime Wal-flu Severe Cold and Cough Natural Honey Lemon FlavorWALGREEN CO.
Western Family Itch ReliefWestern Family Food, Inc.
Western Family Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsQuality Home Products
Winco Foods Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea FlavorsWin Co Foods, Llc
Winco Original Strength Anti-itchWin Co Foods, Llc
Salts
Name/CASStructureProperties
Diphenhydramine citrate
ThumbNot applicableDBSALT001461
Diphenhydramine Hydrochloride
147-24-0
Thumb
  • InChI Key: PCHPORCSPXIHLZ-UHFFFAOYSA-N
  • Monoisotopic Mass: 291.138992038
  • Average Mass: 291.816
DBSALT000056
Diphenhydramine Salicylate
Thumb
  • InChI Key: RTSZUSOHOIFYSY-UHFFFAOYSA-N
  • Monoisotopic Mass: 393.194008357
  • Average Mass: 393.4755
DBSALT000057
Categories
UNII8GTS82S83M
CAS number58-73-1
WeightAverage: 255.3547
Monoisotopic: 255.162314299
Chemical FormulaC17H21NO
InChI KeyZZVUWRFHKOJYTH-UHFFFAOYSA-N
InChI
InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
IUPAC Name
[2-(diphenylmethoxy)ethyl]dimethylamine
SMILES
CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1
Pharmacology
IndicationFor the treatment of symptoms associated with Vertigo/Meniere's disease, nausea and vomiting, motion sickness and insect bite.
Structured Indications
PharmacodynamicsDiphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, diphenhydramine competes with free histamine for binding at HA-receptor sites. Diphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of diphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.
Mechanism of actionDiphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
TargetKindPharmacological actionActionsOrganismUniProt ID
Histamine H1 receptorProteinyes
antagonist
HumanP35367 details
Muscarinic acetylcholine receptor M2Proteinunknown
antagonist
HumanP08172 details
Related Articles
AbsorptionQuickly absorbed with maximum activity occurring in approximately one hour.
Volume of distributionNot Available
Protein binding98 to 99%
Metabolism

Hepatic and renal

SubstrateEnzymesProduct
Diphenhydramine
N-DesmethyldiphenhydramineDetails
Diphenhydramine
Diphenhydramine N-glucuronideDetails
N-Desmethyldiphenhydramine
N,N-DidesmethyldiphenhydramineDetails
N,N-Didesmethyldiphenhydramine
Not Available
Diphenylmethoxyacetic acidDetails
Route of eliminationLittle, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.
Half life1-4 hours
ClearanceNot Available
ToxicityLD50=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Diphenhydramine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Diphenhydramine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Diphenhydramine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Diphenhydramine.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Diphenhydramine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with 7-Nitroindazole.Experimental
AbirateroneThe serum concentration of Diphenhydramine can be increased when it is combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Aceprometazine.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Diphenhydramine.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Diphenhydramine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Agomelatine.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Diphenhydramine.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Diphenhydramine.Approved, Illicit
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Diphenhydramine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Diphenhydramine.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Diphenhydramine.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Diphenhydramine.Approved, Withdrawn
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Diphenhydramine.Approved, Withdrawn
AmiodaroneDiphenhydramine may increase the QTc-prolonging activities of Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Amisulpride.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Diphenhydramine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Amobarbital.Approved, Illicit
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Diphenhydramine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Amperozide.Experimental
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Diphenhydramine.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Diphenhydramine.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Diphenhydramine.Approved
AnagrelideDiphenhydramine may increase the QTc-prolonging activities of Anagrelide.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Diphenhydramine.Approved
AprepitantThe metabolism of Diphenhydramine can be increased when combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Diphenhydramine.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Diphenhydramine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Diphenhydramine.Approved, Investigational
ArmodafinilThe metabolism of Diphenhydramine can be decreased when combined with Armodafinil.Approved, Investigational
Arsenic trioxideDiphenhydramine may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherDiphenhydramine may increase the QTc-prolonging activities of Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Articaine.Approved
AsenapineDiphenhydramine may increase the QTc-prolonging activities of Asenapine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Diphenhydramine.Approved, Withdrawn
AtomoxetineThe metabolism of Diphenhydramine can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Azaperone.Vet Approved
AzelastineDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe metabolism of Azelastine can be decreased when combined with Diphenhydramine.Approved
AzithromycinDiphenhydramine may increase the QTc-prolonging activities of Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Barbital.Illicit
BedaquilineDiphenhydramine may increase the QTc-prolonging activities of Bedaquiline.Approved
BenperidolThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Benperidol.Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Diphenhydramine.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Benzocaine.Approved
BenzphetamineBenzphetamine may decrease the sedative activities of Diphenhydramine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Diphenhydramine.Approved
Benzylpenicilloyl PolylysineDiphenhydramine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Diphenhydramine.Approved, Withdrawn
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Diphenhydramine.Approved
BetaxololThe metabolism of Diphenhydramine can be decreased when combined with Betaxolol.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Diphenhydramine.Approved
BortezomibThe metabolism of Diphenhydramine can be decreased when combined with Bortezomib.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Diphenhydramine.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Bromazepam.Approved, Illicit
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Diphenhydramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Brotizolam.Approved, Withdrawn
BufuralolThe metabolism of Bufuralol can be decreased when combined with Diphenhydramine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Diphenhydramine.Approved, Investigational
BuprenorphineDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Diphenhydramine can be decreased when combined with Bupropion.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Diphenhydramine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Diphenhydramine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Diphenhydramine.Approved, Illicit, Vet Approved
CaffeineThe metabolism of Diphenhydramine can be decreased when combined with Caffeine.Approved
CapecitabineThe metabolism of Diphenhydramine can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe metabolism of Captopril can be decreased when combined with Diphenhydramine.Approved
CarbamazepineThe metabolism of Diphenhydramine can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carfentanil.Illicit, Vet Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Diphenhydramine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carisoprodol.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Diphenhydramine.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Diphenhydramine.Approved, Investigational
CelecoxibThe metabolism of Diphenhydramine can be decreased when combined with Celecoxib.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Diphenhydramine.Approved, Vet Approved
CeritinibThe serum concentration of Diphenhydramine can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Cetirizine.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Diphenhydramine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Diphenhydramine can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Diphenhydramine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chloroprocaine.Approved
ChloroquineDiphenhydramine may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Diphenhydramine.Approved
ChlorphentermineChlorphentermine may decrease the sedative activities of Diphenhydramine.Illicit, Withdrawn
ChlorpromazineDiphenhydramine may increase the QTc-prolonging activities of Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Diphenhydramine.Approved
CholecalciferolThe metabolism of Diphenhydramine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CilostazolThe metabolism of Cilostazol can be decreased when combined with Diphenhydramine.Approved
CimetidineThe metabolism of Diphenhydramine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Diphenhydramine can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Diphenhydramine.Approved, Vet Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Diphenhydramine.Approved
CiprofloxacinDiphenhydramine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideDiphenhydramine may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CitalopramDiphenhydramine may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinDiphenhydramine may increase the QTc-prolonging activities of Clarithromycin.Approved
ClemastineThe metabolism of Diphenhydramine can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Diphenhydramine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Clidinium.Approved
ClobazamThe metabolism of Diphenhydramine can be decreased when combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with clomethiazole.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Diphenhydramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Clonazepam.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Diphenhydramine.Approved
ClopidogrelThe metabolism of Diphenhydramine can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Diphenhydramine.Approved, Illicit
ClotrimazoleThe metabolism of Diphenhydramine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineDiphenhydramine may increase the QTc-prolonging activities of Clozapine.Approved
CobicistatThe serum concentration of Diphenhydramine can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Diphenhydramine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Diphenhydramine.Approved, Illicit
CrizotinibDiphenhydramine may increase the QTc-prolonging activities of Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Cyclizine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Diphenhydramine.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Diphenhydramine.Approved, Investigational
CyclosporineThe metabolism of Diphenhydramine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Cyproheptadine.Approved
Cyproterone acetateThe serum concentration of Diphenhydramine can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
DabrafenibThe serum concentration of Diphenhydramine can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dantrolene.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Diphenhydramine.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Diphenhydramine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Diphenhydramine can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Diphenhydramine can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Diphenhydramine.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Diphenhydramine.Approved
DeferasiroxThe serum concentration of Diphenhydramine can be increased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Diphenhydramine can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Desflurane.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Diphenhydramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dexbrompheniramine.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Diphenhydramine.Approved, Illicit, Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Diphenhydramine.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Diphenhydramine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Diphenhydramine.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Diphenhydramine.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Diphenhydramine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Diphenhydramine.Approved, Illicit, Vet Approved
DiethylpropionDiethylpropion may decrease the sedative activities of Diphenhydramine.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Diphenhydramine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dihydromorphine.Experimental, Illicit
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Diphenhydramine.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dimenhydrinate.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Diphenoxylate.Approved, Illicit
DisopyramideDiphenhydramine may increase the QTc-prolonging activities of Disopyramide.Approved
DofetilideDiphenhydramine may increase the QTc-prolonging activities of Dofetilide.Approved
DolasetronDiphenhydramine may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneDiphenhydramine may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Diphenhydramine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Diphenhydramine.Approved
DoramectinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Doramectin.Vet Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Diphenhydramine.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Diphenhydramine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Diphenhydramine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Diphenhydramine.Approved, Investigational
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved, Illicit
DronedaroneDiphenhydramine may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Drotebanol.Experimental, Illicit
DuloxetineThe metabolism of Diphenhydramine can be decreased when combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Diphenhydramine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Efavirenz.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Diphenhydramine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Diphenhydramine.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Diphenhydramine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Diphenhydramine.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Diphenhydramine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Entacapone.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Diphenhydramine.Approved, Investigational
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Diphenhydramine.Approved, Investigational
ErythromycinDiphenhydramine may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramDiphenhydramine may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe metabolism of Diphenhydramine can be decreased when combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Diphenhydramine.Investigational
EsomeprazoleThe metabolism of Diphenhydramine can be decreased when combined with Esomeprazole.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Diphenhydramine.Approved
EthanolDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Diphenhydramine.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Diphenhydramine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Diphenhydramine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etoperidone.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Diphenhydramine.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etorphine.Illicit, Vet Approved
EtravirineThe metabolism of Diphenhydramine can be decreased when combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Diphenhydramine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Diphenhydramine.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fexofenadine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Diphenhydramine.Approved, Investigational
FlecainideDiphenhydramine may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Flibanserin.Approved
FloxuridineThe metabolism of Diphenhydramine can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Diphenhydramine can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fludiazepam.Approved, Illicit
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Diphenhydramine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Flunitrazepam.Approved, Illicit
FluorouracilThe metabolism of Diphenhydramine can be decreased when combined with Fluorouracil.Approved
FluoxetineDiphenhydramine may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolDiphenhydramine may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Diphenhydramine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Diphenhydramine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fluticasone Propionate.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Diphenhydramine.Approved
FluvoxamineThe metabolism of Diphenhydramine can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Diphenhydramine.Approved, Investigational
FosphenytoinThe metabolism of Diphenhydramine can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Diphenhydramine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with gabapentin enacarbil.Approved
Gadobenic acidDiphenhydramine may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Diphenhydramine.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GefitinibThe metabolism of Gefitinib can be decreased when combined with Diphenhydramine.Approved, Investigational
GemfibrozilThe metabolism of Diphenhydramine can be decreased when combined with Gemfibrozil.Approved
GemifloxacinDiphenhydramine may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GepironeThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Glutethimide.Approved, Illicit
GoserelinDiphenhydramine may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronDiphenhydramine may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GuanfacineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Diphenhydramine.Approved, Illicit, Withdrawn
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Diphenhydramine.Approved
HaloperidolDiphenhydramine may increase the QTc-prolonging activities of Haloperidol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Diphenhydramine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Heroin.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Hexobarbital.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Diphenhydramine.Approved, Investigational
HydrocodoneDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Diphenhydramine.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Diphenhydramine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Diphenhydramine.Approved
IbutilideDiphenhydramine may increase the QTc-prolonging activities of Ibutilide.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Diphenhydramine.Approved
IloperidoneDiphenhydramine may increase the QTc-prolonging activities of Iloperidone.Approved
ImatinibThe metabolism of Imatinib can be decreased when combined with Diphenhydramine.Approved
ImipramineThe metabolism of Diphenhydramine can be decreased when combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Diphenhydramine can be decreased when combined with Indinavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Diphenhydramine.Approved
IrbesartanThe metabolism of Diphenhydramine can be decreased when combined with Irbesartan.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Diphenhydramine.Approved, Vet Approved
IsoniazidThe metabolism of Diphenhydramine can be decreased when combined with Isoniazid.Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Diphenhydramine.Approved
KetamineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ketobemidone.Approved
KetoconazoleThe metabolism of Diphenhydramine can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Diphenhydramine.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lamotrigine.Approved, Investigational
LeflunomideThe metabolism of Diphenhydramine can be decreased when combined with Leflunomide.Approved, Investigational
LenvatinibDiphenhydramine may increase the QTc-prolonging activities of Lenvatinib.Approved
LeuprolideDiphenhydramine may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Diphenhydramine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levocetirizine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Diphenhydramine.Approved
LevofloxacinDiphenhydramine may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Diphenhydramine.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Diphenhydramine.Approved
LidocaineThe metabolism of Diphenhydramine can be decreased when combined with Lidocaine.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Diphenhydramine.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Diphenhydramine.Approved
LithiumThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lofentanil.Illicit
LomustineThe metabolism of Lomustine can be decreased when combined with Diphenhydramine.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Diphenhydramine.Approved
LopinavirDiphenhydramine may increase the QTc-prolonging activities of Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Diphenhydramine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Diphenhydramine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Diphenhydramine.Approved
LosartanThe metabolism of Diphenhydramine can be decreased when combined with Losartan.Approved
LovastatinThe metabolism of Diphenhydramine can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Diphenhydramine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lu AA21004.Investigational
LuliconazoleThe serum concentration of Diphenhydramine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Diphenhydramine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineDiphenhydramine may increase the QTc-prolonging activities of Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved, Vet Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Diphenhydramine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Diphenhydramine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Melperone.Approved
MephedroneMephedrone may decrease the sedative activities of Diphenhydramine.Investigational
MephentermineMephentermine may decrease the sedative activities of Diphenhydramine.Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Diphenhydramine.Investigational, Withdrawn
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Diphenhydramine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Diphenhydramine.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Diphenhydramine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Diphenhydramine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Metaxalone.Approved
MethadoneDiphenhydramine may increase the QTc-prolonging activities of Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methadyl Acetate.Approved, Illicit
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Diphenhydramine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Diphenhydramine.Approved
MethotrimeprazineDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Diphenhydramine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methsuximide.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Diphenhydramine.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Diphenhydramine.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Diphenhydramine.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Diphenhydramine.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Diphenhydramine.Approved, Investigational
MetyrosineDiphenhydramine may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Diphenhydramine can be decreased when combined with Mexiletine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Diphenhydramine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Diphenhydramine.Approved, Illicit
MifepristoneThe serum concentration of Diphenhydramine can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Milnacipran.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Diphenhydramine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Diphenhydramine.Approved
MirtazapineDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may decrease the sedative activities of Diphenhydramine.Experimental, Illicit
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Diphenhydramine.Approved
ModafinilThe metabolism of Diphenhydramine can be decreased when combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Molindone.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Diphenhydramine.Approved, Investigational
MoxifloxacinDiphenhydramine may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Diphenhydramine.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Diphenhydramine.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Diphenhydramine.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Diphenhydramine.Approved, Withdrawn
NelfinavirThe metabolism of Diphenhydramine can be decreased when combined with Nelfinavir.Approved
NetupitantThe metabolism of Netupitant can be decreased when combined with Diphenhydramine.Approved
NevirapineThe metabolism of Diphenhydramine can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Diphenhydramine can be decreased when combined with Nicardipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Diphenhydramine.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Diphenhydramine.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Diphenhydramine.Approved
NilotinibDiphenhydramine may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Nitrazepam.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Diphenhydramine.Approved, Vet Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Normethadone.Approved, Illicit
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Diphenhydramine.Approved
OfloxacinDiphenhydramine may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Diphenhydramine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Olopatadine.Approved
OmeprazoleThe metabolism of Diphenhydramine can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronDiphenhydramine may increase the QTc-prolonging activities of Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Opium.Approved, Illicit
OrphenadrineDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Diphenhydramine can be decreased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Diphenhydramine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Diphenhydramine.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Diphenhydramine.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Diphenhydramine.Approved, Investigational, Vet Approved
PaliperidoneDiphenhydramine may increase the QTc-prolonging activities of Paliperidone.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Diphenhydramine.Approved, Investigational
PanobinostatThe serum concentration of Diphenhydramine can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe metabolism of Diphenhydramine can be decreased when combined with Pantoprazole.Approved
ParaldehydeDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe metabolism of Diphenhydramine can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibDiphenhydramine may increase the QTc-prolonging activities of Pazopanib.Approved
Peginterferon alfa-2bThe serum concentration of Diphenhydramine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentamidineDiphenhydramine may increase the QTc-prolonging activities of Pentamidine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Diphenhydramine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Diphenhydramine.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
PerazineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Perazine.Investigational
PerflutrenDiphenhydramine may increase the QTc-prolonging activities of Perflutren.Approved
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Diphenhydramine.Approved
PerospironeThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Perospirone.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Diphenhydramine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Diphenhydramine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Diphenhydramine.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Diphenhydramine.Approved, Withdrawn
PhenobarbitalThe metabolism of Diphenhydramine can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Phenoxyethanol.Approved
PhenterminePhentermine may decrease the sedative activities of Diphenhydramine.Approved, Illicit
PhenytoinThe metabolism of Diphenhydramine can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideDiphenhydramine may increase the QTc-prolonging activities of Pimozide.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Diphenhydramine.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pipamperone.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Diphenhydramine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Diphenhydramine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pomalidomide.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Diphenhydramine.Approved
PramipexoleDiphenhydramine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenhydramine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Diphenhydramine.Approved
PrimaquineDiphenhydramine may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe metabolism of Diphenhydramine can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideDiphenhydramine may increase the QTc-prolonging activities of Procainamide.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Diphenhydramine.Approved, Investigational, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Diphenhydramine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Diphenhydramine.Approved, Vet Approved
PromazineDiphenhydramine may increase the QTc-prolonging activities of Promazine.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Diphenhydramine.Approved
PropafenoneThe serum concentration of Diphenhydramine can be increased when it is combined with Propafenone.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Diphenhydramine.Approved, Vet Approved
PropofolThe metabolism of Propofol can be decreased when combined with Diphenhydramine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Propoxycaine.Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Diphenhydramine.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Diphenhydramine.Approved
PSD502The risk or severity of adverse effects can be increased when Diphenhydramine is combined with PSD502.Investigational
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Diphenhydramine.Approved
PyrimethamineThe metabolism of Diphenhydramine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe serum concentration of Diphenhydramine can be increased when it is combined with Quazepam.Approved, Illicit
QuetiapineDiphenhydramine may increase the QTc-prolonging activities of Quetiapine.Approved
QuinidineDiphenhydramine may increase the QTc-prolonging activities of Quinidine.Approved
QuinineDiphenhydramine may increase the QTc-prolonging activities of Quinine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ramelteon.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Diphenhydramine.Approved
RanolazineThe metabolism of Diphenhydramine can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Diphenhydramine.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Diphenhydramine.Approved, Withdrawn
repinotanThe metabolism of repinotan can be decreased when combined with Diphenhydramine.Investigational
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Diphenhydramine.Approved
RifampicinThe metabolism of Diphenhydramine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Diphenhydramine can be increased when combined with Rifapentine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Diphenhydramine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative activities of Diphenhydramine.Investigational
RitonavirThe metabolism of Diphenhydramine can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe metabolism of Diphenhydramine can be decreased when combined with Rolapitant.Approved
RomifidineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Romifidine.Vet Approved
RopiniroleDiphenhydramine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Diphenhydramine.Approved
RotigotineDiphenhydramine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Diphenhydramine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Sage 547.Investigational
SaquinavirDiphenhydramine may increase the QTc-prolonging activities of Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Diphenhydramine can be increased when combined with Secobarbital.Approved, Vet Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Diphenhydramine.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Diphenhydramine.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Sevoflurane.Approved, Vet Approved
SildenafilThe metabolism of Sildenafil can be decreased when combined with Diphenhydramine.Approved, Investigational
SimeprevirThe metabolism of Diphenhydramine can be decreased when combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Diphenhydramine.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
SorafenibThe metabolism of Diphenhydramine can be decreased when combined with Sorafenib.Approved, Investigational
SotalolDiphenhydramine may increase the QTc-prolonging activities of Sotalol.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Diphenhydramine.Experimental
StiripentolThe metabolism of Diphenhydramine can be decreased when combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Diphenhydramine.Approved, Investigational
SulfadiazineThe metabolism of Diphenhydramine can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Diphenhydramine can be decreased when combined with Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Diphenhydramine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Diphenhydramine.Approved
SuvorexantDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Diphenhydramine resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Diphenhydramine.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tasimelteon.Approved
Technetium Tc-99m tilmanoceptDiphenhydramine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Diphenhydramine.Investigational, Withdrawn
TelavancinDiphenhydramine may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinDiphenhydramine may increase the QTc-prolonging activities of Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Diphenhydramine.Approved
TenofovirThe metabolism of Diphenhydramine can be decreased when combined with Tenofovir.Approved, Investigational
TerbinafineThe metabolism of Diphenhydramine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Diphenhydramine.Withdrawn
TeriflunomideThe serum concentration of Diphenhydramine can be decreased when it is combined with Teriflunomide.Approved
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Diphenhydramine.Investigational
TetrabenazineDiphenhydramine may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tetrodotoxin.Investigational
ThalidomideDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Diphenhydramine can be decreased when combined with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Diphenhydramine.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Diphenhydramine.Approved
ThiotepaThe metabolism of Diphenhydramine can be decreased when combined with Thiotepa.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tiapride.Investigational
TicagrelorThe metabolism of Diphenhydramine can be decreased when combined with Ticagrelor.Approved
TiclopidineThe metabolism of Diphenhydramine can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tiletamine.Vet Approved
TimololThe metabolism of Timolol can be decreased when combined with Diphenhydramine.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Diphenhydramine.Approved
TipranavirThe metabolism of Diphenhydramine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tizanidine.Approved
TolbutamideThe metabolism of Diphenhydramine can be decreased when combined with Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tolcapone.Approved, Withdrawn
TolterodineThe metabolism of Tolterodine can be decreased when combined with Diphenhydramine.Approved, Investigational
TopiramateThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Topiramate.Approved
ToremifeneDiphenhydramine may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Diphenhydramine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Diphenhydramine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe metabolism of Diphenhydramine can be decreased when combined with Tranylcypromine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Diphenhydramine.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Diphenhydramine.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Diphenhydramine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Diphenhydramine.Approved, Vet Approved
TrimethoprimThe metabolism of Diphenhydramine can be decreased when combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Diphenhydramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Uc1010.Investigational
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Diphenhydramine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Diphenhydramine.Approved, Investigational
ValsartanThe metabolism of Diphenhydramine can be decreased when combined with Valsartan.Approved, Investigational
VandetanibDiphenhydramine may increase the QTc-prolonging activities of Vandetanib.Approved
VemurafenibThe serum concentration of Diphenhydramine can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Diphenhydramine can be decreased when combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Vigabatrin.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Diphenhydramine.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Diphenhydramine.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Diphenhydramine.Approved, Investigational
VoriconazoleThe metabolism of Diphenhydramine can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Diphenhydramine.Approved
XylazineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Xylazine.Vet Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Diphenhydramine.Approved, Vet Approved
ZafirlukastThe metabolism of Diphenhydramine can be decreased when combined with Zafirlukast.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Diphenhydramine.Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Diphenhydramine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zimelidine.Withdrawn
ZiprasidoneDiphenhydramine may increase the QTc-prolonging activities of Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zolazepam.Vet Approved
ZolpidemDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zotepine.Approved
ZuclopenthixolDiphenhydramine may increase the QTc-prolonging activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take with food.
References
Synthesis Reference

Alison B. Lukacsko, Joseph J. Piala, “Effect of a combination of a terbutaline, diphenhydramine and ranitidine composition on gastrointestinal injury produced by nonsteroidal anti-inflammatory compositions.” U.S. Patent US5260333, issued December, 1983.

US5260333
General References
  1. Raphael GD, Angello JT, Wu MM, Druce HM: Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2006 Apr;96(4):606-14. [PubMed:16680933 ]
  2. Abdi A, Rose E, Levine M: Diphenhydramine overdose with intraventricular conduction delay treated with hypertonic sodium bicarbonate and i.v. lipid emulsion. West J Emerg Med. 2014 Nov;15(7):855-8. doi: 10.5811/westjem.2014.8.23407. Epub 2014 Sep 19. [PubMed:25493135 ]
External Links
ATC CodesD04AA32R06AA52R06AA02
AHFS Codes
  • 04:04.04
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.5 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9898
Blood Brain Barrier+0.9381
Caco-2 permeable+0.8744
P-glycoprotein substrateSubstrate0.6211
P-glycoprotein inhibitor INon-inhibitor0.6632
P-glycoprotein inhibitor IINon-inhibitor0.8381
Renal organic cation transporterInhibitor0.7752
CYP450 2C9 substrateNon-substrate0.7897
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.6173
CYP450 1A2 substrateInhibitor0.8306
CYP450 2C9 inhibitorNon-inhibitor0.9144
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9039
CYP450 3A4 inhibitorNon-inhibitor0.934
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7293
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.6495
BiodegradationNot ready biodegradable0.9253
Rat acute toxicity2.7846 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.536
hERG inhibition (predictor II)Inhibitor0.6318
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
LiquidOral50 mg/30mL
Capsule; kitOral
CreamTopical20 mg/mL
CreamTopical2 mL/100mL
PowderOral
PowderOral25 mg/1
LiquidOral12.5 mg
Tablet, coatedOral24 mg/1
Tablet, film coatedOral25 mg/1
SolutionOral12.5 mg
GelTopical2 g/100g
CreamTopical2.0 %
SprayTopical
PatchTopical
TabletOral25 mg
Tablet, coatedOral25 mg/1
Tablet, chewableOral12.5 mg
LiquidTopical
LiquidOral6.25 mg
CreamTopical2 %
ElixirOral12.5 mg
GelTopical20 mg/mL
Tablet, chewableOral25 mg
GelTopical2 %
TabletOral25 mg/250mg
StripOral25 mg
LotionTopical
TabletOral19 mg
StripOral19 mg
SuspensionOral
TabletOral12.5 mg/1
LiquidOral
Tablet, chewableOral12.5 mg/1
LiquidOral12.5 mg/5mL
OintmentTopical
KitOral
TabletOral38.0 mg
Capsule, coatedOral25 mg/1
Injection, solutionIntravenous50 mg/mL
Capsule, liquid filledOral20 mg/1
TabletOral50 mg/1
Capsule, gelatin coatedOral25 mg/1
SyrupOral6.25 mg
LiquidIntravenous50 mg
ElixirOral12.5 mg/5mL
ElixirOral25 mg/10mL
InjectionIntramuscular50 mg/mL
InjectionIntramuscular; Intravenous50 mg/mL
Injection, solutionIntramuscular; Intravenous50 mg/mL
SolutionOral25 mg/10mL
SolutionOral50 mg/20mL
TabletOral
Tablet, film coatedOral
Tablet, coatedOral
SolutionOral50 mg/40mL
KitOral
Aerosol, sprayTopical
SolutionOral12.5 mg/5mL
CapsuleOral25 mg/1
TabletOral25 mg/1
Capsule, coatedOral
Capsule, liquid filledOral25 mg/1
SolutionOral50 mg/30mL
Capsule, liquid filledOral
LiquidTopical20.3 g/L
SprayTopical2 g/100mL
AerosolTopical
SolutionTopical
GelTopical2 g/100mL
TabletOral12.5 mg
Tablet, orally disintegratingOral12.5 mg/1
LinimentTopical
LozengeOral25 mg
StripOral
CapsuleOral25 mg
CapsuleOral50 mg/1
Tablet, film coatedOral50 mg/1
Capsule, liquid filledOral50 mg/21
TabletOral50 mg
Capsule, gelatin coatedOral
ElixirOral2.5 mg
LiquidIntramuscular; Intravenous50 mg
SyrupOral12.5 mg/5mL
GelTopical20.5 mg/mL
SolutionOral
PlasterTopical
SolutionIntramuscular; Intravenous50 mg
GelTopical.2 g/10mL
Kit; tabletOral
Capsule, liquid filledOral50 mg/1
SolutionOral50 mg
Tablet, coatedOral50 mg/1
GelTopical
GelTopical20 mg/g
SprayTopical20 mg/mL
Powder, for solutionOral
SyrupOral
Kit
StripOral12.5 mg
CapsuleOral50 mg
Tablet, chewableOral25 mg/1
LiquidOral6.25 mg/mL
CreamTopical
LiquidOral25 mg/10mL
CapsuleOral
Capsule, gelatin coatedOral50 mg/21
Granule, for solutionOral
SprayTopical2.0 %
LiquidOral50 mg
Prices
Unit descriptionCostUnit
DiphenhydrAMINE HCl 100 50 mg capsule Bottle13.99USD bottle
Diphenhydramine 50 mg/ml3.94USD ml
Diphenhydramine 50 mg/ml vial1.69USD ml
DiphenhydrAMINE HCl 50 mg/ml vial1.44USD vial
Dytan 25 mg tablet chewable1.37USD tablet
Benadryl 50 mg/ml vial1.36USD ml
Diphenmax 25 mg tablet1.24USD tablet
Benadryl allergy 25 mg strips0.45USD strip
Unisom sleep aid tablet0.34USD tablet
Sleep-eze 3 tablet0.29USD tablet
Compoz 50 mg tablet0.27USD tablet
Sominex max str 50 mg caplet0.27USD caplet
Benadryl allergy fastmelt tablet0.26USD tablet
Unisom 25 mg sleeptabs0.25USD tablet
Unisom 50 mg sleepgels0.25USD each
Unisom sleepmelts 25 mg tablet0.24USD tablet
Nytol 25 mg tablet0.23USD tablet
Benadryl allergy-sinus caplet0.22USD caplet
Compoz 25 mg gelcap0.2USD capsule
Benadryl allergy 25 mg softgel0.19USD softgel capsule
Benadryl allergy 25 mg ultratab0.19USD tablet
Benadryl allergy-cold kapgels0.19USD each
Benadryl allergy-sinus kapgels0.19USD each
Benadryl-d allergy-sinus ultratab0.19USD tablet
Diphenhydramine hcl powder0.17USD g
Eql allergy 25 mg tablet0.17USD tablet
Nighttime sleep aid 25 mg cplt0.17USD caplet
Banophen anti-itch 2% cream0.16USD g
Benadryl itch relief stick0.16USD ml
Sominex 25 mg tablet0.16USD tablet
Benadryl allergy 25 mg kapgels0.15USD each
Allergy 25 mg tablet0.14USD tablet
Benadryl 25 mg kapseals0.14USD each
Benadryl itch stopping crm0.14USD g
DiphenhydrAMINE HCl 25 mg capsule0.13USD capsule
Diphenhist with zinc cream0.12USD g
Ra allergy 25 mg tablet0.12USD tablet
CVS Pharmacy allergy 25 mg tablet0.11USD tablet
Diphenhydramine 25 mg minitab0.11USD tablet
Simply sleep 25 mg caplet0.11USD caplet
Sleep ii tablet0.11USD tablet
Diphenhydramine 50 mg capsule0.1USD capsule
Benadryl 2% spray0.09USD ml
Diphenhist 50 mg tablet0.09USD tablet
Genahist 25 mg tablet0.09USD tablet
Ra sleep tablet0.09USD tablet
Banophen 25 mg tablet0.08USD tablet
Wal-dryl anti-itch spray0.08USD ml
CVS Pharmacy allergy 25 mg caplet0.07USD caplet
Nighttime sleep aid 25 mg caplet0.07USD caplet
CVS Pharmacy itch relief spray0.06USD ml
Diphen 25 mg capsule0.06USD capsule
Diphenhist 25 mg caplet0.06USD caplet
Benadryl anti-itch 0.45% gel0.05USD g
Diphenhydramine 50 mg caplet0.05USD caplet
Benadryl itch stopping gel0.04USD g
Child benadryl-d aller-sin liquid0.04USD ml
Diphenhydramine 25 mg capsule0.04USD capsule
Vicks 44d cough & head liquid0.03USD ml
Vicks 44e cough & chest liquid0.03USD ml
Banophen allergy liquid0.02USD ml
Diphenhydramine 25 mg tablet0.02USD tablet
Ra anti-tussive dm syrup0.02USD ml
Siladryl 12.5 mg/5 ml liquid0.02USD ml
Silphen cough syrup0.02USD ml
Silphen dm cough syrup0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8263647 No2002-05-302022-05-30Us
US8883849 No2002-01-172022-01-17Us
US9155718 No2002-01-172022-01-17Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point161-162Martin, H., Hafliger, F.,Gatzi, K.and Grob, A.; U.S. Patent 2,397,799; April 2,1946; assigned to J.R. Geigy AG, Switzerland. Rieveschl, G. Jr.; U.S. Patent 2,421,714; June 3,1947; assigned to Parke, Davis & Co. Rieveschl, G. Jr.; U.S. Patent 2,427,878; September 23,1947; assigned to Parke, Davis & Company.
boiling point150-165 °C at 2.00E+00 mm HgPhysProp
water solubility3060 mg/L (at 37 °C)BEILSTEIN
logP3.27HANSCH,C ET AL. (1995)
pKa8.98SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0752 mg/mLALOGPS
logP3.44ALOGPS
logP3.65ChemAxon
logS-3.5ALOGPS
pKa (Strongest Basic)8.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.47 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity79.93 m3·mol-1ChemAxon
Polarizability29.86 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-0006-0090000000-a71e531b49571f09ab25View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-00kk-0980000000-cce91896f34562beeffaView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-001i-1900000000-4c29bd5e0eab94596eaaView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (Unknown) , Positivesplash10-0a4i-9100000000-ab642e8f86de11af896cView in MoNA
MSMass Spectrum (Electron Ionization)splash10-0a4i-9200000000-b9014c8fc8ccbba24163View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Benzylether
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Piao H, Nagai S, Tsurumaki T, Niki T, Higuchi H: Potentiation by neuropeptide Y of histamine H1 receptor-mediated contraction in rat blood vessels. Vascul Pharmacol. 2007 Apr;46(4):260-70. Epub 2006 Oct 27. [PubMed:17169617 ]
  3. Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. [PubMed:16702624 ]
  4. Hasala H, Moilanen E, Janka-Junttila M, Giembycz MA, Kankaanranta H: First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis. Allergy Asthma Proc. 2007 Jan-Feb;28(1):79-86. [PubMed:17390763 ]
  5. Wang Z, Woolverton WL: Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects. Eur J Pharmacol. 2007 Feb 28;557(2-3):159-60. Epub 2006 Dec 1. [PubMed:17196194 ]
  6. Ishikawa T, Takechi K, Rahman A, Ago J, Matsumoto N, Murakami A, Kamei C: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats. Biol Pharm Bull. 2007 Mar;30(3):477-80. [PubMed:17329841 ]
  7. Havas TE, Cole P, Parker L, Oprysk D, Ayiomamitis A: The effects of combined H1 and H2 histamine antagonists on alterations in nasal airflow resistance induced by topical histamine provocation. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):856-60. [PubMed:2878016 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled acetylcholine receptor activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then trigge...
Gene Name:
CHRM2
Uniprot ID:
P08172
Molecular Weight:
51714.605 Da
References
  1. Liu H, Zheng Q, Farley JM: Antimuscarinic actions of antihistamines on the heart. J Biomed Sci. 2006 May;13(3):395-401. [PubMed:16453179 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. [PubMed:9616188 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular Weight:
55710.075 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on December 04, 2016 02:43