Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.
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March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, et al.
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.
Nature. 1985 Jun 20-26;315(6021):641-7.
- PubMed ID
- 2989698 [ View in PubMed]
- Abstract
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.