The complete islet amyloid polypeptide precursor is encoded by two exons.
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Mosselman S, Hoppener JW, Lips CJ, Jansz HS
The complete islet amyloid polypeptide precursor is encoded by two exons.
FEBS Lett. 1989 Apr 10;247(1):154-8.
- PubMed ID
- 2651160 [ View in PubMed]
- Abstract
Islet amyloid polypeptide (IAPP) is the 37-amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227-232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89-amino acid pre-pro-IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino-terminus of the precursor suggests that IAPP is a secreted protein.