Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein.
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Cohen DE, Green RM, Wu MK, Beier DR
Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein.
Biochim Biophys Acta. 1999 Oct 28;1447(2-3):265-70.
- PubMed ID
- 10542325 [ View in PubMed]
- Abstract
Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11.