A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.
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Westermark P, Wernstedt C, Wilander E, Sletten K
A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.
Biochem Biophys Res Commun. 1986 Nov 14;140(3):827-31.
- PubMed ID
- 3535798 [ View in PubMed]
- Abstract
Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).