Diphenhydramine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (2)Enzymes (7)Transporters (3)

Targets (2)Enzymes (7)Transporters (3)Biointeractions (13)

Identification

Name

Diphenhydramine

Accession Number

DB01075 (APRD00587, DB06975)

Type

Small Molecule

Groups

Approved

Description

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

2-(Benzhydryloxy)-N,N-dimethylethylamine

2-diphenylmethoxy-N,N-demthylethanamine

alpha-(2-Dimethylaminoethoxy)diphenylmethane

beta-Dimethylaminoethanol diphenylmethyl ether

beta-Dimethylaminoethyl benzhydryl ether

Difenhidramina

Diphenhydraminum

N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine

O-benzhydryldimethylaminoethanol

β-dimethylaminoethyl benzhydryl ether

External IDs

Not Available

Product Ingredients

Ingredient	UNII	CAS	InChI Key	Details
Diphenhydramine citrate	4OD433S209	88637-37-0	SPCKHVPPRJWQRZ-UHFFFAOYSA-N	Details
Diphenhydramine hydrochloride	TC2D6JAD40	147-24-0	PCHPORCSPXIHLZ-UHFFFAOYSA-N	Details
Diphenhydramine methylbromide	UJO67AO8YI	31065-89-1	BDQPXVWYFLTETB-UHFFFAOYSA-M	Details
Diphenhydramine salicylate	707L3YC54L	7491-10-3	RTSZUSOHOIFYSY-UHFFFAOYSA-N	Details

Product Images

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Benadryl Inj. 50mg/ml	Liquid	50 mg	Intramuscular; Intravenous	Warner Lambert Canada Inc.	1994-12-31	2000-11-27	Canada
Diphenhydramine HCl Inj USP 50mg/ml	Liquid	50 mg	Intravenous	International Medication Systems, Limited	1974-12-31	1997-08-15	Canada
Diphenhydramine HCl Injection, USP	Solution	50 mg	Intramuscular; Intravenous	Sterimax Inc	1994-12-31	Not applicable	Canada
Diphenhydramine Hydrochloride Injection	Solution	50 mg	Intramuscular; Intravenous	Fresenius Kabi	2012-02-17	Not applicable	Canada
Diphenhydramine Hydrochloride Injection USP	Liquid	50 mg	Intramuscular; Intravenous	Sandoz Canada Incorporated	1983-12-31	Not applicable	Canada
Diphenist 50mg/ml	Liquid	50 mg	Intramuscular; Intravenous	Omega Laboratories Ltd	1997-10-28	Not applicable	Canada
PMS-diphenhydramine Hydrochloride Inj 50mg/ml	Liquid	50 mg	Intramuscular; Intravenous	Pharmascience Inc	1991-12-31	Not applicable	Canada
Scheinpharm Diphenhydramine Inj.50mg/ml	Solution	50 mg	Intramuscular; Intravenous	Schein Pharmaceutical Canada Inc.	1996-09-30	2004-07-26	Canada

Approved Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Diphendydramine Hydrochloride	Capsule	25 mg/1	Oral	Remedy Repack	2010-12-17	2017-06-20	US
Diphenhydramine	Injection, solution	50 mg/mL	Intramuscular; Intravenous	Fresenius Kabi	2002-08-01	Not applicable	US
Diphenhydramine	Injection, solution	50 mg/mL	Intravenous	Remedy Repack	2013-06-13	2017-01-24	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	A S Medication Solutions	1972-11-27	2017-06-20	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	West Ward Pharmaceutical	1972-11-27	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	Remedy Repack	2017-01-06	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Cardinal Health	2011-01-20	Not applicable	US
Diphenhydramine Hydrochloride	Injection, solution	50 mg/mL	Intramuscular; Intravenous	Mylan Institutional	2013-05-09	Not applicable	US
Diphenhydramine Hydrochloride	Injection, solution	50 mg/mL	Intramuscular; Intravenous	Fresenius Kabi	2013-03-26	Not applicable	US
Diphenhydramine Hydrochloride	Elixir	12.5 mg/5mL	Oral	Cardinal Health	1982-02-10	Not applicable	US
Diphenhydramine Hydrochloride	Injection, solution	50 mg/mL	Intramuscular; Intravenous	Hospira, Inc.	1988-11-20	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	Dispensing Solutions, Inc.	1972-11-27	Not applicable	US
Diphenhydramine Hydrochloride	Injection, solution	50 mg/mL	Intramuscular; Intravenous	General Injectables & Vaccines	2010-03-01	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	Cardinal Health	2002-05-28	Not applicable	US
Diphenhydramine Hydrochloride	Injection, solution	50 mg/mL	Intramuscular; Intravenous	Cardinal Health	1988-11-20	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	Rebel Distributors	1972-11-27	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	TYA Pharmaceuticals	1972-11-27	Not applicable	US
Diphenhydramine Hydrochloride	Solution	12.5 mg/5mL	Oral	Pharmaceutical Associates, Inc.	1982-02-10	Not applicable	US
Diphenhydramine Hydrochloride	Injection, solution	50 mg/mL	Intramuscular; Intravenous	General Injectables & Vaccines	2010-07-01	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	Sina Health Inc	1972-11-27	Not applicable	US
Diphenhydramine Hydrochloride	Injection, solution	50 mg/mL	Intramuscular; Intravenous	General Injectables & Vaccines	2017-06-13	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular; Intravenous	Cardinal Health	2011-06-28	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular	Remedy Repack	2013-06-13	2016-12-15	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-05	Not applicable	US
Diphenhydramine Hydrochloride	Solution	12.5 mg/5mL	Oral	Pharmaceutical Associates, Inc.	1982-02-10	Not applicable	US
Diphenhydramine Hydrochloride	Elixir	25 mg/10mL	Oral	Cardinal Health	1982-02-10	Not applicable	US
Diphenhydramine Hydrochloride	Injection	50 mg/mL	Intramuscular	Remedy Repack	2013-06-10	2017-12-08	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Remedy Repack	2013-03-25	2016-04-05	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	State of Florida DOH Central Pharmacy	2009-07-01	Not applicable	US

Approved Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
7 Select Allergy	Tablet	25 mg/1	Oral	7 Eleven	2014-04-22	Not applicable	US
7 Select Allergy Childrens	Solution	12.5 mg/5mL	Oral	7 Eleven	2014-08-05	Not applicable	US
7 Select Night Time Sleep Aid	Liquid	50 mg/30mL	Oral	7 Eleven	2014-04-22	Not applicable	US
Adult Allergy	Solution	50 mg/20mL	Oral	Chain Drug Consortium	2015-05-04	Not applicable	US
Adult Allergy Relief	Solution	50 mg/20mL	Oral	Walmart Stores	2017-05-03	Not applicable	US
After Bite Outdoor	Gel	20 mg/mL	Topical	Tender Corporation	2016-11-01	Not applicable	US
After Bite Plus	Cream	20 mg/mL	Topical	Tender Corporation	2012-07-03	Not applicable	US
After Bite Xtra	Gel	20 mg/mL	Topical	Tender Corporation	2016-11-01	Not applicable	US
After Sting	Gel	20 mg/mL	Topical	Tender Corporation	2016-11-01	Not applicable	US
Afterbite With Antihistimine	Cream	2 mL/100mL	Topical	Tender Corporation	2012-07-03	2016-11-03	US
Alka-seltzer Plus Allergy	Tablet	25 mg/1	Oral	Bayer Health Care Llc, Consumer Care	2011-11-07	Not applicable	US
Aller-aide	Tablet	25 mg	Oral	Teva	1996-05-02	Not applicable	Canada
Aller-aide Elixir	Elixir	12.5 mg	Oral	Teva	1995-12-31	Not applicable	Canada
Aller-aide Plus	Tablet	50 mg	Oral	Teva	1997-02-21	Not applicable	Canada
Aller-aide Plus Capsules 50mg	Capsule	50 mg	Oral	Technilab Pharma Inc.	1996-12-31	1997-08-22	Canada
Aller-G-time	Tablet, film coated	25 mg/1	Oral	Time Cap Laboratories	2012-05-01	Not applicable	US
Allerdryl Cap 25mg	Capsule	25 mg	Oral	Valeant Canada Lp Valeant Canada S.E.C.	1976-12-31	2014-07-30	Canada
Allerdryl Cap 50mg	Capsule	50 mg	Oral	Valeant Canada Lp Valeant Canada S.E.C.	1973-12-31	2014-07-30	Canada
Allergies Relief	Tablet, film coated	25 mg/1	Oral	Medex Merchandising, Llc	2015-10-01	2018-04-02	US
Allergy	Tablet	25 mg/1	Oral	Velocity Pharma	2012-05-12	Not applicable	US
Allergy	Solution	12.5 mg/5mL	Oral	Hyvee	1992-11-11	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Cvs Health	1991-08-14	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Medicine Shoppe International	1990-03-15	Not applicable	US
Allergy	Liquid	12.5 mg/5mL	Oral	Accudial Pharmaceutical, Inc.	2009-10-26	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Cardinal Health (Leader) 49781	2016-01-31	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Western Family Foods	2003-04-09	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Publix Supermarkets, Inc.	1998-05-07	Not applicable	US
Allergy	Liquid	12.5 mg	Oral	Accudial Pharmaceutical, Inc.	2010-01-11	Not applicable	Canada
Allergy	Capsule	25 mg/1	Oral	Cvs Health	1987-12-15	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Mc Kesson	2012-05-17	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Hyvee	2016-03-01	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Mc Kesson	2016-11-25	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Kroger	1990-08-15	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Western Family Foods	2003-02-25	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Mc Kesson	2016-11-25	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Hyvee	1988-12-15	Not applicable	US
Allergy	Tablet, coated	25 mg/1	Oral	Fred's	1990-03-02	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Greenbrier International, Inc.	1990-03-02	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Allegiant Health	2014-12-15	Not applicable	US
Allergy	Liquid	12.5 mg/5mL	Oral	Accudial Pharmaceutical, Inc.	2013-02-01	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Publix Supermarkets, Inc.	1993-08-31	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Mc Kesson	2016-11-25	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Meijer Distribution	1991-01-15	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Meijer Distribution	1991-09-06	Not applicable	US
Allergy	Tablet	25 mg/1	Oral	Kroger	1987-09-15	Not applicable	US
Allergy	Tablet, coated	25 mg/1	Oral	Discount Drug Mart	2016-09-30	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Mc Kesson	2016-11-25	Not applicable	US
Allergy	Liquid	12.5 mg/5mL	Oral	Kroger	1987-07-15	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Topcare (Topco Associates Llc)	2016-07-15	Not applicable	US
Allergy	Solution	12.5 mg/5mL	Oral	H.E.B.	1987-07-15	Not applicable	US
Allergy	Capsule	25 mg/1	Oral	Topcare (Topco Associates Llc)	2013-11-30	Not applicable	US
Allergy Antihistamine	Tablet	25 mg/1	Oral	Cardinal Health (Leader)	2012-10-30	Not applicable	US
Allergy Antihistamine	Tablet	25 mg/1	Oral	P & L Development, LLC	2013-08-27	Not applicable	US
Allergy Antihistamine	Capsule	25 mg/1	Oral	Valu Merchandisers Company (Best Choice)	2010-08-10	Not applicable	US
Allergy Antihistamine	Tablet	25 mg/1	Oral	Valu Merchandisers Company (Best Choice)	2010-08-27	Not applicable	US
Allergy Antihistamine	Capsule	25 mg/1	Oral	Cardinal Health (Leader)	2012-08-30	Not applicable	US
Allergy Antihistamine	Tablet	25 mg/1	Oral	Super Valu (Equaline)	2010-07-22	Not applicable	US
Allergy Antihistamine	Tablet	25 mg/1	Oral	Select Corporation	2012-10-15	Not applicable	US
Allergy Antihistamine	Tablet	25 mg/1	Oral	Super Valu (Equaline)	2010-07-22	Not applicable	US
Allergy Attack Relief To Go	Powder	25 mg/1	Oral	Breakthrough Products Inc.	2012-10-01	Not applicable	US
Allergy Capsules Extra Strength	Capsule	50 mg	Oral	Tanta Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Allergy Childrens	Liquid	12.5 mg/5mL	Oral	We Care Distributors Inc.	2016-06-21	Not applicable	US
Allergy Childrens	Liquid	12.5 mg/5mL	Oral	Cvs Health	1987-07-15	Not applicable	US
Allergy Childrens	Liquid	12.5 mg/5mL	Oral	H.E.B.	2016-02-29	Not applicable	US
Allergy Childrens	Solution	12.5 mg/5mL	Oral	Meijer Distribution	1987-11-15	Not applicable	US
Allergy Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2015-06-30	Not applicable	US
Allergy Complete Relief	Capsule, liquid filled	25 mg/1	Oral	Nash Finch	2001-09-13	Not applicable	US
Allergy Complete Relief	Capsule	25 mg/1	Oral	Nash Finch	1990-03-15	Not applicable	US
Allergy Complete Relief	Tablet	25 mg/1	Oral	Nash Finch	1990-03-02	Not applicable	US
Allergy Dye-free	Solution	12.5 mg	Oral	Accudial Pharmaceutical, Inc.	2012-06-01	Not applicable	Canada
Allergy Elixir	Elixir	12.5 mg	Oral	Tanta Pharmaceuticals Inc	1991-12-31	Not applicable	Canada
Allergy Formula	Tablet	25 mg	Oral	Pharmetics (2011) Inc.	2009-05-08	Not applicable	Canada
Allergy Formula	Tablet	25 mg	Oral	Genvion Corporation	Not applicable	Not applicable	Canada
Allergy Formula	Solution	12.5 mg	Oral	Juno Otc Inc	Not applicable	Not applicable	Canada
Allergy Formula	Tablet	25 mg	Oral	Laboratoires Trianon Inc	2016-09-15	Not applicable	Canada
Allergy Formula	Tablet	25 mg	Oral	Vita Health Products Inc	1997-04-01	Not applicable	Canada
Allergy Formula	Tablet	25 mg	Oral	Pharmascience Inc	Not applicable	Not applicable	Canada
Allergy Formula	Tablet	25 mg	Oral	Teva	2010-07-21	Not applicable	Canada
Allergy Formula Caplets	Tablet	25 mg	Oral	Perrigo International	1997-09-29	Not applicable	Canada
Allergy Formula Elixir	Solution	12.5 mg	Oral	Actavis Pharma Company	2016-10-19	Not applicable	Canada
Allergy Formula Junior Strength	Tablet, chewable	12.5 mg	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Allergy Formula Liquid	Liquid	12.5 mg	Oral	Perrigo International	1997-09-29	Not applicable	Canada
Allergy Formula Liquid Capsules	Capsule	25 mg	Oral	Vita Health Products Inc	2008-07-11	Not applicable	Canada
Allergy Formula Liquid Gels	Capsule	25 mg	Oral	Accucaps Industries Limited	Not applicable	Not applicable	Canada
Allergy Get Relief	Tablet	25 mg/1	Oral	Eagle Distributors,Inc.	2012-06-30	Not applicable	US
Allergy Liquid Gel Capsules	Capsule	25 mg	Oral	Apotex Corporation	Not applicable	Not applicable	Canada
Allergy Medicine	Tablet	25 mg/1	Oral	Costco Wholesale	1990-03-02	Not applicable	US
Allergy Medicine	Tablet, film coated	25 mg/1	Oral	L&R Distributors, Inc.	1990-03-02	Not applicable	US
Allergy Medicine	Capsule	25 mg/1	Oral	L&R Distributors, Inc.	1990-03-15	Not applicable	US
Allergy Rapid Melts Childrens	Tablet, chewable	12.5 mg/1	Oral	Chain Drug Consortium	2011-04-25	Not applicable	US
Allergy Reilef	Capsule	25 mg/1	Oral	Chain Drug Consortium	1990-03-15	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Dolgencorp	1990-03-02	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Meijer	2015-10-31	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Freds, Inc.	2008-09-01	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Lnk International, Inc.	1990-03-02	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	H.E.B.	2016-02-29	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Supervalu	1990-03-02	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Family Dollar (FAMILY WELLNESS)	2016-06-30	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Mc Kesson (Health Mart)	2015-10-31	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Supervalu	1990-03-15	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Target Corporation.	2015-06-30	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Mc Kesson (Health Mart)	1990-03-02	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Health Life Of Usa	2012-05-12	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Army + Air Force Exchange Service	1990-03-02	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Sunmark (Mckesson)	2011-08-26	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Cvs Health	1990-03-02	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Topcare (Topco Associates Llc)	2013-03-31	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Healthy Accents (DZA Brands, LLC)	2013-12-30	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Cvs Health	2016-08-19	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Preferred Plus (Kinray)	2013-11-25	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Foodhold U.S.A.	2016-10-03	Not applicable	US
Allergy Relief	Tablet, chewable	12.5 mg/1	Oral	Amerisource Bergen	2011-04-25	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2017-07-14	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Rite Aid	1990-03-02	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Lnk International, Inc.	1990-03-02	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Family Dollar Services	1990-03-02	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Aldi, Inc	1990-03-15	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Cvs Health	1990-03-15	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Meijer	2014-10-31	Not applicable	US
Allergy Relief	Tablet, coated	25 mg/1	Oral	Cardinal Health	1990-03-02	Not applicable	US
Allergy Relief	Tablet, coated	25 mg/1	Oral	Chain Drug Marketing Association	2014-06-13	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Walmart Stores	1990-03-15	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	International Laboratories, Llc	2016-05-27	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Sunmark (Mckesson)	1990-03-15	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Rite Aid	2001-09-13	Not applicable	US
Allergy Relief	Solution	12.5 mg/5mL	Oral	Bio Pharm, Inc.	2007-12-06	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Better Living Brands	1990-03-02	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Valu Merchandisers Company (Best Choice)	2015-09-30	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Super Valu (Equaline)	2011-08-15	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	We Care Distributor Inc.	2016-01-11	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Sunmark (Mckesson)	2015-09-30	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Chain Drug Marketing Association	2008-11-10	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Rite Aid	1990-03-15	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Mc Kesson (Health Mart)	1990-03-15	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Shopko Stores Operating	2016-10-07	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Meijer Distribution	1990-03-02	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Kareway Product, Inc.	2011-08-18	Not applicable	US
Allergy Relief	Tablet, coated	25 mg/1	Oral	Walmart Stores	1990-03-02	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Army + Air Force Exchange Service	2001-09-13	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Shopko Stores Operating	2013-09-09	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Target Corporation.	1990-03-02	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Army + Air Force Exchange Service	1990-03-15	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	P & L Development, LLC	2015-09-30	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Harmon Store Inc.	1990-03-02	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Cvs Health	2015-07-21	2018-04-30	US
Allergy Relief	Capsule	25 mg/1	Oral	Fred's	2015-12-18	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Hyvee	2015-11-30	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2015-03-31	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Family Dollar Services	1990-03-15	2019-10-25	US
Allergy Relief	Tablet	25 mg/1	Oral	Lidl Us Llc	2017-03-20	Not applicable	US
Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-07-14	Not applicable	US
Allergy Relief	Capsule	25 mg/1	Oral	Lnk International, Inc.	1990-03-15	Not applicable	US
Allergy Relief	Tablet	25 mg/1	Oral	Navarro Discount Pharmacies, LLC	2013-01-01	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Cvs Health	2014-11-21	Not applicable	US
Allergy Relief	Tablet, film coated	25 mg/1	Oral	Spirit Pharmaceuticals, Llc	2016-08-18	Not applicable	US
Allergy Relief	Tablet, coated	24 mg/1	Oral	Sunmark (Mckesson)	1990-03-02	2017-05-02	US
Allergy Relief	Capsule	25 mg/1	Oral	Better Living Brands	1990-03-15	Not applicable	US
Allergy Relief Antihistamine	Capsule, liquid filled	25 mg/1	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2013-05-30	Not applicable	US
Allergy Relief Antihistamine	Tablet	25 mg/1	Oral	Sunmark (Mckesson)	2011-09-28	Not applicable	US
Allergy Relief Antihistamine	Tablet	25 mg/1	Oral	Pld Acquisitions Llc Dba Avéma Pharma Solutions	2010-01-02	Not applicable	US
Allergy Relief Antihistamine	Capsule, liquid filled	25 mg/1	Oral	Fred's	2013-04-08	Not applicable	US
Allergy Relief Antihistamine	Capsule, liquid filled	25 mg/1	Oral	P And L Development Of New York Corporation (Ready In Case)	2013-02-07	Not applicable	US
Allergy Relief Antihistamine	Tablet	25 mg/1	Oral	Fred's	2010-07-22	Not applicable	US
Allergy Relief Antihistamine	Tablet	25 mg/1	Oral	SIMPLY RIGHT (Sam's West, Inc.)	2011-10-30	Not applicable	US
Allergy Relief Antihistamine	Capsule, liquid filled	25 mg/1	Oral	Good Sense (Geiss, Destin & Dunn, Inc.)	2013-06-06	Not applicable	US
Allergy Relief Antihistamine	Tablet	25 mg/1	Oral	Preferred Plus (Kinray)	2010-10-26	Not applicable	US
Allergy Relief Antihistamine	Capsule, liquid filled	25 mg/1	Oral	SMART SENSE (Kmart)	2013-04-01	Not applicable	US
Allergy Relief Antihistamine	Capsule, liquid filled	25 mg/1	Oral	Topcare (Topco Associates Llc)	2013-05-30	Not applicable	US
Allergy Relief Antihistamine	Tablet	25 mg/1	Oral	Cardinal Health (Leader) 49781	2011-09-28	Not applicable	US
Allergy Relief Childrens	Liquid	12.5 mg/5mL	Oral	ASSURED / DOLLAR TREE (Greenbrier International, Inc.)	2016-06-30	Not applicable	US
Allergy Relief Childrens	Tablet, chewable	12.5 mg/1	Oral	Meijer Distribution	2011-04-25	Not applicable	US
Allergy Relief Childrens	Tablet, chewable	12.5 mg/1	Oral	Supervalu	2009-03-20	Not applicable	US
Allergy Relief Childrens	Solution	12.5 mg/5mL	Oral	Cvs Health	2015-09-03	Not applicable	US
Allergy Relief Complete	Capsule	25 mg/1	Oral	Win Co Foods, Llc,	1990-03-15	Not applicable	US
Allergy Relief Complete	Tablet	25 mg/1	Oral	Win Co Foods, Llc,	1990-03-02	Not applicable	US
Allergy Relief Dye Free	Capsule, liquid filled	25 mg/1	Oral	Good Sense (Geiss, Destin & Dunn, Inc.)	2016-03-31	Not applicable	US
Allergy Relief Dye Free	Capsule, liquid filled	25 mg/1	Oral	Topcare (Topco Associates Llc)	2016-02-29	Not applicable	US
Allergy Relief Dye Free	Capsule, liquid filled	25 mg/1	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2015-10-31	Not applicable	US
Allergy Relief Dye Free	Capsule, liquid filled	25 mg/1	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2017-05-31	Not applicable	US
Allergy Relief Dye Free	Capsule, liquid filled	25 mg/1	Oral	Kroger	2016-12-31	Not applicable	US
Allergy Relief Dye Free	Capsule, liquid filled	25 mg/1	Oral	SMART SENSE (Kmart)	2016-07-31	Not applicable	US
Allergy Relief Dye Free	Capsule, liquid filled	25 mg/1	Oral	Western Family Foods	2015-09-30	Not applicable	US
Allergy Relief Dye-free	Capsule, liquid filled	25 mg/1	Oral	Chain Drug Marketing Association	2015-03-01	Not applicable	US
Allergy Relief Dye-free	Tablet	25 mg/1	Oral	Cvs Health	2013-02-07	Not applicable	US
Allergy Relief Dye-free	Capsule, liquid filled	25 mg/1	Oral	Walmart Stores	2015-03-01	Not applicable	US
Allergy Relief Dye-free	Capsule, liquid filled	25 mg/1	Oral	Amerisource Bergen	2015-03-01	Not applicable	US
Allergy Relief Dye-free	Capsule, liquid filled	25 mg/1	Oral	Cvs Health	2015-03-01	Not applicable	US
Allergy Relief Dye-free	Capsule, liquid filled	25 mg/1	Oral	Cardinal Health	2015-03-01	Not applicable	US
Allergy Relief Dye-free	Capsule, liquid filled	25 mg/1	Oral	Harmon Store Inc.	2015-03-01	Not applicable	US
Allergy Relief Dye-free Liquid Gels	Capsule, liquid filled	25 mg/1	Oral	Army + Air Force Exchange Service	2015-03-01	Not applicable	US
Allergy Relief Elixir	Elixir	12.5 mg	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Allergy Relief Extra Strength Nighttime	Tablet	50 mg/1	Oral	P & L Development, LLC	2015-09-30	Not applicable	US
Allergy Relief Extra Strength Nighttime	Tablet	50 mg/1	Oral	Hyvee	2014-11-30	Not applicable	US
Allergy Relief Nighttime	Tablet	25 mg/1	Oral	Meijer	2015-01-20	Not applicable	US
Allergy Relief Nighttime	Tablet, film coated	25 mg/1	Oral	Walgreen	2015-01-20	Not applicable	US
Allergy Softgel	Capsule, liquid filled	25 mg/1	Oral	Allegiant Health	2014-12-15	Not applicable	US
Allergy Softgel	Capsule, liquid filled	25 mg/1	Oral	Ai Ping Pharmaceutical, Inc.	2015-01-31	Not applicable	US
Allergy Tablets 25mg	Tablet	25 mg	Oral	Tanta Pharmaceuticals Inc	1992-12-31	Not applicable	Canada
Allergy Tablets Extra Strength	Tablet	50 mg	Oral	Tanta Pharmaceuticals Inc	1997-04-21	Not applicable	Canada
Allernix	Tablet	25 mg	Oral	Teva	1995-12-31	Not applicable	Canada
Allernix Cap 50mg U	Capsule	50 mg	Oral	Technilab Pharma Inc.	1991-12-31	1997-08-22	Canada
Allernix Elixir	Solution	12.5 mg	Oral	Teva	1991-12-31	Not applicable	Canada
Allernix Extra Strength	Tablet	50 mg	Oral	Teva	1995-12-31	Not applicable	Canada
Allernix HCl Cap 25mg U	Capsule	25 mg	Oral	Technilab Pharma Inc.	1991-12-31	1997-08-22	Canada
Anti-itch	Gel	2 g/100g	Topical	Navarro Discount Pharmacies, LLC	2013-01-18	Not applicable	US
Anti-itch Cream	Cream	2 %	Topical	Taro Pharmaceuticals, Inc.	2007-12-20	Not applicable	Canada
Anti-itch Diphenhydramine Hydrochloride Cream	Cream	2.0 %	Topical	Crls	Not applicable	Not applicable	Canada
Antihistamine Allergy	Capsule	25 mg/1	Oral	H.E.B.	2011-03-23	Not applicable	US
Antihistamine Allergy	Tablet, coated	25 mg/1	Oral	H.E.B.	1990-03-02	Not applicable	US
Antihistamine Allergy	Capsule	25 mg/1	Oral	H.E.B.	1989-07-15	Not applicable	US
Antihistamine Allergy	Tablet	25 mg/1	Oral	H.E.B.	2011-12-01	Not applicable	US
Antihistamine Allergy	Tablet	25 mg/1	Oral	H.E.B.	1989-08-15	Not applicable	US
Antihistimine Allergy	Tablet, coated	25 mg/1	Oral	Avema Pharma Solutions	2012-04-30	2017-04-14	US
Aphenap	Tablet	25 mg/1	Oral	A P J Laboratories Limited	2013-03-01	Not applicable	US
Assured Allergy Relief	Tablet, film coated	25 mg/1	Oral	Spirit Pharmaceuticals, Llc	2016-07-01	Not applicable	US
Aurodryl Childrens Allergy	Solution	12.5 mg/5mL	Oral	Aurohealth LLC	2014-09-10	Not applicable	US
Aurodryl Childrens Allergy	Solution	12.5 mg/5mL	Oral	Aurohealth LLC	2015-05-13	Not applicable	US
Aurozzil Nighttime Sleep-aid	Solution	50 mg/30mL	Oral	Aurohealth LLC	2015-05-15	Not applicable	US
Bactimicina Childrens Allergy	Liquid	12.5 mg/5mL	Oral	DLC Laboratories, Inc.	2015-06-17	Not applicable	US
Banophen	Liquid	12.5 mg/5mL	Oral	Atlantic Biologicals Corp.	2017-03-10	Not applicable	US
Banophen	Capsule	25 mg/1	Oral	Major	1990-03-15	Not applicable	US
Banophen	Tablet	25 mg/1	Oral	Cardinal Health	1990-03-02	Not applicable	US
Banophen	Tablet	25 mg/1	Oral	Carilion Materials Management	1990-03-02	Not applicable	US
Banophen	Capsule	50 mg/1	Oral	Major	2009-11-02	Not applicable	US
Banophen	Tablet	25 mg/1	Oral	Remedy Repack	2017-03-06	Not applicable	US
Banophen	Liquid	12.5 mg/5mL	Oral	Proficient Rx LP	2006-11-20	Not applicable	US
Banophen	Liquid	12.5 mg/5mL	Oral	Major	2006-11-20	Not applicable	US
Banophen	Liquid	12.5 mg/5mL	Oral	Major	2012-08-24	Not applicable	US
Banophen	Capsule	50 mg/1	Oral	Unit Dose Services	2009-01-02	Not applicable	US
Banophen	Capsule	50 mg/1	Oral	Remedy Repack	2015-12-23	2017-04-26	US
Banophen	Tablet	25 mg/1	Oral	Major	1990-03-02	Not applicable	US
Benadryl	Tablet, film coated	25 mg/1	Oral	Remedy Repack	2016-08-31	Not applicable	US
Benadryl	Kit			Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2017-06-12	Not applicable	US
Benadryl	Tablet, film coated	25 mg/1	Oral	Mechanical Servants, Llc	2008-09-01	Not applicable	US
Benadryl	Tablet, film coated	25 mg/1	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2008-09-01	Not applicable	US
Benadryl	Tablet, film coated	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2010-09-16	Not applicable	US
Benadryl 25mg Caplets	Tablet	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1993-12-31	Not applicable	Canada
Benadryl Allergy	Solution	12.5 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benadryl Allergy	Tablet, coated	25 mg/1	Oral	Rebel Distributors	2009-01-01	Not applicable	US
Benadryl Allergy Liqui-gels	Capsule, liquid filled	25 mg/1	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2009-03-01	Not applicable	US
Benadryl Allergy Liquigels	Capsule	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2008-05-05	Not applicable	Canada
Benadryl Allergy Quick Dissolve Strips	Strip	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benadryl Allergy Tablets	Tablet, chewable	12.5 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1998-03-06	Not applicable	Canada
Benadryl Capsules 50mg	Capsule	50 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1994-12-31	2016-01-22	Canada
Benadryl Childrens Liquid 6.25mg/5ml	Liquid	6.25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1991-12-31	Not applicable	Canada
Benadryl Cream 2%	Cream	2 %	Topical	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1993-12-31	Not applicable	Canada
Benadryl Elixir	Elixir	12.5 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1994-12-31	Not applicable	Canada
Benadryl Extra Strength Caplets	Tablet	50 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1999-04-06	Not applicable	Canada
Benadryl Extra Strength Itch Stopping	Gel	20 mg/mL	Topical	Johnson & Johnson	2013-10-01	Not applicable	US
Benadryl Extra Strength Itch Stopping	Gel	20 mg/mL	Topical	Johnson & Johnson	2013-02-13	2019-09-01	US
Benadryl Fast Melts	Tablet, chewable	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benadryl Itch Stopping Gel	Gel	2 %	Topical	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benadryl Ultratabs	Tablet	25 mg/1	Oral	Navajo Manuracturing Company	2016-09-22	Not applicable	US
Benaldryl	Tablet	25 mg/250mg	Oral	Ajes Pharmaceuticals,LLC	2012-09-01	Not applicable	US
Benylin Cough and Cold Night Strips	Strip	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Benylin Night Cough	Capsule	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2007-10-01	2009-08-06	Canada
Benylin Night for Children	Liquid	6.25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2013-01-28	Not applicable	Canada
Benylin Sleep Time	Liquid	12.5 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2012-08-31	Not applicable	Canada
Berkley and Jensen Allergy	Tablet	25 mg/1	Oral	BJWC	2008-10-31	Not applicable	US
Berkley and Jensen Allergy Relief	Tablet	25 mg/1	Oral	BJWC	2013-12-10	Not applicable	US
Calmex Tab 25mg	Tablet	25 mg	Oral	Novopharm Limited	1981-12-31	2015-10-26	Canada
Careall Diphenhydramine	Tablet, coated	25 mg/1	Oral	New World Imports	2016-04-28	Not applicable	US
Careone Allergy	Capsule	25 mg/1	Oral	American Sales Company	2004-07-27	Not applicable	US
Careone Allergy Medication	Tablet	25 mg/1	Oral	American Sales Company	2004-05-24	Not applicable	US
Careone Allergy Relief	Capsule	25 mg/1	Oral	American Sales Company	2016-10-28	Not applicable	US
Careone Childrens Allergy	Solution	12.5 mg/5mL	Oral	American Sales Company	2015-10-28	Not applicable	US
Careone Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	American Sales Company	2016-04-12	Not applicable	US
Careone Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	American Sales Company	2014-01-28	Not applicable	US
Careone Nighttime Sleep Aid	Tablet	25 mg/1	Oral	American Sales Company	2004-04-13	Not applicable	US
Children's Allergy Formula	Liquid	6.25 mg	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	2000-05-02	2002-07-31	Canada
Children's Allergy Formula	Syrup	6.25 mg	Oral	Pharmascience Inc	2004-11-01	Not applicable	Canada
Children's Allergy Relief Liquid	Liquid	6.25 mg	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Children's Benadryl Allergy Fastmelt	Tablet	19 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Children's Benadryl Allergy Strips	Strip	12.5 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Children's Cough, Cold & Allergy Strips	Strip	19 mg	Oral	Vita Health Products Inc	2007-09-07	2011-07-20	Canada
Children's Liquid Allergy Formula	Liquid	6.25 mg	Oral	Jamp Pharma Corporation	2004-06-25	Not applicable	Canada
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Rite Aid	2009-09-04	Not applicable	US
Childrens Allergy	Solution	12.5 mg/5mL	Oral	Dolgencorp	2017-03-18	Not applicable	US
Childrens Allergy	Solution	12.5 mg/5mL	Oral	Amerisource Bergen	2016-05-20	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	De Moulas Market Basket	2012-09-11	Not applicable	US
Childrens Allergy	Tablet, chewable	12.5 mg/1	Oral	L&R Distributors, Inc.	2009-03-20	2017-05-16	US
Childrens Allergy	Solution	12.5 mg/5mL	Oral	Publix Supermarkets, Inc.	2014-02-11	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Rite Aid	2009-07-30	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Aafes/Your Military Exchanges	2015-09-30	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Select Brand Dist.	2015-12-31	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	P & L Development, LLC	2009-07-29	Not applicable	US
Childrens Allergy	Syrup	12.5 mg/5mL	Oral	Target Corporation.	2016-07-31	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Discount Drug Mart	2015-01-12	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2014-06-30	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Family Dollar (FAMILY WELLNESS)	2015-02-28	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Nash Finch	2000-01-01	2017-06-20	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Dollar General	2000-01-01	2017-05-26	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	H.E.B.	2010-03-02	2017-06-29	US
Childrens Allergy	Solution	12.5 mg/5mL	Oral	Chain Drug Consortium	2015-05-04	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Fred's	2015-04-30	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Harris Teeter	2010-01-19	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Safeway	2009-02-03	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Family Dollar	2009-06-30	2017-06-29	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Valu Merchandisers Company (Best Choice)	2015-03-31	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Chain Drug Consortium	2012-09-24	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	American Sales Company	2009-08-29	2017-05-04	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Chain Drug Consortium	2012-09-11	Not applicable	US
Childrens Allergy	Solution	12.5 mg/5mL	Oral	Cdma	2014-09-10	Not applicable	US
Childrens Allergy	Tablet	12.5 mg/1	Oral	Capricorn Pharma Inc.	2010-09-29	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	P & L Development, LLC	2015-03-31	Not applicable	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Best Choice	2009-04-28	2017-04-14	US
Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2014-05-30	Not applicable	US
Childrens Allergy Melts	Tablet, chewable	12.5 mg/1	Oral	Target Corporation.	2009-03-20	Not applicable	US
Childrens Allergy Melts	Tablet, chewable	12.5 mg/1	Oral	Target Corporation.	2011-04-25	Not applicable	US
Childrens Allergy Relief	Liquid	12.5 mg/5mL	Oral	Marc Glassman, Inc.	2014-12-02	Not applicable	US
Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	Kroger	2014-02-04	Not applicable	US
Childrens Allergy Relief	Tablet, chewable	12.5 mg/1	Oral	Walmart Stores	2011-04-25	Not applicable	US
Childrens Allergy Relief	Tablet, chewable	12.5 mg/1	Oral	Cvs Health	2009-03-20	Not applicable	US
Childrens Allergy Relief	Tablet, chewable	12.5 mg/1	Oral	Rite Aid	2011-04-25	Not applicable	US
Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	Lidl Us Llc	2017-05-18	Not applicable	US
Childrens Allergy Relief	Liquid	12.5 mg/5mL	Oral	Rite Aid	2013-11-18	Not applicable	US
Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	Shopko Stores Operating	2013-09-12	Not applicable	US
Childrens Allergy Relief	Liquid	12.5 mg/5mL	Oral	Apta Pharma Inc.	2013-08-21	Not applicable	US
Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	Cardinal Health	2017-05-02	Not applicable	US
Childrens Allergy Relief	Liquid	12.5 mg/5mL	Oral	Mc Kesson	2013-08-08	Not applicable	US
Childrens Allergy Relief Dye Free	Tablet, chewable	12.5 mg/1	Oral	Cvs Health	2015-03-01	Not applicable	US
Childrens Allergy Relief Dye Free Cherry	Liquid	12.5 mg/5mL	Oral	Win Co Foods, Llc,	2014-12-12	Not applicable	US
Childrens Benadryl Allergy	Solution	12.5 mg/5mL	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2008-07-01	Not applicable	US
Childrens Benadryl Chewables	Tablet, chewable	12.5 mg/1	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2016-07-11	Not applicable	US
Childrens Benadryl Dye-free Allergy	Solution	12.5 mg/5mL	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2008-07-01	Not applicable	US
Childrens Complete Allergy	Solution	12.5 mg/5mL	Oral	Western Family Foods	1993-09-08	Not applicable	US
Childrens Dye Free Allergy	Liquid	12.5 mg/5mL	Oral	P & L Development, LLC	2015-02-28	Not applicable	US
Childrens Dye Free Allergy Relief	Solution	12.5 mg/5mL	Oral	Cardinal Health	2017-05-02	Not applicable	US
Childrens Wal-dryl Allergy	Tablet, chewable	12.5 mg/1	Oral	Walgreen	2009-03-20	Not applicable	US
Childrens Wal-dryl Allergy	Tablet, chewable	12.5 mg/1	Oral	Walgreen	2011-04-25	Not applicable	US
Childrens Wal-dryl Single-use Allergy	Liquid	12.5 mg/5mL	Oral	Walgreen	2011-08-25	Not applicable	US
Circle K Allergy Antihistamine	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2014-11-01	Not applicable	US
Circle K Allergy Antihistamine	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2014-11-01	Not applicable	US
Circle K Allergy Antihistamine	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2014-11-01	Not applicable	US
Clear Allergy Formula for Children and Adults	Liquid	6.25 mg	Oral	Perrigo International	1997-09-29	2001-03-09	Canada
Clear Time	Tablet, film coated	25 mg/1	Oral	Hyvee	2015-02-16	Not applicable	US
Cleartime	Tablet, film coated	25 mg/1	Oral	Western Family Foods	2015-03-04	Not applicable	US
Complete Allergy	Capsule, liquid filled	25 mg/1	Oral	Western Family Foods	2013-12-30	Not applicable	US
Complete Allergy	Tablet, film coated	25 mg/1	Oral	Chain Drug Consortium	1990-03-02	Not applicable	US
Complete Allergy	Tablet	25 mg/1	Oral	Great Lakes Wholesale, Marketing, and Sales, Inc.	1990-03-02	Not applicable	US
Complete Allergy Antihistamine	Tablet	25 mg/1	Oral	Chain Drug Consortium	2010-07-13	Not applicable	US
Complete Allergy Medicine	Capsule	25 mg/1	Oral	Salado Sales, Inc.	1990-03-15	Not applicable	US
Complete Allergy Medicine	Tablet	25 mg/1	Oral	Save A Lot Food Stores, Ltd.	1990-03-02	Not applicable	US
Complete Allergy Medicine	Capsule	25 mg/1	Oral	Chain Drug Consortium	2011-03-23	Not applicable	US
Complete Allergy Medicine	Capsule	25 mg/1	Oral	Chain Drug Consortium	2011-03-23	Not applicable	US
Complete Allergy Relief	Tablet, coated	25 mg/1	Oral	New World Imports	2010-11-11	Not applicable	US
Complete Allergy Softgel	Capsule, liquid filled	25 mg/1	Oral	Chain Drug Consortium	2014-12-29	Not applicable	US
Compoz Maximum Strength Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Medtech Laboratories, Inc.	2016-01-15	Not applicable	US
Conrx Allergy	Tablet	25 mg/1	Oral	Eagle Distributors,Inc.	2013-02-15	Not applicable	US
Correct Dose Childrens Allergy Relief	Liquid	12.5 mg/5mL	Oral	Bfs Pharma, Inc.	2011-06-15	Not applicable	US
Cvs Health Childrens Allergy Relief	Liquid	12.5 mg/5mL	Oral	Cvs Health	2015-09-07	Not applicable	US
Cvs Health Nighttime Sleep-aid	Liquid	50 mg/30mL	Oral	Cvs Health	2015-02-11	Not applicable	US
Cvs Maximum Strength Itch Relief	Gel	20.5 mg/mL	Topical	Cvs Health	2011-08-10	Not applicable	US
Cvs Pharmacy Pre-measured Spoon Childrens Allergy Medication	Liquid	12.5 mg/5mL	Oral	Cvs Health	2011-08-25	Not applicable	US
Dalay Maximum Strength	Tablet	25 mg/1	Oral	Genomma Labs	2015-04-21	Not applicable	US
Dg Health Allergy	Tablet	25 mg/1	Oral	Dolgencorp	2010-01-30	Not applicable	US
Dg Health Allergy	Capsule	25 mg/1	Oral	Dolgencorp	2010-02-22	Not applicable	US
Dg Health Allergy Childrens	Solution	12.5 mg/5mL	Oral	Dolgencorp	2010-01-29	Not applicable	US
Dg Health Maximum Strength Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2012-11-29	Not applicable	US
Dg Health Sleep Aid	Tablet	25 mg/1	Oral	Dolgencorp	2009-12-04	Not applicable	US
Dg Health Sleep Aid	Solution	50 mg/30mL	Oral	Dolgencorp	2015-05-11	Not applicable	US
Dg Health Sleep Aid	Tablet	25 mg/1	Oral	Dolgencorp	2010-01-24	Not applicable	US
Dimetane Allergy Tablets	Tablet	38.0 mg	Oral	Pfizer Laboratories Div Pfizer Inc.	2009-01-20	Not applicable	Canada
Diphendydramine Hydrochloride	Capsule	50 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2009-01-02	Not applicable	US
Diphendydramine Hydrochloride	Capsule	25 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-05	Not applicable	US
Diphendydramine Hydrochloride	Capsule	50 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-05	Not applicable	US
Diphenhist	Tablet	25 mg/1	Oral	Rugby	2006-09-26	Not applicable	US
Diphenhist	Capsule	25 mg/1	Oral	Rugby	2014-03-17	Not applicable	US
Diphenhist	Capsule	25 mg/1	Oral	Rugby	2006-05-30	Not applicable	US
Diphenhist	Liquid	12.5 mg/5mL	Oral	Rebel Distributors	2009-09-26	Not applicable	US
Diphenhist	Liquid	12.5 mg/5mL	Oral	Rugby	2009-09-26	Not applicable	US
Diphenhydramine	Capsule	25 mg/1	Oral	Purine Pharma Llc	2014-07-31	Not applicable	US
Diphenhydramine	Capsule	25 mg/1	Oral	Rebel Distributors	2007-01-01	Not applicable	US
Diphenhydramine	Capsule	25 mg/1	Oral	Rebel Distributors	2007-01-01	Not applicable	US
Diphenhydramine	Capsule	25 mg/1	Oral	AAA Pharmaceutical, Inc.	2012-12-22	Not applicable	US
Diphenhydramine	Capsule	50 mg/1	Oral	Purine Pharma Llc	2014-07-31	Not applicable	US
Diphenhydramine	Capsule, coated	25 mg/1	Oral	Sam's West, Inc	1990-03-02	Not applicable	US
Diphenhydramine	Tablet, coated	25 mg/1	Oral	AAA Pharmaceutical, Inc.	2012-12-22	Not applicable	US
Diphenhydramine	Tablet, coated	25 mg/1	Oral	Sam's West, Inc	1990-03-02	Not applicable	US
Diphenhydramine	Tablet	25 mg	Oral	Ranbaxy Inc.	Not applicable	Not applicable	Canada
Diphenhydramine	Capsule	50 mg/1	Oral	H.J. Harkins Company	2011-08-17	Not applicable	US
Diphenhydramine	Tablet, coated	25 mg/1	Oral	New World Imports	2010-09-09	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Blenheim Pharmacal, Inc.	2010-05-12	Not applicable	US
Diphenhydramine HCl	Capsule	50 mg/1	Oral	Cardinal Health	2009-01-02	Not applicable	US
Diphenhydramine HCl	Capsule, liquid filled	25 mg/1	Oral	Agile Pharmachem	2013-10-15	Not applicable	US
Diphenhydramine HCl	Capsule	50 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2010-01-27	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2013-03-27	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2010-01-27	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Sda Laboratories	2010-01-27	Not applicable	US
Diphenhydramine HCl	Tablet	25 mg/1	Oral	Contract Pharmacal Corporation	2004-01-01	Not applicable	US
Diphenhydramine HCl	Tablet	50 mg/1	Oral	Rugby	2007-07-13	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Cardinal Health	2011-06-03	Not applicable	US
Diphenhydramine HCl	Capsule	50 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2010-01-27	Not applicable	US
Diphenhydramine HCl	Capsule, liquid filled	20 mg/1	Oral	Ai Ping Pharmaceutical, Inc.	2015-01-31	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2010-01-27	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Physicians Total Care, Inc.	2010-01-27	Not applicable	US
Diphenhydramine HCl	Capsule	50 mg/1	Oral	Sda Laboratories	2010-01-27	Not applicable	US
Diphenhydramine HCl	Capsule	50 mg/1	Oral	Remedy Repack	2017-05-11	Not applicable	US
Diphenhydramine HCl	Capsule	50 mg/1	Oral	Proficient Rx LP	2010-01-27	Not applicable	US
Diphenhydramine HCl	Tablet	50 mg/1	Oral	Contract Pharmacal Corporation	2004-01-01	Not applicable	US
Diphenhydramine HCl	Capsule, liquid filled	25 mg/1	Oral	Softech Pharma Pvt. Ltd.	2013-01-01	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Remedy Repack	2017-03-02	Not applicable	US
Diphenhydramine HCl 25 mg	Capsule	25 mg/1	Oral	Reliable 1 Laboratories	2015-11-01	Not applicable	US
Diphenhydramine HCl 25 mg	Tablet	25 mg/1	Oral	Reliable 1 Laboratories	2015-11-01	Not applicable	US
Diphenhydramine HCl 25mg 24ct Blister	Capsule, gelatin coated	25 mg/1	Oral	Accucaps Industries Limited	2016-09-21	Not applicable	US
Diphenhydramine HCl Allergy Antihistamine	Tablet	25 mg/1	Oral	Medline Industries	2013-03-30	Not applicable	US
Diphenhydramine HCl Children's Liquid	Syrup	6.25 mg	Oral	Laboratoires Confab Inc	2002-06-19	Not applicable	Canada
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	A S Medication Solutions	2007-05-24	2017-06-20	US
Diphenhydramine Hydrochloride	Solution	50 mg/30mL	Oral	Fred's	2015-01-31	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Red Pharm Drug, Inc.	2000-05-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	A S Medication Solutions	2007-05-24	2017-06-20	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Major	2009-01-02	Not applicable	US
Diphenhydramine Hydrochloride	Capsule, liquid filled	50 mg/1	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2013-04-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Proficient Rx LP	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Richmond Pharmaceuticals	2000-02-15	Not applicable	US
Diphenhydramine Hydrochloride	Tablet, film coated	25 mg/1	Oral	Aurohealth LLC	2016-03-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Advance Pharmaceutical Inc.	1989-10-05	Not applicable	US
Diphenhydramine Hydrochloride	Tablet	25 mg/1	Oral	Simpex Pharma Pvt. Ltd	2012-11-15	Not applicable	US
Diphenhydramine Hydrochloride	Solution	50 mg/20mL	Oral	Ahold U.S.A., Inc.	2015-08-10	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Eon Labs, Inc.	2000-05-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule, liquid filled	25 mg/1	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2014-10-14	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2013-03-19	Not applicable	US
Diphenhydramine Hydrochloride	Solution	50 mg/20mL	Oral	Dolgencorp	2016-02-22	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Remedy Repack	2016-11-07	Not applicable	US
Diphenhydramine Hydrochloride	Capsule, liquid filled	25 mg/1	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2013-04-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2009-01-02	Not applicable	US
Diphenhydramine Hydrochloride	Tablet	25 mg/1	Oral	AAA Pharmaceutical, Inc.	2012-12-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Remedy Repack	2015-03-24	2017-06-09	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Advance Pharmaceutical Inc.	1989-09-12	Not applicable	US
Diphenhydramine Hydrochloride	Tablet, film coated	25 mg/1	Oral	HIMPRIT PHARMACHEM PVT LTD	2010-03-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-30	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	bryant ranch prepack	2000-05-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Remedy Repack	2017-04-19	Not applicable	US
Diphenhydramine Hydrochloride	Solution	50 mg/20mL	Oral	Aurohealth LLC	2014-11-26	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2011-12-05	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Qualitest	2007-05-24	2018-06-30	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Directrx	2015-01-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Epic Pharma, LLC	2016-11-22	Not applicable	US
Diphenhydramine Hydrochloride	Liquid	12.5 mg/5mL	Oral	Physicians Total Care, Inc.	2002-10-22	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Directrx	2014-01-01	Not applicable	US
Diphenhydramine Hydrochloride	Tablet	25 mg/1	Oral	Advance Pharmaceutical Inc.	2006-09-26	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	A S Medication Solutions	2007-05-24	2017-06-20	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	A S Medication Solutions	2007-05-24	2017-06-20	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Clinical Solutions Wholsesale	2007-05-24	2017-07-03	US
Diphenhydramine Hydrochloride	Tablet, coated	25 mg/1	Oral	Avema Pharma Solutions	2010-01-02	2017-04-14	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Major	2009-01-02	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Unit Dose Services	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Central Texas Community Health Centers	1990-03-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule, liquid filled	25 mg/1	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2013-09-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Richmond Pharmaceuticals	2000-02-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	bryant ranch prepack	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Remedy Repack	2016-12-13	Not applicable	US
Diphenhydramine Hydrochloride	Tablet, coated	25 mg/1	Oral	Bonita Pharmaceuticals LLC	2013-05-21	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Remedy Repack	2012-06-07	2017-01-13	US
Diphenhydramine Hydrochloride	Solution	50 mg/20mL	Oral	Cvs Health	2015-11-02	Not applicable	US
Diphenhydramine Hydrochloride	Tablet, film coated	25 mg/1	Oral	HIMPRIT PHARMACHEM PVT LTD	2010-03-01	Not applicable	US
Diphenhydramine Hydrochloride	Solution	50 mg/20mL	Oral	Aurohealth LLC	2015-08-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	A S Medication Solutions	2009-01-02	2017-06-20	US
Diphenhydramine Hydrochloride	Solution	50 mg/20mL	Oral	Amerisource Bergen	2016-05-18	Not applicable	US
Diphenhydramine Hydrochloride	Capsule, liquid filled	50 mg/1	Oral	Spirit Pharmaceuticals, Llc	2010-06-01	Not applicable	US
Diphenhydramine Hydrochloride	Liquid	12.5 mg/5mL	Oral	Physicians Total Care, Inc.	2006-06-29	Not applicable	US
Diphenhydramine Hydrochloride	Solution	50 mg/20mL	Oral	Discount Drug Mart	2016-02-11	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Eon Labs, Inc.	2000-05-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule, liquid filled	50 mg/1	Oral	Humanwell Pura Cap Pharmaceutical (Wuhan), Ltd.	2014-08-13	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2013-03-19	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Proficient Rx LP	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride	Capsule, liquid filled	25 mg/1	Oral	Rite Aid	2016-09-30	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	A S Medication Solutions	2007-05-24	2017-06-20	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	A S Medication Solutions	2007-05-24	2017-06-20	US
Diphenhydramine Hydrochloride	Tablet	25 mg/1	Oral	AAA Pharmaceutical, Inc.	2012-12-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Cardinal Health	2017-01-13	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Remedy Repack	2015-03-26	2017-04-08	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	A S Medication Solutions	2007-05-24	2017-06-20	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	TYA Pharmaceuticals	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Clinical Solutions Wholsesale	2007-05-24	2017-07-03	US
Diphenhydramine Hydrochloride	Tablet, coated	25 mg/1	Oral	Time Cap Laboratories	2010-03-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Qualitest	2007-05-24	2020-03-30	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Epic Pharma, LLC	2016-11-22	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Aventura Pharmaceuticals, Llc	2015-10-14	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	50 mg/1	Oral	Physicians Total Care, Inc.	2000-05-01	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Proficient Rx LP	2009-01-02	Not applicable	US
Diphenhydramine Hydrochloride	Tablet, coated	25 mg/1	Oral	AAA Pharmaceutical, Inc.	2012-12-15	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2000-05-01	Not applicable	US
Diphenhydramine Hydrochloride	Solution	25 mg/10mL	Oral	Aurohealth LLC	2014-11-26	Not applicable	US
Diphenhydramine Hydrochloride	Capsule	25 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2007-05-24	Not applicable	US
Diphenhydramine Hydrochloride 25 Mg Caplet	Tablet	25 mg	Oral	Jamp Pharma Corporation	2005-09-12	Not applicable	Canada
Diphenhydramine Hydrochloride 25 Mg Tablet	Tablet	25 mg	Oral	Nobel Pharm Enr.	2000-02-01	2014-05-27	Canada
Diphenhydramine Hydrochloride 25mg	Capsule	25 mg	Oral	Strides Pharma Inc	Not applicable	Not applicable	Canada
Diphenhydramine Hydrochloride 50 Mg Caplet	Tablet	50 mg	Oral	Nobel Pharm Enr.	2000-02-01	2014-05-27	Canada
Diphenhydramine Hydrochloride 50 Mg Capsule	Capsule	50 mg	Oral	Nobel Pharm Enr.	1983-12-31	2016-08-25	Canada
Diphenhydramine Hydrochloride 50 Mg Capsules USP Extra Strength Sleep Aid	Capsule	50 mg	Oral	Pharmetics (2011) Inc.	2008-07-02	2010-07-12	Canada
Diphenhydramine Hydrochloride 50mg Caplet	Tablet	50 mg	Oral	Jamp Pharma Corporation	2005-09-12	Not applicable	Canada
Diphenhydramine Hydrochloride 50mg USP	Capsule	50 mg	Oral	Strides Pharma Inc	Not applicable	Not applicable	Canada
Diphenhydramine Hydrochloride Caplets 25mg	Tablet	25 mg	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Diphenhydramine Hydrochloride Caplets 50 mg	Tablet	50 mg	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Diphenhydramine Hydrochloride Elixir U.S.P.	Elixir	12.5 mg	Oral	Laboratoires Confab Inc	2004-04-01	2015-12-16	Canada
Diphenhydramine Hydrochloride Elixir USP	Elixir	12.5 mg	Oral	Jamp Pharma Corporation	2009-01-30	Not applicable	Canada
Diphenhydramine Oral Liquid	Liquid	12.5 mg/5mL	Oral	Rij Pharmaceutical Corporation	1999-03-16	Not applicable	US
Dorm-L Tab 25mg	Tablet	25 mg	Oral	Nutribon (1986) Inc.	1995-12-31	1996-09-30	Canada
Dormax	Tablet	50 mg	Oral	Nobel Pharm Enr.	2004-06-11	2013-07-18	Canada
Dormin	Capsule	25 mg/1	Oral	Randob Labs,ltd.	1992-01-01	Not applicable	US
Dormiphen Comprime	Tablet	25 mg	Oral	Laboratoire Lalco Inc.	1998-06-05	Not applicable	Canada
Dormiphen Extra-fort Capsule	Capsule	50 mg	Oral	Laboratoire Lalco Inc.	1980-12-31	Not applicable	Canada
Dormiphen Extra-fort Comprime	Tablet	50 mg	Oral	Laboratoire Lalco Inc.	1998-06-05	Not applicable	Canada
Dormirax 25	Tablet	25 mg	Oral	Laboratoire Riva Inc	Not applicable	Not applicable	Canada
Dormirax 50	Tablet	50 mg	Oral	Laboratoire Riva Inc	Not applicable	Not applicable	Canada
Dreamol Extra Strength	Tablet	50 mg	Oral	Genvion Corporation	2016-04-12	Not applicable	Canada
Dye Free Allergy Childrens	Liquid	12.5 mg/5mL	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2016-02-29	Not applicable	US
Dye Free Wal Dryl Allergy Childrens	Liquid	12.5 mg/5mL	Oral	Walgreens	2015-03-31	Not applicable	US
Dye-free Adult Allergy	Solution	50 mg/20mL	Oral	Cvs Health	2014-11-26	Not applicable	US
Dye-free Allergy	Solution	25 mg/10mL	Oral	Cvs Health	2014-11-26	Not applicable	US
Dye-free Allergy	Capsule, liquid filled	25 mg/1	Oral	Woonsocket Prescription Center, Incorporated	2001-09-13	Not applicable	US
Dye-free Allergy	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-06-27	Not applicable	US
Dye-free Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Pura Vation Pharmaceuticals Inc	2013-09-12	2017-01-04	US
Dye-free Allergy Relief	Capsule, liquid filled	25 mg/1	Oral	Chain Drug Marketing Association	2001-09-13	Not applicable	US
Dye-free Wal-dryl	Capsule, liquid filled	25 mg/1	Oral	Walgreen	2001-09-13	Not applicable	US
Each Relief Equate	Gel	2 g/100mL	Topical	Walmart	2017-04-03	Not applicable	US
Equaline Allergy	Solution	12.5 mg/5mL	Oral	Supervalu	2004-08-10	Not applicable	US
Equaline Allergy	Tablet	25 mg/1	Oral	Supervalu	2004-08-30	Not applicable	US
Equaline Allergy	Capsule	25 mg/1	Oral	Supervalu	2004-08-10	Not applicable	US
Equaline Night Time Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Supervalu	2014-03-07	Not applicable	US
Equaline Night Time Sleep Aid	Solution	50 mg/30mL	Oral	Supervalu	2013-06-28	Not applicable	US
Equate Allergy Relief	Solution	12.5 mg/5mL	Oral	Walmart Stores	1990-08-15	Not applicable	US
Equate Allergy Relief	Tablet	25 mg/1	Oral	Walmart Stores	1999-07-30	Not applicable	US
Equate Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Walmart Stores	2000-05-16	Not applicable	US
Extra Strength Allergy Formula Liquid Capsules	Capsule	50 mg	Oral	Vita Health Products Inc	2009-11-05	Not applicable	Canada
Extra Strength Allergy Formula Nighttime	Capsule	50 mg	Oral	Actavis Pharma Company	Not applicable	Not applicable	Canada
Extra Strength Benadryl Allergy Nighttime	Capsule	50 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2008-05-05	Not applicable	Canada
Extra Strength Dormex Caplets	Tablet	50 mg	Oral	Vita Health Products Inc	2013-11-06	Not applicable	Canada
Extra Strength Dormex Capsules	Capsule	50 mg	Oral	Vita Health Products Inc	2013-11-06	Not applicable	Canada
Extra Strength Nighttime Allergy Liquid Gel Capsules	Capsule	50 mg	Oral	Apotex Corporation	Not applicable	Not applicable	Canada
Extra Strength Nytol Quickgels	Capsule	50 mg	Oral	Medtech Laboratories, Inc.	1999-01-08	Not applicable	Canada
Extra Strength Nytol Tab 50mg	Tablet	50 mg	Oral	Medtech Laboratories, Inc.	1983-12-31	Not applicable	Canada
Extra Strength Simply Sleep Liqui-gels	Capsule	50 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Extra Strength Sleep Aid	Tablet	50 mg	Oral	Vita Health Products Inc	Not applicable	Not applicable	Canada
Extra Strength Sleep Aid	Tablet	50 mg	Oral	Pendopharm Division Of De Pharmascience Inc	2007-06-01	Not applicable	Canada
Extra Strength Sleep Aid Fast	Capsule	50 mg	Oral	Banner Pharmacaps	2003-11-07	2014-09-10	Canada
Extra Strength Sleep Aid Liquid Gels	Capsule	50 mg	Oral	Accucaps Industries Limited	Not applicable	Not applicable	Canada
Ez Nite Sleep	Liquid	50 mg/30mL	Oral	Safeway	2015-06-30	Not applicable	US
Ez Nite Sleep	Liquid	50 mg/30mL	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2013-01-01	Not applicable	US
Ez Nite Sleep	Liquid	50 mg/30mL	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2015-06-30	Not applicable	US
Ez Nite Sleep	Liquid	50 mg/30mL	Oral	Kroger	2015-03-31	Not applicable	US
Ez Nite Sleep	Capsule, liquid filled	25 mg/1	Oral	Preferred Plus (Kinray)	2014-02-12	Not applicable	US
Ez Nite Sleep	Capsule, liquid filled	25 mg/1	Oral	P & L Development Of New York Corporation	2013-11-30	Not applicable	US
Ez Nite Sleep	Liquid	50 mg/30mL	Oral	P & L Development, LLC	2013-01-01	Not applicable	US
Ez Nite Sleep	Capsule, liquid filled	25 mg/1	Oral	Kroger	2014-12-31	Not applicable	US
Ez Nite Sleep Aid	Liquid	50 mg/30mL	Oral	EQUATE (Walmart Stores, Inc.)	2015-10-31	Not applicable	US
Ez Nite Sleep Aid	Liquid	50 mg/30mL	Oral	Aafes/Your Military Exchanges	2015-08-31	Not applicable	US
Ez Nite Sleep Berry	Liquid	50 mg/30mL	Oral	Exchange Select	2013-11-21	Not applicable	US
Ez Nite Sleep Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Family Dollar (FAMILY WELLNESS)	2014-07-31	Not applicable	US
Ez Nite Sleep Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Family Dollar (FAMILY WELLNESS)	2013-10-30	Not applicable	US
Ez Nite Sleep Nighttime Sleep-aid	Capsule, liquid filled	25 mg/1	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2014-07-31	Not applicable	US
Ez Nite Sleep Nighttime Sleep-aid	Capsule, liquid filled	25 mg/1	Oral	Kroger	2013-04-11	Not applicable	US
Ez Nite Sleep Nighttime Sleep-aid	Capsule, liquid filled	25 mg/1	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2013-03-11	Not applicable	US
First Aid Shot Therapy Allergy Relief	Solution	50 mg/40mL	Oral	First Aid Beverages, Inc.	2016-07-01	Not applicable	US
First Aid Shot Therapy Sleep Aid	Solution	50 mg/40mL	Oral	First Aid Beverages, Inc.	2016-07-01	Not applicable	US
Formule Allergie Liquide	Elixir	12.5 mg	Oral	Prodemdis Enr.	Not applicable	Not applicable	Canada
Geri-dryl Allergy Relief	Tablet, coated	25 mg/1	Oral	Gericare Pharmaceuticals	2011-09-01	Not applicable	US
Good Neighbor Pharmacy Allergy	Tablet	25 mg/1	Oral	Amerisource Bergen	1991-08-30	Not applicable	US
Good Neighbor Pharmacy Allergy	Capsule	25 mg/1	Oral	Rebel Distributors	1989-10-15	Not applicable	US
Good Neighbor Pharmacy Allergy	Capsule	25 mg/1	Oral	Amerisource Bergen	1989-10-15	Not applicable	US
Good Neighbor Pharmacy Childrens Allergy	Solution	12.5 mg/5mL	Oral	Lake Erie Medical Dba Quality Care Produts Llc	1989-08-15	Not applicable	US
Good Neighbor Pharmacy Childrens Allergy	Solution	12.5 mg/5mL	Oral	Amerisource Bergen	1989-08-15	Not applicable	US
Good Neighbor Pharmacy Cleartime	Tablet, film coated	25 mg/1	Oral	Amerisource Bergen	2015-03-25	Not applicable	US
Good Neighbor Pharmacy Sleep Aid	Tablet	25 mg/1	Oral	Amerisource Bergen	2001-04-14	Not applicable	US
Good Neighbor Pharmacy Sleep Time	Capsule, liquid filled	25 mg/1	Oral	Amerisource Bergen	2014-01-30	Not applicable	US
Good Neighbor Pharmacy Sleep Time	Solution	50 mg/30mL	Oral	Amerisource Bergen	2013-07-22	Not applicable	US
Good Sense Allergy	Solution	12.5 mg/5mL	Oral	L. Perrigo Company	1989-09-15	Not applicable	US
Good Sense Allergy Relief	Tablet	25 mg/1	Oral	L. Perrigo Company	1991-08-20	Not applicable	US
Good Sense Allergy Relief	Capsule	25 mg/1	Oral	Proficient Rx LP	1989-09-15	Not applicable	US
Good Sense Allergy Relief	Capsule	25 mg/1	Oral	L. Perrigo Company	1989-09-15	Not applicable	US
Good Sense Nighttime Sleep Aid	Tablet	25 mg/1	Oral	L. Perrigo Company	2001-04-25	Not applicable	US
Good Sense Nighttime Sleep Aid	Tablet	25 mg/1	Oral	L. Perrigo Company	2009-09-02	Not applicable	US
Good Sense Sleep Time	Capsule, liquid filled	25 mg/1	Oral	L. Perrigo Company	2014-02-06	Not applicable	US
Good Sense Sleep Time	Solution	50 mg/30mL	Oral	L. Perrigo Company	2013-07-02	Not applicable	US
Handy Solutions Allergy Relief	Tablet	25 mg/1	Oral	Navajo Manuracturing Company	2016-10-22	Not applicable	US
Harris Teeter Childrens Allergy	Solution	12.5 mg/5mL	Oral	Harris Teeter	2015-06-24	Not applicable	US
Health Mart Allergy Childrens	Liquid	12.5 mg/5mL	Oral	Mc Kesson	2012-01-11	Not applicable	US
Health Mart Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	Mc Kesson	2016-03-15	Not applicable	US
Health Mart Maximum Strength Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Mc Kesson	2012-04-06	Not applicable	US
Health Mart Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Mc Kesson	2013-08-13	Not applicable	US
Health Mart Z Sleep	Solution	50 mg/30mL	Oral	Mc Kesson	2013-07-16	Not applicable	US
Health Mart Z-sleep	Capsule, liquid filled	25 mg/1	Oral	Mc Kesson	2014-01-31	Not applicable	US
Healthy Accents Allergy	Solution	12.5 mg/5mL	Oral	Dza Brands,	2008-04-01	Not applicable	US
Healthy Accents Allergy Relief	Capsule	25 mg/1	Oral	Dza Brands,	2008-01-29	Not applicable	US
Healthy Accents Allergy Relief	Tablet	25 mg/1	Oral	Dza Brands,	2008-01-29	Not applicable	US
Healthy Accents Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Dza Brands,	2008-02-24	Not applicable	US
Healthy Accents Sleeptime	Capsule, liquid filled	25 mg/1	Oral	Dza Brands,	2016-05-11	Not applicable	US
Healthy Accents Sleeptime	Solution	50 mg/30mL	Oral	Dza Brands,	2014-05-09	Not applicable	US
Helath Mart Childrens Allergy Relief Dye Free	Liquid	12.5 mg/5mL	Oral	Mc Kesson	2014-09-09	Not applicable	US
Help I Can't Sleep	Tablet	25 mg	Oral	Help Remedies, Inc.	Not applicable	Not applicable	Canada
Help I Cant Sleep	Tablet	25 mg/1	Oral	Help Remedies, Inc.	2009-07-01	Not applicable	US
Histaprin	Tablet	25 mg/1	Oral	Nor Med	2009-01-01	Not applicable	US
Insomnal	Tablet	50 mg	Oral	Teva	2011-02-14	Not applicable	Canada
Insomnal Cap 25mg	Capsule	25 mg	Oral	Welcker Lyster Ltd., Division Of Technilab Inc.	1979-12-31	2004-08-03	Canada
Insomnal DS	Capsule	50 mg	Oral	Rougier Pharma Division Of Ratiopharm Inc	1996-12-31	2015-10-01	Canada
Itch Relief	Liquid	20.3 g/L	Topical	Safetec Of America Inc	2013-05-02	Not applicable	US
Itch Relief	Liquid	20.3 g/L	Topical	Cintas First Aid & Safety	2013-05-13	Not applicable	US
Itch Relief	Spray	2 g/100mL	Topical	Water Jel Technologies	2010-09-25	Not applicable	US
Itch Relief Cream	Cream	2 %	Topical	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Itch Relif Cvs	Gel	2 g/100mL	Topical	Cvs Health	2014-02-14	Not applicable	US
Jack & Jill Bedtime	Liquid	6.25 mg	Oral	The Buckley's Company	2000-08-08	2016-08-02	Canada
Jack & Jill Thin Strips Cough & Cold	Strip	12.5 mg	Oral	The Buckley's Company	2005-08-08	2010-06-21	Canada
Jamp Diphenhydramine Children's Syrup	Syrup	6.25 mg	Oral	Jamp Pharma Corporation	Not applicable	Not applicable	Canada
Junior Strength Allergy Formula	Tablet	12.5 mg	Oral	Teva	2010-12-10	Not applicable	Canada
Junior Strength Allergy Tablets	Tablet	12.5 mg	Oral	Tanta Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Kids-eeze Allergy	Tablet, orally disintegrating	12.5 mg/1	Oral	Pro Phase Labs, Inc.	2010-09-01	Not applicable	US
Leader Allergy	Tablet	25 mg/1	Oral	Cardinal Health	2014-12-22	Not applicable	US
Leader Allergy	Tablet	25 mg/1	Oral	Cardinal Health	1992-05-11	Not applicable	US
Leader Allergy	Capsule	25 mg/1	Oral	Cardinal Health	2015-01-02	Not applicable	US
Leader Allergy	Capsule	25 mg/1	Oral	Cardinal Health	1990-04-15	Not applicable	US
Leader Childrens Allergy	Solution	12.5 mg/5mL	Oral	Cardinal Health	1990-05-15	Not applicable	US
Leader Maximum Strength Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Cardinal Health	2012-06-05	Not applicable	US
Leader Nighttime Sleep-aid	Liquid	50 mg/30mL	Oral	Cardinal Health	2017-01-17	Not applicable	US
Leader Restfully Sleep	Tablet	25 mg/1	Oral	Cardinal Health	2000-09-15	Not applicable	US
Leader Sleeptime	Solution	50 mg/30mL	Oral	Cardinal Health	2013-10-11	Not applicable	US
Leader Sleeptime	Capsule, liquid filled	25 mg/1	Oral	Cardinal Health	2013-12-02	Not applicable	US
Lil Drug Store Nighttime Sleep-aid	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2011-06-02	2017-02-02	US
Lil Drug Store Nighttime Sleep-aid	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2011-06-02	2017-02-02	US
Lil Drug Store Products Allergy Antihistamine	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2015-01-10	Not applicable	US
Lil Drug Store Products Allergy Antihistamine	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2015-01-10	Not applicable	US
Lil Drug Store Products Allergy Antihistamine	Tablet	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2015-01-10	Not applicable	US
Maximum Strength Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-07-12	Not applicable	US
Medique Diphen	Tablet, film coated	25 mg/1	Oral	Unifirst First Aid	2012-01-01	Not applicable	US
Medique Diphen	Tablet, film coated	25 mg/1	Oral	Unifirst First Aid	2012-01-01	Not applicable	US
Multi-symptom Allergy	Capsule	25 mg/1	Oral	Mc Kesson (Health Mart)	2012-02-14	Not applicable	US
Nadryl 25mg	Tablet	25 mg	Oral	Laboratoire Riva Inc	2002-02-14	Not applicable	Canada
Nadryl 50mg	Tablet	50 mg	Oral	Laboratoire Riva Inc	2002-02-14	Not applicable	Canada
Naramin	Solution	12.5 mg/5mL	Oral	National Pharma Industries Inc	2014-05-28	Not applicable	US
Neocitran Thin Strips Nighttime Cough	Lozenge	25 mg	Oral	Novartis	2004-11-19	2013-07-31	Canada
Night Cough Liquid Fastgels	Capsule	25 mg	Oral	Vita Health Products Inc	2008-10-14	Not applicable	Canada
Night Time Sleep Aid	Capsule	50 mg/1	Oral	Hyvee	2014-02-01	Not applicable	US
Night Time Sleep Aid	Solution	50 mg/30mL	Oral	Hyvee	2013-07-08	Not applicable	US
Night Time Sleep Aid	Liquid	50 mg/30mL	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2015-03-31	Not applicable	US
Night Time Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-05-05	Not applicable	US
Night Time Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Harmon Stores	2015-02-28	Not applicable	US
Night Time Sleep-aid	Liquid	50 mg/30mL	Oral	Discount Drug Mart	2013-12-10	Not applicable	US
Nightime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Agile Pharmachem	2014-03-31	Not applicable	US
Nightime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Velocity Pharma	2014-03-31	Not applicable	US
Nighttime	Tablet	25 mg/1	Oral	Western Family Foods	2001-01-28	Not applicable	US
Nighttime Allergy	Tablet	50 mg	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Nighttime Allergy Relief Extra Strength	Tablet	50 mg/1	Oral	Meijer	2014-06-30	Not applicable	US
Nighttime Allergy Relief Extra Strength	Tablet	50 mg/1	Oral	Topcare (Topco Associates Llc)	2014-07-31	Not applicable	US
Nighttime Liquigel Sleep-aid	Capsule	25 mg	Oral	Actavis Pharma Company	Not applicable	Not applicable	Canada
Nighttime Sleep	Tablet, film coated	25 mg/1	Oral	Safeway	2000-06-10	Not applicable	US
Nighttime Sleep Aid	Solution	50 mg/30mL	Oral	Meijer Distribution	2014-12-04	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Cvs Health	2015-03-01	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	We Care Distributor Inc.	2016-02-04	Not applicable	US
Nighttime Sleep Aid	Capsule	50 mg/1	Oral	Valu Merchandisers Company (Best Choice)	2010-07-26	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-06-27	Not applicable	US
Nighttime Sleep Aid	Solution	50 mg	Oral	Juno Otc Inc	Not applicable	Not applicable	Canada
Nighttime Sleep Aid	Liquid	50 mg/30mL	Oral	Care One (American Sales Company)	2015-06-30	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Avema Pharma Solutions	2011-01-16	2017-04-14	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Nash Finch Company (Our Family)	2013-11-30	Not applicable	US
Nighttime Sleep Aid	Solution	50 mg/30mL	Oral	H.E.B.	2013-10-30	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Woonsocket Prescription Center, Incorporated	2004-04-08	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Win Co Foods, Llc,	2014-12-31	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Kroger	2012-11-02	Not applicable	US
Nighttime Sleep Aid	Capsule	50 mg/1	Oral	Super Valu (Equaline)	2012-01-03	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Meijer Distribution	2016-02-07	Not applicable	US
Nighttime Sleep Aid	Capsule	50 mg/1	Oral	Chain Drug Consortium	2010-07-08	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-07-26	Not applicable	US
Nighttime Sleep Aid	Capsule	50 mg/1	Oral	Good Sense (Geiss, Destin & Dunn, Inc.)	2013-04-15	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	H.E.B.	2009-10-09	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Western Family Foods	2010-07-12	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Safeway	2013-05-31	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Valu Merchandisers Company (Best Choice)	2014-02-01	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	H.E.B.	2013-09-30	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Pura Vation Pharmaceuticals Inc	2013-04-15	2017-01-04	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Super Valu (Equaline)	2012-10-31	Not applicable	US
Nighttime Sleep Aid	Tablet, film coated	25 mg/1	Oral	Cvs Health	2000-06-10	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Fred's	2014-11-30	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Topco Associates	2016-07-19	Not applicable	US
Nighttime Sleep Aid	Tablet, film coated	25 mg/1	Oral	Sunmark (Mckesson)	2000-06-10	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Kroger	2001-02-05	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Chain Drug Consortium	2010-07-08	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-06-01	Not applicable	US
Nighttime Sleep Aid	Liquid	50 mg/30mL	Oral	Fred's	2013-10-23	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Win Co Foods, Llc,	2000-06-10	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	EQUATE (Walmart Stores, Inc.)	2013-09-30	Not applicable	US
Nighttime Sleep Aid	Capsule	50 mg/1	Oral	Western Family Foods	2010-07-01	Not applicable	US
Nighttime Sleep Aid	Tablet, film coated	25 mg/1	Oral	Mc Kesson (Health Mart)	2000-06-10	Not applicable	US
Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Chain Drug Marketing Association	2007-06-25	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	ASSURED / DOLLAR TREE (Greenbrier International, Inc.)	2017-05-31	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	H.E.B.	2014-12-31	Not applicable	US
Nighttime Sleep Aid	Tablet, film coated	25 mg/1	Oral	Supervalu	2000-06-10	Not applicable	US
Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Hyvee	2014-11-24	Not applicable	US
Nighttime Sleep Aid	Tablet, film coated	25 mg/1	Oral	Target Corporation.	2000-06-10	Not applicable	US
Nighttime Sleep Aid	Tablet, coated	25 mg/1	Oral	Health Life Of Usa	2012-05-12	Not applicable	US
Nighttime Sleep Aid	Capsule	25 mg	Oral	Apotex Corporation	2014-01-24	Not applicable	Canada
Nighttime Sleep Aid Alcohol Free	Liquid	50 mg/30mL	Oral	Walmart Stores	2016-09-12	Not applicable	US
Nighttime Sleep Aid Liquid	Solution	50 mg	Oral	Perrigo International	2015-05-13	Not applicable	Canada
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Western Family Foods	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Cvs Health	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Nash Finch Company (Our Family)	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	LIVE BETTER (The Great Atlantic & Pacific Tea Company)	2010-07-26	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Chain Drug Consortium	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	EQUATE (Walmart Stores, Inc.)	2010-07-06	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	LIVE BETTER (The Great Atlantic & Pacific Tea Company)	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Tablet, film coated	50 mg/1	Oral	Walgreen	2016-07-31	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Good Sense (Geiss, Destin & Dunn, Inc.)	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Walgreens	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Mc Kesson (Health Mart)	2014-02-01	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	P & L Development, LLC	2011-09-02	2016-12-31	US
Nighttime Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	EQUATE (Walmart Stores, Inc.)	2013-10-31	Not applicable	US
Nighttime Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2014-02-01	Not applicable	US
Nighttime Sleep Aid Non Habit Forming	Capsule, liquid filled	25 mg/1	Oral	Fred's	2013-04-11	Not applicable	US
Nighttime Sleep Aid Softgels	Capsule, gelatin coated	25 mg/1	Oral	Cvs Health	2015-07-14	Not applicable	US
Nighttime Sleep Easy	Tablet	25 mg/1	Oral	P And L Development Of New York Corporation (Ready In Case)	2012-12-04	Not applicable	US
Nighttime Sleep-aid	Liquid	50 mg/30mL	Oral	De Moulas Market Basket	2013-09-19	Not applicable	US
Nighttime Sleep-aid	Tablet	25 mg/1	Oral	Gericare Pharmaceuticals	2004-01-01	Not applicable	US
Nighttime Sleep-aid	Capsule, liquid filled	25 mg/1	Oral	Lil' Drug Store Products, Inc.	2014-09-05	Not applicable	US
Nighttime Sleep-aid	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2015-05-26	Not applicable	US
Nighttime Sleep-aid	Liquid	50 mg	Oral	Teva	2015-02-12	Not applicable	Canada
Nighttime Sleep-aid	Tablet	25 mg/1	Oral	Woonsocket Prescription Center, Incorporated	2013-05-07	2017-02-26	US
Nighttime Sleep-aid	Capsule	25 mg/1	Oral	Safeway	2014-12-31	Not applicable	US
Nighttime Sleep-aid Maximum Strength	Capsule	50 mg/1	Oral	SMART SENSE (Kmart)	2013-03-31	Not applicable	US
Nighttime Sleep-aid Softgel	Capsule, liquid filled	50 mg/21	Oral	Ai Ping Pharmaceutical, Inc.	2015-01-31	Not applicable	US
Nighttime Sleepaid	Capsule, gelatin coated	50 mg/21	Oral	Kareway Product, Inc.	2014-10-22	Not applicable	US
Nighttime Snooze	Capsule	25 mg	Oral	Vita Health Products Inc	Not applicable	Not applicable	Canada
Nite Time Sleep Aid Liquidgels	Capsule, liquid filled	25 mg/1	Oral	Dolgencorp, Inc. (Dollar General)	2013-04-11	Not applicable	US
North Antihistamine	Tablet	25 mg/1	Oral	North Safety Products	2011-12-02	Not applicable	US
Nytol	Tablet	25 mg/1	Oral	Medtech Laboratories, Inc.	2012-06-01	Not applicable	US
Nytol Extra Strength Sleep Aid Caplet 50mg	Tablet	50 mg	Oral	Medtech Laboratories, Inc.	1991-12-31	Not applicable	Canada
Nytol Quickcaps	Tablet, film coated	25 mg/1	Oral	Glaxo Smith Kline Consumer Heathcare Lp	2011-08-12	Not applicable	US
Nytol Tablet 25mg	Tablet	25 mg	Oral	Medtech Laboratories, Inc.	1979-12-31	Not applicable	Canada
On The Go-dose	Solution	12.5 mg/5mL	Oral	Perfect Measure Llc	2014-05-28	Not applicable	US
Pdp-diphenhydramine	Capsule	25 mg	Oral	Pendopharm Division Of De Pharmascience Inc	1990-12-31	Not applicable	Canada
Pdp-diphenhydramine	Capsule	50 mg	Oral	Pendopharm Division Of De Pharmascience Inc	1990-12-31	Not applicable	Canada
Pediacare Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Blacksmith Brands, Inc.	2009-10-29	Not applicable	US
Pediacare Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Blacksmith Brands, Inc.	2010-02-01	Not applicable	US
Pharbedryl	Capsule	25 mg/1	Oral	A S Medication Solutions	2006-10-11	2017-06-20	US
Pharbedryl	Capsule	25 mg/1	Oral	A S Medication Solutions	2006-10-11	2017-06-20	US
Pharbedryl	Capsule	50 mg/1	Oral	Pharbest Pharmaceuticals, Inc.	2006-10-11	Not applicable	US
Pharbedryl	Capsule	50 mg/1	Oral	A S Medication Solutions	2006-10-11	2017-06-20	US
Pharbedryl	Capsule	25 mg/1	Oral	Pharbest Pharmaceuticals, Inc.	2006-10-11	Not applicable	US
Pharbedryl	Capsule	25 mg/1	Oral	A S Medication Solutions	2006-10-11	2017-06-20	US
Plus Pharma	Tablet, film coated	25 mg/1	Oral	Gemini Pharmaceuticals, Inc. dba Plus Pharma	2015-06-12	Not applicable	US
PMS-diphenhydramine Elixir 2.5mg/ml	Elixir	2.5 mg	Oral	Pharmascience Inc	1990-12-31	Not applicable	Canada
Preferred Plus Complete Allergy Medicine	Capsule	25 mg/1	Oral	Kinray	2013-05-07	Not applicable	US
Premier Value Nighttime Sleep Aid Softgels	Capsule, gelatin coated	50 mg/21	Oral	Chain Drug Consortium	2014-11-14	Not applicable	US
Premier Value Nighttime Sleep-aid Liquid Sleep-aid	Liquid	50 mg/30mL	Oral	Chain Drug Consortium	2012-12-10	Not applicable	US
Premier Value Sleep-aid	Capsule	50 mg/1	Oral	Chain Drug Consortium	2013-05-31	Not applicable	US
Q-dryl	Capsule	25 mg/1	Oral	Qualitest	2007-05-24	2018-05-31	US
Qdryl Allergy	Solution	12.5 mg/5mL	Oral	Atlantic Biologicals Corp.	1997-12-01	Not applicable	US
Qdryl Allergy	Solution	12.5 mg/5mL	Oral	A S Medication Solutions	1997-12-01	2017-06-20	US
Qdryl Allergy	Solution	12.5 mg/5mL	Oral	A S Medication Solutions	1997-12-01	2019-10-31	US
Qdryl Allergy	Solution	12.5 mg/5mL	Oral	Lake Erie Medical Dba Quality Care Produts Llc	1997-12-01	Not applicable	US
Qdryl Allergy	Solution	12.5 mg/5mL	Oral	Qualitest	1997-12-01	2019-10-31	US
Qdryl Allergy	Solution	12.5 mg/5mL	Oral	Preferreed Pharmaceuticals Inc.	1997-12-01	Not applicable	US
Qdryl Allergy	Solution	12.5 mg/5mL	Oral	Remedy Repack	2015-03-04	2017-03-16	US
Quenalin Cough	Syrup	12.5 mg/5mL	Oral	Qualitest	1993-12-03	2016-11-15	US
Regular Strength Dormex Capsules	Capsule	25 mg	Oral	Vita Health Products Inc	2013-11-06	Not applicable	Canada
Regular Strength Sleep Aid	Capsule	25 mg	Oral	Vita Health Products Inc	2011-03-31	Not applicable	Canada
Rest Simply	Tablet, film coated	25 mg/1	Oral	Nash Finch	2000-06-10	Not applicable	US
Rest Simply	Tablet, coated	25 mg/1	Oral	Freds, Inc.	2008-09-01	Not applicable	US
Rest Simply	Tablet, coated	25 mg/1	Oral	Chain Drug Marketing Association	2014-06-13	Not applicable	US
Rest Simply	Tablet, film coated	25 mg/1	Oral	Great Lakes Wholesale, Marketing, and Sales, Inc.	2000-06-10	Not applicable	US
Rest Simply	Tablet, film coated	25 mg/1	Oral	Chain Drug Consortium	2000-06-10	Not applicable	US
Restfully Sleep	Tablet, film coated	25 mg/1	Oral	Cardinal Health	2000-06-10	Not applicable	US
Rexall Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Dolgencorp	2013-07-26	Not applicable	US
Rexall Sleep Aid	Tablet	25 mg/1	Oral	Dolgencorp	2010-09-29	Not applicable	US
Rite Aid Maximum Strength Itch Relief	Gel	20.5 mg/mL	Topical	Rite Aid	2011-08-10	Not applicable	US
Rugby Diphenhist	Tablet, film coated	25 mg/1	Oral	Rugby	2014-12-13	Not applicable	US
Sedamo	Tablet	25 mg	Oral	Viva Pharmaceutical Inc.	Not applicable	Not applicable	Canada
Sedicin Tablets 25mg	Tablet	25 mg	Oral	Crombie Kennedy Nasmark Inc.	1960-12-31	2000-07-19	Canada
Select Brand Extra Strength Itch Stopping	Gel	.2 g/10mL	Topical	Select Brand	2012-07-11	Not applicable	US
Select Health Allergy Relief Cherry	Liquid	12.5 mg/5mL	Oral	Axcentria Pharmaceuticals, Llc	2011-09-01	Not applicable	US
Shoprite Allergy Relief	Tablet	25 mg/1	Oral	Wakfern Food Corporation	2016-09-13	Not applicable	US
Shoprite Allergy Relief	Capsule	25 mg/1	Oral	Wakfern Food Corporation	2016-09-12	Not applicable	US
Shoprite Childrens Allergy	Solution	12.5 mg/5mL	Oral	Wakfern Food Corporation	2016-01-11	Not applicable	US
Shoprite Sleep Aid	Solution	50 mg/30mL	Oral	Wakfern Food Corporation	2013-07-17	Not applicable	US
Siladryl Allergy Medicine	Liquid	12.5 mg/5mL	Oral	Rebel Distributors	1997-01-01	Not applicable	US
Siladryl Allergy Medicine	Liquid	12.5 mg/5mL	Oral	Silarx Pharmaceuticals, Inc.	1997-01-01	Not applicable	US
Silphen	Syrup	12.5 mg/5mL	Oral	Silarx Pharmaceuticals, Inc.	1993-12-03	Not applicable	US
Simply Right Diphenhydramine Hydrochloride Allergy Relief	Tablet	25 mg/1	Oral	Sam's West, Inc	2012-01-27	Not applicable	US
Simply Sleep	Tablet, film coated	25 mg/1	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2004-02-01	Not applicable	US
Simply Sleep	Tablet	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2000-03-29	2016-01-22	Canada
Simply Sleep Liqui-gels	Capsule	25 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Sleep	Tablet	25 mg/1	Oral	Salado Sales, Inc.	1990-04-10	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Rite Aid	1990-04-10	Not applicable	US
Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Lnk International, Inc.	2015-02-28	Not applicable	US
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Meijer Distribution	2000-06-10	Not applicable	US
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Rite Aid	2000-06-10	Not applicable	US
Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Pura Cap Pharmaceutical Llc.	2016-07-20	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Allegiant Health	2015-03-03	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Kareway Product, Inc.	2011-08-18	Not applicable	US
Sleep Aid	Tablet	50 mg	Oral	Vita Health Products Inc	1997-06-10	Not applicable	Canada
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Lnk International, Inc.	2000-06-10	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Cvs Health	2000-10-03	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Medicine Shoppe International	2001-06-19	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Meijer Distribution	2004-10-17	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Valu Merchandisers Company (Best Choice)	2014-04-30	Not applicable	US
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Harmon Store Inc.	2000-06-10	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Chain Drug Consortium	1998-11-07	Not applicable	US
Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Cardinal Health	2015-03-01	Not applicable	US
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Harmon Store Inc.	2013-07-01	Not applicable	US
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Rite Aid	2015-07-24	Not applicable	US
Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Cardinal Health	2015-02-28	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Navarro Discount Pharmacies, LLC	2013-02-01	Not applicable	US
Sleep Aid	Solution	50 mg/30mL	Oral	Rite Aid	2016-07-07	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Publix Supermarkets, Inc.	2001-07-24	Not applicable	US
Sleep Aid	Capsule	50 mg/1	Oral	Fred's	2014-02-01	Not applicable	US
Sleep Aid	Capsule	50 mg/1	Oral	Kroger	2010-07-12	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	SMART SENSE (Kmart)	2014-03-31	Not applicable	US
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Hyvee	2001-02-23	Not applicable	US
Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Lnk International, Inc.	2015-03-01	Not applicable	US
Sleep Aid	Capsule, liquid filled	50 mg/1	Oral	Lnk International, Inc.	2004-04-08	Not applicable	US
Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Pura Vation Pharmaceuticals Inc	2013-04-15	2017-01-04	US
Sleep Aid	Tablet, film coated	25 mg/1	Oral	Cardinal Health	2000-06-10	Not applicable	US
Sleep Aid	Capsule	50 mg/1	Oral	Rite Aid	2017-02-28	Not applicable	US
Sleep Aid	Tablet	25 mg/1	Oral	Chain Drug Consortium	2010-07-12	Not applicable	US
Sleep Aid (extra Strength) Tab 50mg	Tablet	50 mg	Oral	Tanta Pharmaceuticals Inc	1997-03-04	Not applicable	Canada
Sleep Aid (regular Strength) Tab 25mg	Tablet	25 mg	Oral	Tanta Pharmaceuticals Inc	1993-12-31	Not applicable	Canada
Sleep Aid Caplets	Tablet	25 mg	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Sleep Aid Dye-free Nighttime	Tablet, film coated	25 mg/1	Oral	Walgreen	2013-07-01	Not applicable	US
Sleep Aid Extra Strength	Capsule	50 mg	Oral	Pharmetics (2011) Inc.	Not applicable	Not applicable	Canada
Sleep Aid Extra Strength	Capsule	50 mg	Oral	Apotex Corporation	Not applicable	Not applicable	Canada
Sleep Aid Liquid Fastgels	Capsule	50 mg	Oral	Vita Health Products Inc	2001-09-01	Not applicable	Canada
Sleep Aid Liquid Gels	Capsule	25 mg	Oral	Accucaps Industries Limited	Not applicable	Not applicable	Canada
Sleep Aid Liquid Gels	Capsule	50 mg	Oral	Perrigo International	2001-08-22	2006-05-15	Canada
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Super Valu (Equaline)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Select Brand Dist.	2014-04-30	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Care One (American Sales Company)	2010-07-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Safeway	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Topcare (Topco Associates Llc)	2013-05-31	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Kroger	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Greenbrier International, Inc.	2004-04-08	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Sam's West, Inc	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Quality Choice (Chain Drug Marketing Association, Inc.)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Meijer	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Sunmark (Mckesson)	2010-07-09	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	SMART SENSE (Kmart)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Cardinal Health (Leader) 49781	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Harris Teeter	2015-02-28	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Target Corporation.	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Care One (American Sales Company)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Topcare (Topco Associates Llc)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	ASSURED / DOLLAR TREE (Greenbrier International, Inc.)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	H.E.B.	2014-05-30	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Dolgencorp, Inc. (Dollar General & Rexall)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	EQUATE (Walmart Stores, Inc.)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	P & L Development, LLC	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Safeway	2013-04-30	Not applicable	US
Sleep Aid Maximum Strength	Capsule, liquid filled	50 mg/1	Oral	Greenbrier International, Inc.	2015-03-01	Not applicable	US
Sleep Aid Maximum Strength	Capsule	50 mg/1	Oral	Sunmark (Mckesson)	2014-02-01	Not applicable	US
Sleep Aid Maximum Strength Nighttime	Capsule, liquid filled	50 mg/1	Oral	Win Co Foods, Llc,	2014-12-31	Not applicable	US
Sleep Aid Nighttime	Tablet, film coated	25 mg/1	Oral	Walgreen	2000-06-10	Not applicable	US
Sleep Aid Nighttime	Capsule, liquid filled	25 mg/1	Oral	P & L Development, LLC	2016-03-31	Not applicable	US
Sleep Aid Nighttime	Tablet	25 mg/1	Oral	Target Corporation.	2016-07-31	Not applicable	US
Sleep Aid Nighttime	Tablet	25 mg/1	Oral	Pld Acquisitions Llc Dba Avéma Pharma Solutions	2010-01-02	Not applicable	US
Sleep Aid Nighttime	Tablet, film coated	25 mg/1	Oral	Family Dollar Services	2000-06-10	Not applicable	US
Sleep Aid Nighttime	Capsule, liquid filled	25 mg/1	Oral	Target Corporation.	2015-02-28	Not applicable	US
Sleep Aid Nighttime	Tablet, film coated	25 mg/1	Oral	Walmart Stores	2000-06-10	Not applicable	US
Sleep Aid Nighttime	Capsule	50 mg/1	Oral	Family Dollar (FAMILY WELLNESS)	2014-02-01	Not applicable	US
Sleep Aid Nighttime	Tablet, film coated	25 mg/1	Oral	Greenbrier International, Inc.	2000-06-10	Not applicable	US
Sleep Aid Nighttime	Tablet	25 mg/1	Oral	Family Dollar (FAMILY WELLNESS)	2016-07-31	Not applicable	US
Sleep Aid Nighttime	Liquid	50 mg/30mL	Oral	Win Co Foods, Llc,	2016-06-30	Not applicable	US
Sleep Aid Nighttime	Liquid	50 mg/30mL	Oral	P & L Development, LLC	2016-08-31	Not applicable	US
Sleep Aid Nighttime	Liquid	50 mg/30mL	Oral	Target Corporation.	2016-07-31	Not applicable	US
Sleep Aid Nighttime	Tablet, film coated	25 mg/1	Oral	Walmart Stores	2015-07-24	Not applicable	US
Sleep Aid Nighttime	Tablet, film coated	25 mg/1	Oral	L&R Distributors, Inc.	2000-06-10	Not applicable	US
Sleep Aid Nighttime	Capsule, liquid filled	25 mg/1	Oral	Walmart Stores	2015-02-28	Not applicable	US
Sleep Aid Nighttime	Tablet, film coated	25 mg/1	Oral	Better Living Brands	2000-06-10	Not applicable	US
Sleep Aid Nighttime	Tablet	25 mg/1	Oral	Cvs Health	2013-08-15	Not applicable	US
Sleep Aid Nighttime	Tablet	25 mg/1	Oral	H.E.B.	2014-08-31	Not applicable	US
Sleep Aid Nite Time	Tablet, film coated	25 mg/1	Oral	Dolgencorp	2000-06-10	2017-05-20	US
Sleep Aid Regular Strength	Tablet	25 mg/1	Oral	Good Sense (Geiss, Destin & Dunn, Inc.)	2014-02-28	Not applicable	US
Sleep Aid Regular Strength	Tablet	25 mg/1	Oral	Geiss, Destin & Dunn, Inc (Goodsense)	2010-08-03	Not applicable	US
Sleep Easy	Tablet, coated	25 mg/1	Oral	Avema Pharma Solutions	2010-01-02	2017-04-14	US
Sleep Eze D Caplet 25mg	Tablet	25 mg	Oral	Whitehall Robins Inc.	1993-12-31	1997-08-07	Canada
Sleep Eze D Extra Strength Cap 50mg	Capsule	50 mg	Oral	Whitehall Robins Inc.	1993-12-31	1997-08-07	Canada
Sleep Eze D Extra Strength Caplet 50mg	Tablet	50 mg	Oral	Whitehall Robins Inc.	1993-12-31	1997-08-07	Canada
Sleep II Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Walgreen	1990-04-10	Not applicable	US
Sleep Nighttime Sleep Aid	Tablet	25 mg/1	Oral	Western Family Foods	2014-02-28	Not applicable	US
Sleep Original Formula	Tablet	25 mg/1	Oral	Valu Merchandisers Company (Best Choice)	2010-07-16	Not applicable	US
Sleep Tabs	Tablet	25 mg/1	Oral	Major	1992-12-25	Not applicable	US
Sleep Tabs	Tablet	25 mg/1	Oral	L&R Distributors, Inc.	1990-04-10	Not applicable	US
Sleep Tabs for Nighttime Use	Tablet	25 mg/1	Oral	Allegiant Health	2015-04-28	Not applicable	US
Sleep Time	Capsule, liquid filled	25 mg/1	Oral	Hyvee	2014-02-01	Not applicable	US
Sleep Time	Liquid	50 mg/30mL	Oral	Hyvee	2013-07-08	Not applicable	US
Sleep Time	Solution	50 mg/30mL	Oral	Lidl Us Llc	2017-05-18	Not applicable	US
Sleep- Aid Nighttime	Capsule	25 mg/1	Oral	Cvs Health	2016-07-31	Not applicable	US
Sleep-aid	Tablet	25 mg/1	Oral	International Laboratories, Llc	2016-05-27	Not applicable	US
Sleep-aid	Tablet	25 mg/1	Oral	Army + Air Force Exchange Service	1990-04-10	Not applicable	US
Sleep-aid Extra Strength	Tablet	50 mg	Oral	Teva	1997-02-06	Not applicable	Canada
Sleep-aid Maximum Strength	Capsule	50 mg/1	Oral	ASSURED / DOLLAR TREE (Greenbrier International, Inc.)	2010-07-06	Not applicable	US
Sleep-aid Maximum Strength	Capsule	50 mg/1	Oral	Fred's	2013-03-15	Not applicable	US
Sleep-aid Nighttime	Tablet, film coated	25 mg/1	Oral	Cvs Health	2015-07-24	Not applicable	US
Sleep-aid Regular Strength	Tablet	25 mg/1	Oral	Cvs Health	1990-04-10	Not applicable	US
Sleep-eze	Tablet	25 mg	Oral	Prestige Brands Inc	2010-08-03	Not applicable	Canada
Sleep-eze D Extra Strength Capsules	Capsule	50 mg	Oral	Medtech Laboratories, Inc.	1998-08-07	2014-03-20	Canada
Sleep-eze Extra Strength Caplets	Tablet	50 mg	Oral	Medtech Laboratories, Inc.	1997-11-12	Not applicable	Canada
Sleep-eze Extra Strength Gelcaps	Capsule	50 mg	Oral	Medtech Laboratories, Inc.	1999-12-14	Not applicable	Canada
Sleep-eze Eze-liquid	Solution	50 mg	Oral	Medtech Laboratories, Inc.	2015-03-30	Not applicable	Canada
Sleep-eze Regular Strength Caplets	Tablet	25 mg	Oral	Medtech Laboratories, Inc.	1997-11-12	Not applicable	Canada
Sleepaid Extra Strength Capsules	Capsule	50 mg	Oral	Tanta Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Sleepinal	Capsule	50 mg/1	Oral	Blairex Laboratories, Inc.	1999-10-01	Not applicable	US
Sleeptime	Capsule, liquid filled	25 mg/1	Oral	Shopko Stores Operating	2016-07-27	Not applicable	US
Sleeptime	Solution	50 mg/30mL	Oral	Shopko Stores Operating	2016-07-27	Not applicable	US
Sleeptime Dry Cough	Solution	12.5 mg	Oral	Perrigo International	Not applicable	Not applicable	Canada
Sleepwell	Tablet	25 mg	Oral	Stella Pharmaceutical Canada Inc.	2001-11-20	2008-06-26	Canada
Smart Sense Allergy	Tablet	25 mg/1	Oral	Kmart Corporation	2011-01-06	Not applicable	US
Smart Sense Allergy	Liquid	12.5 mg/5mL	Oral	Kmart Corporation	2011-01-13	Not applicable	US
Smart Sense Allergy	Capsule	25 mg/1	Oral	Kmart Corporation	1996-01-23	Not applicable	US
Smart Sense Allergy Relief	Tablet	25 mg/1	Oral	Kmart Corporation	2014-02-20	Not applicable	US
Smart Sense Allergy Relief	Capsule	25 mg/1	Oral	Kmart Corporation	2014-02-10	Not applicable	US
Smart Sense Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	Kmart Corporation	2014-02-21	Not applicable	US
Smart Sense Nightime Sleep Aid	Tablet	25 mg/1	Oral	Kmart Corporation	2007-06-29	Not applicable	US
Smart Sense Nighttime Sleep Aid	Solution	50 mg/30mL	Oral	Kmart Corporation	2015-10-21	Not applicable	US
Smart Sense Nighttime Sleep Aid	Capsule, liquid filled	25 mg/1	Oral	Kmart Corporation	2015-10-21	Not applicable	US
Smart Sense Sleep Aid	Tablet	25 mg/1	Oral	Kmart Corporation	2014-04-18	Not applicable	US
Snoozease Nighttime Sleep-aid	Capsule, liquid filled	25 mg/1	Oral	P & L Development Of New York Corporation	2013-04-11	Not applicable	US
Sohmed Allergy	Tablet	25 mg/1	Oral	SOHM Inc.	2013-08-25	Not applicable	US
Sominex	Tablet	25 mg/1	Oral	Medtech Laboratories, Inc.	2012-06-01	Not applicable	US
Sominex	Tablet	25 mg/1	Oral	Glaxo Smith Kline Consumer Heathcare Lp	2010-11-08	Not applicable	US
Sominex	Tablet	25 mg/1	Oral	Navajo Manuracturing Company	2016-09-22	Not applicable	US
Sominex Extra Strength Caplet 50mg	Tablet	50 mg	Oral	Glaxosmithkline Inc	1992-12-31	2012-06-13	Canada
Sominex Max	Tablet	50 mg/1	Oral	Medtech Laboratories, Inc.	2012-06-01	Not applicable	US
Sominex Tablets 25mg	Tablet	25 mg	Oral	Glaxosmithkline Inc	1992-12-31	2012-06-13	Canada
Somnapure Clinical Strength	Tablet, coated	50 mg/1	Oral	Nutra Click, Llc	2015-05-26	Not applicable	US
Somnapure Clinical Strength	Tablet, coated	50 mg/1	Oral	Nutra Click, Llc	2015-04-09	Not applicable	US
Somnitabs	Tablet	25 mg/1	Oral	Great Lakes Wholesale, Marketing, and Sales, Inc.	1992-12-25	Not applicable	US
Somnitabs	Tablet	25 mg/1	Oral	Fred's	1990-04-10	Not applicable	US
Sound Body Childrens Allergy Relief	Solution	12.5 mg/5mL	Oral	Big Lots Stores, Inc.	2016-01-12	Not applicable	US
Sound Body Nighttime Sleep Aid	Solution	50 mg/30mL	Oral	Big Lots Stores, Inc.	2015-04-21	Not applicable	US
Sound Body Sleep Aid	Capsule	25 mg/1	Oral	Allegiant Health	2015-03-03	Not applicable	US
Sun Mark Allergy Relief	Capsule	25 mg/1	Oral	Mc Kesson	2003-07-03	Not applicable	US
Sunmark Allergy Relief	Tablet	25 mg/1	Oral	Mc Kesson	2003-08-21	Not applicable	US
Sunmark Allergy Relief Antihistamine	Solution	12.5 mg/5mL	Oral	Mc Kesson	2003-08-21	Not applicable	US
Sunmark Allergy Relief Antihistamine	Solution	12.5 mg/5mL	Oral	Nucare Pharmaceuticals, Inc.	2003-08-21	Not applicable	US
Sunmark Night Time Sleep Aid	Tablet	25 mg/1	Oral	Mc Kesson	2003-08-21	Not applicable	US
Sunmark Z Sleep	Solution	50 mg/30mL	Oral	Mc Kesson	2013-07-16	Not applicable	US
Sunmark Z-sleep	Capsule, liquid filled	25 mg/1	Oral	Mc Kesson	2014-01-31	Not applicable	US
Texaclear Nighttime Sleep-aid	Liquid	50 mg/30mL	Oral	Gm Pharmaceuticals	2016-06-15	Not applicable	US
The Itch Eraser Max Strength	Gel	20 mg/g	Topical	Tender Corporation	2015-11-17	Not applicable	US
The Itch Eraser Max Strength	Spray	20 mg/mL	Topical	Tender Corporation	2015-12-04	Not applicable	US
The Itch Eraser With Antihistamine	Cream	2 %	Topical	Tender Corporation	Not applicable	Not applicable	Canada
Topcare Allergy	Tablet	25 mg/1	Oral	Topco Associates	1993-12-14	2016-10-29	US
Topcare Allergy	Capsule	25 mg/1	Oral	Topco Associates	1988-01-15	Not applicable	US
Topcare Childrens Allergy	Solution	12.5 mg/5mL	Oral	Topco Associates	1987-12-15	Not applicable	US
Topcare Clear Time	Tablet, film coated	25 mg/1	Oral	Topco Associates	2015-01-14	Not applicable	US
Topcare Sleep Aid	Tablet	25 mg/1	Oral	Topco Associates	2010-11-03	Not applicable	US
Topcare Sleep Aid Nighttime	Tablet	25 mg/1	Oral	Topco Associates	2001-09-11	Not applicable	US
Topcare Zzz Sleep	Solution	50 mg/30mL	Oral	Topco Associates	2013-08-20	Not applicable	US
Topcare Zzz Sleep	Capsule, liquid filled	25 mg/1	Oral	Topco Associates	2014-01-28	Not applicable	US
Tranquil Nighttime	Tablet	25 mg/1	Oral	Alva Amco Pharmacal Companies, Inc.	2010-08-30	Not applicable	US
Triaminic Thin Strips Cough & Runny Nose	Strip	12.5 mg	Oral	Glaxosmithkline Inc	2004-11-19	Not applicable	Canada
Unisom	Tablet	50 mg	Oral	Paladin Labs Inc	1982-12-31	Not applicable	Canada
Unisom C Nightime Sleep Aid Cap 50mg	Capsule	50 mg	Oral	Pfizer Canada Inc., Consumer Healthcare Division	1989-12-31	1998-08-12	Canada
Unisom Sleep Gels	Capsule	25 mg	Oral	Paladin Labs Inc	2012-03-20	Not applicable	Canada
Unisom Sleep Gels Extra Strength	Capsule	50 mg	Oral	Paladin Labs Inc	1996-09-05	Not applicable	Canada
Unisom Sleepgels Nighttime Sleep-aid	Capsule, liquid filled	50 mg/1	Oral	Chattem, Inc.	2007-01-01	Not applicable	US
Unisom Sleepmelts Nighttime Sleep-aid	Tablet, chewable	25 mg/1	Oral	Chattem, Inc.	2008-01-01	Not applicable	US
Unisom Sleepminis Nighttime Sleep-aid	Capsule	25 mg/1	Oral	Chattem, Inc.	2015-04-01	Not applicable	US
Unisom Warming Cherry	Liquid	50 mg/30mL	Oral	Chattem, Inc.	2013-12-02	Not applicable	US
Up and Up Allergy Relief	Capsule	25 mg/1	Oral	Target Corporation.	2009-06-10	Not applicable	US
Up and Up Allergy Relief	Tablet	25 mg/1	Oral	Target Corporation.	2009-06-12	Not applicable	US
Up and Up Childrens Allergy Medication	Liquid	12.5 mg/5mL	Oral	Target Corporation.	2009-07-08	Not applicable	US
Up and Up Dye-free Childrens Allergy	Syrup	12.5 mg/5mL	Oral	Target Corporation.	2015-02-12	Not applicable	US
Up and Up Nighttime Sleep-aid	Liquid	50 mg/30mL	Oral	Target Corporation.	2015-10-20	Not applicable	US
Vanamine Pd	Liquid	6.25 mg/mL	Oral	Gm Pharmaceuticals	2016-04-04	Not applicable	US
Vicks Qlearquil Nighttime Allergy Relief	Tablet	25 mg/1	Oral	Procter And Gamble	2014-03-01	Not applicable	US
Vicks Zzzquil Liquid and Liquicaps Combo	Kit		Oral	Procter And Gamble	2013-05-01	Not applicable	US
Wal Dryl	Solution	50 mg/20mL	Oral	Walgreen	2016-04-25	Not applicable	US
Wal Dryl Allergy Childrens	Solution	12.5 mg/5mL	Oral	Walgreen	1989-07-15	Not applicable	US
Wal Dryl Childrens Allergy	Liquid	12.5 mg/5mL	Oral	Walgreens	2015-04-30	Not applicable	US
Wal Som Nighttime Sleep Aid	Capsule	25 mg/1	Oral	Walgreen	2016-04-04	Not applicable	US
Wal-dryl	Capsule	25 mg/1	Oral	Walgreen	1990-03-15	Not applicable	US
Wal-dryl Allergy	Liquid	25 mg/10mL	Oral	Walgreens	2014-08-31	Not applicable	US
Wal-dryl Allergy	Tablet	25 mg/1	Oral	Walgreen	1990-03-02	Not applicable	US
Wal-dryl Allergy Dye-free	Capsule, liquid filled	25 mg/1	Oral	Walgreen	2015-03-01	Not applicable	US
Wal-sleep Z	Capsule, liquid filled	25 mg/1	Oral	Walgreen	2015-02-28	Not applicable	US
Wal-sleep Z	Tablet, film coated	25 mg/1	Oral	Walgreen	2015-07-24	Not applicable	US
Wal-sleep Z Diphenhydramine HCl / Sleep Aid	Capsule, gelatin coated	50 mg/21	Oral	Walgreen	2011-12-08	Not applicable	US
Wal-sleep Z Nighttime	Liquid	50 mg/30mL	Oral	Walgreen	2016-09-12	Not applicable	US
Wal-som	Tablet	25 mg/1	Oral	Walgreen	2012-08-22	Not applicable	US
X3 On-the-GO First Aid Topical Analgesic Itch Relief Spray	Spray	2.0 %	Topical	Natural Essentials, Inc	2012-04-24	Not applicable	Canada
Z-sleep	Capsule, liquid filled	25 mg/1	Oral	Mc Kesson (Health Mart)	2015-02-28	Not applicable	US
Zzz Sleep	Capsule, liquid filled	25 mg/1	Oral	Western Family Foods	2014-01-28	Not applicable	US
Zzz Sleep	Solution	50 mg/30mL	Oral	Western Family Foods	2013-08-29	Not applicable	US
Zzz Time	Capsule, liquid filled	25 mg/1	Oral	Meijer Distribution	2014-02-07	Not applicable	US
Zzzquil	Capsule, liquid filled	50 mg/21	Oral	Lil' Drug Store Products, Inc.	2015-12-23	Not applicable	US
Zzzquil	Capsule	25 mg	Oral	Procter And Gamble	2013-02-12	Not applicable	Canada
Zzzquil Alcohol Free	Liquid	50 mg	Oral	Procter And Gamble	Not applicable	Not applicable	Canada
Zzzquil Alcohol Free Nighttime Sleep-aid	Solution	50 mg/30mL	Oral	Procter And Gamble	2015-02-03	Not applicable	US
Zzzquil Liquid	Liquid	50 mg	Oral	Procter And Gamble	2014-08-15	Not applicable	Canada
Zzzquil Nightime Sleep-aid	Capsule, gelatin coated	25 mg/1	Oral	Navajo Manuracturing Company	2016-09-29	Not applicable	US
Zzzquil Nighttime Sleep-aid	Capsule, gelatin coated	50 mg/21	Oral	Procter And Gamble	2011-12-08	Not applicable	US
Zzzquil Nighttime Sleep-aid	Solution	50 mg/30mL	Oral	Procter And Gamble	2015-02-03	Not applicable	US
Zzzquil Nighttime Sleep-aid	Liquid	50 mg/30mL	Oral	Procter And Gamble	2011-12-08	Not applicable	US
Zzzsleep	Capsule, liquid filled	25 mg/1	Oral	Velocity Pharma	2013-10-15	Not applicable	US
Zzztime	Liquid	50 mg/30mL	Oral	Meijer Distribution	2013-07-08	Not applicable	US

Unapproved/Other Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Dicopanol	Kit		Oral	Fusion Pharmaceuticals LLC	2010-02-08	Not applicable	US
Dicopanol	Kit		Oral	California Pharmaceuticals, Llc	2016-01-01	Not applicable	US
Diphenhydramine HCl	Capsule	25 mg/1	Oral	Cardinal Health	2011-06-03	2017-07-18	US
Diphenhydramine HCl	Tablet	25 mg/1	Oral	Cardinal Health	2011-06-03	Not applicable	US

International Brands

Name	Company
Aleryl	Not Available
Alledryl	Not Available
Allerdryl	Valeant
Baramine	Not Available
Beldin	Not Available
Belix	Not Available
Benylan	Biogen
Dermodrin	Montavit
Desentol	Meda
Dibondrin	Montavit
Dimedrol	Zdorovie
Diphen	Wockhardt
Dormarex 2	Not Available
Genahist	Not Available
Histaxin	Meda
Hyrexin	Hyrex
Nytol Quickgels	GlaxoSmithKline
Restamin	Kowa Souyaku
Siladryl	Not Available
Silphen Cough	Not Available

Brand mixtures

Name	Labeller	Ingredients
7 Select Ibuprofen PM	7 Eleven	Diphenhydramine Ibuprofen
7 Select Night Time Severe Cold Cough and Flu	7 Eleven	Acetaminophen Diphenhydramine Phenylephrine
7 Select Night Time Severe Cold, Cough and Flu	7 Eleven	Acetaminophen Diphenhydramine Phenylephrine
7 Select Pain Relief PM	7 Eleven	Acetaminophen Diphenhydramine
7-select Advil PM	Lil' Drug Store Products, Inc.	Diphenhydramine Ibuprofen
Aceta-gesic	Rugby	Acetaminophen Diphenhydramine
Acetadryl	Physicians Science & Nature Inc.	Acetaminophen Diphenhydramine
Acetaminophen / Diphenhydramine 500/25 mg	Reliable 1 Laboratories	Acetaminophen Diphenhydramine
Acetaminophen and Diphenhydramine HCl	Rugby	Acetaminophen Diphenhydramine
Acetaminophen and Diphenhydramine Hydrochloride	Walmart Stores	Acetaminophen Diphenhydramine
Acetaminophen Diphenhydramine HCl	Chain Drug Consortium	Acetaminophen Diphenhydramine
Acetaminophen Extra Strength	Save A Lot Food Stores, Ltd.	Acetaminophen Diphenhydramine
Acetaminophen PM	Rite Aid	Acetaminophen Diphenhydramine
Acetaminophen PM Extra Strength	Safeway	Acetaminophen Diphenhydramine
Acetaminophen PM Rapid Release	AAA Pharmaceutical, Inc.	Acetaminophen Diphenhydramine
Acetaminophen Pmextra Strength Extra Strength	Mc Kesson (Health Mart)	Acetaminophen Diphenhydramine
Acetaminophen With Antihistamine Nighttime	Laboratoires Trianon Inc	Acetaminophen Diphenhydramine
Acetaminophen, Diphenhydramine Hydrochloride	AAA Pharmaceutical, Inc.	Acetaminophen Diphenhydramine
Acetaminophen, Diphenhydramine Hydrochloride, Phenylephrine Hydrochloride	AAA Pharmaceutical, Inc.	Acetaminophen Diphenhydramine Phenylephrine
Acetaminophen, Diphenhydramine Hyhrochloride, Phenylephrine Hydrochloride	AAA Pharmaceutical, Inc.	Acetaminophen Diphenhydramine Phenylephrine
Added Strength PM	Western Family Foods	Acetaminophen Diphenhydramine
Advil Cold & Flu	Pfizer Laboratories Div Pfizer Inc.	Diphenhydramine Ibuprofen
Advil Cold, Cough & Flu Nighttime	Pfizer Laboratories Div Pfizer Inc.	Diphenhydramine Ibuprofen
Advil Day/night Convenience Pack	Pfizer Laboratories Div Pfizer Inc.	Diphenhydramine Ibuprofen Ibuprofen
Advil Nighttime	Pfizer Laboratories Div Pfizer Inc.	Diphenhydramine Ibuprofen
Advil Pain & Head Cold Night	Pfizer Laboratories Div Pfizer Inc.	Diphenhydramine Ibuprofen
Advil PM	Lil' Drug Store Products, Inc.	Diphenhydramine Ibuprofen
Airacof	Centurion Labs	Codeine Diphenhydramine Phenylephrine
Alahist Lq	Poly Pharmaceuticals	Diphenhydramine Phenylephrine
Aleve Nighttime	Bayer Inc Consumer Care	Diphenhydramine Naproxen
Aleve PM	Bayer	Diphenhydramine Naproxen
Alka-seltzer Plus Night Severe Cold, Cough and Flu	Bayer Health Care Llc, Consumer Care	Acetaminophen Diphenhydramine Phenylephrine
Allegra Cooling Relief Anti-itch	Chattem, Inc.	Allantoin Diphenhydramine
Allegra Intensive Relief Anti-itch	Chattem, Inc.	Allantoin Diphenhydramine
Allergic Itch Relief	Value Merchandisers	Diphenhydramine Zinc
Allergy	Fred's	Acetaminophen Diphenhydramine
Allergy and Cold	Woonsocket Prescription Center, Incorporated	Acetaminophen Diphenhydramine Phenylephrine
Allergy and Cold PE	Select Brand	Acetaminophen Diphenhydramine Phenylephrine
Allergy and Cold Relief	Target Corporation.	Acetaminophen Diphenhydramine Phenylephrine
Allergy and Sinus Headache	Walmart Stores	Acetaminophen Diphenhydramine Phenylephrine
Allergy and Sinus Headache Relief Complete	Win Co Foods, Llc,	Acetaminophen Diphenhydramine Phenylephrine
Allergy Cream	Gw Pharmaceuticals Ltd.	Diphenhydramine Zinc
Allergy D	Cvs Health	Diphenhydramine Phenylephrine
Allergy Plus Severe Sinus Headache	Amerisource Bergen	Acetaminophen Diphenhydramine Phenylephrine
Allergy Plus Sinus Headache	Top Care	Acetaminophen Diphenhydramine Phenylephrine
Allergy Plus Sinus Relief	Rite Aid	Diphenhydramine Phenylephrine
Allergy Relief Plus Sinus Headache	Chain Drug Marketing Association	Acetaminophen Diphenhydramine Phenylephrine
Allergy Severe	L&R Distributors, Inc.	Acetaminophen Diphenhydramine
Allergy Sinus Headache Caplets	Tanta Pharmaceuticals Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Allergy Sinus Nighttime Relief	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Allergy, Sinus and Headache Relief Medication	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Pseudoephedrine
Allergy/sinus Headache	Dolgencorp	Acetaminophen Diphenhydramine Phenylephrine
Anti Itch	Meijer Distribution	Diphenhydramine Zinc
Anti Itch and Skin Protectant	Rite Aid	Diphenhydramine Zinc
Anti Itch Cream	Neopharm Co., Ltd	Diphenhydramine Zinc
Anti Itch Spray	H.J. Sutton Industries Ltd.	Diphenhydramine Zinc
Anti Itch Topical Analgesic	Chain Drug Marketing Association	Diphenhydramine Zinc
Anti-itch	Amerisource Bergen	Diphenhydramine Zinc
Anti-itch Cream	Trifecta Pharmaceuticals Usa, Llc.	Diphenhydramine Zinc
Anti-itch Extra Strength	Personal Care Products	Diphenhydramine Zinc
Anti-itch Maximum Strength	Fred's	Diphenhydramine Zinc
Anti-itch Plus Cream	Taro Pharmaceuticals, Inc.	Diphenhydramine Zinc
Anti-itch Wal-dryl	Walgreens	Diphenhydramine Zinc
Antiphlamine Coin Plaster	Hanul Trading Co., Ltd.	Camphor Diphenhydramine Menthol
Army and Airforce Exchange Ibuprofen PM	Army + Air Force Exchange Service	Diphenhydramine Ibuprofen
Assured Headache PM (aspirin Free)	Spirit Pharmaceuticals, Llc	Acetaminophen Diphenhydramine
Assured Night Time Cold and Cough	Bio Pharm, Inc.	Diphenhydramine Phenylephrine
Atopalm Itch Relief	Neopharm Co., Ltd	Diphenhydramine Zinc
Auroflu Flu and Sore Throat Warming Relief	Aurohealth LLC	Acetaminophen Diphenhydramine Phenylephrine
Auroflu Night Time Severe Cold and Cough	Aurohealth LLC	Acetaminophen Diphenhydramine Phenylephrine
Auroflu Night Time Severe Cold and Cough Warming Relief	Aurohealth LLC	Acetaminophen Diphenhydramine Phenylephrine
Aurophen Daytime Nighttime	Aurohealth LLC	Acetaminophen Diphenhydramine
Aurophen Pain Away Plus Sleep Aid	Aurohealth LLC	Acetaminophen Diphenhydramine
Aurophen PM Extra Strength	Aurohealth LLC	Acetaminophen Diphenhydramine
Balminil Codeine Night Time + Expectorant	Rougier Pharma Division Of Ratiopharm Inc	Ammonium chloride Codeine Diphenhydramine
Balminil Night-time	Teva	Ammonium chloride Dextromethorphan Diphenhydramine
Banophen	Major	Diphenhydramine Zinc
Bayer PM	Bayer Health Care Llc, Consumer Care	Acetylsalicylic acid Diphenhydramine
Benadryl Allergy & Cold Caplets	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Benadryl Allergy & Sinus	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Diphenhydramine Phenylephrine
Benadryl Allergy Plus Congestion	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	Diphenhydramine Phenylephrine
Benadryl Allergy Rapid Release	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Benadryl Allergy Sinus Caplets	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Benadryl Allergy Sinus Headache	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Benadryl Bug Bite Relief	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Diphenhydramine Zinc
Benadryl Decongestant Tablets	Warner Lambert Canada Inc.	Diphenhydramine Pseudoephedrine
Benadryl Extra Strength Itch Cooling	Johnson & Johnson	Diphenhydramine Zinc
Benadryl Extra Strength Itch Relief	Johnson & Johnson	Diphenhydramine Zinc
Benadryl Extra Strength Itch Stopping	Johnson & Johnson	Diphenhydramine Zinc
Benadryl Original Strength Itch Stopping	Johnson & Johnson	Diphenhydramine Zinc
Benadryl PE Total Extra Strength	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Benadryl PE Total Regular Strength	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Benadryl Readymist Itch Stopping	Johnson & Johnson	Diphenhydramine Zinc
Benadryl Spray	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Diphenhydramine Zinc
Benadryl Total	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Benylin All-IN-one Cold and Flu Night Extra Strength	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Benylin All-IN-one Cold and Flu Night PE Caplets	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Benylin Cold and Sinus Night Caplets	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Benylin for Children All-IN-one Cold & Fever Nightime	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Dextromethorphan Diphenhydramine
Berkley and Jensen Ibuprofen PM	BJWC	Diphenhydramine Ibuprofen
Best Choice Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Bi Electro Extra Strength	Genomma Lab	Acetaminophen Diphenhydramine
Bite and Itch	Weeks & Leo Co., Inc.	Diphenhydramine Pramocaine
Buckley's Complete Cough, Cold & Flu Night	The Buckley's Company	Acetaminophen Diphenhydramine Phenylephrine
Buckley's Complete PM - Nighttime	The Buckley's Company	Acetaminophen Diphenhydramine Menthol
Buckley's Night Time Mixture	The Buckley's Company	Diphenhydramine Menthol
Bye Bye Bite Lot	David D. Daniels Ltd.	Benzocaine Diphenhydramine Menthol
Calmylin	Teva	Ammonium chloride Codeine Diphenhydramine
Calmylin #4 Syr	Technilab Pharma Inc.	Ammonium chloride Dextromethorphan Diphenhydramine
Care One Flu and Severe Cold and Cough Nighttime	American Sales Company	Acetaminophen Diphenhydramine Phenylephrine
Care One Ibuprofen PM	American Sales Company	Diphenhydramine Ibuprofen
Care One Pain Relief and Pain Relief PM	American Sales Company	Acetaminophen Diphenhydramine
Care One Pain Relief PM Extra Strength	American Sales Company	Acetaminophen Diphenhydramine
Careall Non-aspirin PM Extra Strength	New World Imports	Acetaminophen Diphenhydramine
Careone Acetaminophen PM	American Sales Company	Acetaminophen Diphenhydramine
Careone Allergy	American Sales Company	Diphenhydramine Zinc
Careone Day Time Severe Cold Night Time Cold and Flu	American Sales Company	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Careone Ibuprofen PM	American Sales Company	Diphenhydramine Ibuprofen
Careone Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Careone Pain Relief Pain Relief PM	American Sales Company	Acetaminophen Diphenhydramine
Careone Pain Relief PM	American Sales Company	Acetaminophen Diphenhydramine
Careone Triacting Night Time Cold and Cough Childrens	American Sales Company	Diphenhydramine Phenylephrine
Children's Allergy and Sinus Medication Liquid Suspension	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Pseudoephedrine
Children's Benadryl-D Allergy & Sinus	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Diphenhydramine Pseudoephedrine
Children's Benadryl-D Syrup	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Diphenhydramine Phenylephrine
Children's Tylenol Allergy - D Chewable Tablets	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Children's Tylenol Allergy-D Suspension	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Children's Tylenol Cold and Cough Nighttime	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Dextromethorphan Diphenhydramine
Children's Tylenol Complete Cold, Cough & Fever Nighttime	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Dextromethorphan Diphenhydramine
Childrens Allergy Plus Congestion	Hyvee	Diphenhydramine Phenylephrine
Childrens Benadryl Allergy Plus Congestion	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	Diphenhydramine Phenylephrine
Childrens Benadryl-D Allergy and Sinus	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	Diphenhydramine Phenylephrine
Childrens Cold and Cough Nighttime	Walgreens	Diphenhydramine Phenylephrine
Childrens Cough and Cold Nighttime	Cvs Health	Diphenhydramine Phenylephrine
Childrens Delsym Cough Plus Cold Night Time	Reckitt Benckiser	Acetaminophen Diphenhydramine Phenylephrine
Childrens Dimetapp Multi-symptom Cold and Flu	Richmond Division of Wyeth	Acetaminophen Diphenhydramine Phenylephrine
Childrens Dimetapp Nighttime Cold and Congestion	Richmond Division Of Wyeth Llc, A Subsidiary Of Pfizer Inc.	Diphenhydramine Phenylephrine
Childrens Mucinex Multi Symptom Cold and Childrens Mucinex Night Time Multi Symptom Cold	Reckitt Benckiser	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Childrens Mucinex Night Time Multi-symptom Cold	Reckitt Benckiser	Acetaminophen Diphenhydramine Phenylephrine
Childrens Night Time Cold and Cough	Valu Merchandisers Company (Best Choice)	Diphenhydramine Phenylephrine
Childrens Night Time Cough and Cold Relief	Chain Drug Consortium	Diphenhydramine Phenylephrine
Childrens Nighttime Cold and Cough	Family Dollar (FAMILY WELLNESS)	Diphenhydramine Phenylephrine
Childrens Triacting	Western Family Foods	Diphenhydramine Phenylephrine
Childrens Triacting Night Time Cold and Cough	Amerisource Bergen (Good Neighbor Pharmacy) 46122	Diphenhydramine Phenylephrine
Childrens Triacting Nighttime Cold and Cough	Quality Choice (Chain Drug Marketing Association, Inc.)	Diphenhydramine Phenylephrine
Childrens Triacting Nighttime Cold and Cough Readyincase	P & L Development, LLC	Diphenhydramine Phenylephrine
Cold & Flu-IN-one	Vita Health Products Inc	Acetaminophen Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Pseudoephedrine Pseudoephedrine
Cold and Congestion Childrens Nighttime	Walgreens	Diphenhydramine Phenylephrine
Cold and Cough	Meijer Distribution	Diphenhydramine Phenylephrine
Cold and Cough Multi-symptom Daytime / Nighttime	Walgreen	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Cold and Flu	Hyvee	Acetaminophen Diphenhydramine Phenylephrine
Cold and Flu Nighttime	Western Family Foods	Acetaminophen Diphenhydramine Phenylephrine
Cold and Flu Relief	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Phenylephrine
Cold-eeze Childrens Nighttime Cold and Cough Relief	Pro Phase Labs, Inc.	Acetaminophen Diphenhydramine Phenylephrine
Cold-eeze Nighttime Cold and Flu	Pro Phase Labs, Inc.	Acetaminophen Diphenhydramine Phenylephrine
Complete One Cold and Flu Nightime Extra Strength Tablets	Tanta Pharmaceuticals Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Complete One Cold and Flu PE Night	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Phenylephrine
Conrx PM	Eagle Distributors,Inc.	Acetaminophen Diphenhydramine
Contac Cold	Glaxosmithkline Inc	Acetaminophen Diphenhydramine
Contac Cold and Fever Caplets	Glaxosmithkline Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Contac Day & Night Sinus/allergy Caplet	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	Acetaminophen Acetaminophen Diphenhydramine Pseudoephedrine Pseudoephedrine
Contac Night Caplets	Glaxosmithkline Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Contac-C Ext.stren.night Time Cough,cold&flu	Smithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.	Acetaminophen Diphenhydramine Pseudoephedrine
Contrast Allergy Premed Pack	Shertech Laboratories, Llc	Diphenhydramine Prednisone
Coricidin II Night Time Cold and Flu	Schering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.	Acetaminophen Diphenhydramine
Cough Syr W Codeine Diphenhyd HCl & Ammon Cl	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	Ammonium chloride Codeine Diphenhydramine
Cough Syrup	Teva	Ammonium chloride Codeine Diphenhydramine
Cough, Cold & Flu	Vita Health Products Inc	Acetaminophen Acetaminophen Dextromethorphan Diphenhydramine Pseudoephedrine Pseudoephedrine
Cough, Cold and Flu Nightime Caplets	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Cough, Cold and Flu Relief Complete Night Super Strength	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Pseudoephedrine
Counteract Night	Melaleuca, Inc.	Acetaminophen Diphenhydramine Phenylephrine
Counteract PM	Melaleuca, Inc.	Acetaminophen Diphenhydramine
Cvs Cough and Severe Cold Night Time Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Cvs Effervescent Pain Relief PM	Cvs Health	Acetaminophen Diphenhydramine
Cvs Extra Strength Itch Relief	Cvs Health	Diphenhydramine Zinc
Cvs Health Medication and Topical Refill Pouch	Cvs Health	Acetaminophen Acetylsalicylic acid Acetylsalicylic acid Bacitracin Diphenhydramine Isopropyl Alcohol Neomycin Polymyxin B Sulfate
Cvs Health Nighttime Severe Cough and Cold Nighttime Severe Cold and Cough	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Cvs Pharmacy Nighttime Severe Cough and Cold Honey Lemon Infused With Chamomile and White Tea Flavors	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Damylin Avec Codeine Sirop	Laboratoire Atlas Inc	Ammonium chloride Codeine Diphenhydramine
Damylin With Codeine Syrup	Laboratoire Riva Inc	Ammonium chloride Codeine Diphenhydramine
Day and Night Cold	AAA Pharmaceutical, Inc.	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Day and Night Cold PE	Meijer	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Day and Night Sinus Maximum Strength	Walmart Stores	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Daytime and Nighttime Pain Relief	Cvs Health	Acetaminophen Diphenhydramine
Daytime Cold and Cough and Nighttime Cold and Congestion Childrens	Target Corporation.	Brompheniramine Dextromethorphan Diphenhydramine Phenylephrine Phenylephrine
Daytime Mucus Relief Nighttime Cold and Flu	Hyvee	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Daytime Nighttime Cold and Cough Childrens	Walgreens	Dextromethorphan Diphenhydramine Phenylephrine Phenylephrine
Daytime Nighttime Severe Cough and Cold	Cvs Health	Acetaminophen Dextromethorphan Diphenhydramine Phenylephrine
Daytime Severe Cold and Cough Nighttime Severe Cold and Cough	Cvs Health	Acetaminophen Dextromethorphan Diphenhydramine Phenylephrine
Daytime Sinus Nighttime Sinus Maximum Strength	Target Corporation.	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Delsym Childrens Night Time Cough and Cold	Reckitt Benckiser	Diphenhydramine Phenylephrine
Delsym Cough Plus Cold Night Time	Reckitt Benckiser	Acetaminophen Diphenhydramine Phenylephrine
Delsym Night Time Cough and Cold	Reckitt Benckiser	Diphenhydramine Phenylephrine
Dermamine Extra Strength Itch Stopping	Natureplex, LLC	Diphenhydramine Zinc
Dermarest Plus - Gel	Del Pharmaceuticals Inc.	Diphenhydramine Menthol
Dg Health Anti Itch	Dolgencorp	Diphenhydramine Zinc
Dg Health Flu and Severe Cold and Cough	Dolgencorp	Acetaminophen Diphenhydramine Phenylephrine
Dg Health Headache Relief PM	Dolgencorp	Acetaminophen Diphenhydramine
Dg Health Ibuprofen PM	Dolgencorp	Diphenhydramine Ibuprofen
Dg Health Pain Relief PM	Dolgencorp	Acetaminophen Diphenhydramine
Dg Health Pain Relief PM Extra Strength	Dolgencorp	Acetaminophen Diphenhydramine
Dg Health Triacting Night Time Cold and Cough	Dolgencorp	Diphenhydramine Phenylephrine
Dg Health Tussin	Dolgencorp	Acetaminophen Diphenhydramine Phenylephrine
Diabetic Tussin Nighttime Cold and Flu	Health Care Products	Acetaminophen Dextromethorphan Diphenhydramine
Diphenhydramine	Physicians Total Care, Inc.	Diphenhydramine Zinc
Diphenhydramine D	Nexmed Usa Inc	Diphenhydramine Zinc
Diphenhydramine HCl and Zinc Acetate	Perrigo New York Inc.	Diphenhydramine Zinc
Diphenhydramine Hydrochloride and Zinc Acetate	Taro Pharmaceuticals U.S.A., Inc.	Diphenhydramine Zinc
DM Cough Syrup	Prodemdis Enr.	Ammonium chloride Dextromethorphan Diphenhydramine
DM Plus Cough Syrup	Technilab Pharma Inc.	Ammonium chloride Dextromethorphan Diphenhydramine
DM Syrup	Technilab Pharma Inc.	Ammonium chloride Dextromethorphan Diphenhydramine
Doctor Manzanilla Allergy and Decongestant Relief	Mid Valley Pharmaceuticals Llc	Diphenhydramine Phenylephrine
Doctor Manzanilla Cough and Cold	Mid Valley Pharmaceuticals Llc	Diphenhydramine Phenylephrine
Doctor Manzanilla Cough Suppressant and Nasal Decongestant	Mid Valley Pharmaceuticals Llc	Diphenhydramine Phenylephrine
Dr. Cocoa for Children Nighttime Cough + Cold	Infirst Healthcare	Diphenhydramine Phenylephrine
Dr. Cocoa Nighttime Cough and Cold	Infirst Healthcare	Diphenhydramine Phenylephrine
Dr. Sheffield Anti Itch Cream	Faria Llc Dba Sheffield Pharmaceutcials	Diphenhydramine Zinc
Easy Care First Aid Kit - Comprehensive	Tender Corporation	Acetaminophen Acetylsalicylic acid Ammonia Benzalkonium Diphenhydramine Ibuprofen Lidocaine
Equaline Anti Itch	Supervalu	Diphenhydramine Zinc
Equaline Anti-itch	Supervalu	Diphenhydramine Zinc
Equaline Flu and Severe Cold and Cough	Supervalu	Acetaminophen Diphenhydramine Phenylephrine
Equaline Ibuprofen PM	Supervalu	Diphenhydramine Ibuprofen
Equaline Night Time Cold and Cough Childrens	Supervalu	Diphenhydramine Phenylephrine
Equaline Pain Relief PM	Supervalu	Acetaminophen Diphenhydramine
Equaline Pain Relief PM Extra Strength	Supervalu	Acetaminophen Diphenhydramine
Equate Anti Itch	Walmart Stores	Diphenhydramine Zinc
Equate Flu and Severe Cold and Cough	Walmart Stores	Acetaminophen Diphenhydramine Phenylephrine
Equate Ibuprofen PM	Walmart Stores	Diphenhydramine Ibuprofen
Equate Night Time Cold and Cough Childrens	Walmart Stores	Diphenhydramine Phenylephrine
Ergodryl Cap	Erfa Canada 2012 Inc	Caffeine Diphenhydramine Ergotamine
Excedrin PM	Novartis	Acetaminophen Diphenhydramine
Excedrin PM Triple Action Caplets	Glaxo Smith Kline Consumer Healthcare Holdings (Us) Llc	Acetaminophen Acetylsalicylic acid Diphenhydramine
Extra Strength Acetaminophen PM	Mc Kesson	Acetaminophen Diphenhydramine
Extra Strength Allergy Total	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Extra Strength Flu Relief Nightime	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Extra Strength Mapap PM	Major	Acetaminophen Diphenhydramine
Extra Strength Multi-symptom Relief Sugar Free	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Phenylephrine
Extra Strength Neocitran Flu Syrup	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Extra Strength Neocitran Total Symptom Relief - Sugar Free	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Extra Strength Night Time Pain Medicine	Gericare Pharmaceuticals	Acetaminophen Diphenhydramine
Extra Strength Nighttime Pain Reliever / Sleep Aid	Teva	Acetaminophen Diphenhydramine
Extra Strength Non-aspirin PM	Save A Lot Food Stores, Ltd.	Acetaminophen Diphenhydramine
Extra Strength Pain Relief PM	Discount Drug Mart	Acetaminophen Diphenhydramine
Extra Strength Pain Reliever PM	Supervalu	Acetaminophen Diphenhydramine
Extra Strength PM Pain Relief	Dolgencorp	Acetaminophen Diphenhydramine
Extra Strength Sinus Relief Nighttime	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Extra Strength Total Symptom Relief Sugar-free	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Phenylephrine
Extra Strength Tylenol Allergy and Cough	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine
Extra Strength Tylenol Allergy Sinus Nighttime Caplet	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Extra Strength Tylenol Complete Cold, Cough & Flu Nighttime	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Extra Strength Tylenol Flu Nighttime Gelcap	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Extra Strength Tylenol Nighttime	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine
Extra Strength Tylenol Pain and Head Cold Night	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine
Extra Strength Tylenol Pain and Head Cold Night Rapid Release	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine
Extra Strength Wal-dryl Itch Relief	Walgreen	Diphenhydramine Zinc
Facol Cold and Flu Day and Night	Jw Holdings	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Facol Cold and Flu Night	Jw Holdings	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Family Care Anti-itch	United Exchange Corporation	Diphenhydramine Zinc
Family Dollar Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Family Wellness	Zhejiang Jingwei Pharmaceutical Co., Ltd.	Diphenhydramine Zinc
Fast Maximum Night Time Cold and Flu	Amerisource Bergen	Acetaminophen Diphenhydramine Phenylephrine
First Dukes Mouthwash Compounding	Cutis Pharma, Inc.	Diphenhydramine Hydrocortisone Nystatin
First Marys Mouthwash Compounding	Cutis Pharma, Inc.	Diphenhydramine Hydrocortisone Nystatin Tetracycline
Flu and Severe Cold and Cough	Safeway	Acetaminophen Diphenhydramine Phenylephrine
Flu and Severe Cold and Cough Night Time	Meijer Distribution	Acetaminophen Diphenhydramine Phenylephrine
Flu and Severe Cold and Cough Nighttime	Safeway	Acetaminophen Diphenhydramine Phenylephrine
Flu and Severe Cold and Cough Nite Time	Kroger	Acetaminophen Diphenhydramine Phenylephrine
Flu and Severe Cold Nighttime Relief	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Flu and Sore Throat	Select Brand Dist.	Acetaminophen Diphenhydramine Phenylephrine
Flu and Sore Throat Relief	Chain Drug Consortium	Acetaminophen Diphenhydramine Phenylephrine
Flu Relief	Vita Health Products Inc	Acetaminophen Acetaminophen Dextromethorphan Diphenhydramine Pseudoephedrine Pseudoephedrine
Flu Relief Therapy	Walgreens	Acetaminophen Diphenhydramine Phenylephrine
Flu Relief Therapy Night Time	Good Neighbor Pharmacy	Acetaminophen Diphenhydramine Phenylephrine
Flu Relief Therapy Nighttime	Topcare (Topco Associates Llc)	Acetaminophen Diphenhydramine Phenylephrine
Flu Relief Therapy Nighttime Severe Cold	Select Brand Dist.	Acetaminophen Diphenhydramine Phenylephrine
Flu Relief Therapy Severe Cough and Cold Nighttime	Fred's	Acetaminophen Diphenhydramine Phenylephrine
Flu, Cough & Cold Complete Day and Night	Vita Health Products Inc	Acetaminophen Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Pseudoephedrine Pseudoephedrine
Flu, Cough and Sore Throat	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Formu Care Flu and Severe Cold and Cough Night Time	Access Business Group	Acetaminophen Diphenhydramine Phenylephrine
Fulton Street Market Nighttime Flu and Severe Cold and Cough	Access Business Group	Acetaminophen Diphenhydramine Phenylephrine
Good Neighbor Pharmacy Cold and Flu Night Time	Amerisource Bergen	Acetaminophen Diphenhydramine Phenylephrine
Good Neighbor Pharmacy Flu and Severe Cold and Cough	Amerisource Bergen	Acetaminophen Diphenhydramine Phenylephrine
Good Neighbor Pharmacy Flu and Severe Cold and Cough Nighttime	Amerisource Bergen	Acetaminophen Diphenhydramine Phenylephrine
Good Neighbor Pharmacy Headache PM	Amerisource Bergen	Acetaminophen Diphenhydramine
Good Neighbor Pharmacy Ibuprofen PM	Amerisource Bergen	Diphenhydramine Ibuprofen
Good Neighbor Pharmacy Itch Relief Extra Strength	Amerisource Bergen Drug Corportaion	Diphenhydramine Zinc
Good Neighbor Pharmacy Mucus Relief Severe Cold Cold and Flu Night Time	Amerisource Bergen	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Good Neighbor Pharmacy Pain Relief and Pain Relief PM	Amerisource Bergen	Acetaminophen Diphenhydramine
Good Neighbor Pharmacy Pain Relief PM	Amerisource Bergen	Acetaminophen Diphenhydramine
Good Neighbor Pharmacy Sinus Relief Day Time Night Time	Amerisource Bergen	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Good Sense Flu and Severe Cold and Cough	L. Perrigo Company	Acetaminophen Diphenhydramine Phenylephrine
Good Sense Flu and Severe Cold and Cough Nighttime	L. Perrigo Company	Acetaminophen Diphenhydramine Phenylephrine
Good Sense Headache PM	L. Perrigo Company	Acetaminophen Diphenhydramine
Good Sense Ibuprofen PM	L. Perrigo Company	Diphenhydramine Ibuprofen
Good Sense Itch Relief	L. Perrigo Company	Diphenhydramine Zinc
Good Sense Pain Relief PM	L. Perrigo Company	Acetaminophen Diphenhydramine
Good Sense Pain Relief PM Extra Strength	L. Perrigo Company	Acetaminophen Diphenhydramine
Goodys PM Pain Reliever	Medtech Laboratories, Inc.	Acetaminophen Diphenhydramine
Harris Teeter Acetaminophen PM	Harris Teeter	Acetaminophen Diphenhydramine
Harris Teeter Anti-itch	Harris Teeter	Diphenhydramine Zinc
Harris Teeter Ibuprofen PM	Harris Teeter	Diphenhydramine Ibuprofen
Harris Teeter Sinus Relief	Harris Teeter	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Headache Formula PM	Supervalu	Acetaminophen Diphenhydramine
Headache PM	Hyvee	Acetaminophen Diphenhydramine
Headache PM Aspirin Free	Greenbrier International, Inc.	Acetaminophen Diphenhydramine
Headache PM Formula	Hyvee	Acetaminophen Diphenhydramine
Headache Relief PM	Dolgencorp	Acetaminophen Diphenhydramine
Health Mart Ibuprofen PM	Mc Kesson	Diphenhydramine Ibuprofen
Health Mart Severe Cold Cough and Flu	Mc Kesson	Acetaminophen Diphenhydramine Phenylephrine
Healthy Accents Anti Itch	Dza Brands,	Diphenhydramine Zinc
Healthy Accents Ibuprofen PM	Dza Brands,	Diphenhydramine Ibuprofen
Healthy Accents Pain Relief PM	Dza Brands,	Acetaminophen Diphenhydramine
Healthy Accents Pain Relief PM Extra Strength	Dza Brands,	Acetaminophen Diphenhydramine
Healthy Accents Severe Cold	Dza Brands,	Acetaminophen Diphenhydramine Phenylephrine
Healthy Accents Sinus Relief	Dza Brands,	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Healthy Mama Eazzze The Pain	MATERNAL SCIENCE, LLC	Acetaminophen Diphenhydramine
Ibuprofen and Diphenhydramine Citrate	Dr Reddy's Laboratories	Diphenhydramine Ibuprofen
Ibuprofen and Diphenhydramine HCl	P & L Development Of New York Corporation	Diphenhydramine Ibuprofen
Ibuprofen Daytime, Ibuprofen Nighttime	Vita Health Products Inc	Diphenhydramine Ibuprofen Ibuprofen
Ibuprofen Nighttime	Vita Health Products Inc	Diphenhydramine Ibuprofen
Ibuprofen PM	Walgreen	Diphenhydramine Ibuprofen
Instant Itch Relief Cvs	Cvs Health	Diphenhydramine Zinc
Itch Rel Spr Cvs	Cvs Health	Diphenhydramine Zinc
Itch Relief	H.E.B.	Diphenhydramine Zinc
Itch Relief Cream	Pharmacy Vlaue Alliance Llc	Diphenhydramine Zinc
Itch Relief Extra Strength	Safeway	Diphenhydramine Zinc
Itch Relief Spray	Tender Corporation	Diphenhydramine Zinc
Itch Relief Stick	Tender Corporation	Diphenhydramine Zinc
Itch Stopping	Hyvee	Diphenhydramine Zinc
Ivarest	Blistex Corporation	Benzyl alcohol Diphenhydramine Zinc oxide
Jack & Jill Bedtime Cough & Cold	The Buckley's Company	Diphenhydramine Phenylephrine
Kinkan Cool	Kinkando Co., Ltd.	Diphenhydramine Menthol
Kmart - Pain Relief PM	Kmart Corporation	Acetaminophen Diphenhydramine
Kroger Nitetime Cold and Flu	Kroger	Choline Diphenhydramine Phenylephrine
Kroger Nitetime Flu Plus Severe Cold and Cough	Kroger	Acetaminophen Diphenhydramine Phenylephrine
Leader Anti Itch Maximum Strength	Cardinal Health	Diphenhydramine Zinc
Leader Cold and Flu	Cardinal Health	Acetaminophen Diphenhydramine Phenylephrine
Leader Flu and Severe Cold and Cough	Cardinal Health	Acetaminophen Diphenhydramine Phenylephrine
Leader Headache PM Formula	Cardinal Health	Acetaminophen Diphenhydramine
Leader Headache Relief PM	Cardinal Health	Acetaminophen Diphenhydramine
Leader Ibuprofen PM	Cardinal Health	Diphenhydramine Ibuprofen
Leader Night Time Cough and Cold Childrens Triacting	Cardinal Health	Diphenhydramine Phenylephrine
Leader Pain Reliever PM	Cardinal Health	Acetaminophen Diphenhydramine
Legatrin PM	Lil' Drug Store Products, Inc.	Acetaminophen Diphenhydramine
Live Better Anti-itch	The Great Atlantic + Pacific Tea Company	Diphenhydramine Zinc
Lucky Itch Stopping	Delta Brands, Inc	Diphenhydramine Zinc
Meijer Anti-itch	Meijer Distribution	Diphenhydramine Zinc
Meijer Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Midol PM	Bayer	Acetaminophen Diphenhydramine
Motrin PM	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	Diphenhydramine Ibuprofen
Mountain Series Weekender Medical	Tender Corporation Dba Adventure Medical Kits	Acetaminophen Acetylsalicylic acid Bacitracin Benzalkonium Diphenhydramine Ibuprofen Neomycin Polymyxin B Sulfate Povidone-iodine
Mucinex Fast-max Day Time Severe Cold and Mucinex Fast-max Night Time Cold and Flu Maximum Strength	Reckitt Benckiser	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Mucinex Fast-max Day Time Severe Congestion and Cough - Mucinex Fast-max Night Time Cold and Flu Maximum Strength	Reckitt Benckiser	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Mucinex Fast-max Day Time Severe Congestion and Cough and Mucinex Fast-max Night Time Cold and Flu Maximum Strength	Reckitt Benckiser	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Mucinex Fast-max Night Time Cold and Flu	Reckitt Benckiser	Acetaminophen Diphenhydramine Phenylephrine
Mucinex Fast-max Night Time Cold and Flu Clear and Cool	Reckitt Benckiser	Acetaminophen Diphenhydramine Phenylephrine
Mucinex Fast-max Severe Congestion and Cough Clear and Cool and Mucinex Fast-max Night Time Cold and Flu Clear and Cool	Reckitt Benckiser	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Mucinex Sinus-max Day Night Maximum Strength	Reckitt Benckiser	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Mucinex Sinus-max Day Time Severe Congestion Relief and Mucinex Sinus-max Night Time Congestion and Cough Maximum Strength	Reckitt Benckiser	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Mucinex Sinus-max Night Time Congestion and Cough	Reckitt Benckiser	Acetaminophen Diphenhydramine Phenylephrine
Mucus Relief Day Time and Night Time	H.E.B.	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Mucus Relief Daytime/nighttime	Walgreen	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Mucus Relief Daytime/nighttime/maximum Strength	Walgreen	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine Phenylephrine
Mucus Relief Sinus Congestion Daytime Nighttime Maximum Strength	Walgreen	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Mucus Relief Sinus Day and Night	H.E.B.	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Multi Symptom Severe Cold	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Multi Symptom Severe Cold and Nighttime Severe Cold and Cough	Cvs Health	Acetaminophen Dextromethorphan Diphenhydramine Phenylephrine
Multi-symptom Cold and Cough Daytime Nighttime	Rite Aid	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Multi-symptom Wal-phed PE	Walgreen	Acetaminophen Diphenhydramine Phenylephrine
Neocitran Extra Strength Total Cold Night	Glaxosmithkline Inc	Acetaminophen Diphenhydramine Phenylephrine
Neocitran Thin Strips Nighttime Cough and Cold	Novartis	Diphenhydramine Phenylephrine
Neocitran Total Cold Night	Glaxosmithkline Inc	Acetaminophen Diphenhydramine Phenylephrine
Night Time Cold & Flu Liquid	Reckitt Benckiser	Acetaminophen Diphenhydramine Phenylephrine
Night Time Cold and Cough Childrens	Valu Merchandisers Company (Best Choice)	Diphenhydramine Phenylephrine
Night Time Cough and Cold Relief	Chain Drug Consortium	Diphenhydramine Phenylephrine
Night Time Severe Cold and Cough	Family Dollar	Acetaminophen Diphenhydramine Phenylephrine
Night Time Severe Cold and Cough Relief	Chain Drug Consortium	Acetaminophen Diphenhydramine Phenylephrine
Nighttime Cold and Flu Maximum Strength	Walgreens	Acetaminophen Diphenhydramine Phenylephrine
Nighttime Cold and Flu Relief Therapy	Quality Choice (Chain Drug Marketing Association, Inc.)	Acetaminophen Diphenhydramine Phenylephrine
Nighttime Cold and Flu-IN-one Extra Strength	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Nighttime Cold, Cough & Flu	Apotex Corporation	Diphenhydramine Ibuprofen
Nighttime Flu and Severe	Taro Pharmaceuticals U.S.A., Inc.	Acetaminophen Diphenhydramine Phenylephrine
Nighttime Flu Relief Therapy Severe Cold	Amerisource Bergen (Good Neighbor Pharmacy) 46122	Acetaminophen Diphenhydramine Phenylephrine
Nighttime Flu, Cough & Cold Complete Relief Extra Strength	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Nighttime Pain Plus Sleep	Chain Drug Consortium	Acetaminophen Diphenhydramine
Nighttime Pain Relief	Apotex Corporation	Diphenhydramine Ibuprofen
Nighttime Pain Reliever	Marcan Pharmaceuticals Inc	Diphenhydramine Ibuprofen
Nighttime Pain Reliever PM	Walgreen	Acetaminophen Diphenhydramine
Nighttime Severe Cough and Cold	Cardinal Health	Acetaminophen Diphenhydramine Phenylephrine
Nighttime Super Strength Contac Complete	Glaxosmithkline Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Nighttime Symptom Relief Extra Strength for Symptoms Of Cold and Cough	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Phenylephrine
Nighttime Total Cold and Flu	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Nite Time Cold and Cough	Accudial Pharmaceutical, Inc.	Diphenhydramine Phenylephrine
Nite Time Cold and Cough Childrens	Kroger	Diphenhydramine Phenylephrine
Non Aspirin PM Extra Strength	Fred's	Acetaminophen Diphenhydramine
Non-aspirin PM Extra Strength	New World Imports	Acetaminophen Diphenhydramine
Our Family Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Pain Away Plus Sleep Aid	Chain Drug Consortium	Acetaminophen Diphenhydramine
Pain Plus Sleep	Amerisource Bergen	Acetaminophen Diphenhydramine
Pain Relief Acetaminophen PM Extra Strength	Rite Aid	Acetaminophen Diphenhydramine
Pain Relief and Pain Relief PM	Meijer Distribution	Acetaminophen Diphenhydramine
Pain Relief Medicine PM	Army + Air Force Exchange Service	Acetaminophen Diphenhydramine
Pain Relief Pain Relief PM	Meijer Distribution	Acetaminophen Diphenhydramine
Pain Relief Plus Sleep Aid	Dolgencorp	Acetaminophen Diphenhydramine
Pain Relief PM	Target Corporation.	Acetaminophen Diphenhydramine
Pain Relief PM Extra Relief	Greenbrier International, Inc.	Acetaminophen Diphenhydramine
Pain Relief PM Extra Strength	Walgreens	Acetaminophen Diphenhydramine
Pain Relief PM Extra Strength Aspirin Free	Safeway	Acetaminophen Diphenhydramine
Pain Relief PM Nightime Sleep Aid	Select Corporation	Acetaminophen Diphenhydramine
Pain Relief PM Rapid Release	Meijer Distribution	Acetaminophen Diphenhydramine
Pain Reliever Extra Strength PM	L&R Distributors, Inc.	Acetaminophen Diphenhydramine
Pain Reliever PM	Nash Finch	Acetaminophen Diphenhydramine
Pain Reliever PM Extra Strength	Walgreens	Acetaminophen Diphenhydramine
Pain Reliever Sleep Aid Extra Strength	Family Dollar (FAMILY WELLNESS)	Acetaminophen Diphenhydramine
Panadol PM	Glaxo Smith Kline Consumer Healthcare Holdings (Us) Llc	Acetaminophen Diphenhydramine
Pediacare Childrens Allergy and Cold	Blacksmith Brands, Inc.	Diphenhydramine Phenylephrine
Pediacare Childrens Nighttime Multi Symptom Cold	Medtech Laboratories, Inc.	Diphenhydramine Phenylephrine
Percogesic Extra Strength	Medtech Laboratories, Inc.	Acetaminophen Diphenhydramine
Percogesic Original Strength	Medtech Laboratories, Inc.	Acetaminophen Diphenhydramine
Plus Pharma Extra Strength Acetaminophen PM	Gemini Pharmaceuticals, Inc. dba Plus Pharma	Acetaminophen Diphenhydramine
PM Acetaminophen	New World Imports	Acetaminophen Diphenhydramine
PM Get Relief	Eagle Distributors,Inc.	Acetaminophen Diphenhydramine
PM Pain Reliever	Rite Aid	Acetaminophen Diphenhydramine
Preferred Plus Cold and Flu Night Time	Kinray	Acetaminophen Diphenhydramine Phenylephrine
Preferred Plus Severe Cold Cough and Flu	Kinray	Acetaminophen Diphenhydramine Phenylephrine
Preferred Plus Severe Cold Day Time Cold and Flu Night Time	Kinray	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Preferred Plus Sinus Relief Day Tiime Night Time	Kinray	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Premier Value Allergy	TAI GUK PHARM. CO., LTD.	Diphenhydramine Zinc
Premier Value Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Publix Allergy	Publix Supermarkets, Inc.	Diphenhydramine Zinc
Pulmorex DM Syr	Prodemdis Enr.	Ammonium chloride Dextromethorphan Diphenhydramine
Pulmorex Expectorant Liq	Nutribon (1986) Inc.	Ammonium chloride Diphenhydramine Guaifenesin
Quality Choice Extra Strength Anti Itch	Chain Drug Marketing Association	Diphenhydramine Zinc
Quality Choice Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Quality Choice Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Chain Drug Marketing Association	Acetaminophen Diphenhydramine Phenylephrine
Rapid Release Acetaminophen PM Extra Strength	Costco Wholesale	Acetaminophen Diphenhydramine
Rapid Release Pain Relief PM	Meijer Distribution	Acetaminophen Diphenhydramine
Reeses Onetab Allergy and Sinus	Reese Pharmaceutical Company	Acetaminophen Diphenhydramine Phenylephrine
Reeses Onetab Cold and Flu	Reese Pharmaceutical Company	Acetaminophen Diphenhydramine Phenylephrine
Regular Strength Flu Relief Nightime	Vita Health Products Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Rite Aid Maximum Strength Itch Relief	Rite Aid	Diphenhydramine Zinc
Rite Aid Night Time Severe Cold and Cough Honey Lemon With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Rite Aid Nighttime Severe Cold and Cough Relief	Rite Aid	Acetaminophen Diphenhydramine Phenylephrine
Robitussin Night Time Cough and Cold	Richmond Division of Wyeth	Diphenhydramine Phenylephrine
Robitussin Peak Cold Nighttime Multi-symptom Cold	Richmond Division of Wyeth	Acetaminophen Diphenhydramine Phenylephrine
Robitussin Severe Multi-symptom Cough Cold Flu Nighttime	Richmond Division of Wyeth	Acetaminophen Diphenhydramine Phenylephrine
Rugby Acetaminophen 500 Mg and Diphenhydramine HCl 25 Mg Pain Reliever/sleep Aid	Rugby	Acetaminophen Diphenhydramine
Rx Act Flu and Severe Cold and Cough Nighttime	H.E.B.	Acetaminophen Diphenhydramine Phenylephrine
Rx Act Ibuprofen PM	H.E.B.	Diphenhydramine Ibuprofen
Rx Act Pain Relief PM	H.E.B.	Acetaminophen Diphenhydramine
Rx Act Pain Relief PM Extra Strengh Rapid Release	H.E.B.	Acetaminophen Diphenhydramine
Salonpas Medicated Plaster	Hisamitsu Pharmaceutical Co., Inc.	Borneol Camphor Diphenhydramine Menthol Methyl salicylate Olive oil Rosin Thymol Zinc oxide
Sanatos Severe Cold and Cough Nighttime	Pharmadel LLC	Acetaminophen Diphenhydramine Phenylephrine
Select Brand Itch Relief	Select Brand	Diphenhydramine Zinc
Severe Allergy	Walgreen	Acetaminophen Diphenhydramine
Severe Allergy and Sinus Headache	Rite Aid	Acetaminophen Diphenhydramine Phenylephrine
Severe Allergy and Sinus Headache Maximum Strength	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Severe Allergy Plus Sinus Headache	Top Care	Acetaminophen Diphenhydramine Phenylephrine
Severe Allergy Plus Sinus Headache Maximum Strength	Meijer	Acetaminophen Diphenhydramine Phenylephrine
Severe Allergy Relief Plus Sinus Headache	Chain Drug Marketing Association	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold	Chain Drug Marketing Association	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold and Cough Night Time	Dolgencorp, Inc. (Dollar General & Rexall)	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold and Cough Relief Nighttime	H.E.B.	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold and Sinus Relief PE	Rite Aid	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold Cough and Flu	Hyvee	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold Cough and Flu Relief Nighttime	Rite Aid	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold Daytime Cold and Flu Nighttime	Western Family Foods	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Severe Cold PE	Select Brand	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold PE Multi-symptom	Supervalu	Acetaminophen Diphenhydramine Phenylephrine
Severe Cold Relief PE	Woonsocket Prescription Center, Incorporated	Acetaminophen Diphenhydramine Phenylephrine
Severe Congestion and Cough/ Cold and Flu Daytime/nighttime	Rite Aid	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Severe Congestion and Cough/cold and Flu Daytime/nighttime/maximum Strength	Cvs Health	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Severe Cough and Cold	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Shopko Anti-itch	Shopko Stores Operating	Diphenhydramine Zinc
Shopright Childrens Nighttime Cold and Cough	Wakfern Food Corporation	Diphenhydramine Phenylephrine
Shoprite Anti Itch	Wakfern Food Corporation	Diphenhydramine Zinc
Shoprite Ibuprofen PM	Wakfern Food Corporation	Diphenhydramine Ibuprofen
Shoprite Nighttime Flu Plus Severe Cold and Cough	Wakfern Food Corporation	Acetaminophen Diphenhydramine Phenylephrine
Shoprite Non Aspirin	Wakfern Food Corporation	Acetaminophen Diphenhydramine
Shoprite Pain Relief PM	Wakfern Food Corporation	Acetaminophen Diphenhydramine
Signature Care Ibuprofen PM	Safeway	Diphenhydramine Ibuprofen
Signature Care Itch Relief	Safeway	Diphenhydramine Zinc
Signature Care Severe Cold Cough and Flu Nighttime	Safeway	Acetaminophen Diphenhydramine Phenylephrine
Sinus Relief	Kroger	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Sinus Relief Congestion and Cough Maximum Strength	Walgreens	Acetaminophen Diphenhydramine Phenylephrine
Sinus Relief Maximum Strength Daytime and Nighttime Sinus Pain	Cvs Health	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Sinus Relief Nightime Caplets	Pharmetics (2011) Inc.	Acetaminophen Diphenhydramine Pseudoephedrine
Sinutab Daytime/nightime Extra Strength Caplets (combo Pack)	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Acetaminophen Diphenhydramine Pseudoephedrine Pseudoephedrine
Sinutab N.T. Extra Strength Caplets	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Sinutab N.T. Regular Strength Caplets	Warner Lambert Canada Inc.	Acetaminophen Diphenhydramine Pseudoephedrine
Sinutab PE Sinus and Allergy	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Smart Sense Anti Itch Extra Strength	Kmart Corporation	Diphenhydramine Zinc
Smart Sense Childrens Nighttime Cold and Cough	Kmart Corporation	Diphenhydramine Phenylephrine
Smart Sense Flu and Severe Cold and Cough Nighttime	Kmart Corporation	Acetaminophen Diphenhydramine Phenylephrine
Smart Sense Ibuprofen PM	Kmart Corporation	Diphenhydramine Ibuprofen
Smart Sense Itch Stopping	Kmart Corporation	Diphenhydramine Zinc
Smart Sense Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Smart Sense Pain Relief PM Extra Strength	Kmart Corporation	Acetaminophen Diphenhydramine
Smart Sense Sinus Relief	Kmart Corporation	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Smart Sense Topical Analgesic Skin Protectant	Kmart Corporation	Diphenhydramine Zinc
Smart Sense Triacting	Kmart Corporation	Diphenhydramine Phenylephrine
Sohmed Pain Relief PM	SOHM Inc.	Acetaminophen Diphenhydramine
Sound Body Pain Relief PM	Allegiant Health	Acetaminophen Diphenhydramine
Sting Kure - Liq	Wisconsin Pharmacal Company	Benzocaine Camphor Diphenhydramine Phenol
Sting-eze-liq	Wisconsin Pharmacal Company	Benzocaine Camphor Diphenhydramine Phenol
Sudafed PE Cold and Cough	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Phenylephrine
Sudafed PE Day Plus Night Sinus Congestion	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	Diphenhydramine Phenylephrine
Sudafed Sinus Nighttime	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Acetaminophen Diphenhydramine Pseudoephedrine
Sunmark Anti-itch	Mc Kesson	Diphenhydramine Zinc
Sunmark Ibuprofen PM	Mc Kesson	Diphenhydramine Ibuprofen
Sunmark Pain Reliever PM Extra Strength	Mc Kesson	Acetaminophen Diphenhydramine
Suphedrine PE	Target Corporation.	Acetaminophen Diphenhydramine Phenylephrine
Suppress Cough Syr W.cod.diphen.hcl Amm.chl.	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	Ammonium chloride Codeine Diphenhydramine
Tact	Sato Pharmaceutical Inc., Ltd.	Diphenhydramine Menthol
Tact Cool Jelly	Sato Pharmaceutical	Diphenhydramine Menthol
Tecnu Calagel	Tec Laboratories, Inc.	Benzethonium Diphenhydramine Zinc
Texaclear Kids Cold Relief	Gm Pharmaceuticals	Diphenhydramine Phenylephrine
Texaclear Night Time Cough Cold/flu	Gm Pharmaceuticals	Choline Diphenhydramine Phenylephrine
Theraflu Expressmax Daytime Severe Cold and Cough and Theraflu Expressmax Nighttime Severe Cold and Cough	Glaxo Smith Kline Consumer Healthcare Holdings (Us) Llc	Acetaminophen Dextromethorphan Diphenhydramine Phenylephrine
Theraflu Expressmax Flu, Cough, and Sore Throat	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Theraflu Expressmax Nighttime Severe Cold and Cough	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Theraflu Nighttime Multi-symptom Severe Cold Powder	Glaxo Smith Kline Consumer Healthcare Holdings (Us) Llc	Acetaminophen Diphenhydramine Phenylephrine
Theraflu Nighttime Severe Cold and Cough	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Theraflu Sugar Free Nightime Severe Cold and Cough	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Theraflu Warming Relief Flu and Sore Throat	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Theraflu Warming Relief Nighttime Severe Cold and Cough	Novartis	Acetaminophen Diphenhydramine Phenylephrine
Time-gesic	Time Cap Laboratories	Acetaminophen Diphenhydramine
Topcare Anti-itch	Topco Associates	Diphenhydramine Zinc
Topcare Childrens Triacting Nightime Cold and Cough	Topco Associates	Diphenhydramine Phenylephrine
Topcare Flu and Severe Cold and Cough	Topco Associates	Acetaminophen Diphenhydramine Phenylephrine
Topcare Headache PM Formula	Topco Associates	Acetaminophen Diphenhydramine
Topcare Ibuprofen PM	Topco Associates	Diphenhydramine Ibuprofen
Topcare Mucus Relief and Cold and Flu	Topco Associates	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Topcare Night Time Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Topcare Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Topcare (Topco Associates Llc)	Acetaminophen Diphenhydramine Phenylephrine
Topcare Pain Relief PM	Topco Associates	Acetaminophen Diphenhydramine
Topcare Pain Relief PM Extra Strength	Topco Associates	Acetaminophen Diphenhydramine
Topcare Pain Relief PM Extra Strength Non Habit Forming	Topco Associates	Acetaminophen Diphenhydramine
Topcare Sinus Relief Day Time Night Time	Topco Associates	Acetaminophen Diphenhydramine Guaifenesin Phenylephrine
Total Cold & Flu Combo	Vita Health Products Inc	Acetaminophen Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Pseudoephedrine Pseudoephedrine
Triacting Night Time	Safeway	Diphenhydramine Phenylephrine
Triacting Night Time Cold and Cough	Good Neighbor Pharmacy	Diphenhydramine Phenylephrine
Trialyn Syrup	Laboratoires Trianon Inc	Ammonium chloride Dextromethorphan Diphenhydramine
Triaminic Childrens Night Time Cold and Cough	Novartis	Diphenhydramine Phenylephrine
Triaminic Day - Night Club Pack	Novartis	Diphenhydramine Phenylephrine
Triaminic Night Time Cold and Cough	Novartis	Diphenhydramine Phenylephrine
Triaminic Nighttime Cough and Cold	Novartis	Diphenhydramine Phenylephrine
Triaminic Thin Strips Nighttime Cold & Cough	Glaxosmithkline Inc	Diphenhydramine Phenylephrine
Tussin CF Nighttime Cough and Cold	Cvs Health	Acetaminophen Diphenhydramine Phenylephrine
Tylenol PM	Navajo Manuracturing Company	Acetaminophen Diphenhydramine
Tylenol PM Extra Strength	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	Acetaminophen Diphenhydramine
Unisom PM Pain Nighttime Sleep Aid and Pain Reliever	Chattem, Inc.	Acetaminophen Diphenhydramine
Up and Up Acetaminophen PM	Target Corporation.	Acetaminophen Diphenhydramine
Up and Up Acetaminophen PM Extra Strength	Target Corporation.	Acetaminophen Diphenhydramine
Up and Up Childrens Cold and Cough Relief	Target Corporation.	Diphenhydramine Phenylephrine
Up and Up Daytime Severe Cold Nighttime Cold and Flu	Target Corporation.	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Up and Up Flu and Severe Cold and Cough Relief	Target Corporation.	Acetaminophen Diphenhydramine Phenylephrine
Up and Up Ibuprofen PM	Target Corporation.	Diphenhydramine Ibuprofen
Up and Up Itch Relief	Target Corporation.	Diphenhydramine Zinc
Up and Up Nighttime Flu and Severe Cold and Cough	Target Corporation.	Acetaminophen Diphenhydramine Phenylephrine
Vanapain PM	Gm Pharmaceuticals	Choline Diphenhydramine
Wal Flu Severe Cold and Cough	Walgreen	Acetaminophen Diphenhydramine Phenylephrine
Wal-dryl	Walgreen	Diphenhydramine Zinc
Wal-dryl Allergy Plus Cold	Walgreen	Acetaminophen Diphenhydramine Phenylephrine
Wal-dryl Itch Relief	Walgreen	Diphenhydramine Zinc
Wal-dryl Maximum Strength	Walgreen	Acetaminophen Diphenhydramine Phenylephrine
Wal-dryl PE Allergy and Sinus	Walgreen	Diphenhydramine Phenylephrine
Wal-dryl-D	Walgreen	Diphenhydramine Phenylephrine
Wal-nadol PM	Walgreen	Acetaminophen Diphenhydramine
Wal-phed PE	Walgreen	Acetaminophen Diphenhydramine Phenylephrine
Wal-phed PE Pressure Plus Pain Plus Cold Daytime, Nighttime, Multi-symptom	Walgreen	Acetaminophen Dextromethorphan Diphenhydramine Guaifenesin Phenylephrine
Walgreens Anti Itch	Walgreen	Diphenhydramine Zinc
Walgreens Night Time Wal-flu Severe Cold and Cough Honey Lemon Flavor Infused With Chamomile and White Tea Flavors	Walgreen	Acetaminophen Diphenhydramine Phenylephrine
Walgreens Original Strength Anti Itch	Walgreen	Diphenhydramine Zinc
Walgreens Sugar Free Nighttime Wal-flu Severe Cold and Cough Natural Honey Lemon Flavor	Walgreen	Acetaminophen Diphenhydramine Phenylephrine
Weeks and Leo Extra Strength Itch Stopping	Weeks & Leo Co., Inc.	Diphenhydramine Zinc
Western Family Itch Relief	Western Family Food, Inc.	Diphenhydramine Zinc
Western Family Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Quality Home Products	Acetaminophen Diphenhydramine Phenylephrine
Winco Foods Nighttime Severe Cold and Cough Honey Lemon Infused With Chamomile and White Tea Flavors	Win Co Foods, Llc,	Acetaminophen Diphenhydramine Phenylephrine
Winco Original Strength Anti-itch	Win Co Foods, Llc,	Diphenhydramine Zinc

Categories

UNII

8GTS82S83M

CAS number

58-73-1

Weight

Average: 255.3547
Monoisotopic: 255.162314299

Chemical Formula

C₁₇H₂₁NO

InChI Key

ZZVUWRFHKOJYTH-UHFFFAOYSA-N

InChI

InChI=1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3

IUPAC Name

[2-(diphenylmethoxy)ethyl]dimethylamine

SMILES

CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1

Pharmacology

Indication

For the treatment of symptoms associated with Vertigo/Meniere's disease, nausea and vomiting, motion sickness and insect bite.

Structured Indications

Pharmacodynamics

Diphenhydramine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, diphenhydramine competes with free histamine for binding at HA-receptor sites. Diphenhydramine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of diphenhydramine. This anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.

Mechanism of action

Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Histamine H1 receptor	Protein	yes	antagonist	Human	P35367	details
Muscarinic acetylcholine receptor M2	Protein	unknown	antagonist	Human	P08172	details

Absorption

Quickly absorbed with maximum activity occurring in approximately one hour.

Volume of distribution

Not Available

Protein binding

98 to 99%

Metabolism

Hepatic and renal

Substrate	Enzymes	Product
Diphenhydramine	Cytochrome P450 2C9 Cytochrome P450 2C19 Cytochrome P450 1A2 Cytochrome P450 2D6	N-Desmethyldiphenhydramine	Details
Diphenhydramine	Prostaglandin G/H synthase 1	Diphenhydramine N-glucuronide	Details
N-Desmethyldiphenhydramine	Cytochrome P450 2C9 Cytochrome P450 2C19 Cytochrome P450 2D6 Cytochrome P450 1A2	N,N-Didesmethyldiphenhydramine	Details
N,N-Didesmethyldiphenhydramine	Not Available	Diphenylmethoxyacetic acid	Details

Route of elimination

Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.

Half life

1-4 hours

Clearance

Not Available

Toxicity

LD₅₀=500 mg/kg (orally in rats). Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death.

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
2,5-Dimethoxy-4-ethylamphetamine	2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Diphenhydramine.	Experimental, Illicit
3,4-Methylenedioxyamphetamine	3,4-Methylenedioxyamphetamine may decrease the sedative activities of Diphenhydramine.	Experimental, Illicit
3,4-Methylenedioxymethamphetamine	3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Diphenhydramine.	Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine	4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Diphenhydramine.	Experimental, Illicit
4-Methoxyamphetamine	The metabolism of 4-Methoxyamphetamine can be decreased when combined with Diphenhydramine.	Experimental, Illicit
7-Nitroindazole	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with 7-Nitroindazole.	Experimental
Abiraterone	The serum concentration of Diphenhydramine can be increased when it is combined with Abiraterone.	Approved
Acepromazine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Acepromazine.	Approved, Vet Approved
Aceprometazine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Aceprometazine.	Approved
Acetaminophen	The metabolism of Acetaminophen can be decreased when combined with Diphenhydramine.	Approved
Acetylcholine	The metabolism of Acetylcholine can be decreased when combined with Diphenhydramine.	Approved
Adipiplon	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with adipiplon.	Investigational
Agomelatine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Agomelatine.	Approved, Investigational
Ajmaline	The metabolism of Ajmaline can be decreased when combined with Diphenhydramine.	Approved
Alfaxalone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Alfaxalone.	Vet Approved
Alfentanil	The risk or severity of adverse effects can be increased when Alfentanil is combined with Diphenhydramine.	Approved, Illicit
Allopregnanolone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Sage 547.	Investigational
Almotriptan	The metabolism of Almotriptan can be decreased when combined with Diphenhydramine.	Approved, Investigational
Alogliptin	The metabolism of Alogliptin can be decreased when combined with Diphenhydramine.	Approved
Alphacetylmethadol	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Alphacetylmethadol.	Experimental, Illicit
Alprazolam	The risk or severity of adverse effects can be increased when Alprazolam is combined with Diphenhydramine.	Approved, Illicit, Investigational
Alprenolol	The metabolism of Alprenolol can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Aminophenazone	The metabolism of Aminophenazone can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Amiodarone	Diphenhydramine may increase the QTc-prolonging activities of Amiodarone.	Approved, Investigational
Amisulpride	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Amisulpride.	Approved, Investigational
Amitriptyline	The metabolism of Amitriptyline can be decreased when combined with Diphenhydramine.	Approved
Amobarbital	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Amobarbital.	Approved, Illicit
Amoxapine	The metabolism of Amoxapine can be decreased when combined with Diphenhydramine.	Approved
Amperozide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Amperozide.	Experimental
Amphetamine	The metabolism of Amphetamine can be decreased when combined with Diphenhydramine.	Approved, Illicit
Amprenavir	The metabolism of Amprenavir can be decreased when combined with Diphenhydramine.	Approved
Amsacrine	The metabolism of Amsacrine can be decreased when combined with Diphenhydramine.	Approved
Anagrelide	Diphenhydramine may increase the QTc-prolonging activities of Anagrelide.	Approved
Antipyrine	The metabolism of Antipyrine can be decreased when combined with Diphenhydramine.	Approved
Aprepitant	The metabolism of Diphenhydramine can be increased when combined with Aprepitant.	Approved, Investigational
Aprindine	The metabolism of Aprindine can be decreased when combined with Diphenhydramine.	Approved
Arformoterol	The metabolism of Arformoterol can be decreased when combined with Diphenhydramine.	Approved, Investigational
Aripiprazole	The serum concentration of Aripiprazole can be increased when it is combined with Diphenhydramine.	Approved, Investigational
Armodafinil	The metabolism of Diphenhydramine can be decreased when combined with Armodafinil.	Approved, Investigational
Arsenic trioxide	Diphenhydramine may increase the QTc-prolonging activities of Arsenic trioxide.	Approved, Investigational
Artemether	Diphenhydramine may increase the QTc-prolonging activities of Artemether.	Approved
Articaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Articaine.	Approved
Asenapine	Diphenhydramine may increase the QTc-prolonging activities of Asenapine.	Approved
Astemizole	The metabolism of Astemizole can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Atomoxetine	The metabolism of Diphenhydramine can be decreased when combined with Atomoxetine.	Approved
Azelastine	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.	Approved
Azelastine	The metabolism of Azelastine can be decreased when combined with Diphenhydramine.	Approved
Azithromycin	Diphenhydramine may increase the QTc-prolonging activities of Azithromycin.	Approved
Baclofen	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Baclofen.	Approved
Barbital	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Barbital.	Illicit
Bedaquiline	Diphenhydramine may increase the QTc-prolonging activities of Bedaquiline.	Approved
Benperidol	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Benperidol.	Investigational
Benzatropine	The metabolism of Benzatropine can be decreased when combined with Diphenhydramine.	Approved
Benzocaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Benzocaine.	Approved
Benzphetamine	Benzphetamine may decrease the sedative activities of Diphenhydramine.	Approved, Illicit
Benzyl alcohol	The metabolism of Benzyl alcohol can be decreased when combined with Diphenhydramine.	Approved
Benzylpenicilloyl Polylysine	Diphenhydramine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.	Approved
Bepridil	The metabolism of Bepridil can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Betahistine	The therapeutic efficacy of Betahistine can be decreased when used in combination with Diphenhydramine.	Approved
Betaxolol	The metabolism of Diphenhydramine can be decreased when combined with Betaxolol.	Approved
Bisoprolol	The metabolism of Bisoprolol can be decreased when combined with Diphenhydramine.	Approved
Bortezomib	The metabolism of Diphenhydramine can be decreased when combined with Bortezomib.	Approved, Investigational
Brexpiprazole	The serum concentration of Brexpiprazole can be increased when it is combined with Diphenhydramine.	Approved
Brimonidine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Brimonidine.	Approved
Brimonidine	Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved
Bromazepam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Bromazepam.	Approved, Illicit
Brompheniramine	The metabolism of Brompheniramine can be decreased when combined with Diphenhydramine.	Approved
Brotizolam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Brotizolam.	Approved, Withdrawn
Bufuralol	The metabolism of Bufuralol can be decreased when combined with Diphenhydramine.	Experimental, Investigational
Bupivacaine	The metabolism of Bupivacaine can be decreased when combined with Diphenhydramine.	Approved, Investigational
Buprenorphine	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.	Approved, Illicit, Investigational, Vet Approved
Bupropion	The metabolism of Diphenhydramine can be decreased when combined with Bupropion.	Approved
Buspirone	The metabolism of Buspirone can be decreased when combined with Diphenhydramine.	Approved, Investigational
Butabarbital	The risk or severity of adverse effects can be increased when Butabarbital is combined with Diphenhydramine.	Approved, Illicit
Butalbital	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Butalbital.	Approved, Illicit
Butethal	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Butethal.	Approved, Illicit
Butorphanol	The risk or severity of adverse effects can be increased when Butorphanol is combined with Diphenhydramine.	Approved, Illicit, Vet Approved
Caffeine	The metabolism of Diphenhydramine can be decreased when combined with Caffeine.	Approved
Capecitabine	The metabolism of Diphenhydramine can be decreased when combined with Capecitabine.	Approved, Investigational
Captopril	The metabolism of Captopril can be decreased when combined with Diphenhydramine.	Approved
Carbamazepine	The metabolism of Diphenhydramine can be increased when combined with Carbamazepine.	Approved, Investigational
Carbinoxamine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carbinoxamine.	Approved
Carfentanil	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carfentanil.	Illicit, Vet Approved
Cariprazine	The metabolism of Cariprazine can be decreased when combined with Diphenhydramine.	Approved
Carisoprodol	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carisoprodol.	Approved
Carteolol	The metabolism of Carteolol can be decreased when combined with Diphenhydramine.	Approved
Carvedilol	The metabolism of Carvedilol can be decreased when combined with Diphenhydramine.	Approved, Investigational
Celecoxib	The metabolism of Diphenhydramine can be decreased when combined with Celecoxib.	Approved, Investigational
Cephalexin	The metabolism of Cephalexin can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Ceritinib	The serum concentration of Diphenhydramine can be increased when it is combined with Ceritinib.	Approved
Cetirizine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Cetirizine.	Approved
Cevimeline	The metabolism of Cevimeline can be decreased when combined with Diphenhydramine.	Approved
Chloral hydrate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chloral hydrate.	Approved, Illicit, Vet Approved
Chloramphenicol	The metabolism of Diphenhydramine can be decreased when combined with Chloramphenicol.	Approved, Vet Approved
Chlordiazepoxide	The metabolism of Chlordiazepoxide can be decreased when combined with Diphenhydramine.	Approved, Illicit
Chlormezanone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chlormezanone.	Approved, Withdrawn
Chloroprocaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chloroprocaine.	Approved
Chloroquine	Diphenhydramine may increase the QTc-prolonging activities of Chloroquine.	Approved, Vet Approved
Chlorphenamine	The metabolism of Chlorphenamine can be decreased when combined with Diphenhydramine.	Approved
Chlorphentermine	Chlorphentermine may decrease the sedative activities of Diphenhydramine.	Illicit, Withdrawn
Chlorpromazine	Diphenhydramine may increase the QTc-prolonging activities of Chlorpromazine.	Approved, Vet Approved
Chlorprothixene	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chlorprothixene.	Approved, Withdrawn
Chlorzoxazone	The metabolism of Chlorzoxazone can be decreased when combined with Diphenhydramine.	Approved
Cholecalciferol	The metabolism of Diphenhydramine can be decreased when combined with Cholecalciferol.	Approved, Nutraceutical
Cilostazol	The metabolism of Cilostazol can be decreased when combined with Diphenhydramine.	Approved
Cimetidine	The metabolism of Diphenhydramine can be decreased when combined with Cimetidine.	Approved
Cinacalcet	The metabolism of Diphenhydramine can be decreased when combined with Cinacalcet.	Approved
Cinchocaine	The risk or severity of adverse effects can be increased when Cinchocaine is combined with Diphenhydramine.	Approved, Vet Approved
Cinnarizine	The metabolism of Cinnarizine can be decreased when combined with Diphenhydramine.	Approved
Ciprofloxacin	Diphenhydramine may increase the QTc-prolonging activities of Ciprofloxacin.	Approved, Investigational
Cisapride	Diphenhydramine may increase the QTc-prolonging activities of Cisapride.	Approved, Investigational, Withdrawn
Citalopram	Diphenhydramine may increase the QTc-prolonging activities of Citalopram.	Approved
Clarithromycin	Diphenhydramine may increase the QTc-prolonging activities of Clarithromycin.	Approved
Clemastine	The metabolism of Diphenhydramine can be decreased when combined with Clemastine.	Approved
Clevidipine	The metabolism of Clevidipine can be decreased when combined with Diphenhydramine.	Approved
Clidinium	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Clidinium.	Approved
Clobazam	The metabolism of Diphenhydramine can be decreased when combined with Clobazam.	Approved, Illicit
Clomipramine	The metabolism of Clomipramine can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Clonazepam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Clonazepam.	Approved, Illicit
Clonidine	The metabolism of Clonidine can be decreased when combined with Diphenhydramine.	Approved
Clopidogrel	The metabolism of Diphenhydramine can be decreased when combined with Clopidogrel.	Approved, Nutraceutical
Clorazepate	The risk or severity of adverse effects can be increased when Clorazepate is combined with Diphenhydramine.	Approved, Illicit
Clotrimazole	The metabolism of Diphenhydramine can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	Diphenhydramine may increase the QTc-prolonging activities of Clozapine.	Approved
Cobicistat	The serum concentration of Diphenhydramine can be increased when it is combined with Cobicistat.	Approved
Cocaine	The metabolism of Diphenhydramine can be decreased when combined with Cocaine.	Approved, Illicit
Codeine	The therapeutic efficacy of Codeine can be decreased when used in combination with Diphenhydramine.	Approved, Illicit
Crizotinib	Diphenhydramine may increase the QTc-prolonging activities of Crizotinib.	Approved
Cyclizine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Cyclizine.	Approved
Cyclobenzaprine	The metabolism of Cyclobenzaprine can be decreased when combined with Diphenhydramine.	Approved
Cyclophosphamide	The metabolism of Cyclophosphamide can be decreased when combined with Diphenhydramine.	Approved, Investigational
Cyclosporine	The metabolism of Diphenhydramine can be decreased when combined with Cyclosporine.	Approved, Investigational, Vet Approved
Cyproheptadine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Cyproheptadine.	Approved
Cyproterone acetate	The serum concentration of Diphenhydramine can be decreased when it is combined with Cyproterone acetate.	Approved, Investigational
Dabrafenib	The serum concentration of Diphenhydramine can be decreased when it is combined with Dabrafenib.	Approved
Dantrolene	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dantrolene.	Approved
Dapagliflozin	The metabolism of Dapagliflozin can be decreased when combined with Diphenhydramine.	Approved
Dapiprazole	The risk or severity of adverse effects can be increased when Dapiprazole is combined with Diphenhydramine.	Approved
Dapoxetine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dapoxetine.	Investigational
Darifenacin	The metabolism of Diphenhydramine can be decreased when combined with Darifenacin.	Approved, Investigational
Darunavir	The serum concentration of Diphenhydramine can be increased when it is combined with Darunavir.	Approved
Dasabuvir	The metabolism of Dasabuvir can be decreased when combined with Diphenhydramine.	Approved
Debrisoquin	The metabolism of Debrisoquin can be decreased when combined with Diphenhydramine.	Approved
Deferasirox	The serum concentration of Diphenhydramine can be increased when it is combined with Deferasirox.	Approved, Investigational
Delavirdine	The metabolism of Diphenhydramine can be decreased when combined with Delavirdine.	Approved
Deramciclane	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with deramciclane.	Investigational
Desflurane	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Desflurane.	Approved
Desipramine	The metabolism of Desipramine can be decreased when combined with Diphenhydramine.	Approved
Desloratadine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Desloratadine.	Approved, Investigational
Desvenlafaxine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Desvenlafaxine.	Approved
Dexbrompheniramine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dexbrompheniramine.	Approved
Dexfenfluramine	The metabolism of Dexfenfluramine can be decreased when combined with Diphenhydramine.	Approved, Illicit, Withdrawn
Dexmedetomidine	The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Diphenhydramine.	Approved, Vet Approved
Dexmethylphenidate	The metabolism of Dexmethylphenidate can be decreased when combined with Diphenhydramine.	Approved
Dextroamphetamine	The metabolism of Dextroamphetamine can be decreased when combined with Diphenhydramine.	Approved, Illicit
Dextromethorphan	The metabolism of Dextromethorphan can be decreased when combined with Diphenhydramine.	Approved
Dextromoramide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dextromoramide.	Experimental, Illicit
Dextropropoxyphene	The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Diphenhydramine.	Approved, Illicit, Withdrawn
Dezocine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dezocine.	Approved
Diazepam	The risk or severity of adverse effects can be increased when Diazepam is combined with Diphenhydramine.	Approved, Illicit, Vet Approved
Diethylpropion	Diethylpropion may decrease the sedative activities of Diphenhydramine.	Approved, Illicit
Difenoxin	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Difenoxin.	Approved, Illicit
Dihydrocodeine	The metabolism of Dihydrocodeine can be decreased when combined with Diphenhydramine.	Approved, Illicit
Dihydroetorphine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dihydroetorphine.	Experimental, Illicit
Dihydromorphine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dihydromorphine.	Experimental, Illicit
Diltiazem	The metabolism of Diltiazem can be decreased when combined with Diphenhydramine.	Approved
Dimenhydrinate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dimenhydrinate.	Approved
Diphenoxylate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Diphenoxylate.	Approved, Illicit
Disopyramide	Diphenhydramine may increase the QTc-prolonging activities of Disopyramide.	Approved
Dofetilide	Diphenhydramine may increase the QTc-prolonging activities of Dofetilide.	Approved
Dolasetron	Diphenhydramine may increase the QTc-prolonging activities of Dolasetron.	Approved
Domperidone	Diphenhydramine may increase the QTc-prolonging activities of Domperidone.	Approved, Investigational, Vet Approved
Donepezil	The metabolism of Donepezil can be decreased when combined with Diphenhydramine.	Approved
Dopamine	The metabolism of Dopamine can be decreased when combined with Diphenhydramine.	Approved
Doxazosin	The metabolism of Doxazosin can be decreased when combined with Diphenhydramine.	Approved
Doxepin	The metabolism of Doxepin can be decreased when combined with Diphenhydramine.	Approved
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Diphenhydramine.	Approved, Investigational
Doxorubicin	The metabolism of Doxorubicin can be decreased when combined with Diphenhydramine.	Approved, Investigational
Doxylamine	Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved, Vet Approved
Dronabinol	Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved, Illicit
Dronedarone	Diphenhydramine may increase the QTc-prolonging activities of Dronedarone.	Approved
Droperidol	Droperidol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved, Vet Approved
Drotebanol	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Drotebanol.	Experimental, Illicit
Duloxetine	The metabolism of Diphenhydramine can be decreased when combined with Duloxetine.	Approved
Dyclonine	The risk or severity of adverse effects can be increased when Dyclonine is combined with Diphenhydramine.	Approved
Ecgonine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ecgonine.	Experimental, Illicit
Ecopipam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ecopipam.	Investigational
Efavirenz	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Efavirenz.	Approved, Investigational
Eletriptan	The metabolism of Eletriptan can be decreased when combined with Diphenhydramine.	Approved, Investigational
Eliglustat	The serum concentration of Eliglustat can be increased when it is combined with Diphenhydramine.	Approved
Eltanolone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pregnanolone.	Investigational
Encainide	The metabolism of Encainide can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Enclomiphene	The metabolism of Enclomiphene can be decreased when combined with Diphenhydramine.	Investigational
Enflurane	The risk or severity of adverse effects can be increased when Enflurane is combined with Diphenhydramine.	Approved, Vet Approved
Entacapone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Entacapone.	Approved, Investigational
Epinastine	The metabolism of Epinastine can be decreased when combined with Diphenhydramine.	Approved, Investigational
Erlotinib	The metabolism of Erlotinib can be decreased when combined with Diphenhydramine.	Approved, Investigational
Erythromycin	Diphenhydramine may increase the QTc-prolonging activities of Erythromycin.	Approved, Vet Approved
Escitalopram	Diphenhydramine may increase the QTc-prolonging activities of Escitalopram.	Approved, Investigational
Eslicarbazepine acetate	The metabolism of Diphenhydramine can be decreased when combined with Eslicarbazepine acetate.	Approved
Esmirtazapine	The metabolism of Esmirtazapine can be decreased when combined with Diphenhydramine.	Investigational
Esomeprazole	The metabolism of Diphenhydramine can be decreased when combined with Esomeprazole.	Approved, Investigational
Estazolam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Estazolam.	Approved, Illicit
Eszopiclone	The risk or severity of adverse effects can be increased when Eszopiclone is combined with Diphenhydramine.	Approved
Ethanol	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.	Approved
Ethchlorvynol	The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Diphenhydramine.	Approved, Illicit, Withdrawn
Ethosuximide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethosuximide.	Approved
Ethotoin	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethotoin.	Approved
Ethyl carbamate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethyl carbamate.	Withdrawn
Ethyl loflazepate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ethyl loflazepate.	Approved, Illicit
Ethylmorphine	The metabolism of Ethylmorphine can be decreased when combined with Diphenhydramine.	Approved, Illicit
Etidocaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etidocaine.	Approved
Etifoxine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etifoxine.	Withdrawn
Etizolam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etizolam.	Approved
Etomidate	The risk or severity of adverse effects can be increased when Etomidate is combined with Diphenhydramine.	Approved
Etoperidone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etoperidone.	Approved
Etoricoxib	The metabolism of Etoricoxib can be decreased when combined with Diphenhydramine.	Approved, Investigational
Etorphine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etorphine.	Illicit, Vet Approved
Etravirine	The metabolism of Diphenhydramine can be decreased when combined with Etravirine.	Approved
Ezogabine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ezogabine.	Approved
Felbamate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Felbamate.	Approved
Fencamfamine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fencamfamine.	Approved, Illicit, Withdrawn
Fentanyl	The risk or severity of adverse effects can be increased when Fentanyl is combined with Diphenhydramine.	Approved, Illicit, Investigational, Vet Approved
Fesoterodine	The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Diphenhydramine.	Approved
Fexofenadine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fexofenadine.	Approved
Fingolimod	The metabolism of Fingolimod can be decreased when combined with Diphenhydramine.	Approved, Investigational
Flecainide	Diphenhydramine may increase the QTc-prolonging activities of Flecainide.	Approved, Withdrawn
Flibanserin	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Flibanserin.	Approved
Floxuridine	The metabolism of Diphenhydramine can be decreased when combined with Floxuridine.	Approved
Fluconazole	The metabolism of Diphenhydramine can be decreased when combined with Fluconazole.	Approved
Fludiazepam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fludiazepam.	Approved, Illicit
Flunarizine	The metabolism of Flunarizine can be decreased when combined with Diphenhydramine.	Approved
Flunitrazepam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Flunitrazepam.	Approved, Illicit
Fluorouracil	The metabolism of Diphenhydramine can be decreased when combined with Fluorouracil.	Approved
Fluoxetine	Diphenhydramine may increase the QTc-prolonging activities of Fluoxetine.	Approved, Vet Approved
Flupentixol	Diphenhydramine may increase the QTc-prolonging activities of Flupentixol.	Approved, Withdrawn
Fluphenazine	The metabolism of Fluphenazine can be decreased when combined with Diphenhydramine.	Approved
Flurazepam	The risk or severity of adverse effects can be increased when Flurazepam is combined with Diphenhydramine.	Approved, Illicit
Fluspirilene	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fluspirilene.	Approved
Fluticasone propionate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fluticasone Propionate.	Approved
Fluvastatin	The metabolism of Fluvastatin can be decreased when combined with Diphenhydramine.	Approved
Fluvoxamine	The metabolism of Diphenhydramine can be decreased when combined with Fluvoxamine.	Approved, Investigational
Formoterol	The metabolism of Formoterol can be decreased when combined with Diphenhydramine.	Approved, Investigational
Fosphenytoin	The metabolism of Diphenhydramine can be increased when combined with Fosphenytoin.	Approved
Fospropofol	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fospropofol.	Approved, Illicit
Gabapentin	The risk or severity of adverse effects can be increased when Gabapentin is combined with Diphenhydramine.	Approved, Investigational
Gabapentin Enacarbil	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with gabapentin enacarbil.	Approved
Gadobenic acid	Diphenhydramine may increase the QTc-prolonging activities of Gadobenic acid.	Approved
Galantamine	The metabolism of Galantamine can be decreased when combined with Diphenhydramine.	Approved
Gamma Hydroxybutyric Acid	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Gamma Hydroxybutyric Acid.	Approved, Illicit
Gefitinib	The metabolism of Gefitinib can be decreased when combined with Diphenhydramine.	Approved, Investigational
Gemfibrozil	The metabolism of Diphenhydramine can be decreased when combined with Gemfibrozil.	Approved
Gemifloxacin	Diphenhydramine may increase the QTc-prolonging activities of Gemifloxacin.	Approved, Investigational
Gepirone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Gepirone.	Investigational
Glutethimide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Glutethimide.	Approved, Illicit
Goserelin	Diphenhydramine may increase the QTc-prolonging activities of Goserelin.	Approved
Granisetron	Diphenhydramine may increase the QTc-prolonging activities of Granisetron.	Approved, Investigational
Guanfacine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Guanfacine.	Approved, Investigational
Halazepam	The risk or severity of adverse effects can be increased when Halazepam is combined with Diphenhydramine.	Approved, Illicit, Withdrawn
Halofantrine	The metabolism of Halofantrine can be decreased when combined with Diphenhydramine.	Approved
Haloperidol	Diphenhydramine may increase the QTc-prolonging activities of Haloperidol.	Approved
Halothane	The metabolism of Halothane can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Heroin	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Heroin.	Approved, Illicit
Hexobarbital	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Hexobarbital.	Approved
Hyaluronidase	The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Diphenhydramine.	Approved, Investigational
Hydrocodone	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.	Approved, Illicit
Hydromorphone	The metabolism of Hydromorphone can be decreased when combined with Diphenhydramine.	Approved, Illicit
Hydroxyamphetamine	Hydroxyamphetamine hydrobromide may decrease the sedative activities of Diphenhydramine.	Approved
Hydroxyzine	Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved
Ibrutinib	The metabolism of Ibrutinib can be decreased when combined with Diphenhydramine.	Approved
Ibutilide	Diphenhydramine may increase the QTc-prolonging activities of Ibutilide.	Approved
Idarubicin	The metabolism of Idarubicin can be decreased when combined with Diphenhydramine.	Approved
Iloperidone	Diphenhydramine may increase the QTc-prolonging activities of Iloperidone.	Approved
Imatinib	The metabolism of Imatinib can be decreased when combined with Diphenhydramine.	Approved
Imipramine	The metabolism of Diphenhydramine can be decreased when combined with Imipramine.	Approved
Indalpine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Indalpine.	Investigational, Withdrawn
Indinavir	The metabolism of Diphenhydramine can be decreased when combined with Indinavir.	Approved
Ipratropium bromide	The metabolism of Ipratropium bromide can be decreased when combined with Diphenhydramine.	Approved
Irbesartan	The metabolism of Diphenhydramine can be decreased when combined with Irbesartan.	Approved, Investigational
Isoflurane	The risk or severity of adverse effects can be increased when Isoflurane is combined with Diphenhydramine.	Approved, Vet Approved
Isoniazid	The metabolism of Diphenhydramine can be decreased when combined with Isoniazid.	Approved
Ixazomib	The metabolism of Ixazomib can be decreased when combined with Diphenhydramine.	Approved
Ketamine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ketamine.	Approved, Vet Approved
Ketazolam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ketazolam.	Approved
Ketobemidone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ketobemidone.	Approved
Ketoconazole	The metabolism of Diphenhydramine can be decreased when combined with Ketoconazole.	Approved, Investigational
Labetalol	The metabolism of Labetalol can be decreased when combined with Diphenhydramine.	Approved
Lamotrigine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lamotrigine.	Approved, Investigational
Leflunomide	The metabolism of Diphenhydramine can be decreased when combined with Leflunomide.	Approved, Investigational
Lenvatinib	Diphenhydramine may increase the QTc-prolonging activities of Lenvatinib.	Approved
Leuprolide	Diphenhydramine may increase the QTc-prolonging activities of Leuprolide.	Approved, Investigational
Levetiracetam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levetiracetam.	Approved, Investigational
Levobupivacaine	The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Diphenhydramine.	Approved
Levocabastine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levocabastine.	Approved
Levocetirizine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levocetirizine.	Approved
Levodopa	The metabolism of Levodopa can be decreased when combined with Diphenhydramine.	Approved
Levofloxacin	Diphenhydramine may increase the QTc-prolonging activities of Levofloxacin.	Approved, Investigational
Levomethadyl Acetate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Levomethadyl Acetate.	Approved
Levomilnacipran	The metabolism of Levomilnacipran can be decreased when combined with Diphenhydramine.	Approved
Levorphanol	The risk or severity of adverse effects can be increased when Levorphanol is combined with Diphenhydramine.	Approved
Lidocaine	The metabolism of Diphenhydramine can be decreased when combined with Lidocaine.	Approved, Vet Approved
Lisdexamfetamine	Lisdexamfetamine may decrease the sedative activities of Diphenhydramine.	Approved, Investigational
Lisuride	The metabolism of Lisuride can be decreased when combined with Diphenhydramine.	Approved
Lithium	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lithium.	Approved
Lofentanil	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lofentanil.	Illicit
Lomustine	The metabolism of Lomustine can be decreased when combined with Diphenhydramine.	Approved
Loperamide	The metabolism of Loperamide can be decreased when combined with Diphenhydramine.	Approved
Lopinavir	Diphenhydramine may increase the QTc-prolonging activities of Lopinavir.	Approved
Loratadine	The metabolism of Loratadine can be decreased when combined with Diphenhydramine.	Approved
Lorazepam	The risk or severity of adverse effects can be increased when Lorazepam is combined with Diphenhydramine.	Approved
Lorcaserin	The metabolism of Lorcaserin can be decreased when combined with Diphenhydramine.	Approved
Losartan	The metabolism of Diphenhydramine can be decreased when combined with Losartan.	Approved
Lovastatin	The metabolism of Diphenhydramine can be decreased when combined with Lovastatin.	Approved, Investigational
Loxapine	The risk or severity of adverse effects can be increased when Loxapine is combined with Diphenhydramine.	Approved
Luliconazole	The serum concentration of Diphenhydramine can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The serum concentration of Diphenhydramine can be decreased when it is combined with Lumacaftor.	Approved
Lumefantrine	Diphenhydramine may increase the QTc-prolonging activities of Lumefantrine.	Approved
Lurasidone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Lurasidone.	Approved
Magnesium Sulfate	Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved, Vet Approved
Maprotiline	The metabolism of Maprotiline can be decreased when combined with Diphenhydramine.	Approved
Meclizine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Meclizine.	Approved
Melatonin	The risk or severity of adverse effects can be increased when Melatonin is combined with Diphenhydramine.	Approved, Nutraceutical, Vet Approved
Melperone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Melperone.	Approved
Mephedrone	Mephedrone may decrease the sedative activities of Diphenhydramine.	Investigational
Mephentermine	Mephentermine may decrease the sedative activities of Diphenhydramine.	Approved
Mephenytoin	The metabolism of Mephenytoin can be decreased when combined with Diphenhydramine.	Investigational, Withdrawn
Mepivacaine	The risk or severity of adverse effects can be increased when Mepivacaine is combined with Diphenhydramine.	Approved, Vet Approved
Meprobamate	The risk or severity of adverse effects can be increased when Meprobamate is combined with Diphenhydramine.	Approved, Illicit
Mequitazine	The metabolism of Mequitazine can be decreased when combined with Diphenhydramine.	Approved
Mesoridazine	The metabolism of Mesoridazine can be decreased when combined with Diphenhydramine.	Approved
Metaxalone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Metaxalone.	Approved
Methadone	Diphenhydramine may increase the QTc-prolonging activities of Methadone.	Approved
Methadyl Acetate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methadyl Acetate.	Approved, Illicit
Methamphetamine	The metabolism of Methamphetamine can be decreased when combined with Diphenhydramine.	Approved, Illicit
Methapyrilene	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methapyrilene.	Withdrawn
Methaqualone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methaqualone.	Illicit, Withdrawn
Methocarbamol	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methocarbamol.	Approved, Vet Approved
Methohexital	The risk or severity of adverse effects can be increased when Methohexital is combined with Diphenhydramine.	Approved
Methotrimeprazine	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.	Approved
Methoxyflurane	The metabolism of Methoxyflurane can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Methsuximide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methsuximide.	Approved
Methylecgonine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with ECGONINE METHYL ESTER.	Experimental
Methylphenidate	The metabolism of Methylphenidate can be decreased when combined with Diphenhydramine.	Approved, Investigational
Methylphenobarbital	The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Diphenhydramine.	Approved
Methyprylon	The metabolism of Methyprylon can be decreased when combined with Diphenhydramine.	Approved, Illicit, Withdrawn
Metoclopramide	The metabolism of Metoclopramide can be decreased when combined with Diphenhydramine.	Approved, Investigational
Metoprolol	The serum concentration of Metoprolol can be increased when it is combined with Diphenhydramine.	Approved, Investigational
Metyrosine	Diphenhydramine may increase the sedative activities of Metyrosine.	Approved
Mexiletine	The metabolism of Diphenhydramine can be decreased when combined with Mexiletine.	Approved
Mianserin	The metabolism of Mianserin can be decreased when combined with Diphenhydramine.	Approved
Midazolam	The risk or severity of adverse effects can be increased when Midazolam is combined with Diphenhydramine.	Approved, Illicit
Mifepristone	The serum concentration of Diphenhydramine can be increased when it is combined with Mifepristone.	Approved, Investigational
Milnacipran	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Milnacipran.	Approved
Minaprine	The metabolism of Minaprine can be decreased when combined with Diphenhydramine.	Approved
Minocycline	Minocycline may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved, Investigational
Mirabegron	The metabolism of Mirabegron can be decreased when combined with Diphenhydramine.	Approved
Mirtazapine	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.	Approved
MMDA	MMDA may decrease the sedative activities of Diphenhydramine.	Experimental, Illicit
Moclobemide	The metabolism of Moclobemide can be decreased when combined with Diphenhydramine.	Approved
Modafinil	The metabolism of Diphenhydramine can be decreased when combined with Modafinil.	Approved, Investigational
Molindone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Molindone.	Approved
Morphine	The metabolism of Morphine can be decreased when combined with Diphenhydramine.	Approved, Investigational
Moxifloxacin	Diphenhydramine may increase the QTc-prolonging activities of Moxifloxacin.	Approved, Investigational
Nabilone	Nabilone may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved, Investigational
Nalbuphine	The risk or severity of adverse effects can be increased when Nalbuphine is combined with Diphenhydramine.	Approved
Nateglinide	The metabolism of Nateglinide can be decreased when combined with Diphenhydramine.	Approved, Investigational
Nebivolol	The serum concentration of Nebivolol can be increased when it is combined with Diphenhydramine.	Approved, Investigational
Nefazodone	The metabolism of Nefazodone can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Nelfinavir	The metabolism of Diphenhydramine can be decreased when combined with Nelfinavir.	Approved
Netupitant	The metabolism of Netupitant can be decreased when combined with Diphenhydramine.	Approved
Nevirapine	The metabolism of Diphenhydramine can be increased when combined with Nevirapine.	Approved
Nicardipine	The metabolism of Diphenhydramine can be decreased when combined with Nicardipine.	Approved
Nicergoline	The metabolism of Nicergoline can be decreased when combined with Diphenhydramine.	Approved
Nicotine	The metabolism of Nicotine can be decreased when combined with Diphenhydramine.	Approved
Nifedipine	The metabolism of Nifedipine can be decreased when combined with Diphenhydramine.	Approved
Nilotinib	Diphenhydramine may increase the QTc-prolonging activities of Nilotinib.	Approved, Investigational
Nitrazepam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Nitrazepam.	Approved
Nitrofural	The metabolism of Nitrofural can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Nitrous oxide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Nitrous oxide.	Approved, Vet Approved
Norflurane	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with 1,1,1,2 Tetrafluoroethane.	Investigational
Normethadone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Normethadone.	Approved, Illicit
Nortriptyline	The metabolism of Nortriptyline can be decreased when combined with Diphenhydramine.	Approved
Ofloxacin	Diphenhydramine may increase the QTc-prolonging activities of Ofloxacin.	Approved
Olanzapine	The metabolism of Olanzapine can be decreased when combined with Diphenhydramine.	Approved, Investigational
Olopatadine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Olopatadine.	Approved
Omeprazole	The metabolism of Diphenhydramine can be decreased when combined with Omeprazole.	Approved, Investigational, Vet Approved
Ondansetron	Diphenhydramine may increase the QTc-prolonging activities of Ondansetron.	Approved
Opium	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Opium.	Approved, Illicit
Orphenadrine	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.	Approved
Osanetant	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Osanetant.	Investigational
Osimertinib	The serum concentration of Diphenhydramine can be decreased when it is combined with Osimertinib.	Approved
Oxazepam	The risk or severity of adverse effects can be increased when Oxazepam is combined with Diphenhydramine.	Approved
Oxethazaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Oxetacaine.	Investigational
Oxprenolol	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Oxprenolol.	Approved
Oxybuprocaine	The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Diphenhydramine.	Approved
Oxycodone	The metabolism of Oxycodone can be decreased when combined with Diphenhydramine.	Approved, Illicit, Investigational
Oxymorphone	The metabolism of Oxymorphone can be decreased when combined with Diphenhydramine.	Approved, Investigational, Vet Approved
Paliperidone	Diphenhydramine may increase the QTc-prolonging activities of Paliperidone.	Approved
Palonosetron	The metabolism of Palonosetron can be decreased when combined with Diphenhydramine.	Approved, Investigational
Panobinostat	The serum concentration of Diphenhydramine can be increased when it is combined with Panobinostat.	Approved, Investigational
Pantoprazole	The metabolism of Diphenhydramine can be decreased when combined with Pantoprazole.	Approved
Paraldehyde	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.	Approved
Paroxetine	The metabolism of Diphenhydramine can be decreased when combined with Paroxetine.	Approved, Investigational
Pazopanib	Diphenhydramine may increase the QTc-prolonging activities of Pazopanib.	Approved
Peginterferon alfa-2b	The serum concentration of Diphenhydramine can be decreased when it is combined with Peginterferon alfa-2b.	Approved
Pentamidine	Diphenhydramine may increase the QTc-prolonging activities of Pentamidine.	Approved
Pentazocine	The risk or severity of adverse effects can be increased when Pentazocine is combined with Diphenhydramine.	Approved, Vet Approved
Pentobarbital	The risk or severity of adverse effects can be increased when Pentobarbital is combined with Diphenhydramine.	Approved, Vet Approved
Perampanel	Perampanel may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved
Perazine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Perazine.	Investigational
Perflutren	Diphenhydramine may increase the QTc-prolonging activities of Perflutren.	Approved
Perhexiline	The metabolism of Perhexiline can be decreased when combined with Diphenhydramine.	Approved
Perospirone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Perospirone.	Approved
Perphenazine	The metabolism of Perphenazine can be decreased when combined with Diphenhydramine.	Approved
Pethidine	The metabolism of Pethidine can be decreased when combined with Diphenhydramine.	Approved
Phenacetin	The metabolism of Phenacetin can be decreased when combined with Diphenhydramine.	Withdrawn
Phenformin	The metabolism of Phenformin can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Phenobarbital	The metabolism of Diphenhydramine can be increased when combined with Phenobarbital.	Approved
Phentermine	Phentermine may decrease the sedative activities of Diphenhydramine.	Approved, Illicit
Phenytoin	The metabolism of Diphenhydramine can be increased when combined with Phenytoin.	Approved, Vet Approved
Pimozide	Diphenhydramine may increase the QTc-prolonging activities of Pimozide.	Approved
Pindolol	The metabolism of Pindolol can be decreased when combined with Diphenhydramine.	Approved
Pipamperone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pipamperone.	Approved
Piperazine	The metabolism of Piperazine can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Pipotiazine	The metabolism of Pipotiazine can be decreased when combined with Diphenhydramine.	Approved
Piritramide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Piritramide.	Investigational
Pomalidomide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pomalidomide.	Approved
Ponatinib	The metabolism of Ponatinib can be decreased when combined with Diphenhydramine.	Approved
Pramipexole	Diphenhydramine may increase the sedative activities of Pramipexole.	Approved, Investigational
Pramocaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Pramocaine.	Approved
Prazepam	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Prazepam.	Approved, Illicit
Pregabalin	The risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenhydramine.	Approved, Illicit, Investigational
Prilocaine	The risk or severity of adverse effects can be increased when Prilocaine is combined with Diphenhydramine.	Approved
Primaquine	Diphenhydramine may increase the QTc-prolonging activities of Primaquine.	Approved
Primidone	The metabolism of Diphenhydramine can be increased when combined with Primidone.	Approved, Vet Approved
Procainamide	Diphenhydramine may increase the QTc-prolonging activities of Procainamide.	Approved
Procaine	The risk or severity of adverse effects can be increased when Procaine is combined with Diphenhydramine.	Approved, Investigational, Vet Approved
Prochlorperazine	The metabolism of Prochlorperazine can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Progesterone	The metabolism of Progesterone can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Promazine	Diphenhydramine may increase the QTc-prolonging activities of Promazine.	Approved, Vet Approved
Promethazine	The metabolism of Promethazine can be decreased when combined with Diphenhydramine.	Approved
Propafenone	The serum concentration of Diphenhydramine can be increased when it is combined with Propafenone.	Approved
Proparacaine	The risk or severity of adverse effects can be increased when Proparacaine is combined with Diphenhydramine.	Approved, Vet Approved
Propofol	The metabolism of Propofol can be decreased when combined with Diphenhydramine.	Approved, Investigational, Vet Approved
Propoxycaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Propoxycaine.	Approved
Propranolol	The metabolism of Propranolol can be decreased when combined with Diphenhydramine.	Approved, Investigational
Protriptyline	The metabolism of Protriptyline can be decreased when combined with Diphenhydramine.	Approved
Pseudoephedrine	The metabolism of Pseudoephedrine can be decreased when combined with Diphenhydramine.	Approved
Pyrimethamine	The metabolism of Diphenhydramine can be decreased when combined with Pyrimethamine.	Approved, Vet Approved
Quazepam	The serum concentration of Diphenhydramine can be increased when it is combined with Quazepam.	Approved, Illicit
Quetiapine	Diphenhydramine may increase the QTc-prolonging activities of Quetiapine.	Approved
Quinidine	Diphenhydramine may increase the QTc-prolonging activities of Quinidine.	Approved
Quinine	Diphenhydramine may increase the QTc-prolonging activities of Quinine.	Approved
Raclopride	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Raclopride.	Investigational
Ramelteon	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ramelteon.	Approved, Investigational
Ranitidine	The metabolism of Ranitidine can be decreased when combined with Diphenhydramine.	Approved
Ranolazine	The metabolism of Diphenhydramine can be decreased when combined with Ranolazine.	Approved, Investigational
Remifentanil	The risk or severity of adverse effects can be increased when Remifentanil is combined with Diphenhydramine.	Approved
Remoxipride	The metabolism of Remoxipride can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Reserpine	The risk or severity of adverse effects can be increased when Reserpine is combined with Diphenhydramine.	Approved
Rifampicin	The metabolism of Diphenhydramine can be increased when combined with Rifampicin.	Approved
Rifapentine	The metabolism of Diphenhydramine can be increased when combined with Rifapentine.	Approved
Risperidone	The metabolism of Risperidone can be decreased when combined with Diphenhydramine.	Approved, Investigational
Ritanserin	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ritanserin.	Investigational
Ritobegron	Ritobegron may decrease the sedative activities of Diphenhydramine.	Investigational
Ritonavir	The metabolism of Diphenhydramine can be decreased when combined with Ritonavir.	Approved, Investigational
Rolapitant	The metabolism of Diphenhydramine can be decreased when combined with Rolapitant.	Approved
Ropinirole	Diphenhydramine may increase the sedative activities of Ropinirole.	Approved, Investigational
Ropivacaine	The metabolism of Ropivacaine can be decreased when combined with Diphenhydramine.	Approved
Rotigotine	Diphenhydramine may increase the sedative activities of Rotigotine.	Approved
Rufinamide	The risk or severity of adverse effects can be increased when Rufinamide is combined with Diphenhydramine.	Approved
Saquinavir	Diphenhydramine may increase the QTc-prolonging activities of Saquinavir.	Approved, Investigational
Scopolamine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Scopolamine.	Approved
Secobarbital	The metabolism of Diphenhydramine can be increased when combined with Secobarbital.	Approved, Vet Approved
Sepranolone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Uc1010.	Investigational
Sertindole	The metabolism of Sertindole can be decreased when combined with Diphenhydramine.	Approved, Withdrawn
Sertraline	The metabolism of Sertraline can be decreased when combined with Diphenhydramine.	Approved
Sevoflurane	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Sevoflurane.	Approved, Vet Approved
Sildenafil	The metabolism of Sildenafil can be decreased when combined with Diphenhydramine.	Approved, Investigational
Simeprevir	The metabolism of Diphenhydramine can be decreased when combined with Simeprevir.	Approved
Simvastatin	The metabolism of Simvastatin can be decreased when combined with Diphenhydramine.	Approved
Sodium oxybate	Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved
Sorafenib	The metabolism of Diphenhydramine can be decreased when combined with Sorafenib.	Approved, Investigational
Sotalol	Diphenhydramine may increase the QTc-prolonging activities of Sotalol.	Approved
Sparteine	The metabolism of Sparteine can be decreased when combined with Diphenhydramine.	Experimental
Stiripentol	The metabolism of Diphenhydramine can be decreased when combined with Stiripentol.	Approved
Sufentanil	The risk or severity of adverse effects can be increased when Sufentanil is combined with Diphenhydramine.	Approved, Investigational
Sulfadiazine	The metabolism of Diphenhydramine can be decreased when combined with Sulfadiazine.	Approved, Vet Approved
Sulfamethoxazole	The metabolism of Diphenhydramine can be decreased when combined with Sulfamethoxazole.	Approved
Sulfisoxazole	The metabolism of Diphenhydramine can be decreased when combined with Sulfisoxazole.	Approved, Vet Approved
Sulpiride	The risk or severity of adverse effects can be increased when Sulpiride is combined with Diphenhydramine.	Approved
Suvorexant	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.	Approved
Tamoxifen	The serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Diphenhydramine resulting in a loss in efficacy.	Approved
Tamsulosin	The metabolism of Tamsulosin can be decreased when combined with Diphenhydramine.	Approved, Investigational
Tandospirone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tandospirone.	Investigational
Tapentadol	Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.	Approved
Tasimelteon	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tasimelteon.	Approved
Technetium Tc-99m tilmanocept	Diphenhydramine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.	Approved
Tegaserod	The metabolism of Tegaserod can be decreased when combined with Diphenhydramine.	Investigational, Withdrawn
Telavancin	Diphenhydramine may increase the QTc-prolonging activities of Telavancin.	Approved
Telithromycin	Diphenhydramine may increase the QTc-prolonging activities of Telithromycin.	Approved
Temazepam	The risk or severity of adverse effects can be increased when Temazepam is combined with Diphenhydramine.	Approved
Tenofovir disoproxil	The metabolism of Diphenhydramine can be decreased when combined with Tenofovir.	Approved, Investigational
Terbinafine	The metabolism of Diphenhydramine can be decreased when combined with Terbinafine.	Approved, Investigational, Vet Approved
Terfenadine	The metabolism of Terfenadine can be decreased when combined with Diphenhydramine.	Withdrawn
Teriflunomide	The serum concentration of Diphenhydramine can be decreased when it is combined with Teriflunomide.	Approved
Tesmilifene	The metabolism of Tesmilifene can be decreased when combined with Diphenhydramine.	Investigational
Tetrabenazine	Diphenhydramine may increase the QTc-prolonging activities of Tetrabenazine.	Approved
Tetracaine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tetracaine.	Approved, Vet Approved
Tetrodotoxin	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tetrodotoxin.	Investigational
Thalidomide	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.	Approved, Investigational, Withdrawn
Theophylline	The metabolism of Diphenhydramine can be decreased when combined with Theophylline.	Approved
Thiamylal	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Thiamylal.	Approved, Vet Approved
Thiopental	The risk or severity of adverse effects can be increased when Thiopental is combined with Diphenhydramine.	Approved, Vet Approved
Thioridazine	The serum concentration of Thioridazine can be increased when it is combined with Diphenhydramine.	Withdrawn
Thiotepa	The metabolism of Diphenhydramine can be decreased when combined with Thiotepa.	Approved
Thiothixene	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Thiothixene.	Approved
Tiagabine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tiagabine.	Approved
Tiapride	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tiapride.	Approved, Investigational
Ticagrelor	The metabolism of Diphenhydramine can be decreased when combined with Ticagrelor.	Approved
Ticlopidine	The metabolism of Diphenhydramine can be decreased when combined with Ticlopidine.	Approved
Timolol	The metabolism of Timolol can be decreased when combined with Diphenhydramine.	Approved
Tiotropium	The metabolism of Tiotropium can be decreased when combined with Diphenhydramine.	Approved
Tipranavir	The metabolism of Diphenhydramine can be decreased when combined with Tipranavir.	Approved, Investigational
Tizanidine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tizanidine.	Approved
Tolbutamide	The metabolism of Diphenhydramine can be decreased when combined with Tolbutamide.	Approved
Tolcapone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tolcapone.	Approved, Withdrawn
Tolterodine	The metabolism of Tolterodine can be decreased when combined with Diphenhydramine.	Approved, Investigational
Topiramate	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Topiramate.	Approved
Toremifene	Diphenhydramine may increase the QTc-prolonging activities of Toremifene.	Approved, Investigational
Trabectedin	The metabolism of Trabectedin can be decreased when combined with Diphenhydramine.	Approved, Investigational
Tramadol	The therapeutic efficacy of Tramadol can be decreased when used in combination with Diphenhydramine.	Approved, Investigational
Trans-2-Phenylcyclopropylamine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Trans-2-Phenylcyclopropylamine.	Experimental
Tranylcypromine	The metabolism of Diphenhydramine can be decreased when combined with Tranylcypromine.	Approved
Trazodone	The metabolism of Trazodone can be decreased when combined with Diphenhydramine.	Approved, Investigational
Triazolam	The risk or severity of adverse effects can be increased when Triazolam is combined with Diphenhydramine.	Approved
Trifluoperazine	The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Diphenhydramine.	Approved
Triflupromazine	The risk or severity of adverse effects can be increased when Triflupromazine is combined with Diphenhydramine.	Approved, Vet Approved
Trimethoprim	The metabolism of Diphenhydramine can be decreased when combined with Trimethoprim.	Approved, Vet Approved
Trimipramine	The metabolism of Trimipramine can be decreased when combined with Diphenhydramine.	Approved
Triprolidine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Triprolidine.	Approved
Umeclidinium	The metabolism of Umeclidinium can be decreased when combined with Diphenhydramine.	Approved
Valproic Acid	The risk or severity of adverse effects can be increased when Valproic Acid is combined with Diphenhydramine.	Approved, Investigational
Valsartan	The metabolism of Diphenhydramine can be decreased when combined with Valsartan.	Approved, Investigational
Vandetanib	Diphenhydramine may increase the QTc-prolonging activities of Vandetanib.	Approved
Vemurafenib	The serum concentration of Diphenhydramine can be increased when it is combined with Vemurafenib.	Approved
Venlafaxine	The metabolism of Diphenhydramine can be decreased when combined with Venlafaxine.	Approved
Vigabatrin	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Vigabatrin.	Approved
Vilazodone	The metabolism of Vilazodone can be decreased when combined with Diphenhydramine.	Approved
Vinblastine	The metabolism of Vinblastine can be decreased when combined with Diphenhydramine.	Approved
Vinorelbine	The metabolism of Vinorelbine can be decreased when combined with Diphenhydramine.	Approved, Investigational
Voriconazole	The metabolism of Diphenhydramine can be decreased when combined with Voriconazole.	Approved, Investigational
Vortioxetine	The metabolism of Vortioxetine can be decreased when combined with Diphenhydramine.	Approved
Yohimbine	The metabolism of Yohimbine can be decreased when combined with Diphenhydramine.	Approved, Vet Approved
Zafirlukast	The metabolism of Diphenhydramine can be decreased when combined with Zafirlukast.	Approved, Investigational
Zalcitabine	The metabolism of Zalcitabine can be decreased when combined with Diphenhydramine.	Approved
Zaleplon	The risk or severity of adverse effects can be increased when Zaleplon is combined with Diphenhydramine.	Approved, Illicit, Investigational
Ziconotide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Ziconotide.	Approved
Zimelidine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zimelidine.	Withdrawn
Ziprasidone	Diphenhydramine may increase the QTc-prolonging activities of Ziprasidone.	Approved
Zolpidem	Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.	Approved
Zonisamide	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zonisamide.	Approved, Investigational
Zopiclone	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zopiclone.	Approved
Zotepine	The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zotepine.	Approved
Zuclopenthixol	Diphenhydramine may increase the QTc-prolonging activities of Zuclopenthixol.	Approved, Investigational

Food Interactions

Avoid alcohol.
Take with food.

References

Synthesis Reference

Alison B. Lukacsko, Joseph J. Piala, "Effect of a combination of a terbutaline, diphenhydramine and ranitidine composition on gastrointestinal injury produced by nonsteroidal anti-inflammatory compositions." U.S. Patent US5260333, issued December, 1983.

US5260333

General References

Raphael GD, Angello JT, Wu MM, Druce HM: Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2006 Apr;96(4):606-14. [PubMed:16680933 ]
Abdi A, Rose E, Levine M: Diphenhydramine overdose with intraventricular conduction delay treated with hypertonic sodium bicarbonate and i.v. lipid emulsion. West J Emerg Med. 2014 Nov;15(7):855-8. doi: 10.5811/westjem.2014.8.23407. Epub 2014 Sep 19. [PubMed:25493135 ]

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB01927
KEGG Drug	D00300
KEGG Compound	C06960
PubChem Compound	3100
PubChem Substance	46505484
ChemSpider	2989
BindingDB	50017674
ChEBI	4636
ChEMBL	CHEMBL657
Therapeutic Targets Database	DAP000490
PharmGKB	PA449349
IUPHAR	1224
Guide to Pharmacology	1224
HET	2PM
Drug Product Database	182
RxList	http://www.rxlist.com/cgi/generic/dihydram.htm
Drugs.com	http://www.drugs.com/cdi/diphenhydramine.html
Wikipedia	Diphenhydramine

ATC Codes

D04AA32 — Diphenhydramine

D04AA33 — Diphenhydramine methylbromide

R06AA52 — Diphenhydramine, combinations

R06AA02 — Diphenhydramine

AHFS Codes

04:04.04

PDB Entries

Not Available

FDA label

Not Available

MSDS

Download (73.5 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Not Yet Recruiting	Treatment	Post-Traumatic Headaches	1
1	Completed	Not Available	Autonomic Failure / Idiopathic orthostatic hypotension	1
1	Completed	Not Available	Healthy Volunteers	2
1	Completed	Not Available	Therapeutic Equivalence	1
1	Completed	Basic Science	Allergic Rhinitis (AR)	1
1	Completed	Basic Science	Nasal Stuffiness	1
1	Completed	Treatment	Healthy Volunteers	3
1	Completed	Treatment	Major Depressive Disorder (MDD)	1
1	Completed	Treatment	Restless Legs Syndrome (RLS)	1
1	Not Yet Recruiting	Treatment	Pompe's Disease	1
1	Recruiting	Diagnostic	Patients With Suspected Malignancies of the Pituitary Gland	1
1	Recruiting	Diagnostic	A Diagnosis of Any Resectable Lung or Pleural Nodule	1
1	Recruiting	Screening	Fibrosis	1
1	Recruiting	Treatment	Graft Versus Host Disease (GVHD) / Sickle Cell Disorders	1
1	Recruiting	Treatment	Multiple Myeloma (MM)	1
1	Recruiting	Treatment	Transplantation, Liver	1
1	Recruiting	Treatment	Tumors, Solid	1
1	Terminated	Not Available	Healthy Male Volunteers	1
1	Terminated	Basic Science	Drug Metabolism, Poor, CYP2D6-RELATED	1
1	Withdrawn	Diagnostic	Abdominal Pain (AP) / Gallbladder disorders / Gallstone formation / Jaundice / Pancreatitis	1
1, 2	Completed	Treatment	Kidney Diseases / Transplantation, Kidney	1
1, 2	Completed	Treatment	Leukemia, Acute Lymphocytic (ALL) / Leukemia, Acute Myelogenous (AML) / Leukemia, Chronic Myelogenous (CML) / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL)	1
1, 2	Recruiting	Treatment	Adult Living Donor Kidney Transplant Recipients / Living Kidney Donors / Transplant, Kidney	1
1, 2	Recruiting	Treatment	Liver Transplant Recipients / Living Donor (of the Respective Liver Transplant Recipient)	1
1, 2	Recruiting	Treatment	Lung Cancers	1
2	Active Not Recruiting	Treatment	Advanced Stage Diffuse Large B-Cell Non-Hodgkin's Lymphoma / Non-Hodgkin's Lymphoma (NHL)	1
2	Active Not Recruiting	Treatment	Multiple Myeloma (MM)	1
2	Active Not Recruiting	Treatment	Nephritis, Lupus	1
2	Active Not Recruiting	Treatment	Transplantation, Kidney	1
2	Completed	Not Available	Cancers / Tumors, Solid	1
2	Completed	Supportive Care	Stomatitis, Aphthous	1
2	Completed	Treatment	Acute Cerebrovascular Accidents / Edema of the cerebrum	1
2	Completed	Treatment	Blood Cancers / CLL / Graft Versus Host Disease (GVHD) / Hodgkins Disease (HD) / Leukemias / Malignancies / NHL / Smith-Magenis Syndrome	1
2	Completed	Treatment	Cancer, Breast	1
2	Completed	Treatment	Chronic Idiopathic Urticaria	1
2	Completed	Treatment	Depressive State	1
2	Completed	Treatment	Endometrial Cancers	1
2	Completed	Treatment	Lupus Erythematosus, Systemic	1
2	Completed	Treatment	Malignant Lymphomas	1
2	Completed	Treatment	Rejection, Transplant	1
2	Completed	Treatment	Renal Cell Adenocarcinoma	1
2	Completed	Treatment	Restless Legs Syndrome (RLS)	1
2	Completed	Treatment	Vulvodynia	1
2	Recruiting	Treatment	Alcohol Dependence	1
2	Recruiting	Treatment	Cocaine-Related Disorders	1
2	Recruiting	Treatment	Plasma Cell Myeloma	2
2	Recruiting	Treatment	Renal Cancers	1
2	Recruiting	Treatment	T-cell Type Acute Leukemia-Precursor T-lymphoblastic Lymphoma/Leukaemia	1
2	Recruiting	Treatment	Transplant, Kidney	1
2	Terminated	Supportive Care	Nausea / Unspecified Childhood Solid Tumor, Protocol Specific / Vomiting	1
2	Terminated	Treatment	Malignant Neoplasm of Prostate	1
2, 3	Completed	Treatment	Lupus Erythematosus, Systemic	1
2, 3	Completed	Treatment	Vesicular Stomatitis	1
2, 3	Recruiting	Treatment	Malaria caused by Plasmodium falciparum	1
2, 3	Terminated	Treatment	Lupus Erythematosus, Systemic	1
3	Completed	Treatment	Acute Urticaria	1
3	Completed	Treatment	Chronic Idiopathic Urticaria	1
3	Completed	Treatment	Elective Caesarean Section Surgeries	1
3	Completed	Treatment	Healthy Volunteers	1
3	Completed	Treatment	Migraines	1
3	Completed	Treatment	Nephritis, Lupus	1
3	Not Yet Recruiting	Treatment	Acute Urticaria	1
3	Recruiting	Treatment	Anxiety Disorder / Dementias / Depressive State / Psychosomatic Disorders / Schizophrenic Disorders	1
3	Recruiting	Treatment	Headaches / Intranasal Ketamine	1
3	Unknown Status	Treatment	Sleeplessness	1
3	Withdrawn	Treatment	Coughing / Inflammatory Reaction / Rhinitis	1
4	Active Not Recruiting	Supportive Care	Adjunct Anesthesia Medication / Colonoscopy	1
4	Active Not Recruiting	Treatment	Infections, Bacterial	1
4	Completed	Diagnostic	Asthma Bronchial	1
4	Completed	Prevention	Hypnotic / Specified Sedative	1
4	Completed	Treatment	Cough Reflex Sensitivity	1
4	Completed	Treatment	Headaches	1
4	Completed	Treatment	Migraines	2
4	Completed	Treatment	Migrainous Headache / Nausea / Restlessness	1
4	Completed	Treatment	Nasal Stuffiness	1
4	Completed	Treatment	Extra-pyramidal symptoms / Nausea	1
4	Completed	Treatment	Neurogenic Intermittent Claudication / Spinal Stenosis of Lumbar Region	1
4	Completed	Treatment	Occasional Sleeplessness	1
4	Suspended	Treatment	Migrainous Headache	1
Not Available	Active Not Recruiting	Screening	Alcoholism	1
Not Available	Completed	Not Available	Pain, Neuropathic	1
Not Available	Completed	Basic Science	Hyperalgesia	1
Not Available	Completed	Basic Science	Memory, Long-Term / Memory, Short-Term	1
Not Available	Completed	Prevention	General Surgery / Pain	1
Not Available	Completed	Prevention	Headaches	1
Not Available	Completed	Supportive Care	Focus of Study: Absorption of the Three Components in the Topical ABH Gel in Healthy Volunteers, and Determine if There Are Any Adverse Effects / Healthy Volunteers	1
Not Available	Completed	Supportive Care	Nausea / Vomiting	1
Not Available	Completed	Treatment	Benign Paroxysmal Positional Vertigo (BPPV)	1
Not Available	Completed	Treatment	Endometriosis	1
Not Available	Completed	Treatment	Endoscopy / Sedation therapy	1
Not Available	Completed	Treatment	Itching	1
Not Available	Completed	Treatment	Pain	1
Not Available	Enrolling by Invitation	Treatment	Migrainous Headache	1
Not Available	Recruiting	Treatment	Alcohol-Related Disorders / Brain Injury / Chronic Diseases / Depressive State / Mild Cognitive Impairment (MCI) / Pain / Posttraumatic Stress Disorders / Quality of Life / Substance-Related Disorders / Suicidal Ideation / Wounds and Injuries	1
Not Available	Recruiting	Treatment	Anxiety Disorder / Moods Disorders / Pain Disorders / Somatization Disorder	1
Not Available	Suspended	Diagnostic	Bulimia Nervosa (BN) / Catechol-O-methyltransferase / Dopamine / Eating Disorders / Reward	1
Not Available	Terminated	Treatment	Human Immunodeficiency Virus (HIV) Infections	1
Not Available	Terminated	Treatment	Primary Headaches (Includes Migraines, Tension, Cluster Headaches)	1
Not Available	Unknown Status	Supportive Care	Endoscopic Retrograde Cholangiopancreatography (ERCP) / Endoscopic Ultrasound (EUS)	1
Not Available	Unknown Status	Treatment	Post Operative Nausea and Vomiting (PONV) / Rescue Emetic Therapy	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Advance Pharmaceutical
Advent Pharmaceuticals Inc.
Amend
APP Pharmaceuticals
A-S Medication Solutions LLC
Auriga Pharmaceuticals LLC
Barr Pharmaceuticals
Baxter International Inc.
Bergen Brunswig
Bioniche Pharma
Bryant Ranch Prepack
C.O. Truxton Inc.
Cardinal Health
Carlisle Laboratories Inc.
Chattem Chemicals Inc.
Concord Labs
Consolidated Midland Corp.
Contract Pharm
CVS Pharmacy
Darby Dental Supply Co. Inc.
Dept Health Central Pharmacy
Direct Dispensing Inc.
DispenseXpress Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Eon Labs
Equaline Vitamins
Fusion Pharmaceuticals LLC
General Injectables and Vaccines Inc.
GlaxoSmithKline Inc.
Goldline Laboratories Inc.
Group Health Cooperative
Hawthorn Pharmaceuticals
Heartland Repack Services LLC
Hospira Inc.
Innoviant Pharmacy Inc.
Ivax Pharmaceuticals
Kraft Pharmaceutical Co. Inc.
Liberty Pharmaceuticals
Lnk International Inc.
Major Pharmaceuticals
Martin Surgical Supply
McNeil Laboratories
Medique Products
Medtech Labs
Merit Pharmaceuticals
Midlothian Labs
Mississippi State Dept Health
Murfreesboro Pharmaceutical Nursing Supply
Nexgen Pharma Inc.
North Safety Products
Nucare Pharmaceuticals Inc.
Patient First Corp.
PCA LLC
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Pfizer Inc.
Pharmaceutical Association
Pharmedix
Physicians Total Care Inc.
Poly Pharmaceuticals Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Prescript Pharmaceuticals
Procter & Gamble
Provident Pharmaceuticals LLC
Remedy Repack
Rite Aid Corp.
River's Edge Pharmaceuticals
Rugby Laboratories
Sandhills Packaging Inc.
Scientific Laboratories Inc.
Silarx Pharmaceuticals
Southwood Pharmaceuticals
St Mary's Medical Park Pharmacy
Tya Pharmaceuticals
UDL Laboratories
United Research Laboratories Inc.
Vangard Labs Inc.
Walgreen Co.

Dosage forms

Form	Route	Strength
Liquid	Oral	50 mg/30mL
Capsule; kit	Oral
Cream	Topical	20 mg/mL
Cream	Topical	2 mL/100mL
Powder	Oral
Powder	Oral	25 mg/1
Liquid	Oral	12.5 mg
Tablet, coated	Oral	24 mg/1
Tablet, chewable	Oral	12.5 mg/1
Tablet, film coated	Oral	25 mg/1
Solution	Oral	12.5 mg
Gel	Topical	2 g/100g
Cream	Topical	2.0 %
Spray	Topical
Patch	Topical
Kit
Tablet	Oral	25 mg
Tablet, coated	Oral	25 mg/1
Tablet, chewable	Oral	12.5 mg
Liquid	Topical
Liquid	Oral	6.25 mg
Cream	Topical	2 %
Elixir	Oral	12.5 mg
Gel	Topical	20 mg/mL
Tablet, chewable	Oral	25 mg
Gel	Topical	2 %
Tablet	Oral	25 mg/250mg
Strip	Oral	25 mg
Lotion	Topical
Tablet	Oral	19 mg
Strip	Oral	19 mg
Suspension	Oral
Tablet	Oral	12.5 mg/1
Liquid	Oral
Liquid	Oral	12.5 mg/5mL
Ointment	Topical
Kit	Topical
Kit	Oral
Tablet	Oral	38.0 mg
Capsule	Oral	25 mg/1
Capsule, coated	Oral	25 mg/1
Injection, solution	Intravenous	50 mg/mL
Capsule, liquid filled	Oral	20 mg/1
Tablet	Oral	50 mg/1
Capsule, gelatin coated	Oral	25 mg/1
Syrup	Oral	6.25 mg
Liquid	Intravenous	50 mg
Elixir	Oral	12.5 mg/5mL
Elixir	Oral	25 mg/10mL
Injection	Intramuscular	50 mg/mL
Injection	Intramuscular; Intravenous	50 mg/mL
Injection, solution	Intramuscular; Intravenous	50 mg/mL
Solution	Oral	25 mg/10mL
Solution	Oral	50 mg/20mL
Kit	Oral; Topical
Tablet	Oral
Tablet, film coated	Oral
Solution	Oral	50 mg/40mL
Kit	Oral
Aerosol, spray	Topical
Solution	Oral	12.5 mg/5mL
Tablet, coated	Oral
Tablet	Oral	25 mg/1
Capsule, coated	Oral
Capsule, liquid filled	Oral	25 mg/1
Solution	Oral	50 mg/30mL
Capsule, liquid filled	Oral
Liquid	Topical	20.3 g/L
Spray	Topical	2 g/100mL
Aerosol	Topical
Solution	Topical
Gel	Topical	2 g/100mL
Strip	Oral	12.5 mg
Tablet	Oral	12.5 mg
Tablet, orally disintegrating	Oral	12.5 mg/1
Liniment	Topical
Lozenge	Oral	25 mg
Strip	Oral
Capsule	Oral	25 mg
Solution	Oral	50 mg
Capsule	Oral	50 mg/1
Tablet, film coated	Oral	50 mg/1
Capsule, liquid filled	Oral	50 mg/21
Tablet	Oral	50 mg
Capsule, gelatin coated	Oral
Elixir	Oral	2.5 mg
Liquid	Intramuscular; Intravenous	50 mg
Syrup	Oral	12.5 mg/5mL
Gel	Topical	20.5 mg/mL
Solution	Oral
Plaster	Topical
Solution	Intramuscular; Intravenous	50 mg
Gel	Topical	.2 g/10mL
Capsule, liquid filled	Oral	50 mg/1
Tablet, coated	Oral	50 mg/1
Gel	Topical
Gel	Topical	20 mg/g
Spray	Topical	20 mg/mL
Powder, for solution	Oral
Syrup	Oral
Kit; tablet	Oral
Kit
Capsule	Oral	50 mg
Tablet, chewable	Oral	25 mg/1
Liquid	Oral	6.25 mg/mL
Cream	Topical
Liquid	Oral	25 mg/10mL
Capsule	Oral
Capsule, gelatin coated	Oral	50 mg/21
Granule, for solution	Oral
Spray	Topical	2.0 %
Liquid	Oral	50 mg

Prices

Unit description	Cost	Unit
DiphenhydrAMINE HCl 100 50 mg capsule Bottle	13.99USD	bottle
Diphenhydramine 50 mg/ml	3.94USD	ml
Diphenhydramine 50 mg/ml vial	1.69USD	ml
DiphenhydrAMINE HCl 50 mg/ml vial	1.44USD	vial
Dytan 25 mg tablet chewable	1.37USD	tablet
Benadryl 50 mg/ml vial	1.36USD	ml
Diphenmax 25 mg tablet	1.24USD	tablet
Benadryl allergy 25 mg strips	0.45USD	strip
Unisom sleep aid tablet	0.34USD	tablet
Sleep-eze 3 tablet	0.29USD	tablet
Compoz 50 mg tablet	0.27USD	tablet
Sominex max str 50 mg caplet	0.27USD	caplet
Benadryl allergy fastmelt tablet	0.26USD	tablet
Unisom 25 mg sleeptabs	0.25USD	tablet
Unisom 50 mg sleepgels	0.25USD	each
Unisom sleepmelts 25 mg tablet	0.24USD	tablet
Nytol 25 mg tablet	0.23USD	tablet
Benadryl allergy-sinus caplet	0.22USD	caplet
Compoz 25 mg gelcap	0.2USD	capsule
Benadryl allergy 25 mg softgel	0.19USD	softgel capsule
Benadryl allergy 25 mg ultratab	0.19USD	tablet
Benadryl allergy-cold kapgels	0.19USD	each
Benadryl allergy-sinus kapgels	0.19USD	each
Benadryl-d allergy-sinus ultratab	0.19USD	tablet
Diphenhydramine hcl powder	0.17USD	g
Eql allergy 25 mg tablet	0.17USD	tablet
Nighttime sleep aid 25 mg cplt	0.17USD	caplet
Banophen anti-itch 2% cream	0.16USD	g
Benadryl itch relief stick	0.16USD	ml
Sominex 25 mg tablet	0.16USD	tablet
Benadryl allergy 25 mg kapgels	0.15USD	each
Allergy 25 mg tablet	0.14USD	tablet
Benadryl 25 mg kapseals	0.14USD	each
Benadryl itch stopping crm	0.14USD	g
DiphenhydrAMINE HCl 25 mg capsule	0.13USD	capsule
Diphenhist with zinc cream	0.12USD	g
Ra allergy 25 mg tablet	0.12USD	tablet
CVS Pharmacy allergy 25 mg tablet	0.11USD	tablet
Diphenhydramine 25 mg minitab	0.11USD	tablet
Simply sleep 25 mg caplet	0.11USD	caplet
Sleep ii tablet	0.11USD	tablet
Diphenhydramine 50 mg capsule	0.1USD	capsule
Benadryl 2% spray	0.09USD	ml
Diphenhist 50 mg tablet	0.09USD	tablet
Genahist 25 mg tablet	0.09USD	tablet
Ra sleep tablet	0.09USD	tablet
Banophen 25 mg tablet	0.08USD	tablet
Wal-dryl anti-itch spray	0.08USD	ml
CVS Pharmacy allergy 25 mg caplet	0.07USD	caplet
Nighttime sleep aid 25 mg caplet	0.07USD	caplet
CVS Pharmacy itch relief spray	0.06USD	ml
Diphen 25 mg capsule	0.06USD	capsule
Diphenhist 25 mg caplet	0.06USD	caplet
Benadryl anti-itch 0.45% gel	0.05USD	g
Diphenhydramine 50 mg caplet	0.05USD	caplet
Benadryl itch stopping gel	0.04USD	g
Child benadryl-d aller-sin liquid	0.04USD	ml
Diphenhydramine 25 mg capsule	0.04USD	capsule
Vicks 44d cough & head liquid	0.03USD	ml
Vicks 44e cough & chest liquid	0.03USD	ml
Banophen allergy liquid	0.02USD	ml
Diphenhydramine 25 mg tablet	0.02USD	tablet
Ra anti-tussive dm syrup	0.02USD	ml
Siladryl 12.5 mg/5 ml liquid	0.02USD	ml
Silphen cough syrup	0.02USD	ml
Silphen dm cough syrup	0.02USD	ml

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US8263647	No	2002-05-30	2022-05-30	US
US8883849	No	2002-01-17	2022-01-17	US
US9155718	No	2002-01-17	2022-01-17	US

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	161-162	Martin, H., Hafliger, F.,Gatzi, K.and Grob, A.; U.S. Patent 2,397,799; April 2,1946; assigned to J.R. Geigy AG, Switzerland. Rieveschl, G. Jr.; U.S. Patent 2,421,714; June 3,1947; assigned to Parke, Davis & Co. Rieveschl, G. Jr.; U.S. Patent 2,427,878; September 23,1947; assigned to Parke, Davis & Company.
boiling point (°C)	150-165 °C at 2.00E+00 mm Hg	PhysProp
water solubility	3060 mg/L (at 37 °C)	BEILSTEIN
logP	3.27	HANSCH,C ET AL. (1995)
pKa	8.98	SANGSTER (1994)

Predicted Properties

Property	Value	Source
Water Solubility	0.0752 mg/mL	ALOGPS
logP	3.44	ALOGPS
logP	3.65	ChemAxon
logS	-3.5	ALOGPS
pKa (Strongest Basic)	8.87	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	12.47 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	79.93 m³·mol^-1	ChemAxon
Polarizability	29.86 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9898
Blood Brain Barrier	+	0.9381
Caco-2 permeable	+	0.8744
P-glycoprotein substrate	Substrate	0.6211
P-glycoprotein inhibitor I	Non-inhibitor	0.6632
P-glycoprotein inhibitor II	Non-inhibitor	0.8381
Renal organic cation transporter	Inhibitor	0.7752
CYP450 2C9 substrate	Non-substrate	0.7897
CYP450 2D6 substrate	Substrate	0.8919
CYP450 3A4 substrate	Substrate	0.6173
CYP450 1A2 substrate	Inhibitor	0.8306
CYP450 2C9 inhibitor	Non-inhibitor	0.9144
CYP450 2D6 inhibitor	Inhibitor	0.8932
CYP450 2C19 inhibitor	Non-inhibitor	0.9039
CYP450 3A4 inhibitor	Non-inhibitor	0.934
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.7293
Ames test	Non AMES toxic	0.9132
Carcinogenicity	Non-carcinogens	0.6495
Biodegradation	Not ready biodegradable	0.9253
Rat acute toxicity	2.7846 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.536
hERG inhibition (predictor II)	Inhibitor	0.6318

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum Type	Description	Splash Key
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)	splash10-0006-0090000000-a71e531b49571f09ab25	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)	splash10-00kk-0980000000-cce91896f34562beeffa	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)	splash10-001i-1900000000-4c29bd5e0eab94596eaa	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - EI-B (Unknown) , Positive	splash10-0a4i-9100000000-ab642e8f86de11af896c	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-0ccd6de9ca58593fd490	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-3568aae4c27ffe333c0e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-22e0c745355c836f1535	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-6bb69a66a343440c64f8	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-1b87d83415d22bb17f1b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0gb9-0900000000-50251362d768cd1b1c4f	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0gb9-0900000000-9f37a733a05f5b01d313	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-014i-0900000000-7d73b95ed09ea2d72260	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0gb9-2900000000-1666a8ab5a6d81c0bd01	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-014i-0900000000-3f31841d858381760f03	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-014i-0900000000-de872e048c7e12cef490	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-014i-0900000000-de872e048c7e12cef490	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-014i-0900000000-789a4a3fe118d5bf2456	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-014i-2900000000-8ef94659f614b9ff24ca	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0002-2950000000-7c7a9841f2f0b6428d69	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	Not Available
MS	Mass Spectrum (Electron Ionization)	splash10-0a4i-9200000000-b9014c8fc8ccbba24163	View in MoNA
1D NMR	1H NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of chemical entities known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.

Kingdom

Chemical entities

Super Class

Organic compounds

Class

Benzenoids

Sub Class

Benzene and substituted derivatives

Direct Parent

Diphenylmethanes

Alternative Parents

Benzylethers / Trialkylamines / Dialkyl ethers / Organopnictogen compounds / Hydrocarbon derivatives

Substituents

Diphenylmethane / Benzylether / Tertiary aliphatic amine / Tertiary amine / Ether / Dialkyl ether / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound / Hydrocarbon derivative

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

tertiary amino compound, ether (CHEBI:4636 ) / a small molecule (CPD-10890 )

Targets

Details

1. Histamine H1 receptor

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: antagonist

General Function:: Histamine receptor activity
Specific Function:: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:: HRH1
Uniprot ID:: P35367
Molecular Weight:: 55783.61 Da

References

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Piao H, Nagai S, Tsurumaki T, Niki T, Higuchi H: Potentiation by neuropeptide Y of histamine H1 receptor-mediated contraction in rat blood vessels. Vascul Pharmacol. 2007 Apr;46(4):260-70. Epub 2006 Oct 27. [PubMed:17169617 ]
Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. [PubMed:16702624 ]
Hasala H, Moilanen E, Janka-Junttila M, Giembycz MA, Kankaanranta H: First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis. Allergy Asthma Proc. 2007 Jan-Feb;28(1):79-86. [PubMed:17390763 ]
Wang Z, Woolverton WL: Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects. Eur J Pharmacol. 2007 Feb 28;557(2-3):159-60. Epub 2006 Dec 1. [PubMed:17196194 ]
Ishikawa T, Takechi K, Rahman A, Ago J, Matsumoto N, Murakami A, Kamei C: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats. Biol Pharm Bull. 2007 Mar;30(3):477-80. [PubMed:17329841 ]
Havas TE, Cole P, Parker L, Oprysk D, Ayiomamitis A: The effects of combined H1 and H2 histamine antagonists on alterations in nasal airflow resistance induced by topical histamine provocation. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):856-60. [PubMed:2878016 ]

Details

2. Muscarinic acetylcholine receptor M2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: antagonist

General Function:: G-protein coupled acetylcholine receptor activity
Specific Function:: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then trigge...
Gene Name:: CHRM2
Uniprot ID:: P08172
Molecular Weight:: 51714.605 Da

References

Liu H, Zheng Q, Farley JM: Antimuscarinic actions of antihistamines on the heart. J Biomed Sci. 2006 May;13(3):395-401. [PubMed:16453179 ]

Enzymes

Details

1. Cytochrome P450 2D6

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Steroid hydroxylase activity
Specific Function:: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:: CYP2D6
Uniprot ID:: P10635
Molecular Weight:: 55768.94 Da

References

Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. [PubMed:9616188 ]
Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

2. Cytochrome P450 1A2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:: CYP1A2
Uniprot ID:: P05177
Molecular Weight:: 58293.76 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Details

3. Cytochrome P450 2C9

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:: CYP2C9
Uniprot ID:: P11712
Molecular Weight:: 55627.365 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Details

4. Cytochrome P450 2C19

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid hydroxylase activity
Specific Function:: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:: CYP2C19
Uniprot ID:: P33261
Molecular Weight:: 55930.545 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Details

5. Cytochrome P450 2C18

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP2C18
Uniprot ID:: P33260
Molecular Weight:: 55710.075 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Details

6. Cytochrome P450 2B6

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:: CYP2B6
Uniprot ID:: P20813
Molecular Weight:: 56277.81 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Details

7. Prostaglandin G/H synthase 1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Prostaglandin-endoperoxide synthase activity
Specific Function:: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:: PTGS1
Uniprot ID:: P23219
Molecular Weight:: 68685.82 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Transporters

Details

1. Solute carrier family 22 member 2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Quaternary ammonium group transmembrane transporter activity
Specific Function:: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:: SLC22A2
Uniprot ID:: O15244
Molecular Weight:: 62579.99 Da

References

Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]

Details

2. Solute carrier family 22 member 1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Secondary active organic cation transmembrane transporter activity
Specific Function:: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:: SLC22A1
Uniprot ID:: O15245
Molecular Weight:: 61153.345 Da

References

Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. [PubMed:11758759 ]

Details

3. Solute carrier family 22 member 5

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Symporter activity
Specific Function:: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:: SLC22A5
Uniprot ID:: O76082
Molecular Weight:: 62751.08 Da

References

Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]

Drug created on June 13, 2005 07:24 / Updated on July 21, 2017 17:47

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Structure for DB01075 (Diphenhydramine)

Targets

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Enzymes

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Transporters

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